David M Lucas

David M Lucas

UNVERIFIED PROFILE

Are you David M Lucas?   Register this Author

Register author
David M Lucas

David M Lucas

Publications by authors named "David M Lucas"

Are you David M Lucas?   Register this Author

80Publications

1955Reads

5Profile Views

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.

J Nat Prod 2017 03 16;80(3):648-658. Epub 2016 Dec 16.

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jnatprod.6b00924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365359PMC
March 2017

Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model.

Small 2016 Jan 19;12(3):308-20. Epub 2015 Nov 19.

Department of Mechanical and Aerospace Engineering, College of Engineering, Biophysics Graduate Program, The Ohio State University, Columbus, OH, 43210, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/smll.201502118
Publisher Site
http://dx.doi.org/10.1002/smll.201502118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879968PMC
January 2016

BRAF induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation.

Leuk Res 2015 Sep 5. Epub 2015 Sep 5.

Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, College of Medicine; The Ohio State University, Columbus, OH, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2015.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779435PMC
September 2015

Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album.

J Antibiot (Tokyo) 2015 Mar 24;68(3):191-6. Epub 2014 Sep 24.

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ja.2014.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372511PMC
March 2015

Cotreatment of hairy cell leukemia and melanoma with the BRAF inhibitor dabrafenib.

J Natl Compr Canc Netw 2015 Jan;13(1):9-13; quiz 13

From the Division of Hematology, Department of Internal Medicine, Department of Pathology, and Division of Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6004/jnccn.2015.0004DOI Listing
January 2015

Therapeutic potential of the translation inhibitor silvestrol in hepatocellular cancer.

PLoS One 2013 26;8(9):e76136. Epub 2013 Sep 26.

Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, Ohio, United States of America ; Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784426PMC
July 2014

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species.

Nat Prod Rep 2014 Jul 2;31(7):924-39. Epub 2014 May 2.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c4np00006dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091845PMC
July 2014

Potentiating effect of the flavonolignan (-)-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line.

Phytother Res 2013 Nov 28;27(11):1735-8. Epub 2012 Dec 28.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ptr.4903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639301PMC
November 2013

Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis.

Nucleic Acids Res 2013 Nov 16;41(20):9284-95. Epub 2013 Aug 16.

Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814372PMC
November 2013

Bioactive constituents of Indigofera spicata.

J Nat Prod 2013 Aug 30;76(8):1498-504. Epub 2013 Jul 30.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/np400567cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806331PMC
August 2013

High-sensitivity TFA-free LC-MS for profiling histones.

Proteomics 2011 Aug;11(16):3326-34

Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201000445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517135PMC
August 2011

Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL.

Blood 2011 Jan 22;117(3):862-71. Epub 2010 Nov 22.

Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, the Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-05-284638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035078PMC
January 2011

Potential of plant-derived natural products in the treatment of leukemia and lymphoma.

Curr Drug Targets 2010 Jul;11(7):812-22

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 410 W. 12th Avenue, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892601PMC
http://dx.doi.org/10.2174/138945010791320809DOI Listing
July 2010

Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.

Haematologica 2010 Jul 11;95(7):1098-105. Epub 2010 May 11.

Division of Hematology and Oncology and the Comprehensive Cancer Center, Department of Medicine, The Ohio State University, B310 Starling-Loving Hall, 320 West 10 Avenue, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2009.017103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895033PMC
July 2010

Effects of motexafin gadolinium in a phase II trial in refractory chronic lymphocytic leukemia.

Leuk Lymphoma 2009 Dec;50(12):1977-82

Division of Hematology-Oncology, The Ohio State University, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/10428190903288464DOI Listing
December 2009

Prolonged myelosuppression with clofarabine in the treatment of patients with relapsed or refractory, aggressive non-Hodgkin lymphoma.

Leuk Lymphoma 2009 Mar;50(3):349-56

Division of Hematology-Oncology, Department of Internal Medicine, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428190902730227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695225PMC
March 2009

PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.

J Biol Chem 2009 Jan 7;284(1):455-64. Epub 2008 Nov 7.

Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M802840200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610515PMC
January 2009

Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia.

Br J Haematol 2007 Dec 19;139(5):837-44. Epub 2007 Oct 19.

Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2141.2007.06878.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2007.06878.xDOI Listing
December 2007

Novel agents and strategies for treatment of p53-defective chronic lymphocytic leukemia.

Best Pract Res Clin Haematol 2007 Sep;20(3):545-56

Division of Hematology-Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.beha.2007.03.005DOI Listing
September 2007

Liquid chromatography mass spectrometry profiling of histones.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 May 7;850(1-2):440-54. Epub 2007 Jan 7.

Department of Chemistry, Human Cancer Genetics, College of Medicine and Public Health, The Ohio State University Columbus, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2006.12.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694509PMC
May 2007

TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia.

J Clin Oncol 2005 Jun 4;23(17):3877-85. Epub 2005 Apr 4.

Division of Human Cancer Genetics, Department of Medicine, The Ohio State University, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2005.02.196DOI Listing
June 2005

Pentostatin in steroid-refractory acute graft-versus-host disease.

J Clin Oncol 2005 Apr;23(12):2661-8

Division of Hematologic Malignancies, Department of Oncology, Johns Hopkins Univeristy, Baltimore, MD 21231, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2005.06.130DOI Listing
April 2005

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

Blood 2005 Feb 5;105(3):959-67. Epub 2004 Oct 5.

Department of Internal Medicine, Division of Hematology-Oncology, Starling Loving Hall, Rm 302, The Ohio State University, Columbus, OH 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2004-05-1693DOI Listing
February 2005

Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets.

Cancer Res 2004 Apr;64(7):2424-33

Department of Veterinary Biosciences, Comprehensive Cancer Center and The Ohio State University, Columbus, Ohio 43210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.can-03-2870DOI Listing
April 2004