Publications by authors named "David L Akey"

25Publications

Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.

J Mol Biol 2019 05 5;431(10):1956-1965. Epub 2019 Apr 5.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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May 2019

Extended surface for membrane association in Zika virus NS1 structure.

Nat Struct Mol Biol 2016 09 25;23(9):865-7. Epub 2016 Jul 25.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.

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September 2016

Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal.

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):359-74. Epub 2016 Mar 1.

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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March 2016

Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):346-58. Epub 2016 Mar 1.

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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March 2016

Efficient merging of data from multiple samples for determination of anomalous substructure.

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):296-302. Epub 2016 Mar 1.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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March 2016

Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly.

J Virol 2015 Aug 10;89(16):8632-42. Epub 2015 Jun 10.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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August 2015

Structure-guided insights on the role of NS1 in flavivirus infection.

Bioessays 2015 May 11;37(5):489-94. Epub 2015 Mar 11.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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May 2015

Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1.

Acta Crystallogr D Biol Crystallogr 2014 Oct 27;70(Pt 10):2719-29. Epub 2014 Sep 27.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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October 2014

Insights from the sea: structural biology of marine polyketide synthases.

Nat Prod Rep 2012 Oct 13;29(10):1038-49. Epub 2012 Apr 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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October 2012

The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets.

EMBO J 2011 May 5;30(10):2031-43. Epub 2011 Apr 5.

Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

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May 2011

A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.

Bioorg Med Chem Lett 2010 Oct 25;20(19):5939-42. Epub 2010 May 25.

Department of Medicinal Chemistry, University of Minnesota, 717 Delaware Street SE, Room 456, Minneapolis, MN 55414-2959, USA.

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October 2010

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Structure 2010 Jan;18(1):94-105

Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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January 2010

Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway.

J Biol Chem 2009 Feb 22;284(8):5021-9. Epub 2008 Dec 22.

Life Science Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2009