David Malkin

David Malkin

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David Malkin

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An eHealth decision-support tool to prioritize referral practices for genetic evaluation of patients with Wilms tumor.

Int J Cancer 2019 Jul 8. Epub 2019 Jul 8.

Division of Hematology-Oncology, Montreal Children's Hospital, Department of Pediatrics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1002/ijc.32561DOI Listing
July 2019

Management of orbital rhabdomyosarcoma in a child with Li-Fraumeni syndrome.

J AAPOS 2019 Jun 8;23(3):182-185. Epub 2019 Apr 8.

Department of Ophthalmology, The Hospital for Sick Children, Toronto, Ontario.

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https://linkinghub.elsevier.com/retrieve/pii/S10918531193006
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http://dx.doi.org/10.1016/j.jaapos.2019.01.013DOI Listing
June 2019

Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome.

Pediatr Blood Cancer 2019 May 4;66(5):e27629. Epub 2019 Feb 4.

Program in Personalized Health, University of Utah, Salt Lake City, Utah.

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http://dx.doi.org/10.1002/pbc.27629DOI Listing
May 2019

Aggressive embryonal rhabdomyosarcoma in a 3-month-old boy: A clinical and molecular analysis.

Pediatr Hematol Oncol 2018 Oct - Nov;35(7-8):407-414. Epub 2019 Feb 26.

a Division of Haematology/Oncology, The Hospital for Sick Children, Department of Pediatrics , University of Toronto , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/08880018.2019.1569185DOI Listing
April 2019

Second rhabdoid tumor 8 years after treatment of atypical teratoid/rhabdoid tumor in a child with germline SMARCB1 mutation.

Pediatr Blood Cancer 2019 Mar 4;66(3):e27546. Epub 2018 Nov 4.

Pediatric Brain Tumour Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pbc.27546
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http://dx.doi.org/10.1002/pbc.27546DOI Listing
March 2019

Medulloblastoma.

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

Report of a bi-allelic truncating germline mutation in TP53.

Fam Cancer 2019 01;18(1):101-104

Murdoch Children's Research Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s10689-018-0087-1DOI Listing
January 2019

"A change in perspective": Exploring the experiences of adolescents with hereditary tumor predisposition.

Pediatr Blood Cancer 2019 Jan 11;66(1):e27445. Epub 2018 Sep 11.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27445DOI Listing
January 2019

Retrospective evaluation of a decision-support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors.

Pediatr Blood Cancer 2018 12 16;65(12):e27390. Epub 2018 Aug 16.

Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/pbc.27390
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http://dx.doi.org/10.1002/pbc.27390DOI Listing
December 2018

Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9.

Nucleic Acids Res 2018 09;46(17):9252

Departments of Pediatrics, Microbiology & Immunology, and Pathology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.

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http://dx.doi.org/10.1093/nar/gky674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158599PMC
September 2018

Evidence for genetic anticipation in vonHippel-Lindau syndrome.

J Med Genet 2018 06 7;55(6):395-402. Epub 2018 Feb 7.

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2017-104882DOI Listing
June 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

Pediatric oncologist willingness to offer germline TP53 testing in osteosarcoma.

Cancer 2018 03 3;124(6):1242-1250. Epub 2018 Jan 3.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.31212DOI Listing
March 2018

Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.

Cell Stem Cell 2018 03;22(3):414-427.e6

Molecular Pathology, Cancer Center, and Regenerative Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02129, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354590PMC
March 2018

DICER1 syndrome: Approach to testing and management at a large pediatric tertiary care center.

Pediatr Blood Cancer 2018 Jan 27;65(1). Epub 2017 Sep 27.

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26720DOI Listing
January 2018

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

The Future of Surveillance in the Context of Cancer Predisposition: Through the Murky Looking Glass.

Clin Cancer Res 2017 Nov;23(21):e133-e137

Children's Hospital of Philadelphia, and the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2026DOI Listing
November 2017

Pediatric imaging in DICER1 syndrome.

Pediatr Radiol 2017 Sep 4;47(10):1292-1301. Epub 2017 May 4.

Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00247-017-3875-0DOI Listing
September 2017

Executive function in paediatric medulloblastoma: The role of cerebrocerebellar connections.

J Neuropsychol 2017 06 4;11(2):174-200. Epub 2015 Aug 4.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/jnp.12082DOI Listing
June 2017

The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma.

Cell Rep 2017 06;19(11):2304-2318

Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Center of Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Stem Cell Institute, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563075PMC
June 2017

Inherited Mutations and the Li-Fraumeni Syndrome.

Cold Spring Harb Perspect Med 2017 Apr 3;7(4). Epub 2017 Apr 3.

Division of Hematology/Oncology and Genetics and Genome Biology Program, The Hospital for Sick Children; Departments of Pediatrics and Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1101/cshperspect.a026187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378014PMC
April 2017

Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk.

Hum Mutat 2017 03 23;38(3):265-268. Epub 2017 Jan 23.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.23154DOI Listing
March 2017

Underlying undiagnosed inherited marrow failure syndromes among children with cancer.

Pediatr Blood Cancer 2017 02 31;64(2):302-305. Epub 2016 Aug 31.

Marrow Failure and Myelodysplasia Program, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26120DOI Listing
February 2017

Intellectual Outcome in Molecular Subgroups of Medulloblastoma.

J Clin Oncol 2016 12 31;34(34):4161-4170. Epub 2016 Oct 31.

Iska Moxon-Emre, Michael D. Taylor, Eric Bouffet, David Malkin, Cynthia Hawkins, Normand Laperriere, Vijay Ramaswamy, Ute Bartels, Nadia Scantlebury, Laura Janzen, Nicole Law, and Donald J. Mabbott, Hospital for Sick Children; Iska Moxon-Emre, Michael D. Taylor, David Malkin, Cynthia Hawkins, Normand Laperriere, Laura Janzen, Nicole Law, and Donald J. Mabbott, University of Toronto; Iska Moxon-Emre and David Malkin, Pediatric Oncology Group of Ontario; Normand Laperriere, Princess Margaret Hospital, Toronto, ON, Canada; Kristina Hardy and Karin S. Walsh, Children's National Health System, Washington, DC; and Cynthia J. Campen, Lucile Packard Children's Hospital, Palo Alto, CA.

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http://dx.doi.org/10.1200/JCO.2016.66.9077DOI Listing
December 2016

p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis.

Cell Cycle 2016 Dec 18;15(23):3210-3219. Epub 2016 Oct 18.

a Department of Medical Biophysics , University of Toronto , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/15384101.2016.1241917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176156PMC
December 2016

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Biochemical and imaging surveillance in Li-Fraumeni syndrome - Authors' reply.

Lancet Oncol 2016 11;17(11):e473

The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30525-3DOI Listing
November 2016

Genome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.

J Clin Oncol 2016 Oct;34(30):3697-3704

Nardin Samuel, Gavin Wilson, James Tran, Meredith Irwin, Rosanna Weksberg, Thomas J. Hudson, and David Malkin, University of Toronto; Nardin Samuel, Badr Id Said, Youliang Lou, Weili Li, Ana Novokmet, James Tran, Sanaa Choufani, Marc Remke, Vijay Ramaswamy, Florence M.G. Cavalli, Michael D. Taylor, Uri Tabori, Meredith Irwin, Rosanna Weksberg, Jonathan D. Wasserman, Andrew D. Paterson, and David Malkin, The Hospital for Sick Children; Nardin Samuel, Gavin Wilson, Mathieu Lemire, and Thomas J. Hudson, Ontario Institute for Cancer Research; Christine Elser, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Diana Merino, National Institutes of Health, Bethesda, MD; Kim E. Nichols, St Jude Children's Research Hospital, Memphis, TN; Jonathan L. Finlay, Nationwide Children's Hospital, Columbus, OH; Lynn Meister, Joe DiMaggio Children's Hospital, Hollywood, FL; Jordan R. Hansford, Children's Cancer Centre, Royal Children's Hospital, Melbourne, Victoria, Australia; and Maria Isabel W. Achatz, Hospital AC Camargo, São Paulo, Brazil.

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http://dx.doi.org/10.1200/JCO.2016.67.6940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366343PMC
October 2016

Super-Transactivation TP53 Variant in the Germline of a Family with Li-Fraumeni Syndrome.

Hum Mutat 2016 09 27;37(9):889-92. Epub 2016 Jun 27.

Department of Pediatrics, Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/humu.23025DOI Listing
September 2016

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study.

Lancet Oncol 2016 Sep 5;17(9):1295-305. Epub 2016 Aug 5.

Department of Pediatrics, University of Toronto, Toronto, ON, Canada; Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada; Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30249-2DOI Listing
September 2016

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.

J Clin Oncol 2016 07 21;34(19):2206-11. Epub 2016 Mar 21.

Eric Bouffet, Brittany B. Campbell, Daniele Merico, Richard de Borja, Carol Durno, Joerg Krueger, Vanja Cabric, Vijay Ramaswamy, Nataliya Zhukova, Peter Dirks, Michael Taylor, David Malkin, Cynthia E. Hawkins, Adam Shlien, and Uri Tabori, The Hospital for Sick Children, Toronto; Melyssa Aronson, and Zane Cohen, Zane Cohen Centre for Digestive Diseases, Mount Sinai, Ontario; Valérie Larouche and Rachel Laframboise, Université Laval, Quebec City; Jeffrey Atkinson, Montreal Children's Hospital; Steffen Albrecht, Roy W.R. Dudley, and Nada Jabado, McGill University, Montreal, Montreal, Quebec; Samina Afzal, IWK Health Centre, Halifax, Nova Scotia; Vanan Magimairajan, Cancer Care Manitoba and University of Manitoba, Winnipeg, Manitoba, Canada; Gary Mason, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA; Roula Farah, Saint George Hospital University Medical Center, Beirut, Lebanon; Michal Yalon and Gideon Rechavi, Sheba Medical Center, Tel Hashomer; Shlomi Constantini, Rina Dvir, and Ronit Elhasid, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Michael F. Walsh, Memorial Sloan Kettering Center, New York, NY; Alyssa Reddy, University of Alabama at Birmingham, Birmingham, AL; Michael Osborn, Women's and Children's Hospital, North Adelaide, South Australia; Michael Sullivan, Jordan Hansford, and Andrew Dodgshun, Royal Children's Hospital, Melbourne, Victoria, Australia; and Nancy Klauber-Demore, Lindsay Peterson, Sunil Patel, and Scott Lindhorst, Medical University of South Carolina, Charleston, SC.

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http://dx.doi.org/10.1200/JCO.2016.66.6552DOI Listing
July 2016

Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group.

Pediatr Blood Cancer 2016 Jun 23;63(6):973-82. Epub 2016 Feb 23.

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.25939DOI Listing
June 2016

Somatic DICER1 mutations in adult-onset pulmonary blastoma.

Eur Respir J 2016 06 28;47(6):1879-82. Epub 2016 Apr 28.

Dept of Human Genetics, McGill University, Montreal, QC, Canada Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada Dept of Medical Genetics, Research Institute of the McGill University Health Centre, Montreal, QC, Canada Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.1183/13993003.00172-2016DOI Listing
June 2016

CANCER. The cancer predisposition revolution.

Science 2016 May;352(6289):1052-3

Sage Bionetworks, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/science.aag0832DOI Listing
May 2016

Translational Childhood Cancer Genomics: The Future Is Now.

JAMA Oncol 2016 Mar;2(3):384-5

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada4Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada5The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children.

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http://dx.doi.org/10.1001/jamaoncol.2015.5076DOI Listing
March 2016

Li-Fraumeni Syndrome and p53 in 2015: Celebrating their Silver Anniversary.

Authors:
David Malkin

Clin Invest Med 2016 Feb 1;39(1):E37-47. Epub 2016 Feb 1.

.

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February 2016

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

Predisposition to pediatric and hematologic cancers: a moving target.

Am Soc Clin Oncol Educ Book 2014 :e44-55

From the Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA; and Division of Pediatric Hematology/Oncology, Department of Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e44DOI Listing
December 2015

Management of Acute Myeloblastic Leukemia in a Child With Biallelic Mismatch Repair Deficiency.

J Pediatr Hematol Oncol 2015 Nov;37(8):e490-3

*Department of Pediatric Hemato-Oncology †The Gilbert Israeli Neurofibromatosis Center (GINFC) ‡Department of Pathology, Diagnostic and Research Cancer Center, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel §Division of Hematology/Oncology, Institute of Medical Sciences ¶Department of Laboratory Medicine and Pathobiology, Division of Pathology, The Hospital for Sick Children, The University of Toronto ∥Zane Cohen Centre, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/MPH.0000000000000415DOI Listing
November 2015

Visualization and segmentation of reciprocal cerebrocerebellar pathways in the healthy and injured brain.

Hum Brain Mapp 2015 Jul 14;36(7):2615-28. Epub 2015 Apr 14.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/hbm.22795DOI Listing
July 2015

Genotype Versus Phenotype: The Yin and Yang of Germline TP53 Mutations in Li-Fraumeni Syndrome.

J Clin Oncol 2015 Jul 22;33(21):2331-3. Epub 2015 Jun 22.

The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://ascopubs.org/doi/10.1200/JCO.2015.61.5757
Publisher Site
http://dx.doi.org/10.1200/JCO.2015.61.5757DOI Listing
July 2015

Ovarian embryonal rhabdomyosarcoma is a rare manifestation of the DICER1 syndrome.

Hum Pathol 2015 Jun 5;46(6):917-22. Epub 2015 Mar 5.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 0G4; Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2; Department of Medical Genetics, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada H3H 2R9; Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada H2W 1S6. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2015.02.008DOI Listing
June 2015

A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome.

Cancer Genet 2015 Jan-Feb;208(1-2):47-51. Epub 2014 Dec 31.

Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2014.12.003DOI Listing
May 2015

Phenotypic and genotypic characterisation of biallelic mismatch repair deficiency (BMMR-D) syndrome.

Eur J Cancer 2015 May 13;51(8):977-83. Epub 2015 Apr 13.

Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ejca.2015.02.008DOI Listing
May 2015

Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.

Cancer Cell 2015 May;27(5):712-27

Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458854PMC
May 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.

J Clin Oncol 2015 Mar 9;33(9):1015-22. Epub 2015 Feb 9.

Matthew Mistry, Nataliya Zhukova, Daniele Merico, Rahul Krishnatry, Mary Shago, James Stavropoulos, Noa Alon, Peter N. Ray, Vilma Navickiene, Joshua Mangerel, Marc Remke, Vijay Ramaswamy, Ana Guerreiro Stucklin, Martin Li, Edwin J. Young, Cindy Zhang, Pedro Castelo-Branco, Doua Bakry, Suzanne Laughlin, James T. Rutka, Peter B. Dirks, Michael D. Taylor, Mark Greenberg, David Malkin, Annie Huang, Eric Bouffet, Cynthia E. Hawkins, and Uri Tabori; The Hospital for Sick Children; Matthew Mistry, Patricia Rakopoulos, Rahul Krishnatry, Joshua Mangerel, Pawel Buczkowicz, Ana Guerreiro Stucklin, Doua Bakry, Adam Shlien, Mark Greenberg, David Malkin, Annie Huang, Eric Bouffet, Cynthia E. Hawkins, and Uri Tabori, University of Toronto; Jason D. Pole, Pediatric Oncology Group of Ontario, Toronto, Ontario; Jennifer Chan, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Pedro Castelo-Branco, Universidade do Algarve, Faro, Portugal; Keith L. Ligon, Dana-Farber/Boston Children's Cancer Center, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2014.58.3922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356711PMC
March 2015

Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study.

J Clin Oncol 2015 Feb 12;33(6):602-9. Epub 2015 Jan 12.

Jonathan D. Wasserman, Ana Novokmet, Claudia Eichler-Jonsson, and David Malkin, The Hospital for Sick Children; Jonathan D. Wasserman and David Malkin, University of Toronto; Jonathan D. Wasserman and David Malkin, SickKids Research Institute, Toronto, Ontario, Canada; Raul C. Ribeiro and Gerard P. Zambetti, St Jude Children's Research Hospital, Memphis, TN; and Carlos Rodriguez-Galindo, Dana-Farber/Children's Hospital Cancer Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2013.52.6863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517369PMC
February 2015

Parent decision-making around the genetic testing of children for germline TP53 mutations.

Cancer 2015 Jan 15;121(2):286-93. Epub 2014 Sep 15.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.29027DOI Listing
January 2015

p53 and hereditary cancer.

Subcell Biochem 2014 ;85:1-16

Division of Hematology/Oncology, Program in Genetics and Genome Biology, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-94-017-9211-0_1DOI Listing
December 2014

Management of familial cancer: sequencing, surveillance and society.

Nat Rev Clin Oncol 2014 12 14;11(12):723-31. Epub 2014 Oct 14.

1] Department of Medical Biophysics, University of Toronto, Division of Hematology/Oncology and Genetics &Genome Biology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. [2] Department of Pediatrics and Institute of Medical Science, University of Toronto, Division of Hematology/Oncology and Genetics &Genome Biology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2014.169DOI Listing
December 2014

Surveillance for children at genetic risk for cancer: are we ready?

Authors:
David Malkin

Pediatr Blood Cancer 2014 Aug 11;61(8):1337-8. Epub 2014 Apr 11.

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario; Departments of Pediatrics and Medical Biophysics, University of Toronto, Toronto, Ontario.

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http://dx.doi.org/10.1002/pbc.25061DOI Listing
August 2014

De-escalation of therapy for pediatric medulloblastoma: trade-offs between quality of life and survival.

Pediatr Blood Cancer 2014 Jul 24;61(7):1300-4. Epub 2014 Feb 24.

Centre for Health Evaluation and Outcome Sciences, Providence Health Care Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/pbc.24990DOI Listing
July 2014

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.

Cancer Cell 2014 Jul 19;26(1):33-47. Epub 2014 Jun 19.

Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, Hospital for Sick Children (HSC), Toronto, ON M5G 1L7, Canada; Program in Developmental and Stem Cell Biology, HSC, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441014PMC
July 2014

Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma.

J Clin Oncol 2014 Jun 10;32(17):1760-8. Epub 2014 Feb 10.

Iska Moxon-Emre, Eric Bouffet, Michael D. Taylor, Nadia Scantlebury, Nicole Law, Brenda J. Spiegler, David Malkin, Laura Janzen, and Donald Mabbott, Hospital for Sick Children; Iska Moxon-Emre, Michael D. Taylor, Normand Laperriere, Brenda J. Spiegler, David Malkin, and Laura Janzen, University of Toronto; and Normand Laperriere, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://jco.ascopubs.org/content/early/2014/02/10/JCO.2013.52
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.52.3290
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http://dx.doi.org/10.1200/JCO.2013.52.3290DOI Listing
June 2014

Proteomic analyses of CSF aimed at biomarker development for pediatric brain tumors.

J Neurooncol 2014 Jun 26;118(2):225-238. Epub 2014 Apr 26.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11060-014-1432-3DOI Listing
June 2014

Metachronous neuroblastoma in an infant with germline translocation resulting in partial trisomy 2p: a role for ALK?

J Pediatr Hematol Oncol 2014 Apr;36(3):e193-6

*Department of Paediatrics, Division of Haematology/Oncology ‡Division of Molecular Genetics §Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada †Haematology/Oncology Service, KK Women's and Children's Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1097/MPH.0b013e3182a8f25dDOI Listing
April 2014

Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.

Cancer 2014 Apr 30;120(7):1068-75. Epub 2013 Dec 30.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Pediatric Hematology/ Oncology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, Massachusetts; Joslin Diabetes Center, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173134PMC
April 2014

Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium.

Eur J Cancer 2014 Mar 15;50(5):987-96. Epub 2014 Jan 15.

Division of Hematology/Oncology, The Hospital for Sick Children, Institute of Medical Sciences, The University of Toronto, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Arthur and Sonia Labbatt Brain Tumor Research Center, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.12.005DOI Listing
March 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013