David M Thomas

David M Thomas

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David M Thomas

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Therapeutic implications of germline genetic findings in cancer.

Nat Rev Clin Oncol 2019 06;16(6):386-396

Cancer Division, Garvan Institute of Medical Research, Sydney, Australia.

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http://dx.doi.org/10.1038/s41571-019-0179-3DOI Listing
June 2019

A quantitative model to predict pathogenicity of missense variants in the TP53 gene.

Hum Mutat 2019 Jun 18;40(6):788-800. Epub 2019 Mar 18.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/humu.23739DOI Listing
June 2019

Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts.

BMC Med Genet 2019 May 3;20(1):69. Epub 2019 May 3.

The Curtin UWA Centre for Genetic Origins of Health and Disease, Faculty of Health Sciences, Curtin University and Faculty of Health and Medical Sciences, M409 The University of Western Australia, 35 Stirling Hwy, Crawley, 6009, Western Australia.

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-019-0808-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499942PMC
May 2019

Evaluation of the proximal coronary arteries in suspected pulmonary embolism: diagnostic images in 51% of patients using non-gated, dual-source CT pulmonary angiography.

Emerg Radiol 2019 Apr 12;26(2):189-194. Epub 2018 Dec 12.

Radiology Department, Vancouver General Hospital, 889 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.

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http://dx.doi.org/10.1007/s10140-018-01661-0DOI Listing
April 2019

Diagnosis of fusion genes using targeted RNA sequencing.

Nat Commun 2019 03 27;10(1):1388. Epub 2019 Mar 27.

Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, 2010, NSW, Australia.

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http://dx.doi.org/10.1038/s41467-019-09374-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437215PMC
March 2019

Translating genomic risk into an early detection strategy for sarcoma.

Genes Chromosomes Cancer 2019 02 29;58(2):130-136. Epub 2018 Nov 29.

Cancer Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1002/gcc.22697DOI Listing
February 2019

Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk.

J Genet Couns 2018 09 17;27(5):1055-1066. Epub 2018 Feb 17.

The Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1007/s10897-018-0223-yDOI Listing
September 2018

Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer.

Genome Res 2018 05 4;28(5):726-738. Epub 2018 Apr 4.

Genomics and Epigenetics Division, Garvan Institute of Medical Research, New South Wales 2010, Australia.

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http://dx.doi.org/10.1101/gr.227975.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932612PMC
May 2018

Locally Aggressive Connective Tissue Tumors.

J Clin Oncol 2018 01 8;36(2):202-209. Epub 2017 Dec 8.

Mrinal M. Gounder and William D. Tap, Memorial Sloan Kettering Cancer Center and Weil Cornell Medical School, New York, NY; and David M. Thomas, Garvan Institute of Medical Research, Darlinghurst, Australia.

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http://dx.doi.org/10.1200/JCO.2017.75.8482DOI Listing
January 2018

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging.

JAMA Oncol 2017 12;3(12):1735-1736

Cancer Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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http://dx.doi.org/10.1001/jamaoncol.2017.1355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824268PMC
December 2017

Is Li-Fraumeni syndrome really much more common?

Authors:
David M Thomas

Hum Mutat 2017 12;38(12):1619

Garvan Institute of Medical Research, Darlinghurst, Australia.

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http://dx.doi.org/10.1002/humu.23342DOI Listing
December 2017

Estimating Mutation Carrier Probability in Families with Li-Fraumeni Syndrome Using LFSPRO.

Cancer Epidemiol Biomarkers Prev 2017 06 30;26(6):837-844. Epub 2017 Jan 30.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-16-0695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457344PMC
June 2017

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting.

Nat Commun 2017 02 24;8:14607. Epub 2017 Feb 24.

Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, 3002 Victoria, Australia.

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http://dx.doi.org/10.1038/ncomms14607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333095PMC
February 2017

Sarcoma and germ-line DICER1 mutations - Authors' reply.

Lancet Oncol 2016 11;17(11):e471

Garvan Institute of Medical Research, The Kinghorn Cancer Centre and Cancer Division, Darlinghurst, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30527-7DOI Listing
November 2016

Diagnosis and Management of Hereditary Sarcoma.

Recent Results Cancer Res 2016 ;205:169-89

The Kinghorn Cancer Centre & Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1007/978-3-319-29998-3_10DOI Listing
July 2016

International survey of awareness of genetic risk in the clinical sarcoma community.

Asia Pac J Clin Oncol 2016 Jun 29;12(2):133-42. Epub 2016 Feb 29.

Department of Cancer Medicine, The Chris O'Brien Lifehouse, Sydney Medical School, University of Sydney, Camperdown, New South Wales, Australia.

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http://dx.doi.org/10.1111/ajco.12457DOI Listing
June 2016

The life history of neochromosomes revealed.

Mol Cell Oncol 2015 Oct-Dec;2(4):e1000698. Epub 2015 Jan 23.

Peter MacCallum Cancer Centre; East Melbourne, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research; Sydney, Australia; University of New South Wales; Sydney, Australia.

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http://dx.doi.org/10.1080/23723556.2014.1000698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905327PMC
June 2016

Timing and context: important considerations in the return of genetic results to research participants.

J Community Genet 2016 Jan 26;7(1):11-20. Epub 2015 May 26.

Familial Cancer Centre, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia.

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http://dx.doi.org/10.1007/s12687-015-0231-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715816PMC
January 2016

Cancer 2015: a longitudinal whole-of-system study of genomic cancer medicine.

Drug Discov Today 2015 Dec 19;20(12):1429-32. Epub 2015 Oct 19.

School of Public Health & Preventive Medicine, Department of Epidemiology & Preventive Medicine, Monash Faculty of Medicine Nursing & Health Sciences, Alfred Hospital, Prahran,, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/j.drudis.2015.10.009DOI Listing
December 2015

Distinguishing activity from progress.

Lancet Oncol 2015 Dec;16(16):1586-8

Genomic Cancer Medicine, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Faculty of Medicine, University of New South Wales Kensington, NSW, Australia.

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http://dx.doi.org/10.1016/S1470-2045(15)00466-0DOI Listing
December 2015

The growing problem of benign connective tissue tumours.

Authors:
David M Thomas

Lancet Oncol 2015 Aug 12;16(8):879-80. Epub 2015 Jul 12.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00147-3DOI Listing
August 2015

Surveillance recommendations for patients with germline TP53 mutations.

Curr Opin Oncol 2015 Jul;27(4):332-7

aSir Peter MacCallum Department of Oncology, University of Melbourne bResearch Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia cHereditary Cancer Program, BC Cancer Agency, Vancouver, British Columbia, Canada dThe Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/CCO.0000000000000200DOI Listing
July 2015

Clinical implications of genomics for cancer risk genetics.

Lancet Oncol 2015 Jun 27;16(6):e303-8. Epub 2015 May 27.

Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/S1470-2045(15)70026-4DOI Listing
June 2015

Etiologic, environmental and inherited risk factors in sarcomas.

J Surg Oncol 2015 Apr 21;111(5):490-5. Epub 2014 Oct 21.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.

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http://doi.wiley.com/10.1002/jso.23809
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http://dx.doi.org/10.1002/jso.23809DOI Listing
April 2015

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

Authors:
Zhaoming Wang Bin Zhu Mingfeng Zhang Hemang Parikh Jinping Jia Charles C Chung Joshua N Sampson Jason W Hoskins Amy Hutchinson Laurie Burdette Abdisamad Ibrahim Christopher Hautman Preethi S Raj Christian C Abnet Andrew A Adjei Anders Ahlbom Demetrius Albanes Naomi E Allen Christine B Ambrosone Melinda Aldrich Pilar Amiano Christopher Amos Ulrika Andersson Gerald Andriole Irene L Andrulis Cecilia Arici Alan A Arslan Melissa A Austin Dalsu Baris Donald A Barkauskas Bryan A Bassig Laura E Beane Freeman Christine D Berg Sonja I Berndt Pier Alberto Bertazzi Richard B Biritwum Amanda Black William Blot Heiner Boeing Paolo Boffetta Kelly Bolton Marie-Christine Boutron-Ruault Paige M Bracci Paul Brennan Louise A Brinton Michelle Brotzman H Bas Bueno-de-Mesquita Julie E Buring Mary Ann Butler Qiuyin Cai Geraldine Cancel-Tassin Federico Canzian Guangwen Cao Neil E Caporaso Alfredo Carrato Tania Carreon Angela Carta Gee-Chen Chang I-Shou Chang Jenny Chang-Claude Xu Che Chien-Jen Chen Chih-Yi Chen Chung-Hsing Chen Constance Chen Kuan-Yu Chen Yuh-Min Chen Anand P Chokkalingam Lisa W Chu Francoise Clavel-Chapelon Graham A Colditz Joanne S Colt David Conti Michael B Cook Victoria K Cortessis E David Crawford Olivier Cussenot Faith G Davis Immaculata De Vivo Xiang Deng Ti Ding Colin P Dinney Anna Luisa Di Stefano W Ryan Diver Eric J Duell Joanne W Elena Jin-Hu Fan Heather Spencer Feigelson Maria Feychting Jonine D Figueroa Adrienne M Flanagan Joseph F Fraumeni Neal D Freedman Brooke L Fridley Charles S Fuchs Manuela Gago-Dominguez Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Reina Garcia-Closas Julie M Gastier-Foster J Michael Gaziano Daniela S Gerhard Carol A Giffen Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Michael Goggins Nalan Gokgoz Alisa M Goldstein Carlos Gonzalez Richard Gorlick Mark H Greene Myron Gross H Barton Grossman Robert Grubb Jian Gu Peng Guan Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Patricia Hartge Claudia Hattinger Richard B Hayes Qincheng He Lee Helman Brian E Henderson Roger Henriksson Judith Hoffman-Bolton Chancellor Hohensee Elizabeth A Holly Yun-Chul Hong Robert N Hoover H Dean Hosgood Chin-Fu Hsiao Ann W Hsing Chao Agnes Hsiung Nan Hu Wei Hu Zhibin Hu Ming-Shyan Huang David J Hunter Peter D Inskip Hidemi Ito Eric J Jacobs Kevin B Jacobs Mazda Jenab Bu-Tian Ji Christoffer Johansen Mattias Johansson Alison Johnson Rudolf Kaaks Ashish M Kamat Aruna Kamineni Margaret Karagas Chand Khanna Kay-Tee Khaw Christopher Kim In-Sam Kim Jin Hee Kim Yeul Hong Kim Young-Chul Kim Young Tae Kim Chang Hyun Kang Yoo Jin Jung Cari M Kitahara Alison P Klein Robert Klein Manolis Kogevinas Woon-Puay Koh Takashi Kohno Laurence N Kolonel Charles Kooperberg Christian P Kratz Vittorio Krogh Hideo Kunitoh Robert C Kurtz Nilgun Kurucu Qing Lan Mark Lathrop Ching C Lau Fernando Lecanda Kyoung-Mu Lee Maxwell P Lee Loic Le Marchand Seth P Lerner Donghui Li Linda M Liao Wei-Yen Lim Dongxin Lin Jie Lin Sara Lindstrom Martha S Linet Jolanta Lissowska Jianjun Liu Börje Ljungberg Josep Lloreta Daru Lu Jing Ma Nuria Malats Satu Mannisto Neyssa Marina Giuseppe Mastrangelo Keitaro Matsuo Katherine A McGlynn Roberta McKean-Cowdin Lorna H McNeill Robert R McWilliams Beatrice S Melin Paul S Meltzer James E Mensah Xiaoping Miao Dominique S Michaud Alison M Mondul Lee E Moore Kenneth Muir Shelley Niwa Sara H Olson Nick Orr Salvatore Panico Jae Yong Park Alpa V Patel Ana Patino-Garcia Sofia Pavanello Petra H M Peeters Beata Peplonska Ulrike Peters Gloria M Petersen Piero Picci Malcolm C Pike Stefano Porru Jennifer Prescott Xia Pu Mark P Purdue You-Lin Qiao Preetha Rajaraman Elio Riboli Harvey A Risch Rebecca J Rodabough Nathaniel Rothman Avima M Ruder Jeong-Seon Ryu Marc Sanson Alan Schned Fredrick R Schumacher Ann G Schwartz Kendra L Schwartz Molly Schwenn Katia Scotlandi Adeline Seow Consol Serra Massimo Serra Howard D Sesso Gianluca Severi Hongbing Shen Min Shen Sanjay Shete Kouya Shiraishi Xiao-Ou Shu Afshan Siddiq Luis Sierrasesumaga Sabina Sierri Alan Dart Loon Sihoe Debra T Silverman Matthias Simon Melissa C Southey Logan Spector Margaret Spitz Meir Stampfer Par Stattin Mariana C Stern Victoria L Stevens Rachael Z Stolzenberg-Solomon Daniel O Stram Sara S Strom Wu-Chou Su Malin Sund Sook Whan Sung Anthony Swerdlow Wen Tan Hideo Tanaka Wei Tang Ze-Zhang Tang Adonina Tardon Evelyn Tay Philip R Taylor Yao Tettey David M Thomas Roberto Tirabosco Anne Tjonneland Geoffrey S Tobias Jorge R Toro Ruth C Travis Dimitrios Trichopoulos Rebecca Troisi Ann Truelove Ying-Huang Tsai Margaret A Tucker Rosario Tumino David Van Den Berg Stephen K Van Den Eeden Roel Vermeulen Paolo Vineis Kala Visvanathan Ulla Vogel Chaoyu Wang Chengfeng Wang Junwen Wang Sophia S Wang Elisabete Weiderpass Stephanie J Weinstein Nicolas Wentzensen William Wheeler Emily White John K Wiencke Alicja Wolk Brian M Wolpin Maria Pik Wong Margaret Wrensch Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Yong-Bing Xiang Jun Xu Hannah P Yang Pan-Chyr Yang Yasushi Yatabe Yuanqing Ye Edward D Yeboah Zhihua Yin Chen Ying Chong-Jen Yu Kai Yu Jian-Min Yuan Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Lisa Mirabello Sharon A Savage Peter Kraft Stephen J Chanock Meredith Yeager Maria Terese Landi Jianxin Shi Nilanjan Chatterjee Laufey T Amundadottir

Hum Mol Genet 2014 Dec 15;23(24):6616-33. Epub 2014 Jul 15.

Division of Cancer Epidemiology and Genetics,

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http://kooperberg.fhcrc.org/papers/2014wang.pdf
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http://hmg.oxfordjournals.org/content/23/24/6616.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu363
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http://dx.doi.org/10.1093/hmg/ddu363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240198PMC
December 2014

Translational biology of osteosarcoma.

Nat Rev Cancer 2014 Nov 16;14(11):722-35. Epub 2014 Oct 16.

1] Research Division, Peter MacCallum Cancer Centre, Melbourne, 3002, Victoria, Australia. [2] Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, 3010, Victoria, Australia. [3] The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, 2010, New South Wales, Australia.

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http://dx.doi.org/10.1038/nrc3838DOI Listing
November 2014

The architecture and evolution of cancer neochromosomes.

Cancer Cell 2014 Nov 10;26(5):653-67. Epub 2014 Nov 10.

Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. Electronic address:

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http://www.cell.com/cms/attachment/2020782748/2040814140/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S153561081400373
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http://dx.doi.org/10.1016/j.ccell.2014.09.010DOI Listing
November 2014

Stress-induced cellular adaptive strategies: ancient evolutionarily conserved programs as new anticancer therapeutic targets.

Bioessays 2014 Jun 6;36(6):552-60. Epub 2014 Apr 6.

Sarcoma Genomics and Genetics, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/bies.201300170DOI Listing
June 2014

Li-Fraumeni syndrome: cancer risk assessment and clinical management.

Nat Rev Clin Oncol 2014 May 18;11(5):260-71. Epub 2014 Mar 18.

The Familial Cancer Centre, Sir Peter MacCallum Department of Oncology, University of Melbourne, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1038/nrclinonc.2014.41DOI Listing
May 2014

Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling.

Cancer Res 2014 Feb 13;74(3):921-31. Epub 2013 Dec 13.

Authors' Affiliations: Sarcoma Research Group, Discipline of Medicine, Centre for Personalised Cancer Medicine, Faculty of Health Sciences, School of Molecular and Biomedical Science, Departments of Orthopaedics and Trauma and Haematology, Cancer Clinical Trials Unit, Royal Adelaide Hospital; Department of Surgery, Royal Adelaide Hospital and University of Adelaide; ACRF Cancer Genomics Facility, Centre for Cancer Biology, Division of Tissue Pathology, SA Pathology; Centre for Neurological Diseases, Hanson Institute and SA Pathology; Department of Radiology, Queen Elizabeth Hospital; Department of Haematology and Oncology, Basil Hetzel Institute and Queen Elizabeth Hospital; University of Adelaide, Discipline of Surgery, Basil Hetzel Institute, Adelaide; Sarcoma Genomics and Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia; and Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Australia.

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http://cancerres.aacrjournals.org/content/early/2014/01/23/0
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http://cancerres.aacrjournals.org/content/early/2013/12/13/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2424DOI Listing
February 2014

Behavioral and neurochemical effects of repeated MDMA administration during late adolescence in the rat.

Prog Neuropsychopharmacol Biol Psychiatry 2014 Jan 10;48:229-35. Epub 2013 Oct 10.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1016/j.pnpbp.2013.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348097PMC
January 2014

RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma.

Oncoimmunology 2014 Jan 3;3(1):e27569. Epub 2014 Jan 3.

Peter MacCallum Cancer Centre; Sarcoma Genomics and Genetics Laboratory, Research Division; Melbourne, VIC Australia ; The Kinghorn Cancer Centre and Garvan Institute; Sydney, NSW Australia.

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http://dx.doi.org/10.4161/onci.27569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006854PMC
January 2014

Multiomics medicine in oncology: assessing effectiveness, cost-effectiveness and future research priorities for the molecularly unique individual.

Pharmacogenomics 2013 Sep;14(12):1405-17

Centre for Health Economics, Faculty of Business & Economics, Room 278, Level 2, Building 75, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.2217/pgs.13.142DOI Listing
September 2013

Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.

Sarcoma 2013 28;2013:608964. Epub 2013 Feb 28.

Centre for Cancer Research, Monash Institute of Medical Research, Monash University, 27-31 Wright St, Clayton, VIC 3168, Australia.

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http://dx.doi.org/10.1155/2013/608964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603321PMC
July 2013

The Hippo pathway and human cancer.

Nat Rev Cancer 2013 Apr 7;13(4):246-57. Epub 2013 Mar 7.

Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1038/nrc3458DOI Listing
April 2013

Tobacco smoke modulates ozone-induced toxicity in rat lungs and central nervous system.

Inhal Toxicol 2013 Jan;25(1):21-8

Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, USA.

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http://dx.doi.org/10.3109/08958378.2012.751143DOI Listing
January 2013

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.

Pharmacol Ther 2012 Nov 11;136(2):153-68. Epub 2012 Aug 11.

Sarcoma Service, Peter MacCallum Cancer Centre, 12 St. Andrew's Place, A'Beckitt Street, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.pharmthera.2012.08.004DOI Listing
November 2012

Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma.

Oncoimmunology 2012 Nov;1(8):1313-1322

Cancer Immunology Program; Peter MacCallum Cancer Centre; East Melbourne, Australia.

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http://dx.doi.org/10.4161/onci.21680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518504PMC
November 2012

Hereditary and environmental epidemiology of sarcomas.

Clin Sarcoma Res 2012 Oct 4;2(1):13. Epub 2012 Oct 4.

Division of Cancer Medicine, Sir Peter MacCallum Department of Oncology, University of Melbourne, East Melbourne, Australia.

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http://dx.doi.org/10.1186/2045-3329-2-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496692PMC
October 2012

RANKL, denosumab, and giant cell tumor of bone.

Authors:
David M Thomas

Curr Opin Oncol 2012 Jul;24(4):397-403

Department of Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.

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https://insights.ovid.com/crossref?an=00001622-201207000-000
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http://dx.doi.org/10.1097/CCO.0b013e328354c129DOI Listing
July 2012

Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity.

J Neurochem 2012 Jun 13;121(6):974-84. Epub 2012 Apr 13.

Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07739.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371128PMC
June 2012

Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.

Clin Sarcoma Res 2012 Feb 1;2(1). Epub 2012 Feb 1.

Department of Medical Oncology, St, Vincent's University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1186/2045-3329-2-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351706PMC
February 2012

The relationship between unmet needs and distress amongst young people with cancer.

Support Care Cancer 2012 Jan 11;20(1):75-85. Epub 2011 Feb 11.

Victorian Adolescent and Young Adult Cancer Service, Peter MacCallum Cancer Centre, 12 St. Andrews Place, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1007/s00520-010-1059-7DOI Listing
January 2012

RECK in osteosarcoma: a novel role in tumour vasculature and inhibition of tumorigenesis in an orthotopic model.

Cancer 2011 Aug 1;117(15):3517-28. Epub 2011 Feb 1.

Department of Orthopedics, St Vincent's Hospital, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1002/cncr.25757DOI Listing
August 2011

Novel approaches to treatment of leiomyosarcomas.

Curr Oncol Rep 2011 Aug;13(4):316-22

Division of Cancer Medicine, Peter MacCallum Cancer Center, St. Andrew's Place, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1007/s11912-011-0173-0DOI Listing
August 2011

Targeting the p53 Pathway in Ewing Sarcoma.

Sarcoma 2011 9;2011:746939. Epub 2010 Dec 9.

Sarcoma Research Group, Discipline of Medicine, University of Adelaide and Hanson Institute, Frome Road, Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.1155/2011/746939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005944PMC
July 2011

Liposarcoma: molecular genetics and therapeutics.

Sarcoma 2011 27;2011:483154. Epub 2010 Dec 27.

Sarcoma Genomics & Genetics, Peter MacCallum Cancer Centre, 12 St Andrews Place, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1155/2011/483154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021868PMC
July 2011

Lessons from the deep study of rare tumours.

Authors:
David M Thomas

J Pathol 2011 Jul;224(3):306-8

Sarcoma Genomics and Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/path.2928DOI Listing
July 2011

Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage.

Neurotoxicology 2010 Dec 1;31(6):738-46. Epub 2010 Jul 1.

Research & Development Service, John D. Dingell VA Medical Center, Detroit, MI, USA.

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http://dx.doi.org/10.1016/j.neuro.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974036PMC
December 2010

The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum.

J Neurochem 2010 Nov 6;115(3):595-605. Epub 2010 Sep 6.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06950.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974310PMC
November 2010

Adolescent and young adult oncology: an emerging field.

J Clin Oncol 2010 Nov 23;28(32):4781-2. Epub 2010 Aug 23.

Peter MacCallum Cancer Center, East Melbourne, Australia.

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http://ascopubs.org/doi/10.1200/JCO.2010.30.5128
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November 2010

The hard and soft sides of cancer programming.

Authors:
David M Thomas

Bioessays 2010 Oct;32(10):837-8

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http://dx.doi.org/10.1002/bies.201090036DOI Listing
October 2010

Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse.

Int J Radiat Biol 2010 Jun;86(6):436-44

Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3109/09553001003674863DOI Listing
June 2010

Specific targets in sarcoma and developmental therapeutics.

J Natl Compr Canc Netw 2010 Jun;8(6):677-85; quiz 686

Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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June 2010

Wnts, bone and cancer.

Authors:
David M Thomas

J Pathol 2010 Jan;220(1):1-4

Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

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http://dx.doi.org/10.1002/path.2635DOI Listing
January 2010

Cancer-associated neochromosomes: a novel mechanism of oncogenesis.

Bioessays 2009 Nov;31(11):1191-200

Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1002/bies.200800208DOI Listing
November 2009

Other targetable sarcomas.

Semin Oncol 2009 Aug;36(4):358-71

Sarcoma Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2009.06.008DOI Listing
August 2009

Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.

Expert Rev Anticancer Ther 2009 Aug;9(8):1145-57

Peter MacCallum Cancer Centre, St Andrew's Place East Melbourne Victoria, Australia.

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http://www.tandfonline.com/doi/full/10.1586/era.09.77
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August 2009

Gender-specific activity of chemotherapy correlates with outcomes in chemosensitive cancers of young adulthood.

Int J Cancer 2009 Jul;125(2):426-31

onTrac@PeterMac, Victorian Adolescent and Young Adult Cancer Service, Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/ijc.24376DOI Listing
July 2009

Giant cell tumour of bone.

Curr Opin Oncol 2009 Jul;21(4):338-44

Departments of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/CCO.0b013e32832c951dDOI Listing
July 2009

Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity.

J Neurochem 2009 Jun 28;109(6):1745-55. Epub 2009 Apr 28.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06094.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821503PMC
June 2009

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.

J Clin Invest 2009 Apr 23;119(4):837-51. Epub 2009 Mar 23.

Ian Potter Foundation Centre for Cancer Genetics and Preventative Medicine, and Sir Donald and Lady Trescowthick Laboratories, Peter MacCallumCancer Centre, Melbourne, Victoria, Australia.

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http://www.jci.org/articles/view/37175
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http://dx.doi.org/10.1172/JCI37175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662557PMC
April 2009

Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice.

Proc Natl Acad Sci U S A 2008 Nov 19;105(47):18402-7. Epub 2008 Nov 19.

Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.

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http://dx.doi.org/10.1073/pnas.0805925105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585042PMC
November 2008