David M Loeb

David M Loeb

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David M Loeb

David M Loeb

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Enolate-forming compounds provide protection from platinum neurotoxicity.

Chem Biol Interact 2020 Jan 21;317:108961. Epub 2020 Jan 21.

Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, 10467, USA.

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http://dx.doi.org/10.1016/j.cbi.2020.108961DOI Listing
January 2020

Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition.

Cell Death Dis 2018 11 26;9(12):1161. Epub 2018 Nov 26.

Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center, College Station, TX, 77845, USA.

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http://dx.doi.org/10.1038/s41419-018-1203-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255770PMC
November 2018

Knock-in of the R394W mutation causes MDS and cooperates with to drive aggressive myeloid neoplasms in mice.

Oncotarget 2018 Oct 19;9(82):35313-35326. Epub 2018 Oct 19.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.oncotarget.com/fulltext/26238
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http://dx.doi.org/10.18632/oncotarget.26238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219680PMC
October 2018

Consensus and controversies regarding the treatment of rhabdomyosarcoma.

Pediatr Blood Cancer 2018 Feb 14;65(2). Epub 2017 Sep 14.

Division of Pediatric Hematology/Oncology, University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1002/pbc.26809DOI Listing
February 2018

Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma.

Oncotarget 2017 Oct 21;8(45):78265-78276. Epub 2017 Jul 21.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.19432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667961PMC
October 2017

Size-based detection of sarcoma circulating tumor cells and cell clusters.

Oncotarget 2017 Oct 24;8(45):78965-78977. Epub 2017 Aug 24.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.20697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668012PMC
October 2017

Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties.

Oncotarget 2017 Sep 24;8(44):77292-77308. Epub 2017 Aug 24.

The Faris D. Virani Ewing Sarcoma Center at The Texas Children's Cancer and Hematology Centers, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.18632/oncotarget.20467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652780PMC
September 2017

Treatment pathway of bone sarcoma in children, adolescents, and young adults.

Cancer 2017 Jun 21;123(12):2206-2218. Epub 2017 Mar 21.

Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, Connecticut.

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http://dx.doi.org/10.1002/cncr.30589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485018PMC
June 2017

Targeted therapy for soft tissue sarcomas in adolescents and young adults.

Adolesc Health Med Ther 2017 30;8:41-55. Epub 2017 Mar 30.

Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.2147/AHMT.S70377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384699PMC
March 2017

Induction of Immune Response after Allogeneic Wilms' Tumor 1 Dendritic Cell Vaccination and Donor Lymphocyte Infusion in Patients with Hematologic Malignancies and Post-Transplantation Relapse.

Biol Blood Marrow Transplant 2016 12 12;22(12):2149-2154. Epub 2016 Sep 12.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2016.08.028DOI Listing
December 2016

High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia.

J Pediatr Hematol Oncol 2016 11;38(8):627-635

Departments of *Oncology, Division of Pediatric Oncology †Pediatrics, The Division of Hematology ‡Medicine, The Division of Hematology §Pathology, The Division of Transfusion Medicine ¶The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD ∥Department of Pathology and Lab Medicine, The Division of Transfusion Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074865PMC
http://dx.doi.org/10.1097/MPH.0000000000000647DOI Listing
November 2016

Desmoplastic small round cell tumor: postoperative retroperitoneal mass.

Radiol Case Rep 2016 Sep 17;11(3):248-50. Epub 2016 Jun 17.

Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 401 North Broadway St., Suite 1440, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1016/j.radcr.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996917PMC
September 2016

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

PLoS One 2015 14;10(7):e0133152. Epub 2015 Jul 14.

Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY, United States of America; Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, United States of America; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133152PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501840PMC
April 2016

A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model.

Oncotarget 2016 Apr;7(16):21114-23

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

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http://www.oncotarget.com/fulltext/8522
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http://dx.doi.org/10.18632/oncotarget.8522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008272PMC
April 2016

Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells.

PLoS One 2015 20;10(3):e0119837. Epub 2015 Mar 20.

Department of Oncology, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119837PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368825PMC
February 2016

An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis.

Clin Exp Metastasis 2015 Oct 18;32(7):703-15. Epub 2015 Aug 18.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting-Blaustein Cancer Research Building, Room 2M51, 1650 Orleans St., Baltimore, MD, 21231, USA.

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http://link.springer.com/10.1007/s10585-015-9738-x
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http://dx.doi.org/10.1007/s10585-015-9738-xDOI Listing
October 2015

Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma.

Br J Cancer 2015 Sep 20;113(6):894-901. Epub 2015 Aug 20.

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/bjc.2015.298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578089PMC
September 2015

Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line.

Front Cell Dev Biol 2015 9;3:15. Epub 2015 Mar 9.

Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Baltimore, MD, USA ; Ron Matricaria Institute of Molecular Medicine, Phoenix Children's Hospital, University of Arizona Phoenix, AZ, USA.

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http://journal.frontiersin.org/Article/10.3389/fcell.2015.00
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http://dx.doi.org/10.3389/fcell.2015.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353378PMC
March 2015

Population pharmacokinetics of bevacizumab in children with osteosarcoma: implications for dosing.

Clin Cancer Res 2014 May 17;20(10):2783-92. Epub 2014 Mar 17.

Authors' Affiliations: Departments of Pharmaceutical Sciences, Oncology, Biostatistics, and Surgery; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas; Department of Pediatrics, Stanford School of Medicine, Palo Alto, California; and Department of Oncology, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024352PMC
May 2014

WT1 regulates angiogenesis in Ewing Sarcoma.

Oncotarget 2014 May;5(9):2436-49

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058017PMC
http://dx.doi.org/10.18632/oncotarget.1610DOI Listing
May 2014

Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.

PLoS Genet 2014 Jan 16;10(1):e1004107. Epub 2014 Jan 16.

Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894165PMC
January 2014

Beyond Palliation: Therapeutic Applications of Samarium-EDTMP.

Clin Exp Pharmacol 2013 Jun;3(3)

Department of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.4172/2161-1459.1000131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319527PMC
June 2013

LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling.

Front Oncol 2013 15;3:81. Epub 2013 Apr 15.

Keck School of Medicine, University Southern California Los Angeles, CA, USA ; Department of Pediatrics, University of Michigan Ann Arbor, MI, USA.

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http://dx.doi.org/10.3389/fonc.2013.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625903PMC
April 2013

Epithelioid sarcoma: one institution's experience with a rare sarcoma.

J Surg Res 2012 Sep 1;177(1):116-22. Epub 2012 May 1.

Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1016/j.jss.2012.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715113PMC
September 2012

Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma.

Pediatr Blood Cancer 2012 Jul 18;59(1):179-81. Epub 2011 Aug 18.

Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21287, USA.

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http://doi.wiley.com/10.1002/pbc.23321
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http://dx.doi.org/10.1002/pbc.23321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273568PMC
July 2012

Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acid therapy of high-risk osteosarcoma.

J Nucl Med 2012 Feb 17;53(2):215-24. Epub 2012 Jan 17.

Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.

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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.111.096677
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http://dx.doi.org/10.2967/jnumed.111.096677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291096PMC
February 2012

WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia.

J Biol Chem 2011 Dec 26;286(51):43634-43. Epub 2011 Oct 26.

Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.310128
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http://dx.doi.org/10.1074/jbc.M111.310128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243556PMC
December 2011

Targeted treatment in sarcoma patients.

Authors:
David M Loeb

Clin Adv Hematol Oncol 2011 Dec;9(12):934-5

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.

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December 2011

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

J Neurosurg 2011 Oct 24;115(4):760-9. Epub 2011 Jun 24.

Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.3171/2011.5.JNS11185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273567PMC
October 2011

Tandem dosing of samarium-153 ethylenediamine tetramethylene phosphoric acid with stem cell support for patients with high-risk osteosarcoma.

Cancer 2010 Dec 16;116(23):5470-8. Epub 2010 Aug 16.

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1002/cncr.25518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991401PMC
December 2010

High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.

PLoS One 2010 Nov 11;5(11):e13943. Epub 2010 Nov 11.

Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013943PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978678PMC
November 2010

Is there a role for immunotherapy in osteosarcoma?

Authors:
David M Loeb

Cancer Treat Res 2009 ;152:447-57

Oncology and Pediatrics, Musculoskeletal Tumor Program, Johns Hopkins University, Bunting-Blaustein Cancer Research Building, Room 2M51, 1650 Orleans St, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1007/978-1-4419-0284-9_25DOI Listing
October 2010

WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.

Pediatr Blood Cancer 2009 Dec;53(6):1136-9

Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1002/pbc.22142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926132PMC
December 2009

Dose-finding study of 153Sm-EDTMP in patients with poor-prognosis osteosarcoma.

Cancer 2009 Jun;115(11):2514-22

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1002/cncr.24286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974628PMC
June 2009

Congenital T cell deficiency in a patient with CHARGE syndrome.

J Pediatr 2009 Jan;154(1):140-2

McKusick-Nathans Institute of Genetic Medicine, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.jpeds.2008.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293037PMC
January 2009

Pediatric soft tissue sarcomas.

Surg Clin North Am 2008 Jun;88(3):615-27, vii

Oncology and Pediatrics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting-Blaustein Cancer Research Building, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.suc.2008.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273573PMC
June 2008

Intravenous pentamidine is effective as second line Pneumocystis pneumonia prophylaxis in pediatric oncology patients.

Pediatr Blood Cancer 2008 Apr;50(4):779-83

Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.21287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273575PMC
April 2008

Treatment of hepatitis-associated aplastic anemia with high-dose cyclophosphamide.

Pediatr Blood Cancer 2007 Dec;49(7):947-51

Department of Pediatric Oncology, Johns Hopkins Hospital, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.21143DOI Listing
December 2007

The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis.

Expert Rev Mol Med 2007 May 24;9(14):1-17. Epub 2007 May 24.

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1017/S1462399407000336DOI Listing
May 2007

The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy.

Blood 2006 Jun 16;107(12):4695-702. Epub 2006 Feb 16.

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1182/blood-2005-10-4025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895805PMC
June 2006

WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members.

Authors:
David M Loeb

Cell Cycle 2006 Jun;5(12):1249-53

Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Bunting Blaustein Cancer Research Building, Room 254, 1650 Orleans St., Baltimore, Maryland 21231 USA.

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http://dx.doi.org/10.4161/cc.5.12.2807DOI Listing
June 2006

Significant responses to platinum-based chemotherapy in renal medullary carcinoma.

Pediatr Blood Cancer 2005 Apr;44(4):407-11

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.20292DOI Listing
April 2005

Remission of severe autoimmune enteropathy after treatment with high-dose cyclophosphamide.

J Pediatr Gastroenterol Nutr 2003 May;36(5):639-43

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21187-2631, USA.

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http://dx.doi.org/10.1097/00005176-200305000-00010DOI Listing
May 2003

Images in clinical medicine. Tumor pseudosyncytiae.

N Engl J Med 2003 Apr;348(14):1348

Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1056/NEJMicm980667DOI Listing
April 2003

Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy.

J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):478-81

Department of Oncology Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/00043426-200208000-00014DOI Listing
December 2002

What is the optimal therapy for childhood AML?

Oncology (Williston Park) 2002 Aug;16(8):1057-66; discussion 1066, 1068-70

Johns Hopkins Oncology Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231, USA.

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August 2002

The role of WT1 in oncogenesis: tumor suppressor or oncogene?

Int J Hematol 2002 Aug;76(2):117-26

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1007/bf02982573DOI Listing
August 2002

Cyclin E is a target of WT1 transcriptional repression.

J Biol Chem 2002 May 27;277(22):19627-32. Epub 2002 Mar 27.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1074/jbc.M201336200DOI Listing
May 2002