David M Weinstock

David M Weinstock

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David M Weinstock

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TFH lymphomas: the times they aza-changin'?

Blood 2019 Oct;134(17):1364-1365

Memorial Sloan Kettering Cancer Center.

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http://dx.doi.org/10.1182/blood.2019002806DOI Listing
October 2019

Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type.

J Invest Dermatol 2018 11 30;138(11):2365-2376. Epub 2018 May 30.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200585PMC
November 2018

Challenges and implications of genomics for T-cell lymphomas.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):63-68

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/asheducation-2018.1.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246015PMC
November 2018

Targeting minimal residual disease: a path to cure?

Nat Rev Cancer 2018 04 29;18(4):255-263. Epub 2018 Jan 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA, and at the Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nrc.2017.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398166PMC
April 2018

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.

Cell 2018 04 15;173(2):470-484.e18. Epub 2018 Mar 15.

Department of Systems Biology, Beckman Research Institute, and City of Hope Comprehensive Cancer Center, Monrovia, CA 91016, USA; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284818PMC
April 2018

Clinicogenetic risk modeling in ATL.

Blood 2018 01;131(2):159-160

Dana-Farber Cancer Institute.

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http://dx.doi.org/10.1182/blood-2017-11-815472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757693PMC
January 2018

The promises and challenges of using gene mutations for patient stratification in follicular lymphoma.

Blood 2017 09 7;130(13):1491-1498. Epub 2017 Aug 7.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2017-07-737353DOI Listing
September 2017

Cancer models: The next best thing.

Nature 2017 09 30;549(7670):39-41. Epub 2017 Aug 30.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature23545DOI Listing
September 2017

It Takes a Village to Unmask HSTL.

Cancer Discov 2017 04;7(4):352-353

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381813PMC
April 2017

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

Nat Commun 2017 04 27;8:15110. Epub 2017 Apr 27.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms15110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414184PMC
April 2017

Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation.

J Clin Oncol 2017 Jan 24;35(1):24-31. Epub 2016 Oct 24.

Alex F. Herrera, Matthew Mei, Lawrence Low, Joo Y. Song, Victoria Bedell, Lithua Budde, Wing C. Chan, Robert Chen, Joyce Murata-Collins, Auayporn P. Nademanee, Raju Pillai, Leslie Popplewell, Tanya Siddiqi, Jasmine Zain, Steven T. Rosen, Larry W. Kwak, Stephen J. Forman, Dennis D. Weisenburger, Young Kim, Amrita Krishnan, Tanya Paris, Tracey Stiller, Joycelynne M. Palmer, City of Hope National Medical Center, Duarte, CA; Haesook T. Kim, Jennifer R. Brown, Matthew S. Davids, Arnold S. Freedman, David C. Fisher, Eric D. Jacobsen, Caron A. Jacobson, Ann S. LaCasce, David M. Weinstock, Scott J. Rodig, Philippe Armand, Dana-Farber Cancer Institute; Gabriel K. Griffin, Reid W. Merryman, Christine Pak, Heather Sun, Brigham and Women's Hospital; German A. Pihan, Beth Israel Deaconess Medical Center; and Aliyah R. Sohani, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.68.2740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455688PMC
January 2017

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Buying cures versus renting health: Financing health care with consumer loans.

Sci Transl Med 2016 Feb;8(327):327ps6

MIT Laboratory for Financial Engineering, Sloan School of Management, Cambridge, MA, USA. MIT Department of Electrical Engineering and Computer Science, Cambridge, MA, USA. MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA. AlphaSimplex Group LLC, Cambridge, MA, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad6913DOI Listing
February 2016

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.

Sci Adv 2015 Sep 18;1(8):e1500221. Epub 2015 Sep 18.

Institut Cochin, Département Développement, Reproduction, Cancer, CNRS, UMR 8104, INSERM U1016, Paris 75014, France. ; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris 75005, France. ; Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris 75013, France.

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http://dx.doi.org/10.1126/sciadv.1500221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643770PMC
September 2015

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia.

Cell Rep 2015 Jun 21;11(9):1446-57. Epub 2015 May 21.

INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.063DOI Listing
June 2015

A roadmap for discovery and translation in lymphoma.

Blood 2015 Mar;125(13):2175-7

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2015-01-623777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375113PMC
March 2015

Public health and medical preparedness for a nuclear detonation: the nuclear incident medical enterprise.

Health Phys 2015 Feb;108(2):149-60

*Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC; †Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD; ‡Dana Farber Cancer Institute, Harvard Medical School, Boston, MA; §Radiation Injury Treatment Network, National Marrow Donor Program, Minneapolis, MN; **Office of Policy and Planning, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC; ††Division of Strategic National Stockpile, Office of Public Health Preparedness and Response; Centers for Disease Control and Prevention, Atlanta, GA; ‡‡Radiation Studies Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA; §§Gryphon Scientific, LLC, Rockville, MD; ***Biomedical Advanced Research & Development Authority, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC; †††Radiation/Nuclear Countermeasures Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/HP.0000000000000249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295641PMC
February 2015

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Br J Haematol 2015 Jan 26;168(2):230-8. Epub 2014 Sep 26.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Haematology, UCL Cancer Institute, University College London, London, UK.

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http://dx.doi.org/10.1111/bjh.13115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303513PMC
January 2015

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.

Database (Oxford) 2014 25;2014:bau007. Epub 2014 Feb 25.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA, Department of Biological Chemistry, Johns Hopkins University School of Medicine, 733 N. Broadway, Maryland, 21205, USA, Department of Oncology, Johns Hopkins University School of Medicine, 733 N. Broadway, Maryland, 21205, USA, Department of Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Maryland, 21205, USA, Institute of Bioinformatics, International Technology Park, Bangalore 560066, India, Manipal University, Madhav Nagar, Manipal 576104, India, Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA, Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mailcode L592, Portland, OR 97239, USA and Immunology Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue S&C, Seattle, WA 98101, USA.

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https://academic.oup.com/database/article-lookup/doi/10.1093
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http://dx.doi.org/10.1093/database/bau007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935308PMC
August 2014

Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.

J Biol Chem 2014 Aug 12;289(33):22739-48. Epub 2014 Jun 12.

From the Division of Hematology-Oncology, Dept of Internal Medicine, and the Cancer Center, University Of New Mexico, Albuquerque, New Mexico 87131,

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http://dx.doi.org/10.1074/jbc.M114.550459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132780PMC
August 2014

Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling.

Cell Commun Signal 2013 Apr 17;11(1):27. Epub 2013 Apr 17.

Helmholtz Zentrum München, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, D-81377, Germany.

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http://dx.doi.org/10.1186/1478-811X-11-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641951PMC
April 2013

The evolving contribution of hematopoietic progenitor cells to lymphomagenesis.

Blood 2012 Sep 6;120(13):2553-61. Epub 2012 Aug 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1182/blood-2012-05-414995DOI Listing
September 2012

TSLP signaling network revealed by SILAC-based phosphoproteomics.

Mol Cell Proteomics 2012 Jun 16;11(6):M112.017764. Epub 2012 Feb 16.

McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, 21205 Maryland, USA.

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http://dx.doi.org/10.1074/mcp.M112.017764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433886PMC
June 2012

Repair at single targeted DNA double-strand breaks in pluripotent and differentiated human cells.

PLoS One 2011 25;6(5):e20514. Epub 2011 May 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020514PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102116PMC
September 2011

Triage and treatment tools for use in a scarce resources-crisis standards of care setting after a nuclear detonation.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S111-21

Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Rockville, MD 20852, USA.

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http://www.journals.cambridge.org/abstract_S1935789300003827
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http://dx.doi.org/10.1001/dmp.2011.22DOI Listing
March 2011

Scarce resources for nuclear detonation: project overview and challenges.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S13-9

Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, USA.

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http://dx.doi.org/10.1001/dmp.2011.15DOI Listing
March 2011

Allocation of scarce resources after a nuclear detonation: setting the context.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S20-31

Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, USA.

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http://dx.doi.org/10.1001/dmp.2011.25DOI Listing
March 2011

Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S32-44

Radiation/Nuclear Countermeasures Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA.

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http://dx.doi.org/10.1001/dmp.2011.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643117PMC
March 2011

Resource allocation after a nuclear detonation incident: unaltered standards of ethical decision making.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S46-53

Department of Epidemiology, Biostatistics and Occupational Health, McGill University.

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http://dx.doi.org/10.1001/dmp.2011.14DOI Listing
March 2011

Health care system planning for and response to a nuclear detonation.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S73-88

Hennepin County Medical Center, University of Minnesota, Minneapolis, MN 55415, USA.

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http://www.journals.cambridge.org/abstract_S1935789300003797
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http://dx.doi.org/10.1001/dmp.2011.28DOI Listing
March 2011

Medical response to a nuclear detonation: creating a playbook for state and local planners and responders.

Disaster Med Public Health Prep 2011 Mar;5 Suppl 1:S89-97

Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, USA.

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http://dx.doi.org/10.1001/dmp.2011.13DOI Listing
March 2011

Epstein-Barr virus, lymphoma risk and the potential role of HIV infection in IBD patients undergoing immunosuppression.

Dig Dis 2010 30;28(3):519-24. Epub 2010 Sep 30.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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https://www.karger.com/Article/FullText/320411
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http://dx.doi.org/10.1159/000320411DOI Listing
January 2011

Assessing surge capacity for radiation victims with marrow toxicity.

Biol Blood Marrow Transplant 2010 Oct 24;16(10):1436-41. Epub 2010 Apr 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.bbmt.2010.04.007DOI Listing
October 2010

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.

J Cell Biol 2010 Oct 27;191(1):31-43. Epub 2010 Sep 27.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201001160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953432PMC
October 2010

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.

Cancer Genet Cytogenet 2010 Jul;200(2):184-90

Division of Hematology-Oncology, Cancer Research and Treatment Center, Department of Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904321PMC
July 2010

Medical management of radiation victims in the United States.

Health Phys 2010 Jun;98(6):833-7

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/01.HP.0000346701.04476.0dDOI Listing
June 2010

BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.

Blood 2009 Aug 1;114(9):1813-9. Epub 2009 Jul 1.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2008-07-172148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738569PMC
August 2009

Chromosomal translocations induced at specified loci in human stem cells.

Proc Natl Acad Sci U S A 2009 Jun 23;106(26):10620-5. Epub 2009 Jun 23.

Department of Medicine, Developmental Biology Program and Sloan-Kettering Institute Stem Cell Research Facility, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902076106
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http://dx.doi.org/10.1073/pnas.0902076106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700748PMC
June 2009