Publications by authors named "David M Clarke"

100Publications

Measuring postnatal demoralisation: adaptation of the Demoralisation Scale-II (DS-II) for postnatal use.

J Reprod Infant Psychol 2018 11 25;36(5):561-577. Epub 2018 Sep 25.

a Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University , Melbourne , Australia.

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http://dx.doi.org/10.1080/02646838.2018.1519781DOI Listing
November 2018

Symptom attribution and treatment seeking in Australian veterans.

J Health Psychol 2020 Sep 7;25(10-11):1498-1510. Epub 2018 Mar 7.

Monash University, Australia.

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http://dx.doi.org/10.1177/1359105318760156DOI Listing
September 2020

Medical student psychological distress and academic performance.

Med Teach 2018 12 21;40(12):1257-1263. Epub 2018 Jan 21.

a School of Clinical Sciences at Monash Health , Monash University , Clayton , Australia.

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http://dx.doi.org/10.1080/0142159X.2018.1427222DOI Listing
December 2018

A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate.

Biochem Pharmacol 2017 12 29;145:27-33. Epub 2017 Aug 29.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.014DOI Listing
December 2017

Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.

Biochem Biophys Res Commun 2017 07 19;488(4):573-577. Epub 2017 May 19.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.05.106DOI Listing
July 2017

Corrector VX-809 promotes interactions between cytoplasmic loop one and the first nucleotide-binding domain of CFTR.

Biochem Pharmacol 2017 07 31;136:24-31. Epub 2017 Mar 31.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.03.020DOI Listing
July 2017

Attachment of a 'molecular spring' restores drug-stimulated ATPase activity to P-glycoprotein lacking both Q loop glutamines.

Biochem Biophys Res Commun 2017 01 23;483(1):366-370. Epub 2016 Dec 23.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.12.137DOI Listing
January 2017

Refinement and revalidation of the demoralization scale: The DS-II-internal validity.

Cancer 2016 07 12;122(14):2251-9. Epub 2016 May 12.

School of Psychological Sciences, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1002/cncr.30015DOI Listing
July 2016

Refinement and revalidation of the demoralization scale: The DS-II-external validity.

Cancer 2016 Jul 12;122(14):2260-7. Epub 2016 May 12.

School of Psychological Sciences, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1002/cncr.30012DOI Listing
July 2016

Drugs Modulate Interactions between the First Nucleotide-Binding Domain and the Fourth Cytoplasmic Loop of Human P-Glycoprotein.

Biochemistry 2016 05 11;55(20):2817-20. Epub 2016 May 11.

Departments of Medicine and Biochemistry, University of Toronto , Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/acs.biochem.6b00233DOI Listing
May 2016

P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface.

Biochem Biophys Res Commun 2016 Apr 2;472(2):379-83. Epub 2016 Mar 2.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.02.124DOI Listing
April 2016

Health Anxiety and Its Relationship to Disability and Service Use: Findings From a Large Epidemiological Survey.

Psychosom Med 2016 Jan;78(1):13-25

From the Department of Psychiatry, School of Clinical Sciences at Monash Health, Monash University and Monash Health (Bobevski, Clarke, Meadows), Melbourne, Australia; and Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University (Bobevski), Melbourne, Australia.

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http://dx.doi.org/10.1097/PSY.0000000000000252DOI Listing
January 2016

Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.

J Biol Chem 2015 Dec 26;290(49):29389-401. Epub 2015 Oct 26.

From the Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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http://dx.doi.org/10.1074/jbc.M115.695171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705942PMC
December 2015

Developing a brief depression screen and identifying associations with comorbid physical and psychological illness in Australian Gulf War veterans.

J Psychosom Res 2015 Dec 13;79(6):566-73. Epub 2015 Aug 13.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.jpsychores.2015.08.003DOI Listing
December 2015

Early postnatal demoralisation among primiparous women in the community: measurement, prevalence and associated factors.

BMC Pregnancy Childbirth 2015 Oct 12;15:259. Epub 2015 Oct 12.

Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1186/s12884-015-0680-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603773PMC
October 2015

Symptom attribution and symptom reporting in Australian Gulf War veterans.

J Psychosom Res 2015 Dec 30;79(6):674-9. Epub 2015 Apr 30.

Department of Epidemiology & Preventive Medicine, Monash University, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychores.2015.04.012DOI Listing
December 2015

The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein.

J Biol Chem 2015 Jul 18;290(27):16954-63. Epub 2015 May 18.

From the Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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http://dx.doi.org/10.1074/jbc.M115.652602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505440PMC
July 2015

Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation.

Biochem Pharmacol 2014 Dec 22;92(4):558-66. Epub 2014 Oct 22.

Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.10.006DOI Listing
December 2014

Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.

J Biol Chem 2014 Sep 22;289(36):24749-58. Epub 2014 Jul 22.

From the Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

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http://dx.doi.org/10.1074/jbc.M114.583021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155644PMC
September 2014

GILZ: Glitzing up our understanding of the glucocorticoid receptor in psychopathology.

Brain Res 2014 Jul 12;1574:60-9. Epub 2014 Jun 12.

Department of Medicine, Monash University, Wellington Rd, Clayton, VIC, Australia.

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http://dx.doi.org/10.1016/j.brainres.2014.06.008DOI Listing
July 2014

Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.

J Biol Chem 2014 Mar 12;289(12):8484-92. Epub 2014 Feb 12.

From the Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M114.552075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961673PMC
March 2014

The INSPIRED study: a randomised controlled trial of the Whole Person Model of disease self-management for people with type 2 diabetes.

BMC Public Health 2014 Feb 8;14:134. Epub 2014 Feb 8.

Department of Psychological Medicine, Monash University and Monash Health, Level 3, P Block, Monash Medical Centre, 246 Clayton Rd, Clayton, 3168 Melbourne, VIC, Australia.

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http://dx.doi.org/10.1186/1471-2458-14-134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933337PMC
February 2014

The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds.

Biochem Pharmacol 2014 Mar 9;88(1):46-57. Epub 2014 Jan 9.

Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8; Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.12.027DOI Listing
March 2014

Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.

J Biol Chem 2014 Jan 25;289(1):229-36. Epub 2013 Nov 25.

From the Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M113.527804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879546PMC
January 2014

Drug rescue distinguishes between different structural models of human P-glycoprotein.

Biochemistry 2013 Oct 2;52(41):7167-9. Epub 2013 Oct 2.

Departments of Medicine and Biochemistry, University of Toronto , Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi401269mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798097PMC
October 2013

Psychosocial treatment approaches to difficult-to-treat depression.

Med J Aust 2013 09;199(S6):S52-5

School of Psychology and Psychiatry, Monash University, Melbourne, VIC, Australia.

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September 2013

Bithiazole correctors rescue CFTR mutants by two different mechanisms.

Biochemistry 2013 Aug 22;52(31):5161-3. Epub 2013 Jul 22.

Departments of Medicine and Biochemistry, University of Toronto , Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi4008758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737597PMC
August 2013

Corrector VX-809 stabilizes the first transmembrane domain of CFTR.

Biochem Pharmacol 2013 Sep 5;86(5):612-9. Epub 2013 Jul 5.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.bcp.2013.06.028DOI Listing
September 2013

Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.

J Biol Chem 2013 Jul 3;288(28):20326-33. Epub 2013 Jun 3.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M113.484550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711299PMC
July 2013

Support mechanisms and vulnerabilities in relation to PTSD in veterans of the Gulf War, Iraq War, and Afghanistan deployments: a systematic review.

J Trauma Stress 2013 Jun 13;26(3):310-8. Epub 2013 May 13.

Department of Epidemiology & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/jts.21809DOI Listing
June 2013

A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein.

Biochemistry 2013 May 3;52(19):3194-6. Epub 2013 May 3.

Departments of Medicine and Biochemistry, University of Toronto , Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi400425kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656768PMC
May 2013

Niemann-Pick NPC1: sterols to the rescue and beyond.

Chem Biol 2013 Mar;20(3):297-8

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.chembiol.2013.03.001DOI Listing
March 2013

Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).

Bioorg Med Chem 2012 Jul 7;20(14):4290-302. Epub 2012 Jun 7.

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, United States.

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http://dx.doi.org/10.1016/j.bmc.2012.05.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400123PMC
July 2012

The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together.

J Biol Chem 2012 Aug 14;287(32):26806-16. Epub 2012 Jun 14.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M112.376202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411018PMC
August 2012

Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).

J Med Chem 2012 May 10;55(10):4683-99. Epub 2012 May 10.

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.

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http://dx.doi.org/10.1021/jm3004398DOI Listing
May 2012

Corrector-mediated rescue of misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump.

Biochem Pharmacol 2012 Feb 28;83(3):345-54. Epub 2011 Nov 28.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.bcp.2011.11.014DOI Listing
February 2012

Meeting the challenge in care of co-occurring disorders.

Med J Aust 2011 Aug;195(3):S5-6

Turning Point Alcohol and Drug Centre, Eastern Health, Melbourne, VIC, Australia.

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August 2011

Repair of CFTR folding defects with correctors that function as pharmacological chaperones.

Methods Mol Biol 2011 ;741:23-37

Department of Medicine, University of Toronto, M5S 1AS, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-117-8_3DOI Listing
September 2011

No cancer health without mental health.

Authors:
David M Clarke

Med J Aust 2010 09;193(S5):S43

Monash Medical Centre, Melbourne, VIC.

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September 2010

Benzbromarone stabilizes ΔF508 CFTR at the cell surface.

Biochemistry 2011 May 3;50(21):4393-5. Epub 2011 May 3.

Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/bi2004813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100783PMC
May 2011

The W232R suppressor mutation promotes maturation of a truncation mutant lacking both nucleotide-binding domains and restores interdomain assembly and activity of P-glycoprotein processing mutants.

Biochemistry 2011 Feb 11;50(5):672-85. Epub 2011 Jan 11.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi1016809DOI Listing
February 2011

The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface.

Biochemistry 2010 Aug;49(30):6352-7

Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/bi100807hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911077PMC
August 2010

Pessimism, worthlessness, anhedonia, and thoughts of death identify DSM-IV major depression in hospitalized, medically ill patients.

Psychosomatics 2010 Jul-Aug;51(4):302-11

Monash Centre for Occupational and Environmental Health, Dept. of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria, 3004 Australia.

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http://dx.doi.org/10.1176/appi.psy.51.4.302DOI Listing
October 2010

Human P-glycoprotein is active when the two halves are clamped together in the closed conformation.

Biochem Biophys Res Commun 2010 May 13;395(3):436-40. Epub 2010 Apr 13.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbrc.2010.04.057DOI Listing
May 2010

Which factors predict the persistence of DSM-IV depression, anxiety, and somatoform disorders in the medically ill three months post hospital discharge?

J Psychosom Res 2010 Jan;68(1):21-8

Psychological and Behavioural Medicine Unit, Monash University School of Psychiatry, Psychology, and Psychological Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia.

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http://dx.doi.org/10.1016/j.jpsychores.2009.08.004DOI Listing
January 2010

Correctors enhance maturation of DeltaF508 CFTR by promoting interactions between the two halves of the molecule.

Biochemistry 2009 Oct;48(41):9882-90

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi9004842DOI Listing
October 2009

Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis.

J Biol Chem 2009 Sep 6;284(36):24074-87. Epub 2009 Jul 6.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M109.023267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782001PMC
September 2009

Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence.

Med J Aust 2009 04;190(S7):S54-60

Psychological Medicine, Monash University, Melbourne, VIC, Australia.

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April 2009

Depression and physical illness: more complex than simple comorbidity.

Authors:
David M Clarke

Med J Aust 2009 04;190(S7):S52-3

Psychological Medicine, Monash University, Melbourne, VIC, Australia.

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April 2009

Somatic symptoms, hypochondriasis and psychological distress: a study of somatisation in Australian general practice.

Med J Aust 2008 Nov;189(10):560-4

Monash University, Melbourne, VIC, Australia.

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November 2008

Impact of an educational intervention on general practitioners' skills in cognitive behavioural strategies: a randomised controlled trial.

Med J Aust 2008 06;188(S12):S129-32

Department of General Practice, University of Melbourne, Melbourne, VIC, Australia.

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June 2008

What do general practitioners think depression is? A taxonomy of distress and depression for general practice.

Med J Aust 2008 06;188(S12):S110-3

Monash University, Melbourne, VIC, Australia.

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June 2008

Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.

J Biol Chem 2008 Sep 2;283(36):24860-70. Epub 2008 Jul 2.

Department of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M803351200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259837PMC
September 2008

Correctors promote folding of the CFTR in the endoplasmic reticulum.

Biochem J 2008 Jul;413(1):29-36

Department of Medicine and Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://www.biochemj.org/content/ppbiochemj/413/1/29.full.pdf
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http://biochemj.org/lookup/doi/10.1042/BJ20071690
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http://dx.doi.org/10.1042/BJ20071690DOI Listing
July 2008

Mutational analysis of ABC proteins.

Arch Biochem Biophys 2008 Aug 5;476(1):51-64. Epub 2008 Mar 5.

Department of Medicine, University of Toronto, 1 King's College Circle, Rm. 7342, Medical Sciences Building, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.abb.2008.02.025DOI Listing
August 2008

Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.

J Biol Chem 2008 Feb 13;283(8):4501-11. Epub 2007 Nov 13.

Division of Molecular Structure and Function, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M705473200
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http://dx.doi.org/10.1074/jbc.M705473200DOI Listing
February 2008

Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein.

J Biol Chem 2007 Nov 2;282(46):33247-51. Epub 2007 Oct 2.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.C700175200DOI Listing
November 2007

Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites.

J Biol Chem 2007 Nov 11;282(44):32043-52. Epub 2007 Sep 11.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M706175200DOI Listing
November 2007

Nucleotide binding, ATP hydrolysis, and mutation of the catalytic carboxylates of human P-glycoprotein cause distinct conformational changes in the transmembrane segments.

Biochemistry 2007 Aug 18;46(32):9328-36. Epub 2007 Jul 18.

Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi700837yDOI Listing
August 2007

Chemical and pharmacological chaperones as new therapeutic agents.

Expert Rev Mol Med 2007 Jun 28;9(16):1-18. Epub 2007 Jun 28.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1017/S1462399407000361DOI Listing
June 2007

Growing old and getting sick: maintaining a positive spirit at the end of life.

Authors:
David M Clarke

Aust J Rural Health 2007 Jun;15(3):148-54

Discipline of Psychological Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1440-1584.2007.00867.xDOI Listing
June 2007

Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants.

Biochem J 2007 Sep;406(2):257-63

Department of Medicine, University of Toronto, Rm 7342, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1042/BJ20070478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948964PMC
September 2007

A review of psychosocial aspects of motor neurone disease.

J Neurol Sci 2007 Jul 19;258(1-2):4-10. Epub 2007 Apr 19.

Monash University, Department of Psychological Medicine, Monash Medical Centre, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.jns.2007.03.001DOI Listing
July 2007

Somatising disorders: untangling the pathology.

Aust Fam Physician 2007 Apr;36(4):234-9

SIGPET, New South Wales, Australia.

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April 2007

Adjusting to illness and other major life events: how can GPs help?

Aust Fam Physician 2007 Apr;36(4):206-10

School of Psychology, Psychiatry and Psychological Medicine, Monash University, Victoria, Australia.

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April 2007

Supportive-expressive group therapy for women with metastatic breast cancer: survival and psychosocial outcome from a randomized controlled trial.

Psychooncology 2007 Apr;16(4):277-86

Department of Psychiatry and Behavioural Sciences, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/pon.1185DOI Listing
April 2007

Modulating the folding of P-glycoprotein and cystic fibrosis transmembrane conductance regulator truncation mutants with pharmacological chaperones.

Mol Pharmacol 2007 Mar 28;71(3):751-8. Epub 2006 Nov 28.

Department of Medicine, University of Toronto, Rm. 7342, 1 King's College Circle, Toronto, Ontario, M5S 1A8 Canada.

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http://dx.doi.org/10.1124/mol.106.029926DOI Listing
March 2007

A qualitative examination of the experience of 'depression' in hospitalized medically ill patients.

Psychopathology 2006 13;39(6):303-12. Epub 2006 Sep 13.

Department of Psychological Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1159/000095778DOI Listing
January 2007

Insertion of an arginine residue into the transmembrane segments corrects protein misfolding.

J Biol Chem 2006 Oct 22;281(40):29436-40. Epub 2006 Aug 22.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.C600209200DOI Listing
October 2006

Psychological morbidity and quality of life in women with advanced breast cancer: a cross-sectional survey.

Palliat Support Care 2006 Mar;4(1):47-56

University of Melbourne Centre for Palliative Care, Departments of Medicine and Psychiatry, St. Vincent's Hospital and Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1017/s1478951506060068DOI Listing
March 2006

Sense of coherence as a protective factor for demoralisation in women with a recent diagnosis of gynaecological cancer.

Psychooncology 2007 Mar;16(3):189-95

Department of Psychological Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1002/pon.1044DOI Listing
March 2007

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.

Biochem J 2006 Oct;399(2):351-9

Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1042/BJ20060715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609921PMC
October 2006

Rescue of folding defects in ABC transporters using pharmacological chaperones.

J Bioenerg Biomembr 2005 Dec;37(6):501-7

Department of Medicine, University of Toronto, Rm. 7342, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s10863-005-9499-3DOI Listing
December 2005

Demoralization, anhedonia and grief in patients with severe physical illness.

World Psychiatry 2005 Jun;4(2):96-105

Department of Psychological Medicine, Monash Medical Centre, Clayton, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414748PMC
June 2005

Specific rescue of cystic fibrosis transmembrane conductance regulator processing mutants using pharmacological chaperones.

Mol Pharmacol 2006 Jul 19;70(1):297-302. Epub 2006 Apr 19.

Department of Medicine, University of Toronto, Rm. 7342, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1124/mol.106.023994DOI Listing
July 2006

Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR.

J Physiol 2006 Apr 23;572(Pt 2):312. Epub 2006 Feb 23.

Department of Medicine and Biochemistry, University of Toronto, Canada.

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http://dx.doi.org/10.1113/jphysiol.2006.108159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779679PMC
April 2006

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.

Biochem J 2006 Jun;396(3):537-45

Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1042/BJ20060012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482826PMC
June 2006

Hazardous or harmful alcohol use in Royal Australian Navy veterans of the 1991 Gulf War: identification of high risk subgroups.

Addict Behav 2006 Sep 7;31(9):1683-94. Epub 2006 Feb 7.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.addbeh.2005.12.027DOI Listing
September 2006

The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants.

Biochem J 2006 May;395(3):537-42

Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1042/BJ20060013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462697PMC
May 2006

A comparison of psychosocial and physical functioning in patients with motor neurone disease and metastatic cancer.

J Palliat Care 2005 ;21(3):173-9

Monash University, Department of Psychological Medicine, Monash Medical Centre, Melbourne, Victoria, Australia.

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February 2006

Rescue of DeltaF508 and other misprocessed CFTR mutants by a novel quinazoline compound.

Mol Pharm 2005 Sep-Oct;2(5):407-13

Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/mp0500521DOI Listing
January 2006

ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein.

Biochemistry 2005 Aug;44(30):10250-8

Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi050705jDOI Listing
August 2005

Disulfiram metabolites permanently inactivate the human multidrug resistance P-glycoprotein.

Mol Pharm 2004 Nov-Dec;1(6):426-33

CIHR Group in Membrane Biology, Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1021/mp049917lDOI Listing
September 2005

Do drug substrates enter the common drug-binding pocket of P-glycoprotein through "gates"?

Biochem Biophys Res Commun 2005 Apr;329(2):419-22

Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1016/j.bbrc.2005.01.134DOI Listing
April 2005

The Demoralization Scale: a report of its development and preliminary validation.

J Palliat Care 2004 ;20(4):269-76

Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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March 2005

The dileucine motif at the COOH terminus of human multidrug resistance P-glycoprotein is important for folding but not activity.

J Biol Chem 2005 Jan 12;280(4):2522-8. Epub 2004 Nov 12.

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M411483200DOI Listing
January 2005

Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein.

Biochem Biophys Res Commun 2004 Dec;325(2):580-5

Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.bbrc.2004.10.070DOI Listing
December 2004

Effect of cognitive-existential group therapy on survival in early-stage breast cancer.

J Clin Oncol 2004 Nov 27;22(21):4255-60. Epub 2004 Sep 27.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, 1242 Second Ave, New York, NY 10021, USA.

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http://ascopubs.org/doi/10.1200/JCO.2004.12.129
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http://dx.doi.org/10.1200/JCO.2004.12.129DOI Listing
November 2004

Supportive-expressive group therapy: the transformation of existential ambivalence into creative living while enhancing adherence to anti-cancer therapies.

Psychooncology 2004 Nov;13(11):755-68

Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/pon.798DOI Listing
November 2004

The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

Biochemistry 2004 Sep;43(38):12081-9

CIHR Group in Membrane Biology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1021/bi049045tDOI Listing
September 2004

The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.

J Biol Chem 2004 Sep 21;279(38):39620-7. Epub 2004 Jul 21.

Canadian Institutes of Health Research Group in Membrane Biology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M407887200
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http://dx.doi.org/10.1074/jbc.M407887200DOI Listing
September 2004

Screening for depression in women with metastatic breast cancer: a comparison of the Beck Depression Inventory Short Form and the Hospital Anxiety and Depression Scale.

Aust N Z J Psychiatry 2004 Jul;38(7):526-31

School of Psychological Science, La Trobe University, Bundoora, Victoria 3086, Australia.

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http://dx.doi.org/10.1080/j.1440-1614.2004.01385.xDOI Listing
July 2004

Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains.

J Biol Chem 2004 Sep 9;279(37):38395-401. Epub 2004 Jul 9.

Canadian Institutes of Health Research Group in Membrane Biology, Departments of Medicine and Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M405623200DOI Listing
September 2004