David MacPherson

David MacPherson

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David MacPherson

David MacPherson

Publications by authors named "David MacPherson"

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Delivering a STINGing Blow to Small Cell Lung Cancer via Synergistic Inhibition of DNA-Damage Response and Immune-Checkpoint Pathways.

Cancer Discov 2019 May;9(5):584-586

Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0234DOI Listing
May 2019

Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).

J Thorac Oncol 2017 04 19;12(4):704-713. Epub 2016 Dec 19.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; Genomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Genome Sciences, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669801PMC
April 2017

Genomic landscape of retinoblastoma in Rb p130 mice resembles human retinoblastoma.

Genes Chromosomes Cancer 2017 03 21;56(3):231-242. Epub 2016 Nov 21.

Department of Clinical Genetics, VU University Medical Center, Amsterdam, 1081BT, The Netherlands.

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http://dx.doi.org/10.1002/gcc.22429DOI Listing
March 2017

Lung Cancer Subtypes Generate Unique Immune Responses.

J Immunol 2016 12 31;197(11):4493-4503. Epub 2016 Oct 31.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;

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http://dx.doi.org/10.4049/jimmunol.1600576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116260PMC
December 2016

NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer.

Oncotarget 2016 Sep;7(36):57514-57524

Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.18632/oncotarget.11583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295369PMC
September 2016

Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.

Genes Dev 2016 06;30(11):1289-99

Division of human Biology, Fred Hutchinson Cancer Research Center,Seattle,Washington 98109, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA;

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http://dx.doi.org/10.1101/gad.279307.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911928PMC
June 2016

Radiolabeled metabolite and disposition studies in support of safety assessment.

Bioanalysis 2015 ;7(5):507-11

Department of Environmental Sciences, Charles River, Edinburgh, EH33 2NE, UK.

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http://dx.doi.org/10.4155/bio.15.18DOI Listing
December 2015

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.

J Thorac Oncol 2015 Apr;10(4):553-64

*Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, TX; †Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX; ‡Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands; §Departments of Pediatrics and Genetics, Stanford University, Stanford, CA; ‖Center for Cancer Research, National Cancer Institute, Bethesda, MD; ¶Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; #David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142; **Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; and ††Departementd'Anatomie et Cytologie Pathologiques, INSERM Unit 823, Centre Hospitalier Universitaire Albert Michallon, and Institut Albert Bonniot University, Grenoble, France.

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http://dx.doi.org/10.1097/JTO.0000000000000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523224PMC
April 2015

Veteran, primary care provider, and specialist satisfaction with electronic consultation.

JMIR Med Inform 2015 Jan 14;3(1):e5. Epub 2015 Jan 14.

VA Pittsburgh Healthcare System, Center for Health Equity Research and Promotion, Pittsburgh, PA, United States.

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http://dx.doi.org/10.2196/medinform.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319072PMC
January 2015

Treating transcriptional addiction in small cell lung cancer.

Cancer Cell 2014 Dec;26(6):783-784

Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.012DOI Listing
December 2014

Management of early stage cutaneous Merkel cell carcinoma of the head and neck.

Br J Oral Maxillofac Surg 2014 Nov 27;52(9):806-9. Epub 2014 Aug 27.

Oral and Maxillofacial Surgery Department, Queen Alexandra Hospital, Portsmouth PO16 3LY, UK.

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http://dx.doi.org/10.1016/j.bjoms.2014.06.009DOI Listing
November 2014

RET mutation and expression in small-cell lung cancer.

J Thorac Oncol 2014 Sep;9(9):1316-23

*Division of Hematology and Oncology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio; †Department of Medicine, MedStar Good Samaritan Hospital, Baltimore, Maryland; ‡Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio; §Division of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio; and ‖Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1097/JTO.0000000000000234DOI Listing
September 2014

Primary care staff perspectives on a virtual learning collaborative to support medical home implementation.

J Gen Intern Med 2014 Jul;29 Suppl 2:S579-88

Center for Evaluation of Patient Aligned Care Teams (CEPACT), Philadelphia Veterans Affairs Medical Center, 3900 Woodland Ave, Building 4100, Philadelphia, PA, 19104, USA,

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http://dx.doi.org/10.1007/s11606-013-2668-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070246PMC
July 2014

PTEN is a potent suppressor of small cell lung cancer.

Mol Cancer Res 2014 May 30;12(5):654-9. Epub 2014 Jan 30.

Authors' Affiliations: Department of Embryology, Carnegie Institution, Baltimore, Maryland; 2Fred Hutchinson Cancer Research Center, Seattle, Washington; and 3Department of Biomedical Sciences, Cornell University, Ithaca, New York.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020961PMC
May 2014

Cooperation between Rb and Arf in suppressing mouse retinoblastoma.

J Clin Invest 2012 May 9;122(5):1726-33. Epub 2012 Apr 9.

Department of Embryology, Carnegie Institution, Baltimore, Maryland 21218, USA.

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http://dm5migu4zj3pb.cloudfront.net/manuscripts/61000/61403/
Web Search
http://www.jci.org/articles/view/61403
Publisher Site
http://dx.doi.org/10.1172/JCI61403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336990PMC
May 2012

Update in general internal medicine: evidence published in 2011.

Ann Intern Med 2012 May 18;156(9):649-53. Epub 2012 Apr 18.

University of Pittsburgh School of Medicine, Veterans Affairs Pittsburgh Healthcare System, PA, USA.

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http://dx.doi.org/10.7326/0003-4819-156-9-201205010-00410DOI Listing
May 2012

Small cell lung cancer: new insights into origins.

Authors:
David MacPherson

Cell Cycle 2011 Oct 15;10(20):3432. Epub 2011 Oct 15.

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http://dx.doi.org/10.4161/cc.10.20.17664DOI Listing
October 2011

Oral elastofibromatous lesions: a review and case series.

Head Neck Pathol 2011 Sep 18;5(3):254-8. Epub 2011 Jun 18.

Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1007/s12105-011-0274-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173539PMC
September 2011

miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.

Genes Dev 2011 Aug 4;25(16):1734-45. Epub 2011 Aug 4.

Department of Embryology, Carnegie Institution, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1101/gad.17027411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165937PMC
August 2011

On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines.

Chem Commun (Camb) 2011 Jul 31;47(26):7491-3. Epub 2011 May 31.

School of Chemistry, University of Nottingham, Nottingham, NG7 2RD.

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http://xlink.rsc.org/?DOI=c1cc11870f
Publisher Site
http://dx.doi.org/10.1039/c1cc11870fDOI Listing
July 2011

Metabolism of [(14)c]chlorantraniliprole in the lactating goat.

J Agric Food Chem 2011 Feb 11;59(4):1316-23. Epub 2011 Jan 11.

DuPont Crop Protection, Stine-Haskell Research Center, Newark, Delaware 19714-0030, United States.

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http://dx.doi.org/10.1021/jf103558nDOI Listing
February 2011

Active care management supported by home telemonitoring in veterans with type 2 diabetes: the DiaTel randomized controlled trial.

Diabetes Care 2010 Mar 15;33(3):478-84. Epub 2009 Dec 15.

Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.2337/dc09-1012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827492PMC
March 2010

Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine.

Bioorg Med Chem Lett 2010 Feb 11;20(4):1368-72. Epub 2010 Jan 11.

Department of Medicinal Chemistry, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.012DOI Listing
February 2010

Regioselective synthesis of N-aminoisoindolones and mono-N- and di-N,N'-substituted phthalazones utilizing hydrazine nucleophiles in a palladium-catalyzed three-component cascade process.

J Org Chem 2008 Nov 10;73(21):8352-6. Epub 2008 Oct 10.

Molecular Innovation Diversity and Automated Synthesis Centre, School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1021/jo800822pDOI Listing
November 2008

Severe tissue necrosis following intra-arterial injection of endodontic calcium hydroxide: a case series.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 May;105(5):666-9

St Richards Hospital, Chichester, West Sussex, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S107921040700873
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http://dx.doi.org/10.1016/j.tripleo.2007.11.026DOI Listing
May 2008

Insights from mouse models into human retinoblastoma.

Authors:
David Macpherson

Cell Div 2008 May 19;3. Epub 2008 May 19.

Department of Embryology, Carnegie Institution, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/1747-1028-3-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430952PMC
May 2008

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

Bioorg Med Chem Lett 2008 Feb 15;18(3):1011-6. Epub 2007 Dec 15.

Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2007.12.017DOI Listing
February 2008

Karapandzic flap for reconstruction of lip defects.

J Oral Maxillofac Surg 2007 Dec;65(12):2512-7

Maxillofacial Unit, St Richard's Hospital, Chichester, United Kingdom.

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http://dx.doi.org/10.1016/j.joms.2006.10.018DOI Listing
December 2007

Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy.

Cancer Res 2007 Aug;67(16):7547-50

Department of Embryology, Carnegie Institution, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0276DOI Listing
August 2007

Lipomatous lesions of the parotid gland.

J Oral Maxillofac Surg 2006 Nov;64(11):1583-6

Department of Oral and Maxillofacial Surgery, St Richard's Hospital, Chichester, West Sussex, UK.

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http://dx.doi.org/10.1016/j.joms.2005.10.059DOI Listing
November 2006

Diabetes preventive care and non-traumatic lower extremity amputation rates.

J Healthc Qual 2004 Sep-Oct;26(5):12-7

VA Pittsburgh Healthcare System, PA, USA.

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November 2004

Cell type-specific effects of Rb deletion in the murine retina.

Genes Dev 2004 Jul 1;18(14):1681-94. Epub 2004 Jul 1.

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1203304
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http://dx.doi.org/10.1101/gad.1203304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478190PMC
July 2004

Relevance of carotid stenosis progression as a predictor of ischemic neurological outcomes.

Arch Intern Med 2003 Oct;163(19):2285-9

Division of Vascular Surgery, Pittsburgh Veterans Affairs Medical Center/University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1001/archinte.163.19.2285DOI Listing
October 2003

Promotion criteria for clinician-educators.

J Gen Intern Med 2003 Sep;18(9):711-6

Division of General Internal Medicine, Cambridge Hospital and Harvard Medical School, 1493 Cambridge Street, Macht Room 429, Cambridge, MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1494922PMC
http://dx.doi.org/10.1046/j.1525-1497.2003.10425.xDOI Listing
September 2003

Guideline chaos: conflicting recommendations for preoperative cardiac assessment.

Am J Cardiol 2003 Jun;91(11):1299-303

Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Section of General Medicine, 11th Floor (130-U), UniversityDrive C, Pittsburgh, PA 15240, USA.

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http://dx.doi.org/10.1016/s0002-9149(03)00317-5DOI Listing
June 2003

The case against routine preoperative laboratory testing.

Med Clin North Am 2003 Jan;87(1):7-40

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/s0025-7125(02)00147-5DOI Listing
January 2003

ARF mutation accelerates pituitary tumor development in Rb+/- mice.

Proc Natl Acad Sci U S A 2002 Dec 16;99(26):16865-70. Epub 2002 Dec 16.

Department of Biology and Center for Cancer Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.262499599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139235PMC
December 2002

ARF is not required for apoptosis in Rb mutant mouse embryos.

Curr Biol 2002 Jan;12(2):159-63

MIT Department of Biology and Center for Cancer Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/s0960-9822(01)00659-5DOI Listing
January 2002