Publications by authors named "David M Barrett"

67Publications

Thoracic duct lymphatic fluid harbors phenotypically naive T cells for use in adoptive T-cell therapy.

Cytotherapy 2020 Oct 1;22(10):529-535. Epub 2020 Jul 1.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jcyt.2020.05.004DOI Listing
October 2020

Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach.

Clin Cancer Res 2020 Jul 3;26(14):3505-3513. Epub 2020 Mar 3.

Division of Oncology, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367708PMC
July 2020

Partially CD3-Depleted Unrelated and Haploidentical Donor Peripheral Stem Cell Transplantation Has Favorable Graft-versus-Host Disease and Survival Rates in Pediatric Hematologic Malignancy.

Biol Blood Marrow Transplant 2020 Mar 22;26(3):493-501. Epub 2019 Nov 22.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.11.022DOI Listing
March 2020

Cellular therapy: Immune-related complications.

Immunol Rev 2019 07;290(1):114-126

Divisions of Hematology and Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/imr.12768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041800PMC
July 2019

Improving CAR T cell immunotherapy-mediated remissions for pediatric leukemia.

Authors:
David M Barrett

J Clin Invest 2019 04 15;129(5):1842-1844. Epub 2019 Apr 15.

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http://dx.doi.org/10.1172/JCI128743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486350PMC
April 2019

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 04 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.devcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346PMC
April 2019

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy.

Mol Ther 2019 04 2;27(4):747-756. Epub 2019 Feb 2.

BioNTech RNA Pharmaceuticals, Mainz, Germany.

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http://dx.doi.org/10.1016/j.ymthe.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453504PMC
April 2019

Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers.

Cancer Discov 2019 04 10;9(4):492-499. Epub 2019 Jan 10.

Division of Oncology, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676489PMC
April 2019

CD3/CD19 Depleted Matched and Mismatched Unrelated Donor Hematopoietic Stem Cell Transplant with Targeted T Cell Addback Is Associated with Excellent Outcomes in Pediatric Patients with Nonmalignant Hematologic Disorders.

Biol Blood Marrow Transplant 2019 03 9;25(3):549-555. Epub 2018 Oct 9.

Cellular Therapy and Transplant Section, Division of Oncology Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183061
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http://dx.doi.org/10.1016/j.bbmt.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122955PMC
March 2019

Getting the most from your CAR target.

Authors:
David M Barrett

Blood 2018 10;132(14):1467-1468

Children's Hospital of Philadelphia.

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http://dx.doi.org/10.1182/blood-2018-08-869552DOI Listing
October 2018

High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model.

Cancer Immunol Res 2018 01 27;6(1):36-46. Epub 2017 Nov 27.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004321PMC
January 2018

Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function.

Cytotherapy 2017 07 11;19(7):867-880. Epub 2017 May 11.

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jcyt.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676485PMC
July 2017

Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.

Crit Care Med 2017 Feb;45(2):e124-e131

1Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 2Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 3Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 4Department of Biostatistics and Epidemiology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1097/CCM.0000000000002053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452983PMC
February 2017

The Beginning of the End of Package Deal Therapy for Patients With High-Risk Neuroblastoma?

J Clin Oncol 2016 07 9;34(21):2437-9. Epub 2016 May 9.

Children's Hospital of Philadelphia, Philadelphia, PA

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http://dx.doi.org/10.1200/JCO.2016.67.2774DOI Listing
July 2016

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.

Cancer Discov 2016 06 13;6(6):664-79. Epub 2016 Apr 13.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448406PMC
June 2016

T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.

Oncoimmunology 2016;5(1):e1040216. Epub 2015 Aug 12.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1040216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760344PMC
August 2015

Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies.

Sci Transl Med 2016 Jan;8(320):320ra3

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad5222DOI Listing
January 2016

Current status of chimeric antigen receptor therapy for haematological malignancies.

Br J Haematol 2016 Jan 12;172(1):11-22. Epub 2015 Nov 12.

Abramson Cancer Center and the Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bjh.13792DOI Listing
January 2016

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Cancer Discov 2015 Dec 29;5(12):1282-95. Epub 2015 Oct 29.

Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Cell & Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670800PMC
December 2015

Donor-derived CD19 chimeric antigen receptor T cells.

Curr Opin Hematol 2015 Nov;22(6):503-8

aDepartment of Medicine, University of Pennsylvania bDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000179DOI Listing
November 2015

Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.

J Immunol 2015 Aug;195(3):755-61

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

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http://dx.doi.org/10.4049/jimmunol.1500751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507286PMC
August 2015

Roadblocks to success for RNA CARs in solid tumors.

Oncoimmunology 2014 Dec 7;3(12):e962974. Epub 2015 Jan 7.

Division of Oncology; Children's Hospital of Philadelphia ; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/21624011.2014.962974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353174PMC
December 2014

Chimeric antigen receptor T cells for sustained remissions in leukemia.

N Engl J Med 2014 Oct;371(16):1507-17

From the Division of Oncology, Children's Hospital of Philadelphia (S.L.M., R.A., D.M.B., N.J.B., S.R.R., D.T.T., S.A.G.), the Departments of Pediatrics (S.L.M., R.A., D.M.B., N.J.B., S.R.R., D.T.T., S.A.G.), Biostatistics and Epidemiology (P.A.S., R.A.), and Pathology and Laboratory Medicine (J.J.M., B.L.L., C.H.J., S.A.G.), the Division of Hematology-Oncology (N.F., D.L.P.), and Abramson Cancer Center (N.F., A.C., V.E.G., Z.Z., S.F.L., Y.D.M., J.J.M., B.L.L., C.H.J., D.L.P., S.A.G.), Perelman School of Medicine, University of Pennsylvania - all in Philadelphia; and Novartis Pharmaceuticals, East Hanover, NJ (A.S.).

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http://dx.doi.org/10.1056/NEJMoa1407222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531PMC
October 2014

Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma.

Cancer Immunol Res 2014 Nov 7;2(11):1059-70. Epub 2014 Aug 7.

Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584373PMC
November 2014

Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy.

Cytotherapy 2014 May 16;16(5):619-30. Epub 2014 Jan 16.

Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jcyt.2013.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988256PMC
May 2014

Toxicity management for patients receiving novel T-cell engaging therapies.

Curr Opin Pediatr 2014 Feb;26(1):43-9

Division of Pediatric Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOP.0000000000000043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198063PMC
February 2014

Chimeric antigen receptor therapy for cancer.

Annu Rev Med 2014 20;65:333-47. Epub 2013 Nov 20.

Abramson Cancer Center and the Departments of Medicine, Pediatrics, and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email:

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http://dx.doi.org/10.1146/annurev-med-060512-150254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120077PMC
September 2014

Candida krusei arthritis in an adolescent with acute myelogenous leukemia.

Pediatr Infect Dis J 2013 Oct;32(10):1142-4

From the *Division of Infectious Diseases, †Division of Oncology, ‡The University of Pennsylvania School of Medicine, and §Center for Pediatric Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1097/INF.0b013e318294b012DOI Listing
October 2013

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.

Blood 2013 Feb 14;121(7):1165-74. Epub 2012 Dec 14.

Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2012-06-438002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575759PMC
February 2013

The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer.

Clin Cancer Res 2012 05;18(10):2780-90

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1104, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-1920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119811PMC
May 2012

Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling.

Blood 2011 Oct 19;118(15):e112-7. Epub 2011 Aug 19.

Department of Pediatrics, Division of Oncology, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-04-34
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http://dx.doi.org/10.1182/blood-2011-04-346528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204743PMC
October 2011

Treatment of advanced leukemia in mice with mRNA engineered T cells.

Hum Gene Ther 2011 Dec 23;22(12):1575-86. Epub 2011 Sep 23.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1089/hum.2011.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237694PMC
December 2011

Pulsatile LH secretion and ovarian follicular wave emergence and growth in anestrous ewes.

Theriogenology 2010 Oct 23;74(6):912-21. Epub 2010 May 23.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

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http://dx.doi.org/10.1016/j.theriogenology.2010.04.016DOI Listing
October 2010

Ovarian follicular dominance and the induction of daily follicular waves in the ewe.

Biol Reprod 2010 Jul 24;83(1):122-9. Epub 2010 Mar 24.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

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http://dx.doi.org/10.1095/biolreprod.109.081950DOI Listing
July 2010

Relationships of changes in ultrasonographic image attributes to ovulatory and steroidogenic capacity of large antral follicles in sheep.

Anim Reprod Sci 2009 Nov 29;116(1-2):73-84. Epub 2009 Jan 29.

Department of Biomedical Sciences, University of Guelph, ON, Canada.

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http://dx.doi.org/10.1016/j.anireprosci.2009.01.011DOI Listing
November 2009

The artificial genitourinary sphincter.

BJU Int 2008 Aug;102(5):644-58

Department of Urology, Lahey Clinic Medical Center, Burlington, USA.

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http://doi.wiley.com/10.1111/j.1464-410X.2008.07872.x
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http://dx.doi.org/10.1111/j.1464-410X.2008.07872.xDOI Listing
August 2008

Index of suspicion.

Pediatr Rev 2008 Jun;29(6):201-6

The Children's Hospital of Philadelphia, Philadelphia, Pa.

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http://pedsinreview.aappublications.org/cgi/doi/10.1542/pir.
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http://dx.doi.org/10.1542/pir.29-6-201DOI Listing
June 2008

Differential effects of various estradiol-17beta treatments on follicle-stimulating hormone peaks, luteinizing hormone pulses, basal gonadotropin concentrations, and antral follicle and luteal development in cyclic ewes.

Biol Reprod 2007 Aug 11;77(2):252-62. Epub 2007 Apr 11.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4.

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http://dx.doi.org/10.1095/biolreprod.106.058842DOI Listing
August 2007

Suppression of follicle wave emergence in cyclic ewes by supraphysiologic concentrations of estradiol-17beta and induction with a physiologic dose of exogenous ovine follicle-stimulating hormone.

Biol Reprod 2006 Oct 12;75(4):633-41. Epub 2006 Jul 12.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4.

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http://dx.doi.org/10.1095/biolreprod.105.048702DOI Listing
October 2006

Ovarian and endocrine responses to prostaglandin F2alpha (PGF2alpha) given at the expected time of the endogenous FSH peak at mid-cycle in ewes.

Theriogenology 2006 Sep 10;66(4):811-21. Epub 2006 Mar 10.

Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ont. N1G 2W1, Canada.

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http://dx.doi.org/10.1016/j.theriogenology.2006.01.057DOI Listing
September 2006

Photoselective potassium-titanyl-phosphate laser vaporization of the benign obstructive prostate: observations on long-term outcomes.

J Urol 2005 Oct;174(4 Pt 1):1344-8

Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1097/01.ju.0000173913.41401.67DOI Listing
October 2005

The temporal relationship between patterns of LH and FSH secretion, and development of ovulatory-sized follicles during the mid- to late-luteal phase of sheep.

Theriogenology 2005 Jul 23;64(2):393-407. Epub 2005 Jan 23.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Sask., S7N 5B4, Canada.

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http://dx.doi.org/10.1016/j.theriogenology.2004.12.006DOI Listing
July 2005

A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon.

Mol Cell Biol 2004 Jul;24(14):6194-204

Massey Cancer Center, Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298-0037, USA.

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http://dx.doi.org/10.1128/MCB.24.14.6194-6204.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC434230PMC
July 2004

Current Indications for the Use of The Artificial Genitourinary Sphincter and Management of It's Complications.

ScientificWorldJournal 2004 7;4:114-127. Epub 2004 Jun 7.

Mayo Clinic, Department of Urology, Rochester, MN, USA.

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http://dx.doi.org/10.1100/tsw.2004.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956414PMC
June 2004

Patterns of antral follicular wave dynamics and accompanying endocrine changes in cyclic and seasonally anestrous ewes treated with exogenous ovine follicle-stimulating hormone during the inter-wave interval.

Biol Reprod 2004 Mar 19;70(3):821-7. Epub 2003 Nov 19.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4.

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http://dx.doi.org/10.1095/biolreprod.103.023739DOI Listing
March 2004

Effects of a 6-day treatment with medroxyprogesterone acetate after prostaglandin F2 alpha-induced luteolysis at midcycle on antral follicular development and ovulation rate in nonprolific Western white-faced ewes.

Biol Reprod 2003 Apr 31;68(4):1403-12. Epub 2002 Oct 31.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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http://dx.doi.org/10.1095/biolreprod.102.007278DOI Listing
April 2003

Physician leadership: an interview with David M. Barrett, MD. Interview by Ronald B. Goodspeed and Zach Gerbarg.

Authors:
David M Barrett

J Ambul Care Manage 2002 Oct;25(4):7-9

Lahey Clinic, Burlington, Massachusetts, USA.

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October 2002