David Klimstra

David Klimstra

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David Klimstra

David Klimstra

Publications by authors named "David Klimstra"

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Clinical-grade computational pathology using weakly supervised deep learning on whole slide images.

Nat Med 2019 08 15;25(8):1301-1309. Epub 2019 Jul 15.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-019-0508-1DOI Listing
August 2019

The 2019 WHO classification of tumours of the digestive system.

Histopathology 2019 Aug 21. Epub 2019 Aug 21.

International Agency for Research on Cancer, World Health Organization, Lyon, France.

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http://dx.doi.org/10.1111/his.13975DOI Listing
August 2019

Limited role of Chromogranin A as clinical biomarker for pancreatic neuroendocrine tumors.

HPB (Oxford) 2019 05 23;21(5):612-618. Epub 2018 Oct 23.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1365182X183446
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http://dx.doi.org/10.1016/j.hpb.2018.09.016DOI Listing
May 2019

Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Am J Surg Pathol 2019 May;43(5):601-609

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/PAS.0000000000001218DOI Listing
May 2019

Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.

Hum Pathol 2019 01 17;83:1-6. Epub 2018 Aug 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365190PMC
January 2019

Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy.

J Gastrointest Oncol 2017 Oct;8(5):E65-E72

Department of Gastrointestinal Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.21037/jgo.2017.06.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674258PMC
October 2017

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:
Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 08;23(8):1004

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http://dx.doi.org/10.1038/nm0817-1004cDOI Listing
August 2017

Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver.

Am J Surg Pathol 2017 Jul;41(7):915-922

*Department of Pathology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA †Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY ‡Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1097/PAS.0000000000000876DOI Listing
July 2017

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:
Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 Jun 8;23(6):703-713. Epub 2017 May 8.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://www.nature.com/doifinder/10.1038/nm.4333
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http://dx.doi.org/10.1038/nm.4333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461196PMC
June 2017

MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression.

Oncotarget 2017 May;8(22):35902-35918

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.18632/oncotarget.16277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482626PMC
May 2017

Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases.

Am J Surg Pathol 2017 Mar;41(3):313-325

Departments of *Pathology #Surgery, Memorial Sloan Kettering Cancer Center, New York, NY †Departments of Pathology, Emory University School of Medicine, Atlanta, GA ‡Departments of Pathology, University of Verona and Negrar Hospital, Verona, Italy §Departments of Pathology, Hakujikai Memorial Hospital, Tokyo, Japan ∥Departments of Pathology, Centro Hospitalar São João/University of Porto and Institute for Research and Innovation in Health/Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal. ¶Departments of Pathology, Heinrich-Heine-University of Düsseldorf, Düsseldorf **Departments of Pathology, Technical University, Munich, Germany.

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http://dx.doi.org/10.1097/PAS.0000000000000782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309137PMC
March 2017

Cytology assessment can predict survival for patients with metastatic pancreatic neuroendocrine neoplasms.

Cancer Cytopathol 2017 Mar 17;125(3):188-196. Epub 2017 Jan 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/cncy.21817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352475PMC
March 2017

Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients With Pancreatic Adenocarcinoma.

Ann Surg 2017 01;265(1):185-191

*Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY †Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY ‡Department of Surgery, Massachusetts General Hospital, Boston, MA §Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ¶Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD ||Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD **Department of Pathology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/SLA.0000000000001763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611666PMC
January 2017

Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.

Neoplasia 2016 Dec 25;18(12):785-794. Epub 2016 Nov 25.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01605; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 01605; Cancer Center, University of Massachusetts Medical School, Worcester, MA, 01605. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126137PMC
December 2016

Cyst Fluid Analysis in Pancreatic Intraductal Papillary Mucinous Neoplasms.

Clin Cancer Res 2016 Oct 29;22(20):4966-4967. Epub 2016 Aug 29.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1462DOI Listing
October 2016

p53 and p16/p19 Loss Promotes Different Pancreatic Tumor Types from PyMT-Expressing Progenitor Cells.

Neoplasia 2016 Oct 21;18(10):610-617. Epub 2016 Sep 21.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035259PMC
http://dx.doi.org/10.1016/j.neo.2016.08.003DOI Listing
October 2016

Biliary carcinomas: pathology and the role of DNA mismatch repair deficiency.

Chin Clin Oncol 2016 Oct;5(5):62

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.21037/cco.2016.10.04DOI Listing
October 2016

Colorectal Cancer Liver Metastases: Biopsy of the Ablation Zone and Margins Can Be Used to Predict Oncologic Outcome.

Radiology 2016 09 24;280(3):949-59. Epub 2016 Mar 24.

From the Section of Interventional Radiology, Department of Radiology (V.S.S., E.N.P., J.P.E., K.T.B., A.M.C., W.A., L.A.B., S.B.S., C.T.S.), Departments of Epidemiology and Biostatistics (M.G.), Pathology (D.S.K.), Radiology (R.K.G.D., A.R.G.), Molecular Cytology (A.B., K.O.M.), Surgery (R.P.D.), and Medicine (N.E.K.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; and Department of Pathology, University of Southern California University Hospital, Los Angeles, Calif (L.M.P.).

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http://dx.doi.org/10.1148/radiol.2016151005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006720PMC
September 2016

Acinar neoplasms of the pancreas-A summary of 25 years of research.

Semin Diagn Pathol 2016 Sep 13;33(5):307-18. Epub 2016 May 13.

Department of Anatomic Pathology, Emory University, Atlanta, GA.

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http://dx.doi.org/10.1053/j.semdp.2016.05.009DOI Listing
September 2016

Undifferentiated Carcinoma With Osteoclastic Giant Cells of the Pancreas: Clinicopathologic Analysis of 38 Cases Highlights a More Protracted Clinical Course Than Currently Appreciated.

Am J Surg Pathol 2016 09;40(9):1203-16

Departments of *Pathology and Laboratory Medicine ∥Radiology #Surgery, Emory University School of Medicine, Atlanta, GA †Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ¶Department of Pathology, Detroit Medical Center, Detroit, MI ‡Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea §Department of Pathology, Marmara University, Istanbul, Turkey.

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http://dx.doi.org/10.1097/PAS.0000000000000689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987218PMC
September 2016

ARID1A expression in early stage colorectal adenocarcinoma: an exploration of its prognostic significance.

Hum Pathol 2016 07 2;53:97-104. Epub 2016 Mar 2.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994515PMC
July 2016

Reassessing the grade of gastroenteropancreatic neuroendocrine neoplasms.

Authors:
David S Klimstra

Endocrine 2016 Jul 5;53(1):4-6. Epub 2016 May 5.

Department of Pathology, James Ewing Alumni Chair in Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA.

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http://dx.doi.org/10.1007/s12020-016-0966-xDOI Listing
July 2016

Recurrence and Survival After Resection of Small Intraductal Papillary Mucinous Neoplasm-associated Carcinomas (≤20-mm Invasive Component): A Multi-institutional Analysis.

Ann Surg 2016 Apr;263(4):793-801

*Department of Surgery and the Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA †Department of Pathology, Thomas Jefferson University, Philadelphia, PA ‡Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY §Department of Pathology, Massachusetts General Hospital, Boston, MA ¶Department of Surgery, Massachusetts General Hospital, Boston, MA ||Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA **Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA ††Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/SLA.0000000000001319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957241PMC
April 2016

The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.

Am Soc Clin Oncol Educ Book 2015 :92-103

From the Memorial Sloan Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY; Yale Cancer Center, New Haven, CT; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.

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http://dx.doi.org/10.14694/EdBook_AM.2015.35.92DOI Listing
February 2016

Follicular pancreatitis: a distinct form of chronic pancreatitis-an additional mimic of pancreatic neoplasms.

Hum Pathol 2016 Feb 3;48:154-62. Epub 2015 Oct 3.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2015.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023064PMC
February 2016

Pathologic Classification of Neuroendocrine Neoplasms.

Authors:
David S Klimstra

Hematol Oncol Clin North Am 2016 Feb 24;30(1):1-19. Epub 2015 Oct 24.

Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2015.08.005DOI Listing
February 2016

Cytological features contributing to the misclassification of pancreatic neuroendocrine tumors.

J Am Soc Cytopathol 2016 Sep - Oct;5(5):266-276. Epub 2016 Feb 2.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, New York.

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http://dx.doi.org/10.1016/j.jasc.2016.01.001DOI Listing
February 2016

Esophageal Adenocarcinoma and Squamous Cell Carcinoma in Children and Adolescents: Report of 3 Cases and Comprehensive Literature Review.

J Pediatr Surg Case Rep 2016 Feb;5:23-29

Pediatric Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.epsc.2015.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819333PMC
February 2016

Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

JAMA Oncol 2016 Jan;2(1):104-11

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York6Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering, New York, New York9Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1001/jamaoncol.2015.5208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477989PMC
January 2016

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.

Am J Surg Pathol 2015 Dec;39(12):1730-41

*Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ‡Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD §Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA §§Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH †Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea ∥Department of Pathology, Medica Sur Clinic and Foundation, Mexico City, Mexico ¶Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK #Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands **Department of Pathology, Jichi Medical University, Shimotsuke ††Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research ¶¶Department of Pathology, Hakujikai Memorial Hospital †††Division of Cancer Genomics, National Cancer Center Research Institute §§§Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo ##Department of Surgery, Kyoto University, Kyoto, Japan ‡‡Department of Pathology, Technical University Munich, Munich ∥∥Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Bonn ‡‡‡Institute of Pathology, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany ***Service d'Anatomie Pathologique, Hôpital Cochin, Paris, France.

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http://dx.doi.org/10.1097/PAS.0000000000000533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646710PMC
December 2015

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Gastroenterology 2015 Nov 4;149(6):1501-10. Epub 2015 Aug 4.

The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, Maryland; Department of Surgery, The Johns Hopkins University, Baltimore, Maryland; Department of Medicine, The Johns Hopkins University, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782782PMC
November 2015