David M A Mann

David M A Mann

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David M A Mann

David M A Mann

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No association between head injury with loss of consciousness and Alzheimer disease pathology-Findings from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age.

Int J Geriatr Psychiatry 2019 Aug 10;34(8):1262-1266. Epub 2019 May 10.

Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.1002/gps.5129DOI Listing
August 2019

Pathological Correlates of Cognitive Impairment in The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age.

J Alzheimers Dis 2018 ;64(2):483-496

Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience& Experimental Psychology, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.3233/JAD-180171DOI Listing
July 2019

Association between semantic dementia and progressive supranuclear palsy.

J Neurol Neurosurg Psychiatry 2019 Jan 16;90(1):115-117. Epub 2018 Apr 16.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/jnnp-2017-317839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327859PMC
January 2019

Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease.

Analyst 2018 Dec;143(24):5959-5964

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.

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http://dx.doi.org/10.1039/c8an01205aDOI Listing
December 2018

Raman Spectroscopy to Diagnose Alzheimer's Disease and Dementia with Lewy Bodies in Blood.

ACS Chem Neurosci 2018 11 14;9(11):2786-2794. Epub 2018 Jun 14.

School of Pharmacy and Biomedical Sciences , University of Central Lancashire , Preston PR1 2HE , U.K.

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http://dx.doi.org/10.1021/acschemneuro.8b00198DOI Listing
November 2018

Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology.

Dement Geriatr Cogn Disord 2018 25;45(1-2):79-90. Epub 2018 Apr 25.

Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, University of Manchester, Salford Royal Hospital, Salford, United Kingdom.

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http://dx.doi.org/10.1159/000486827DOI Listing
October 2018

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome.

Acta Neuropathol Commun 2018 07 4;6(1):56. Epub 2018 Jul 4.

Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital, Stott Lane, Salford, M6 8HD, England.

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http://dx.doi.org/10.1186/s40478-018-0559-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030772PMC
July 2018

Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease.

Neuropathology 2018 May 10. Epub 2018 May 10.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.1111/neup.12472DOI Listing
May 2018

Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies.

Amyotroph Lateral Scler Frontotemporal Degener 2018 02 2;19(1-2):102-111. Epub 2017 Aug 2.

a Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health , University of Manchester, Salford Royal Hospital , Salford , UK.

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http://dx.doi.org/10.1080/21678421.2017.1359304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836993PMC
February 2018

Frontotemporal lobar degeneration: Pathogenesis, pathology and pathways to phenotype.

Brain Pathol 2017 11 2;27(6):723-736. Epub 2017 Mar 2.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1111/bpa.12486DOI Listing
November 2017

Differential diagnosis of Alzheimer's disease using spectrochemical analysis of blood.

Proc Natl Acad Sci U S A 2017 09 5;114(38):E7929-E7938. Epub 2017 Sep 5.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1701517114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617251PMC
September 2017

Semantic dementia, progressive non-fluent aphasia and their association with amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2017 08 29;88(8):711-712. Epub 2017 May 29.

Cerebral Function Unit, Manchester Academic Health Sciences Centre, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.

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http://dx.doi.org/10.1136/jnnp-2016-314912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537533PMC
August 2017

Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration.

Acta Neuropathol Commun 2017 06 30;5(1):54. Epub 2017 Jun 30.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK.

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http://dx.doi.org/10.1186/s40478-017-0454-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493127PMC
June 2017

Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Acta Neuropathol 2016 11 15;132(5):753-755. Epub 2016 Sep 15.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Salford Royal Hospital, University of Manchester, Salford, Manchester, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-016-1617-2DOI Listing
November 2016

Magnetite pollution nanoparticles in the human brain.

Proc Natl Acad Sci U S A 2016 09 6;113(39):10797-801. Epub 2016 Sep 6.

Neurotoxicology Laboratory, The University of Montana, Missoula, MT 59812; Universidad del Valle de México, Mexico City, 04850, Mexico.

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http://www.pnas.org/content/113/39/10797.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047173PMC
http://dx.doi.org/10.1073/pnas.1605941113DOI Listing
September 2016

Co-Occurrence of Language and Behavioural Change in Frontotemporal Lobar Degeneration.

Dement Geriatr Cogn Dis Extra 2016 May-Aug;6(2):205-13. Epub 2016 Jun 1.

Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, Manchester, UK; Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1159/000444848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913762PMC
June 2016

Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy.

Acta Neuropathol Commun 2016 Mar 31;4:33. Epub 2016 Mar 31.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1186/s40478-016-0301-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818389PMC
March 2016

Cognitive-behavioural features of progressive supranuclear palsy syndrome overlap with frontotemporal dementia.

J Neurol 2015 7;262(4):916-22. Epub 2015 Feb 7.

Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK,

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http://dx.doi.org/10.1007/s00415-015-7657-zDOI Listing
January 2016

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.

Neurobiol Dis 2015 Jul 30;79:81-99. Epub 2015 Apr 30.

Department of Biochemistry, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates; College of Science, Engineering and Technology, HBKU, Education City, Qatar Foundation, Doha, Qatar. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.04.009DOI Listing
July 2015

p62/SQSTM1 analysis in frontotemporal lobar degeneration.

Neurobiol Aging 2015 Mar 18;36(3):1603.e5-9. Epub 2014 Oct 18.

Faculty of Medical and Human Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.035DOI Listing
March 2015

Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration.

Neurobiol Aging 2015 Mar 18;36(3):1603.e1-4. Epub 2014 Oct 18.

Faculty of Human and Medical Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK; Cerebral Function Unit, Department of Neurology, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504979PMC
March 2015

Histone deacetylases (HDACs) in frontotemporal lobar degeneration.

Neuropathol Appl Neurobiol 2015 Feb;41(2):245-57

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.1111/nan.12153DOI Listing
February 2015

Do NIA-AA criteria distinguish Alzheimer's disease from frontotemporal dementia?

Alzheimers Dement 2015 Feb 9;11(2):207-15. Epub 2014 Jul 9.

Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.04.516DOI Listing
February 2015

Dipeptide repeat protein toxicity in frontotemporal lobar degeneration and in motor neurone disease associated with expansions in C9ORF72-a cautionary note.

Authors:
David M A Mann

Neurobiol Aging 2015 Feb 16;36(2):1224-6. Epub 2014 Oct 16.

Clinical and Cognitive Neuroscience Research Group, Institute of Brain Behaviour and Mental Health, University of Manchester, Salford Royal Hospital, Salford, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580140066
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http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.011DOI Listing
February 2015

C9ORF72 in dementia with Lewy bodies.

J Neurol Neurosurg Psychiatry 2014 Dec 19;85(12):1435-6. Epub 2014 Mar 19.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.1136/jnnp-2014-307622DOI Listing
December 2014

No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease.

Neuropathol Appl Neurobiol 2014 Dec;40(7):844-54

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford.

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http://doi.wiley.com/10.1111/nan.12155
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http://dx.doi.org/10.1111/nan.12155DOI Listing
December 2014

LRRK2 exonic variants and risk of multiple system atrophy.

Neurology 2014 Dec 5;83(24):2256-61. Epub 2014 Nov 5.

From the Section of Biostatistics (M.G.H., N.N.D.) and Departments of Neuroscience (A.I.S.-O., S.R., K.O., M.E.M., D.W.D., O.A.R.) and Neurology (S.F., W.P.C., R.J.U., Z.K.W.), Mayo Clinic, Jacksonville, FL; Department of Molecular Neuroscience (L.S., A.S., H.H.), Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Department of Medical Genetics (M.J.F.), University of British Columbia, Vancouver, Canada; Laboratory of Neurogenetics (A.B.S.), National Institute on Aging, Bethesda, MD; Institute of Genetic Medicine (P.F.C., M.J.K.), Newcastle University, Central Parkway, Newcastle upon Tyne; Neuropathology Unit (S.M.G.), Department of Medicine, Imperial College London; Queen Square Brain Bank for Neurological Disorders (J.L.H., K.A.), Department of Molecular Neuroscience, UCL Institute of Neurology, University College London; Clinical and Cognitive Sciences Research Group (D.M.A.M.), Institute of Brain, Behavior and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford; and MRC London Neurodegenerative Diseases Brain Bank (S.A.-S., C.T.), King's College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277668PMC
December 2014

Patterns of microglial cell activation in frontotemporal lobar degeneration.

Neuropathol Appl Neurobiol 2014 Oct;40(6):686-96

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, UK.

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http://dx.doi.org/10.1111/nan.12092DOI Listing
October 2014

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease.

Sci Rep 2013 ;3:2540

Division of Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, LA1 4AY, UK.

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http://dx.doi.org/10.1038/srep02540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756331PMC
June 2014

3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease.

Acta Neuropathol 2014 Feb 9;127(2):303-5. Epub 2013 Nov 9.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, 156-8506, Japan,

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http://dx.doi.org/10.1007/s00401-013-1191-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895182PMC
February 2014

Classification and pathology of primary progressive aphasia.

Neurology 2013 Nov 18;81(21):1832-9. Epub 2013 Oct 18.

From the Manchester Academic Health Sciences Centre (J.M.H., C.G., J.C.T., A.M.T.R., D.N., D.d.P., P.P., D.M.A.M., J.S.S., M.J.), Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford; and Institute of Brain, Behaviour and Mental Health (J.M.H., D.N., D.M.A.M., J.S.S., M.J.), University of Manchester, UK.

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http://dx.doi.org/10.1212/01.wnl.0000436070.28137.7bDOI Listing
November 2013

Amyloid or tau: the chicken or the egg?

Acta Neuropathol 2013 Oct 8;126(4):609-13. Epub 2013 Aug 8.

Institute of Brain, Behaviour and Mental Health, Salford Royal Hospital, University of Manchester, Salford, M6 8HD, UK,

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http://dx.doi.org/10.1007/s00401-013-1162-1DOI Listing
October 2013

Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.

Acta Neuropathol Commun 2013 Oct 14;1:68. Epub 2013 Oct 14.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK.

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http://dx.doi.org/10.1186/2051-5960-1-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893586PMC
October 2013

Correlation of Aβ oligomer levels in matched cerebrospinal fluid and serum samples.

Neurosci Lett 2013 Sep 27;551:17-22. Epub 2013 Jun 27.

Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S030439401300576
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http://dx.doi.org/10.1016/j.neulet.2013.06.029DOI Listing
September 2013

Pathological assessments for the presence of hexanucleotide repeat expansions in C9ORF72 in Alzheimer's disease.

Acta Neuropathol Commun 2013 Aug 12;1:50. Epub 2013 Aug 12.

Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Foundation NHS Trust, Salford M6 8HD, UK.

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http://dx.doi.org/10.1186/2051-5960-1-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893394PMC
August 2013

Prion-like properties of pathological TDP-43 aggregates from diseased brains.

Cell Rep 2013 Jul 3;4(1):124-34. Epub 2013 Jul 3.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1016/j.celrep.2013.06.007DOI Listing
July 2013

Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia.

Neurology 2013 May 17;80(20):1881-7. Epub 2013 Apr 17.

Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.

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http://dx.doi.org/10.1212/WNL.0b013e318292a342DOI Listing
May 2013

Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington's disease.

Brain Res 2013 Apr 16;1504:16-24. Epub 2013 Feb 16.

Wolfson Molecular Imaging Centre, School of Cancer and Enabling Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.brainres.2013.02.012DOI Listing
April 2013

Frontotemporal dementia with amyotrophic lateral sclerosis: a clinical comparison of patients with and without repeat expansions in C9orf72.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Apr 19;14(3):172-6. Epub 2013 Feb 19.

Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.

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http://dx.doi.org/10.3109/21678421.2013.765485DOI Listing
April 2013

Prion-like spreading of pathological α-synuclein in brain.

Brain 2013 Apr 6;136(Pt 4):1128-38. Epub 2013 Mar 6.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1093/brain/awt037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613715PMC
April 2013

Molecular analysis and biochemical classification of TDP-43 proteinopathy.

Brain 2012 Nov 3;135(Pt 11):3380-91. Epub 2012 Oct 3.

Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

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http://dx.doi.org/10.1093/brain/aws230DOI Listing
November 2012

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects.

Acta Neuropathol 2012 Sep 10;124(3):373-82. Epub 2012 Aug 10.

Neuroscience Research Australia, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1007/s00401-012-1030-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445027PMC
September 2012

Analysis of the hexanucleotide repeat in C9ORF72 in Alzheimer's disease.

Neurobiol Aging 2012 Aug 10;33(8):1846.e5-6. Epub 2012 Mar 10.

Mental Health and Neurodegeneration Research Group, Faculty of Human and Medical Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.01.109DOI Listing
August 2012

The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships.

Brain 2011 Sep 11;134(Pt 9):2478-92. Epub 2011 Aug 11.

Cerebral Function Unit, Greater Manchester Neuroscience centre, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK.

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http://dx.doi.org/10.1093/brain/awr189DOI Listing
September 2011

Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology.

Acta Neuropathol 2011 May 18;121(5):635-49. Epub 2011 Jan 18.

Mental Health and Neurodegeneration Research Group, School of Community Based Medicine, Faculty of Medical and Human Sciences, Hope Hospital, Greater Manchester Neurosciences Centre, University of Manchester, Stott Lane, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-011-0798-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122037PMC
May 2011

No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.

Neurobiol Aging 2011 Apr 14;32(4):754-5. Epub 2009 May 14.

Clinical Neurosciences Research Group, Faculty of Human and Medical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.04.009DOI Listing
April 2011

Effect of topographical distribution of α-synuclein pathology on TDP-43 accumulation in Lewy body disease.

Acta Neuropathol 2010 Dec 29;120(6):789-801. Epub 2010 Jul 29.

Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, UK.

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http://link.springer.com/10.1007/s00401-010-0731-9
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http://dx.doi.org/10.1007/s00401-010-0731-9DOI Listing
December 2010

Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.

Biochemistry 2010 Apr;49(15):3261-72

Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1021/bi100144mDOI Listing
April 2010

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Authors:
Vivianna M Van Deerlin Patrick M A Sleiman Maria Martinez-Lage Alice Chen-Plotkin Li-San Wang Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Murray Grossman Steven E Arnold David M A Mann Stuart M Pickering-Brown Harro Seelaar Peter Heutink John C van Swieten Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman John Hodges Maria Grazia Spillantini Sid Gilman Andrew P Lieberman Jeffrey A Kaye Randall L Woltjer Eileen H Bigio Marsel Mesulam Safa Al-Sarraj Claire Troakes Roger N Rosenberg Charles L White Isidro Ferrer Albert Lladó Manuela Neumann Hans A Kretzschmar Christine Marie Hulette Kathleen A Welsh-Bohmer Bruce L Miller Ainhoa Alzualde Adolfo Lopez de Munain Ann C McKee Marla Gearing Allan I Levey James J Lah John Hardy Jonathan D Rohrer Tammaryn Lashley Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Steven T Dekosky Julie van der Zee Samir Kumar-Singh Christine Van Broeckhoven Richard Mayeux Jean Paul G Vonsattel Juan C Troncoso Jillian J Kril John B J Kwok Glenda M Halliday Thomas D Bird Paul G Ince Pamela J Shaw Nigel J Cairns John C Morris Catriona Ann McLean Charles DeCarli William G Ellis Stefanie H Freeman Matthew P Frosch John H Growdon Daniel P Perl Mary Sano David A Bennett Julie A Schneider Thomas G Beach Eric M Reiman Bryan K Woodruff Jeffrey Cummings Harry V Vinters Carol A Miller Helena C Chui Irina Alafuzoff Päivi Hartikainen Danielle Seilhean Douglas Galasko Eliezer Masliah Carl W Cotman M Teresa Tuñón M Cristina Caballero Martínez David G Munoz Steven L Carroll Daniel Marson Peter F Riederer Nenad Bogdanovic Gerard D Schellenberg Hakon Hakonarson John Q Trojanowski Virginia M-Y Lee

Nat Genet 2010 Mar 14;42(3):234-9. Epub 2010 Feb 14.

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work.

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http://dx.doi.org/10.1038/ng.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828525PMC
March 2010

Recent origin and spread of a common Welsh MAPT splice mutation causing frontotemporal lobar degeneration.

Neurogenetics 2009 Oct 14;10(4):313-8. Epub 2009 Apr 14.

Laboratory of Human Molecular Biology and Genetics, Catholic University of the Sacred Heart, Piazza Buonarroti 30, 20145, Milan, Italy.

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http://link.springer.com/10.1007/s10048-009-0189-x
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October 2009

TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.

Acta Neuropathol 2009 Sep 28;118(3):359-69. Epub 2009 Mar 28.

Clinical Neuroscience Research Group, Faculty of Medical and Human Sciences, Greater Manchester Neurosciences Centre, School of Translational Medicine, Hope Hospital, University of Manchester, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-009-0526-zDOI Listing
September 2009

Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.

Brain 2009 Apr 20;132(Pt 4):1093-101. Epub 2009 Jan 20.

Division of Biomedical and Life Sciences, School of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1093/brain/awn349DOI Listing
April 2009

Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Acta Neuropathol 2009 Jan 7;117(1):55-62. Epub 2008 Nov 7.

Department of Neurology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-0841, Japan.

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http://dx.doi.org/10.1007/s00401-008-0456-1DOI Listing
January 2009

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration.

Acta Neuropathol 2008 Aug 28;116(2):141-6. Epub 2008 May 28.

Division of Biomedical and Life Sciences, School of Health and Medicine, University of Lancaster, Lancaster, UK.

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http://dx.doi.org/10.1007/s00401-008-0389-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464623PMC
August 2008

Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations.

Brain 2008 Mar 11;131(Pt 3):721-31. Epub 2008 Jan 11.

Clinical Neuroscience Research Group, Faculty of Medical and Human Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/brain/awm331DOI Listing
March 2008

Familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of Alzheimer disease.

Arch Neurol 2007 Oct;64(10):1535-9

Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool L9 7LJ, England.

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http://dx.doi.org/10.1001/archneur.64.10.1535DOI Listing
October 2007

Progressive anomia revisited: focal degeneration associated with progranulin gene mutation.

Neurocase 2007 Oct;13(5):366-77

School of Translational Medicine, University of Manchester, Hope Hospital, Salford, UK.

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http://dx.doi.org/10.1080/13554790701851510DOI Listing
October 2007

An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid.

Brain Res 2007 Sep 20;1170:103-11. Epub 2007 Jul 20.

Biomedical Sciences Unit, Department of Biological Sciences, Lancaster University, Lancaster LA1 4YQ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S000689930701653
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http://dx.doi.org/10.1016/j.brainres.2007.07.027DOI Listing
September 2007

Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.

Acta Neuropathol 2007 May 12;113(5):521-33. Epub 2007 Jan 12.

Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK,

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http://dx.doi.org/10.1007/s00401-006-0189-yDOI Listing
May 2007

TDP-43 gene analysis in frontotemporal lobar degeneration.

Neurosci Lett 2007 May 24;419(1):1-4. Epub 2007 Mar 24.

Division of Regenerative Medicine, Department of Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.neulet.2007.03.044DOI Listing
May 2007

Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease.

Dement Geriatr Cogn Disord 2007 14;23(1):60-6. Epub 2006 Nov 14.

Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK.

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http://dx.doi.org/10.1159/000097038DOI Listing
February 2007

Dementia lacking distinctive histology (DLDH) revisited.

Acta Neuropathol 2006 Nov 10;112(5):551-9. Epub 2006 Aug 10.

Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00401-006-0123-3DOI Listing
November 2006

Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study.

J Am Geriatr Soc 2006 Sep;54(9):1395-400

Division of Psychiatry, Education and Research Center, South Manchester University Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1111/j.1532-5415.2006.00841.xDOI Listing
September 2006

Apolipoprotein E epsilon4 allele frequency in vascular dementia.

Dement Geriatr Cogn Disord 2006 25;22(1):15-9. Epub 2006 Apr 25.

Clinical Neuroscience Research Group, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK.

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http://dx.doi.org/10.1159/000092960DOI Listing
August 2006

A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease.

Acta Neuropathol 2006 Jan 22;111(1):15-20. Epub 2005 Nov 22.

Clinical Neuroscience Research Group, University of Manchester, Hope Hospital, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-005-1108-3DOI Listing
January 2006

Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation.

Acta Neuropathol 2005 Nov 13;110(5):501-12. Epub 2005 Oct 13.

Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-005-1079-4DOI Listing
November 2005

Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads.

J Neuropathol Exp Neurol 2005 Aug;64(8):665-74

Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1097/01.jnen.0000173890.79058.1dDOI Listing
August 2005

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.

Neurosci Lett 2005 Jul 21;382(3):221-6. Epub 2005 Apr 21.

Molecular Psychiatry Department, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Birmingham B15 2QZ, UK.

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http://dx.doi.org/10.1016/j.neulet.2005.03.016DOI Listing
July 2005

Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation.

Neurotox Res 2005 ;7(1-2):69-76

Prince of Wales Medical Research Institute, Sydney, 2031 Australia.

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April 2005

No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort.

Neurosci Lett 2004 Aug;366(2):126-9

Molecular Psychiatry Department, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Birmingham B15 2QZ, UK.

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http://dx.doi.org/10.1016/j.neulet.2004.05.023DOI Listing
August 2004

Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.

Am J Pathol 2004 Jul;165(1):273-81

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Bunkyo-ku, Hongo, Tokyo 113-0033, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618534PMC
http://dx.doi.org/10.1016/s0002-9440(10)63295-6DOI Listing
July 2004