David Knopman

David Knopman

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David Knopman

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Cognitive function after surgery with regional or general anesthesia: A population-based study.

Alzheimers Dement 2019 Oct 5;15(10):1243-1252. Epub 2019 Sep 5.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.06.4949DOI Listing
October 2019

Associations Between Left Ventricular Structure, Function, and Cerebral Amyloid: The ARIC-PET Study.

Stroke 2019 Oct 10:STROKEAHA119027220. Epub 2019 Oct 10.

From the The Johns Hopkins University School of Medicine, Baltimore, MD (M.C.J., D.F.W., R.F.G.).

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http://dx.doi.org/10.1161/STROKEAHA.119.027220DOI Listing
October 2019

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.

Alzheimers Dement 2019 Oct 23. Epub 2019 Oct 23.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2019.07.009DOI Listing
October 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Authors:
Sven J van der Lee Olivia J Conway Iris Jansen Minerva M Carrasquillo Luca Kleineidam Erik van den Akker Isabel Hernández Kristel R van Eijk Najada Stringa Jason A Chen Anna Zettergren Till F M Andlauer Monica Diez-Fairen Javier Simon-Sanchez Alberto Lleó Henrik Zetterberg Marianne Nygaard Cornelis Blauwendraat Jeanne E Savage Jonas Mengel-From Sonia Moreno-Grau Michael Wagner Juan Fortea Michael J Keogh Kaj Blennow Ingmar Skoog Manuel A Friese Olga Pletnikova Miren Zulaica Carmen Lage Itziar de Rojas Steffi Riedel-Heller Ignacio Illán-Gala Wei Wei Bernard Jeune Adelina Orellana Florian Then Bergh Xue Wang Marc Hulsman Nina Beker Niccolo Tesi Christopher M Morris Begoña Indakoetxea Lyduine E Collij Martin Scherer Estrella Morenas-Rodríguez James W Ironside Bart N M van Berckel Daniel Alcolea Heinz Wiendl Samantha L Strickland Pau Pastor Eloy Rodríguez Rodríguez Bradley F Boeve Ronald C Petersen Tanis J Ferman Jay A van Gerpen Marcel J T Reinders Ryan J Uitti Lluís Tárraga Wolfgang Maier Oriol Dols-Icardo Amit Kawalia Maria Carolina Dalmasso Mercè Boada Uwe K Zettl Natasja M van Schoor Marian Beekman Mariet Allen Eliezer Masliah Adolfo López de Munain Alexander Pantelyat Zbigniew K Wszolek Owen A Ross Dennis W Dickson Neill R Graff-Radford David Knopman Rosa Rademakers Afina W Lemstra Yolande A L Pijnenburg Philip Scheltens Thomas Gasser Patrick F Chinnery Bernhard Hemmer Martijn A Huisman Juan Troncoso Fermin Moreno Ellen A Nohr Thorkild I A Sørensen Peter Heutink Pascual Sánchez-Juan Danielle Posthuma Jordi Clarimón Kaare Christensen Nilüfer Ertekin-Taner Sonja W Scholz Alfredo Ramirez Agustín Ruiz Eline Slagboom Wiesje M van der Flier Henne Holstege

Acta Neuropathol 2019 Aug 27;138(2):237-250. Epub 2019 May 27.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-019-02026-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660501PMC
August 2019

Quantity and quality of mental activities and the risk of incident mild cognitive impairment.

Neurology 2019 Aug 10;93(6):e548-e558. Epub 2019 Jul 10.

From Translational Neuroscience and Aging Laboratory (J.K.-R., Y.E.G.) and Departments of Psychiatry and Psychology (Y.E.G.) and Neurology (Y.E.G.), Mayo Clinic, Scottsdale, AZ; Departments of Health Sciences Research (J.A.S., M.V., M.M. Mielke, W.K.K., Y.E.G.), Psychiatry and Psychology (M.M. Machulda), and Neurology (M.M. Mielke, D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; and Institute of Sports and Sports Science (J.K.-R.), Karlsruhe Institute of Technology, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710000PMC
August 2019

Frontal lobe H MR spectroscopy in asymptomatic and symptomatic mutation carriers.

Neurology 2019 Aug 17;93(8):e758-e765. Epub 2019 Jul 17.

From the Department of Radiology (Q.C., J.L.G., K.K.), Department of Neurology (B.F.B., C.D., L.F., D.G., J.G.-R., D.J., D.K., R.K.), Department of Health Sciences Research (N.T., T.L., D.B., J.S.), Department of Psychology and Psychiatry (J.F., M.L.), Department of Clinical Genomic and Neurology (R.G.), Alzheimer's Disease Research Center (B.F.B., D.B., C.D., L.F., D.G., J.G.-R., D.J., D.K., R.K., R.R., K.K.), and Research Services (D.H.), Mayo Clinic, Rochester, MN; Department of Neurology (Q.C.), West China Hospital of Sichuan University, Chengdu, Sichuan; Departments of Neurology (N.G.-R., Z.K.W.) and Neuroscience (R.R.), Mayo Clinic, Jacksonville, FL; and Memory and Aging Center (H.R., A.L.B.), University of California San Francisco.

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http://dx.doi.org/10.1212/WNL.0000000000007961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711662PMC
August 2019

Association of white matter microstructural integrity with cognition and dementia.

Neurobiol Aging 2019 Aug 29;83:63-72. Epub 2019 Aug 29.

Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.021DOI Listing
August 2019

Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging.

Neurobiol Aging 2019 07 18;79:43-49. Epub 2019 Mar 18.

Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591044PMC
July 2019

Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging.

Alzheimers Dement 2019 Jul 23;15(7):878-887. Epub 2019 May 23.

Department of Neurology, College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646057PMC
July 2019

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults.

Neurology 2019 Jul 30;93(1):e29-e39. Epub 2019 May 30.

From the Departments of Radiology (V.J.L., T.J.B., H.-K.M., P.F., M.L.S., M.K.P., K.K., D.T.J., P.V., C.G.S., C.R.J.), Health Sciences Research (H.J.W., S.D.W., T.M.T., M.M. Mielke, R.O.R.), Information Technology (M.L.S.), Neurology (B.F.B., K.A.J., D.T.J., J.G.-R., M.M. Mielke, D.S.K., R.C.P.), Neuroscience (M.E.M.), and Psychiatry and Psychology (M.M. Machulda), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000007728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659005PMC
July 2019

Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures.

Neurology 2019 Jul 10;93(3):e252-e260. Epub 2019 Jun 10.

From the Departments of Health Sciences Research (M.M. Mielke, J.A.S., W.K.K., R.C.P., S.K.), Neurology (M.M. Mielke, D.S.K., R.C.P.), Radiology (P.V., C.J.), and Psychiatry and Psychology (M.M. Machulda), Mayo Clinic, Rochester, MN; Department of Psychiatry and Neurochemistry (K.B., H.Z., I.S., S.K.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Institute of Neurology (H.Z.), University College London, Queen Square; and UK Dementia Research Institute at UCL (H.Z.), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000007767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656645PMC
July 2019

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.

Alzheimers Dement 2019 Jul 1. Epub 2019 Jul 1.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.04.007DOI Listing
July 2019

High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change.

J Am Geriatr Soc 2019 Jul 30. Epub 2019 Jul 30.

Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia.

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http://dx.doi.org/10.1111/jgs.16092DOI Listing
July 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
Publisher Site
http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

A brief history of "Alzheimer disease": Multiple meanings separated by a common name.

Neurology 2019 May 26;92(22):1053-1059. Epub 2019 Apr 26.

From the Departments of Neurology (D.S.K., R.C.P.) and Radiology (C.R.J.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000007583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556090PMC
May 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:
Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2019 May 1;10(1):2068. Epub 2019 May 1.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1038/s41467-019-10160-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494826PMC
May 2019

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

Alzheimers Dement 2019 May 11. Epub 2019 May 11.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15525260193004
Publisher Site
http://dx.doi.org/10.1016/j.jalz.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842665PMC
May 2019

Chronic Systemic Inflammation Is Associated With Symptoms of Late-Life Depression: The ARIC Study.

Am J Geriatr Psychiatry 2019 May 21. Epub 2019 May 21.

Department of Neurology (KAW), Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.05.011DOI Listing
May 2019

Lowering of Amyloid-Beta by β-Secretase Inhibitors - Some Informative Failures.

Authors:
David S Knopman

N Engl J Med 2019 04;380(15):1476-1478

From the Department of Neurology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1056/NEJMe1903193DOI Listing
April 2019

Neural correlates of domain-specific cognitive decline: The ARIC-NCS Study.

Neurology 2019 03 6;92(10):e1051-e1063. Epub 2019 Feb 6.

From the Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Radiology (M.L.S., J.L.G., C.G.S. C.R.J.), Information Technology (M.L.S., J.L.G.), and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Epidemiology (A.W., A.G., R.F.G., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Johns Hopkins University Center on Aging and Health (A.G.), Baltimore, MD; and Department of Geriatrics (T.H.M.), University of Mississippi Medical Center, Jackson.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000007042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442014PMC
March 2019

Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study.

Neurology 2019 Mar 13;92(11):e1256-e1267. Epub 2019 Feb 13.

From the Departments of Neurology (K.A.W., R.F.G.) and Epidemiology (R.F.G., A.W., A.L.G., E.S.), Johns Hopkins University, Baltimore, MD; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Medicine (T.H.M., B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.

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http://dx.doi.org/10.1212/WNL.0000000000007094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511107PMC
March 2019

Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study.

Alzheimers Dement 2019 Feb 12;15(2):273-281. Epub 2018 Oct 12.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368879PMC
February 2019

Bad news and good news in AD, and how to reconcile them.

Authors:
David S Knopman

Nat Rev Neurol 2019 02;15(2):61-62

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41582-018-0131-7DOI Listing
February 2019

The influence of β-amyloid on [F]AV-1451 in semantic variant of primary progressive aphasia.

Neurology 2019 02 11;92(7):e710-e722. Epub 2019 Jan 11.

From the Departments of Radiology (J.L.W., C.G.S., I.S., M.L.S., C.R.J., V.J.L.), Health Science Research (Biostatistics) (P.R.M., S.D.W.), Neurology (Speech Pathology) (J.R.D., H.M.C., R.L.U.), Psychiatry and Psychology (M.M.M.), Neurology (Behavioral Neurology) (H.B., J.G.-R., D.T.J., B.F.B., D.S.K., R.C.P., K.A.J.), and Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; and Department of Neuroscience (N.E.-T.), Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1212/WNL.0000000000006913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382367PMC
February 2019

Neuroimaging findings in midlife and risk of late-life dementia over 20 years of follow-up.

Neurology 2019 02 18;92(9):e917-e923. Epub 2019 Jan 18.

From the Department of Preventive Medicine (N.A.W.) and Department of Medicine (B.G.W., T.H.M.), Division of Geriatrics, University of Mississippi Medical Center, Jackson; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Radiology (D.K.S.), University of Washington Medical Center, Seattle; and Division of Public Health Sciences (L.H.C.), Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1212/WNL.0000000000006989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404467PMC
February 2019

Early-Phase Randomized Clinical Trials-Expectations vs Hard Reality.

Authors:
David S Knopman

JAMA Neurol 2019 Jan;76(1):15-16

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1001/jamaneurol.2018.3301DOI Listing
January 2019

Cerebral microbleeds: Prevalence and relationship to amyloid burden.

Neurology 2019 01 19;92(3):e253-e262. Epub 2018 Dec 19.

From the Departments of Neurology (J.G.-R., H.B., A.A.R., K.D.F., R.D.B., M.M.M., R.O.R., D.S.K., R.C.P.), Radiology (J.L.G., J.H., G.M.P., M.L.S., V.J.L., P.V., C.R.J., K.K.), and Health Sciences Research (S.A.P., T.L., M.M.M., R.O.R., W.K.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000006780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340386PMC
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.

J Alzheimers Dis 2019 ;68(2):517-521

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JAD-180785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443418PMC
January 2019

Amyloid- and tau-PET imaging in a familial prion kindred.

Neurol Genet 2018 Dec 3;4(6):e290. Epub 2018 Dec 3.

Department of Neurology (D.T.J., R.A.T., J.G.-R., H.B., D.S.K., R.C.P., B.F.B.) and Department of Radiology (D.T.J., C.R.J., V.J.L.), Mayo Clinic, Rochester, MN.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283453PMC
December 2018

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.

Acta Anaesthesiol Scand 2018 11;62(10):1473-1480

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/aas.13250DOI Listing
November 2018

Association of Hospitalization, Critical Illness, and Infection with Brain Structure in Older Adults.

J Am Geriatr Soc 2018 10 24;66(10):1919-1926. Epub 2018 Sep 24.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://doi.wiley.com/10.1111/jgs.15470
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181772PMC
October 2018

ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology.

Neurology 2018 09 24;91(12):e1182-e1195. Epub 2018 Aug 24.

From the Department of Neuroscience (D.W.D., M.E.M., A.I.S., R.W., N.E.-T., G.B., O.A.R.), Division of Biomedical Statistics and Informatics (M.G.H., N.N.D.), and Departments of Neurology (J.A.v.G., R.J.U., Z.K.W., N.E.-T., N.R.G.-R.) and Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (D.S.K., R.C.P., B.F.B.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000006212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161556PMC
September 2018

The Telephone Interview for Cognitive Status.

Authors:
David S Knopman

Cogn Behav Neurol 2018 09;31(3):158

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

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September 2018

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Nat Commun 2018 09 26;9(1):3945. Epub 2018 Sep 26.

The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214PMC
September 2018