Publications by authors named "David L Akey"

25Publications

Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.

Authors:
Scott B Biering David L Akey Marcus P Wong W Clay Brown Nicholas T N Lo Henry Puerta-Guardo Francielle Tramontini Gomes de Sousa Chunling Wang Jamie R Konwerski Diego A Espinosa Nicholas J Bockhaus Dustin R Glasner Jeffrey Li Sophie F Blanc Evan Y Juan Stephen J Elledge Michael J Mina P Robert Beatty Janet L Smith Eva Harris

Science 2021 01;371(6525):194-200

Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

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January 2021

Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.

Authors:
Min Su Amanda L Erwin Anne M Campbell Tasia M Pyburn Lauren E Salay Jessica L Hanks D Borden Lacy David L Akey Timothy L Cover Melanie D Ohi

J Mol Biol 2019 05 5;431(10):1956-1965. Epub 2019 Apr 5.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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May 2019

Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin.

Authors:
Marouane Libiad Nicole Motl David L Akey Naoya Sakamoto Eric R Fearon Janet L Smith Ruma Banerjee

J Biol Chem 2018 02 18;293(8):2675-2686. Epub 2018 Jan 18.

From the Department of Biological Chemistry,

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February 2018

Extended surface for membrane association in Zika virus NS1 structure.

Authors:
W Clay Brown David L Akey Jamie R Konwerski Jeffrey T Tarrasch Georgios Skiniotis Richard J Kuhn Janet L Smith

Nat Struct Mol Biol 2016 09 25;23(9):865-7. Epub 2016 Jul 25.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.

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September 2016

Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal.

Authors:
Thomas C Terwilliger Gábor Bunkóczi Li Wei Hung Peter H Zwart Janet L Smith David L Akey Paul D Adams

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):359-74. Epub 2016 Mar 1.

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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March 2016

Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.

Authors:
Thomas C Terwilliger Gábor Bunkóczi Li Wei Hung Peter H Zwart Janet L Smith David L Akey Paul D Adams

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):346-58. Epub 2016 Mar 1.

Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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March 2016

Efficient merging of data from multiple samples for determination of anomalous substructure.

Authors:
David L Akey Thomas C Terwilliger Janet L Smith

Acta Crystallogr D Struct Biol 2016 Mar 1;72(Pt 3):296-302. Epub 2016 Mar 1.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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March 2016

Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly.

Authors:
Laura A VanBlargan Kaitlin A Davis Kimberly A Dowd David L Akey Janet L Smith Theodore C Pierson

J Virol 2015 Aug 10;89(16):8632-42. Epub 2015 Jun 10.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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August 2015

Structure-guided insights on the role of NS1 in flavivirus infection.

Authors:
David L Akey W Clay Brown Joyce Jose Richard J Kuhn Janet L Smith

Bioessays 2015 May 11;37(5):489-94. Epub 2015 Mar 11.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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May 2015

Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.

Authors:
Steffen M Bernard David L Akey Ashootosh Tripathi Sung Ryeol Park Jamie R Konwerski Yojiro Anzai Shengying Li Fumio Kato David H Sherman Janet L Smith

ACS Chem Biol 2015 May 26;10(5):1340-51. Epub 2015 Feb 26.

‡Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.

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May 2015

Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1.

Authors:
David L Akey W Clay Brown Jamie R Konwerski Craig M Ogata Janet L Smith

Acta Crystallogr D Biol Crystallogr 2014 Oct 27;70(Pt 10):2719-29. Epub 2014 Sep 27.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA.

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October 2014

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

Authors:
David L Akey W Clay Brown Somnath Dutta Jamie Konwerski Joyce Jose Thomas J Jurkiw James DelProposto Craig M Ogata Georgios Skiniotis Richard J Kuhn Janet L Smith

Science 2014 Feb 6;343(6173):881-5. Epub 2014 Feb 6.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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February 2014

Insights from the sea: structural biology of marine polyketide synthases.

Authors:
David L Akey Jennifer J Gehret Dheeraj Khare Janet L Smith

Nat Prod Rep 2012 Oct 13;29(10):1038-49. Epub 2012 Apr 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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October 2012

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Authors:
Joseph A Chemler Tonia J Buchholz Todd W Geders David L Akey Christopher M Rath George E Chlipala Janet L Smith David H Sherman

J Am Chem Soc 2012 May 23;134(17):7359-66. Epub 2012 Apr 23.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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May 2012

A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

Authors:
David L Akey Shengying Li Jamie R Konwerski Laura A Confer Steffen M Bernard Yojiro Anzai Fumio Kato David H Sherman Janet L Smith

J Mol Biol 2011 Oct 23;413(2):438-50. Epub 2011 Aug 23.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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October 2011

The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets.

Authors:
Chandan Bhambhani Jinhee L Chang David L Akey Ken M Cadigan

EMBO J 2011 May 5;30(10):2031-43. Epub 2011 Apr 5.

Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

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May 2011

A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.

Authors:
Erick K Leggans David L Akey Janet L Smith Robert A Fecik

Bioorg Med Chem Lett 2010 Oct 25;20(19):5939-42. Epub 2010 May 25.

Department of Medicinal Chemistry, University of Minnesota, 717 Delaware Street SE, Room 456, Minneapolis, MN 55414-2959, USA.

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October 2010

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Authors:
Jamie B Scaglione David L Akey Rachel Sullivan Jeffrey D Kittendorf Christopher M Rath Eung-Soo Kim Janet L Smith David H Sherman

Angew Chem Int Ed Engl 2010 Aug;49(33):5726-30

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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August 2010

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Authors:
David L Akey Jamie R Razelun Jason Tehranisa David H Sherman William H Gerwick Janet L Smith

Structure 2010 Jan;18(1):94-105

Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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January 2010

Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway.

Authors:
Heather B Claxton David L Akey Monica K Silver Suzanne J Admiraal Janet L Smith

J Biol Chem 2009 Feb 22;284(8):5021-9. Epub 2008 Dec 22.

Life Science Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2009