Publications by authors named "David L Rimm"

100Publications

Antibody validation for protein expression on tissue slides: a protocol for immunohistochemistry.

Biotechniques 2020 Aug 27. Epub 2020 Aug 27.

Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2144/btn-2020-0095DOI Listing
August 2020

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

NPJ Breast Cancer 2020 12;6:17. Epub 2020 May 12.

21Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41523-020-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217863PMC
May 2020

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.

NPJ Breast Cancer 2020 12;6:16. Epub 2020 May 12.

74Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41523-020-0154-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217824PMC
May 2020

Digital quantitative assessment of PD-L1 using digital spatial profiling.

Lab Invest 2020 Oct 6;100(10):1311-1317. Epub 2020 Apr 6.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41374-020-0424-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502436PMC
October 2020

Advances in quantitative immunohistochemistry and their contribution to breast cancer.

Expert Rev Mol Diagn 2020 May 30;20(5):509-522. Epub 2020 Mar 30.

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737159.2020.1743178DOI Listing
May 2020

The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice.

J Pathol 2020 04 9;250(5):667-684. Epub 2020 Apr 9.

Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.5406DOI Listing
April 2020

Association between low estrogen receptor positive breast cancer and staining performance.

NPJ Breast Cancer 2020 5;6. Epub 2020 Feb 5.

1Department of Pathology, Yale University School of Medicine, New Haven, CT USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41523-020-0146-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002746PMC
February 2020

Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non-Small Cell Lung Cancer.

J Thorac Oncol 2019 12 9;14(12):2084-2096. Epub 2019 Oct 9.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut; Department of Medicine (Oncology), Yale University School of Medicine, New Haven, Connecticut. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2019.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951804PMC
December 2019

Closed system RT-qPCR as a potential companion diagnostic test for immunotherapy outcome in metastatic melanoma.

J Immunother Cancer 2019 09 18;7(1):254. Epub 2019 Sep 18.

Department of Pathology, Yale University School of Medicine, 310 Cedar Street, PO Box 208023, New Haven, CT, 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0731-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751819PMC
September 2019

Artificial intelligence in digital pathology - new tools for diagnosis and precision oncology.

Nat Rev Clin Oncol 2019 11 9;16(11):703-715. Epub 2019 Aug 9.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41571-019-0252-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880861PMC
November 2019

Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma.

J Immunother Cancer 2019 07 23;7(1):194. Epub 2019 Jul 23.

Department of Pathology, Yale School of Medicine, New Haven, CT, 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0675-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651990PMC
July 2019

False-positive pathology: improving reproducibility with the next generation of pathologists.

Lab Invest 2019 09 24;99(9):1260-1265. Epub 2019 Apr 24.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41374-019-0257-2DOI Listing
September 2019

Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the , , and Genes: A Study of the College of American Pathologists Molecular Oncology Committee.

Arch Pathol Lab Med 2019 10 10;143(10):1203-1211. Epub 2019 Apr 10.

From the Office of the Director, The Joint Pathology Center, Silver Spring, Maryland (Dr Moncur); the Department of Pathology, St Joseph Mercy Hospital, Ypsilanti, Michigan (Dr Bartley); the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha (Dr Bridge); the Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada (Dr Kamel-Reid); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Lazar); the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs Lindeman and Kim); Biostatistics (Mr Long) and Proficiency Testing (Ms Vasalos), College of American Pathologists, Northfield, Illinois; the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill (Dr Merker); the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York (Dr Rai); the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Rimm); and the Department of Pathology and Laboratory Medicine, Strong Memorial Hospital, University of Rochester Medical Center and Pathology and Laboratory Medicine, Molecular Diagnostic Laboratory, Rochester, New York (Dr Rothberg). Dr Moncur is employed by the US Army. The identification of specific products or scientific instrumentation is considered an integral part of the scientific endeavor and does not constitute endorsement or implied endorsement on the part of the authors, the Department of Defense, or any component agency. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or US government. The other authors have no relevant financial interest in the products or companies described in this article.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2018-0396-CPDOI Listing
October 2019

Immune Checkpoint Inhibitor-Associated Pericarditis.

J Thorac Oncol 2019 06 7;14(6):1102-1108. Epub 2019 Mar 7.

Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut; Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2019.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617516PMC
June 2019

Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes.

Clin Cancer Res 2019 08 1;25(15):4592-4602. Epub 2019 Mar 1.

Department of Medicine (Section of Medical Oncology), Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-1538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679805PMC
August 2019

CD68, CD163, and matrix metalloproteinase 9 (MMP-9) co-localization in breast tumor microenvironment predicts survival differently in ER-positive and -negative cancers.

Breast Cancer Res 2018 12 17;20(1):154. Epub 2018 Dec 17.

Department of Pathology, Yale School of Medicine, 310 Cedar Street, P.O. Box 208023, New Haven, CT, 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13058-018-1076-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298021PMC
December 2018

Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma.

Oral Oncol 2018 11 11;86:278-287. Epub 2018 Oct 11.

University of Pittsburgh Medical Center, Department of Pathology, Pittsburgh, PA 15213, United States.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13688375183035
Publisher Site
http://dx.doi.org/10.1016/j.oraloncology.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260977PMC
November 2018

Immune Marker Profiling and Programmed Death Ligand 1 Expression Across NSCLC Mutations.

J Thorac Oncol 2018 12 26;13(12):1884-1896. Epub 2018 Sep 26.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251746PMC
December 2018

Correlating nuclear morphometric patterns with estrogen receptor status in breast cancer pathologic specimens.

NPJ Breast Cancer 2018 4;4:32. Epub 2018 Sep 4.

1Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, 2250 Alcazar Street, CSC 240, Los Angeles, CA 90089-9075 USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41523-018-0084-4
Publisher Site
http://dx.doi.org/10.1038/s41523-018-0084-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123433PMC
September 2018

Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study.

Lab Invest 2019 01 4;99(1):107-117. Epub 2018 Sep 4.

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41374-018-0123-7DOI Listing
January 2019

Not Just Digital Pathology, Intelligent Digital Pathology.

JAMA Oncol 2018 03;4(3):403-404

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaoncol.2017.5449DOI Listing
March 2018

Implications of the tumor immune microenvironment for staging and therapeutics.

Mod Pathol 2018 02 1;31(2):214-234. Epub 2017 Dec 1.

Department of Pathology, The Johns Hopkins University SOM and Bloomberg-Kimmel Institute for Immunotherapy, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/modpathol.2017.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132263PMC
February 2018

Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer.

J Immunother Cancer 2017 10 17;5(1):81. Epub 2017 Oct 17.

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-017-0285-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644103PMC
October 2017

B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes.

Clin Cancer Res 2017 Sep 24;23(17):5202-5209. Epub 2017 May 24.

Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-16-3107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581684PMC
September 2017

Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival.

Mol Cancer Res 2017 07 8;15(7):942-952. Epub 2017 Mar 8.

Department of Experimental Pathology, Yale School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-16-0408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500411PMC
July 2017

Proof of the quantitative potential of immunofluorescence by mass spectrometry.

Lab Invest 2017 03 16;97(3):329-334. Epub 2017 Jan 16.

Department of Pathology, Yale University Medical School, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/labinvest.2016.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334147PMC
March 2017

EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma.

J Thorac Oncol 2016 11 20;11(11):1901-1911. Epub 2016 Jul 20.

Department of Pathology, Yale University Medical School, New Haven, Connecticut; Department of Internal Medicine, Yale University Medical School, New Haven, Connecticut. Electronic address:

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075503PMC
http://dx.doi.org/10.1016/j.jtho.2016.06.025DOI Listing
November 2016

A proposal for validation of antibodies.

Nat Methods 2016 10 5;13(10):823-7. Epub 2016 Sep 5.

Biofluid Biomarker Center, Niigata University, Niigata, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3995DOI Listing
October 2016

Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer.

Breast Cancer Res 2016 07 29;18(1):78. Epub 2016 Jul 29.

Department of Pathology, Yale School of Medicine, Yale University, 310 Cedar St., PO Box 208023, New Haven, CT, 06520-8023, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13058-016-0737-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966732PMC
July 2016

Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells.

Cell Rep 2016 07 23;16(2):457-471. Epub 2016 Jun 23.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.05.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945411PMC
July 2016

PD-L1 Expression in Lung Cancer.

J Thorac Oncol 2016 07 23;11(7):964-75. Epub 2016 Apr 23.

Department of Medicine/Medical Oncology, University of Colorado Cancer Center, University of Colorado, Denver, Colorado; Department of Pathology, University of Colorado, Denver, Colorado. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353357PMC
July 2016

Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence.

Sci Transl Med 2016 Apr;8(334):334ra53

Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA. Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA. Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aad3001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256931PMC
April 2016

Early and multiple origins of metastatic lineages within primary tumors.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2140-5. Epub 2016 Feb 8.

Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511

View Article

Download full-text PDF

Source
http://www.pnas.org/content/113/8/2140.full.pdf
Web Search
http://www.pnas.org/lookup/doi/10.1073/pnas.1525677113
Publisher Site
http://dx.doi.org/10.1073/pnas.1525677113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776530PMC
February 2016

Validation of the IHC4 Breast Cancer Prognostic Algorithm Using Multiple Approaches on the Multinational TEAM Clinical Trial.

Arch Pathol Lab Med 2016 Jan;140(1):66-74

From the Transformative Pathology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada (Dr Bartlett); Biomarker and Companion Diagnostic Group, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, United Kingdom (Dr Bartlett and Ms Piper); Research and Development (Dr Christiansen) and Medical Affairs (Dr Gustavson), Genoptix, Inc, Carlsbad, California; the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Rimm); the Departments of Surgery (Dr van de Velde) and Medical Statistics and Bioinformatics (Dr Putter), Leiden University Medical Center, Leiden, The Netherlands; the Department of Gynecological Oncology, University Medical Center Freiburg, Freiburg, Germany (Dr Hasenburg); the Department of Obstetrics and Gynecology, Elblandklinikum, Riesa, Germany (Dr Kieback); the Department of Surgery, Athens University Medical School, Athens, Greece (Dr Markopoulos); Oncology Center, Sint-Augustinus, Wilrijk-Antwerp, Belgium (Dr Dirix); the Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands (Dr Seynaeve); and Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom (Dr Rea). Dr Christiansen is now with Diagnostic Development at Ignyta, Inc, San Diego, California. Dr Gustavson is now with Diagnostics Department at MetaStat, Inc, Boston, Massachusetts. Dr Kieback is now with the Department of Obstetrics and Gynecology at Klinikum Vest Medical Center, Marl, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2014-0599-OADOI Listing
January 2016

miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer.

Cancer Res 2016 Feb 16;76(4):927-39. Epub 2015 Dec 16.

Institute for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755913PMC
February 2016

Loss of antigenicity with tissue age in breast cancer.

Lab Invest 2016 Mar 16;96(3):264-9. Epub 2015 Nov 16.

Yale Pathology Tissue Services, Department of Pathology, Yale University Medical School, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/labinvest.2015.138DOI Listing
March 2016

Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma.

Clin Cancer Res 2016 Jan 25;22(2):374-82. Epub 2015 Aug 25.

Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-15-1162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821426PMC
January 2016

Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer.

J Natl Cancer Inst 2015 Aug 19;107(8). Epub 2015 May 19.

: Department of Pathology (DECH, KAS, DLR) and Medical Oncology (LP), Yale University School of Medicine, New Haven, CT; Attikon University Hospital, Athens, Greece (AP); Translational Research Section, Hellenic Cooperative Oncology Group, Data Office, Athens, Greece (KTK); Department of Medical Oncology, "Papageorgiou" Hospital (KTK, GF), Department of Pathology (VK), and Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research (VK, GF), Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.

View Article

Download full-text PDF

Source
http://jnci.oxfordjournals.org/content/107/8/djv136.full.pdf
Web Search
http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djv136
Publisher Site
http://dx.doi.org/10.1093/jnci/djv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554192PMC
August 2015

Expertise vs evidence in assessment of breast biopsies: an atypical science.

JAMA 2015 Mar;313(11):1109-10

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2015.1945DOI Listing
March 2015