Publications by authors named "David M Sansom"

50Publications

Dimers Aren't Forever: CD80 Breaks up with PD-L1.

Immunity 2019 12;51(6):972-974

UCL Institute of Immunity and Transplantation, Royal Free Hospital, London NW3 2PF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.11.011DOI Listing
December 2019

Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells.

Methods Mol Biol 2019 ;1899:87-101

UCL Institute of Immunity and Transplantation, University College London, London, UK.

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http://link.springer.com/10.1007/978-1-4939-8938-6_7
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http://dx.doi.org/10.1007/978-1-4939-8938-6_7DOI Listing
June 2019

Characterization of CTLA4 Trafficking and Implications for Its Function.

Biophys J 2018 10 23;115(7):1330-1343. Epub 2018 Aug 23.

Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Centre for Individualised Infection Medicine, Hannover, Germany; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495183097
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http://dx.doi.org/10.1016/j.bpj.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170599PMC
October 2018

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.

J Allergy Clin Immunol 2018 12 4;142(6):1932-1946. Epub 2018 May 4.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215742PMC
December 2018

Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.

Clin Immunol 2018 03 3;188:94-102. Epub 2018 Jan 3.

Seccion de Infectología e Inmunopatología, Unidad de Pediatria, Hospital Virgen del Rocío, Sevilla, Instituto de Biomedicina de Sevilla (IBiS), Spain.

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http://dx.doi.org/10.1016/j.clim.2018.01.001DOI Listing
March 2018

CTLA-4: a moving target in immunotherapy.

Blood 2018 01 8;131(1):58-67. Epub 2017 Nov 8.

Institute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2017-06-741033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317697PMC
January 2018

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint.

J Autoimmun 2018 03 21;88:50-60. Epub 2017 Oct 21.

Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK; Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

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http://dx.doi.org/10.1016/j.jaut.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854374PMC
March 2018

1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.

J Immunol 2015 Sep 14;195(6):2657-65. Epub 2015 Aug 14.

Institute of Immunity and Transplantation, University College London and Royal Free Hospital, London NW3 2PF, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1500306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560489PMC
September 2015

IMMUNOLOGY. Moving CTLA-4 from the trash to recycling.

Authors:
David M Sansom

Science 2015 Jul 23;349(6246):377-8. Epub 2015 Jul 23.

Institute of Immunity and Transplantation, University College London, Royal Free Hospital, London, UK.

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http://dx.doi.org/10.1126/science.aac7888DOI Listing
July 2015

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.

J Immunol 2015 Mar 28;194(5):2148-59. Epub 2015 Jan 28.

Division of Infection and Immunity, Department of Immunology, Institute of Immunity and Transplantation, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1401876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522736PMC
March 2015

Confusing signals: recent progress in CTLA-4 biology.

Trends Immunol 2015 Feb 9;36(2):63-70. Epub 2015 Jan 9.

Institute for Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, NW3 2PF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323153PMC
February 2015

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.

Proc Natl Acad Sci U S A 2015 Jan 29;112(2):524-9. Epub 2014 Dec 29.

Institute of Immunity and Transplantation, University College London Division of Infection and Immunity, London, United Kingdom NW3 2PF; and

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http://dx.doi.org/10.1073/pnas.1414576112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299196PMC
January 2015

A transendocytosis perspective on the CD28/CTLA-4 pathway.

Adv Immunol 2014 ;124:95-136

UCL Institute of Immunity and Transplantation, Royal Free Campus, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-800147-9.00004-2DOI Listing
May 2015

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis.

Gastroenterology 2014 Jul 12;147(1):221-232.e7. Epub 2014 Apr 12.

Centre for Liver Research and National Institute for Health Research Biomedical Research Unit in Liver Disease, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961260PMC
July 2014

Regulatory T cells and COPD.

Thorax 2013 Dec 21;68(12):1176-8. Epub 2013 Oct 21.

University of Birmingham School of Experimental Medicine, College of Medical and Dental Sciences, , Birmingham, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2013-203878DOI Listing
December 2013

Comparison of the intracellular trafficking itinerary of ctla-4 orthologues.

PLoS One 2013 2;8(4):e60903. Epub 2013 Apr 2.

The MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060903PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614947PMC
September 2013

CD28 costimulation: walking the immunological tightrope.

Eur J Immunol 2013 Jan;43(1):42-5

MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/eji.201243211DOI Listing
January 2013

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.

J Immunol 2012 Dec 19;189(11):5155-64. Epub 2012 Oct 19.

Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham College of Medical and Dental Sciences, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1200786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504609PMC
December 2012

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.

J Immunol 2012 Aug 29;189(3):1118-22. Epub 2012 Jun 29.

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1200972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442233PMC
August 2012

Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation.

J Biol Chem 2012 Mar 19;287(12):9429-40. Epub 2012 Jan 19.

MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham Medical School, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.304329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308817PMC
March 2012

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.

Nat Rev Immunol 2011 11 25;11(12):852-63. Epub 2011 Nov 25.

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1038/nri3108DOI Listing
November 2011

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.

Science 2011 Apr 7;332(6029):600-3. Epub 2011 Apr 7.

Medical Research Council (MRC) Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1126/science.1202947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198051PMC
April 2011

1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.

J Immunol 2009 Nov;183(9):5458-67

Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0803217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810518PMC
November 2009

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.

J Immunol 2009 Jan;182(1):274-82

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.182.1.274DOI Listing
January 2009

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.

J Immunol 2008 Aug;181(3):1683-91

Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758479PMC
http://dx.doi.org/10.4049/jimmunol.181.3.1683DOI Listing
August 2008

Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease.

J Steroid Biochem Mol Biol 2007 Mar;103(3-5):316-21

Burns and Allen Research Institute, Division of Endocrinology, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2006.12.078DOI Listing
March 2007

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology.

Immunol Rev 2006 Aug;212:131-48

MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK.

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http://dx.doi.org/10.1111/j.0105-2896.2006.00419.xDOI Listing
August 2006

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.

Eur J Immunol 2006 Jun;36(6):1413-22

MRC Centre for Immune Regulation, University of Birmingham Medical School, UK.

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http://dx.doi.org/10.1002/eji.200535170DOI Listing
June 2006

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.

J Immunol 2005 Apr;174(8):4803-11

Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.174.8.4803DOI Listing
April 2005

CTLA4 gene polymorphism and autoimmunity.

Immunol Rev 2005 Apr;204:102-15

Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B9 5SS, UK.

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http://dx.doi.org/10.1111/j.0105-2896.2005.00249.xDOI Listing
April 2005

Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.

Immunology 2004 May;112(1):38-43

Department of Fetal Medicine, Division of Reproduction and Child Health, University of Birmingham, Birmingham Women's Hospital, Birmingham, United Kingdom.

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http://doi.wiley.com/10.1111/j.1365-2567.2004.01869.x
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http://dx.doi.org/10.1111/j.1365-2567.2004.01869.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782465PMC
May 2004

CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.

J Immunol 2004 Mar;172(5):2778-84

Medical Research Council Center for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.172.5.2778DOI Listing
March 2004

Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition.

J Biol Chem 2004 Jan 14;279(2):1297-303. Epub 2003 Oct 14.

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1074/jbc.M307333200DOI Listing
January 2004

What's the difference between CD80 and CD86?

Trends Immunol 2003 Jun;24(6):314-9

MRC Centre for Immune Regulation, University of Birmingham Medical School Vincent Drive, UK.

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http://www.cell.com/trends/immunology/pdf/S1471-4906(03)0011
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http://dx.doi.org/10.1016/s1471-4906(03)00111-xDOI Listing
June 2003

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.

Eur J Immunol 2002 Oct;32(10):2888-96

MRC Centre for Immune Regulation, University of Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, GB, UK.

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http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2888::AID-IMMU2888>3.0.CO;2-FDOI Listing
October 2002