David M Shackleford

David M Shackleford

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David M Shackleford

David M Shackleford

Publications by authors named "David M Shackleford"

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63Publications

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Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.

J Med Chem 2020 Mar 19. Epub 2020 Mar 19.

College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 986125, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00069DOI Listing
March 2020

Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial.

Clin Cancer Res 2019 Nov 21. Epub 2019 Nov 21.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Melbourne, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-2641DOI Listing
November 2019

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations.

Mol Pharm 2018 12 13;15(12):5678-5696. Epub 2018 Nov 13.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00858
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00858DOI Listing
December 2018

SAR of a new antischistosomal urea carboxylic acid.

Bioorg Med Chem Lett 2018 12 25;28(23-24):3648-3651. Epub 2018 Oct 25.

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301076PMC
December 2018

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.

Pharm Res 2018 Sep 17;35(11):210. Epub 2018 Sep 17.

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1007/s11095-018-2493-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156755PMC
September 2018

Muscarinic M receptors modulate ethanol seeking in rats.

Neuropsychopharmacology 2018 06 5;43(7):1510-1517. Epub 2018 Feb 5.

The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1038/s41386-017-0007-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983544PMC
June 2018

Progress in antischistosomal N,N'-diaryl urea SAR.

Bioorg Med Chem Lett 2018 02 29;28(3):244-248. Epub 2017 Dec 29.

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.12.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026081PMC
February 2018

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978).

J Med Chem 2016 12 28;59(23):10705-10718. Epub 2016 Nov 28.

College of Pharmacy, University of Nebraska Medical Center , 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150661PMC
December 2016

Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.

J Pharmacol Exp Ther 2016 Nov 14;359(2):354-365. Epub 2016 Sep 14.

Drug Discovery Biology (K.H.C.C., D.T.M, C.J.L, P.M.S, J.R.L, A.C.), Centre for Drug Candidate Optimization (D.M.S., R.T.P.), and Medicinal Chemistry (S.N.M, P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia; and Melbourne Neuropsychiatry Centre, Department of Psychiatry and Centre for Neural Engineering, University of Melbourne, Melbourne, Australia (C.P.)

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http://dx.doi.org/10.1124/jpet.116.235788DOI Listing
November 2016

Quantifying Uncertainty in the Ratio of Two Measured Variables: A Recap and Example.

J Pharm Sci 2016 11 14;105(11):3462-3463. Epub 2016 Sep 14.

Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549164160
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http://dx.doi.org/10.1016/j.xphs.2016.07.019DOI Listing
November 2016

PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice.

J Pharm Sci 2015 May 5;104(5):1848-55. Epub 2015 Mar 5.

Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1002/jps.24412DOI Listing
May 2015

The effect of intravenous sulfobutylether7 -β-cyclodextrin on the pharmacokinetics of a series of adamantane-containing compounds.

J Pharm Sci 2015 Apr 8;104(4):1492-8. Epub 2015 Jan 8.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549153017
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http://dx.doi.org/10.1002/jps.24331DOI Listing
April 2015

Evaluation of the impact of sulfobutylether7 -β-cyclodextrin on the liquid chromatography-mass spectrometry analysis of biological samples arising from in vivo pharmacokinetic studies.

J Pharm Sci 2015 Apr 12;104(4):1561-2. Epub 2015 Jan 12.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1002/jps.24348DOI Listing
April 2015

Practical lessons in murine thoracic lymph duct cannulations: observations in female and male mice across four different strains that impact on "cannulatability".

J Pharm Sci 2015 Mar 23;104(3):1207-9. Epub 2014 Dec 23.

Drug Delivery Disposition Dynamics Group, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1002/jps.24312DOI Listing
March 2015

3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.

Bioorg Med Chem Lett 2013 Dec 8;23(24):6868-73. Epub 2013 Oct 8.

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.09.100DOI Listing
December 2013

Discovery and structure-activity relationships of pyrrolone antimalarials.

J Med Chem 2013 Apr 21;56(7):2975-90. Epub 2013 Mar 21.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm400009cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624797PMC
April 2013

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.

Bioorg Med Chem Lett 2013 Jan 29;23(2):455-9. Epub 2012 Nov 29.

Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland 4111, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.056DOI Listing
January 2013

Probing a potential in vivo drug-excipient interaction: temporal effects of a modified β-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand.

J Pharm Sci 2012 Sep 1;101(9):3381-9. Epub 2012 May 1.

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S002235491531447
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http://dx.doi.org/10.1002/jps.23177DOI Listing
September 2012

Antimalarial pyrido[1,2-a]benzimidazoles.

J Med Chem 2011 Jul 16;54(13):4581-9. Epub 2011 Jun 16.

Department of Chemistry, University of Cape Town, Rondebosch, South Africa.

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http://dx.doi.org/10.1021/jm200227rDOI Listing
July 2011

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system.

Biopharm Drug Dispos 2010 Nov;31(8-9):450-4

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1002/bdd.725DOI Listing
November 2010

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE(7)-beta-CD on the disposition of chlorpromazine in the rat.

J Pharm Sci 2010 Jul;99(7):2999-3008

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1002/jps.22064DOI Listing
July 2010

Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Oct 17;877(27):2989-95. Epub 2009 Jul 17.

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.jchromb.2009.07.015DOI Listing
October 2009

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism.

Pharm Res 2009 Jun 12;26(6):1486-95. Epub 2009 Mar 12.

Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1007/s11095-009-9860-zDOI Listing
June 2009

Loading-washout studies of the stereoselective sinusoidal uptake of (R)- and (s)-2-phenylpropionyl acyl glucuronide.

Curr Drug Metab 2006 Oct;7(7):817-26

Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.2174/138920006778520589DOI Listing
October 2006

Stereoselective hepatic disposition of model diastereomeric acyl glucuronides.

J Pharmacokinet Pharmacodyn 2004 Feb;31(1):1-27

Centre for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences. University of South Australia, Frome Road, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1023/b:jopa.0000029486.60317.25DOI Listing
February 2004

The effects of the phytoestrogenic isoflavone genistein on the hepatic disposition of preformed and hepatically generated gemfibrozil 1-O-acyl glucuronide in the isolated perfused rat liver.

J Pharm Pharmacol 2003 Oct;55(10):1433-9

Centre for Pharmaceutical Research, School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, SA 5000, Australia.

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http://doi.wiley.com/10.1211/0022357022016
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http://dx.doi.org/10.1211/0022357022016DOI Listing
October 2003

Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs.

J Pharmacol Exp Ther 2003 Sep 13;306(3):925-33. Epub 2003 Jun 13.

Department of Pharmaceutics, Victorian College of Pharmacy, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1124/jpet.103.052522DOI Listing
September 2003

Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs.

Pharm Res 2003 Sep;20(9):1460-5

Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1023/a:1025718513246DOI Listing
September 2003

Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?

Biopharm Drug Dispos 2003 May;24(4):153-7

Department of Pharmaceutics, Victorian College of Pharmacy, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1002/bdd.351DOI Listing
May 2003

Self-micellization of gemfibrozil 1-O-beta acyl glucuronide in aqueous solution.

Pharm Res 2003 Mar;20(3):465-70

Department of Pharmaceutics, Victorian College of Pharmacy, Monash University (Parkville campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1023/a:1022672608657DOI Listing
March 2003