David K Simon

David K Simon

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Altered muscle electrical tissue properties in a mouse model of premature aging.

Muscle Nerve 2019 Sep 18. Epub 2019 Sep 18.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA.

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http://dx.doi.org/10.1002/mus.26714DOI Listing
September 2019

Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.

Neurol Genet 2019 Aug 9;5(4):e348. Epub 2019 Jul 9.

Laboratory of Neurogenetics (H.I., C.B., H.L.L., F.F., D.G.H., A.B.S., M.A.N.), National Institute on Aging, National Institutes of Health, Bethesda; Data Tecnica International (H.I., M.A.N.), Glen Echo, MD; Precision Neurology Program (G.L., C.R.S.), Harvard Medical School, Brigham and Women's Hospital; Neurogenomics Laboratory (G.L., C.R.S.), Harvard Medical School, Brigham and Women's Hospital; Ann Romney Center for Neurologic Diseases (G.L., C.R.S.), Brigham and Women's Hospital, Boston, MA; The Norwegian Centre for Movement Disorders (J.M.-G., G.A.), Stavanger University Hospital; Department of Chemistry (J.M.-G., G.A.), Bioscience and Environmental Engineering, University of Stavanger, Norway; Assistance-Publique Hôpitaux de Paris (J.-C.C.), ICM, INSERM UMRS 1127, CNRS 7225, ICM, Department of Neurology and CIC Neurosciences, Pitié-Salpêtrière Hospital, Paris, France; Department of Neurology (L.P., M.T.), Oslo University Hospital, Norway; Department of Neurology (M.N., B.R.B., B.P.W.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Michael J Fox Foundation (S.J.H.), New York; Translational Genome Sciences (K.-D.H.N, K.E.), Biogen, Cambridge, MA; Department of Neurology University of Pennsylvania (J.R.), Philadelphia, PA; Department of Biostatistics and Computational Biology (S.E.), University of Rochester, NY; Department of Computer Science (F.F.), University of Illinois Urbana-Champaign; Department of Neurology (P.A.), Center for Health + Technology, University of Rochester, NY; Department of Clinical Neurosciences (K.M.S., R.W.), University of Cambridge, John van Geest Centre for Brain Repair, UK; Department of Pathology and Laboratory Medicine (V.M.V.D.), Center for Neurodegenerative Disease Research, Parelman School of Medicine at the University of Pennsylvania, Philadelphia; Genetics and Pharmacogenomics (A.G.D.-W.), Merck Research Laboratory, Boston, MA; Statistical Genetics (A.G.D.-W.), Biogen, Cambridge, MA; Institut du cerveau et de la moelle épinière ICM (A.B., F.D.); Sorbonne Université SU (A.B.); INSERM UMR (A.B.), Paris, France; Department of Neurology (G.A.), Stavanger University Hospital, Norway; Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London; Department of Molecular Neuroscience (A.J.N.), UCL Institute of Neurology, London, UK; Department of Neurology (O.-B.T.), Haukeland University Hospital; University of Bergen (O.-B.T.), Bergen, Norway; Department of Neurology (J.R.E.), Nottingham University NHS Trust, UK; Centre for Clinical Brain Sciences (D.P.B.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (D.P.B.), University of Edinburgh; Usher Institute of Population Health Sciences and Informatics (D.P.B.), University of Edinburgh, Scotland; Department of Medical and Molecular Genetics (C.E.W.), Indiana University, Indianapolis; Department of Neurology (D.K.S.), Beth Israel Deaconess Medical Center; Harvard Medical School (D.K.S.), Boston; Voyager Therapeutics (B.R.), Cambridge, MA; Department of Neurology (B.R.), University of Rochester School of Medicine, NY; Institute of Clinical Medicine (M.T.), University of Oslo, Norway; German Center for Neurodegenerative Diseases-Tubingen (P.H.); HIH Tuebingen (P.H.), Germany; Department of Psychiatry (D.W.), University of Pennsylvania School of Medicine; Department of Veterans Affairs (D.W.), Philadelphia, PA; and Department of Clinical Neurosciences (R.A.B., C.H.W.-G.), University of Cambridge, UK; Department of Neurology (J.J.V.H.), Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1212/NXG.0000000000000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659137PMC
August 2019

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.

Neurology 2019 Feb;92(7):329-337

From the UC Gardner Neuroscience Institute and Gardner Family Center for Parkinson's Disease and Movement Disorders (A.J.E., J.A.V., L.M., A.M.), Department of Neurology, University of Cincinnati, OH; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L., A.F.), Toronto Western Hospital, University of Toronto; Krembil Research Institute (A.E.L., A.F.), Toronto, Canada; Parkinson's Disease and Movement Disorders Center (D.K.S.), Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; College of Medicine (K.A.J.), Mayo Clinic, Rochester, MN; Institute of Molecular and Clinical Sciences (F.M.), St George's University of London, UK; Division of Movement Disorders (R.S.), Department of Neurology and Department of Health Science Research, Mayo Clinic College of Medicine, Rochester, MN; Department of Neurology and the Pittsburgh Institute for Neurodegenerative Diseases (J.T.G., F.C.), University of Pittsburgh, PA; Department of Neurology (T.R.Y.), University of Kentucky, Lexington; Parkinson's Disease Research, Education and Clinical Center (C.M.T.), Neurology, San Francisco Veterans Affairs Medical Center; Department of Neurology (C.M.T.), University of California-San Francisco; Department of Neurology & Neurosurgery, Montreal Neurological Institute, and Department of Human Genetics (Z.G.-O.), McGill University, Canada; Parkinson & Other Movement Disorders Center UC San Diego (I.L.), Department of Neurosciences, Altman Clinical Translational Research Institute, La Jolla, CA; VA Puget Sound Health Care System and Department of Neurology (I.F.M., CP.Z.), University of Washington, Seattle; Department of Neurology (I.F.M.), University of Washington School of Medicine, Seattle; Center for Neurodegenerative Science (P.B.), Van Andel Research Institute, Grand Rapids, MI; Center for Neurological Restoration (H.H.F.) and Lou Ruvo Center for Brain Health, Neurological Institute (J.B.L.), Cleveland Clinic, OH; Department of Neurology (D.G.S.), University of Alabama at Birmingham; Consultorio y Laboratorio de Neurogenética (M.A.K.), Centro Universitario de Neurología "José María Ramos Mejía" y División Neurología, Hospital JM Ramos Mejía, Facultad de Medicina, UBA; Programa de Medicina de Precision y Genomica Clinica (M.A.K.), Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, Universidad Austral-CONICET, Buenos Aires, Argentina; Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston; Division of Neuroscience (S.P.S.), Sanofi-Genzyme, Framingham, MA; Michael J. Fox Foundation for Parkinson's Research (T.S.), New York, NY; and College of Sciences (G.P.), University of Texas at San Antonio.

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http://dx.doi.org/10.1212/WNL.0000000000006926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382364PMC
February 2019

Inverse probability weighted Cox regression for doubly truncated data.

Biometrics 2018 06 8;74(2):481-487. Epub 2017 Sep 8.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, U.S.A.

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http://dx.doi.org/10.1111/biom.12771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843502PMC
June 2018

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration.

Mol Neurodegener 2018 05 24;13(1):28. Epub 2018 May 24.

Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, 333 Bostwick Ave, Michigan, 49503, USA.

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http://dx.doi.org/10.1186/s13024-018-0260-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968614PMC
May 2018

Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.

Neurology 2017 Oct 29;89(17):1789-1794. Epub 2017 Sep 29.

From the Department of Neurology (M.L.) and Department of Clinical Pharmacy (J.L.B.), Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora; Department of Biostatistics (S.L., Y.Z.), University of Texas Health Science Center at Houston; Center for Human Experimental Therapeutics (S.S.), University of Rochester, NY; Department of Neurology (A.-M.A.W.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Pharmacy (P.S.W.), Singapore General Hospital; Department of Neurology (D.K.S.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Department of Pathology, Anatomy, & Cell Biology (J.S.), Thomas Jefferson University, Philadelphia, PA; Department of Biostatistics (Y.Z.), School of Public Health, University of Texas Health Science Center, Houston; Department of Biostatistics (A.P.), School of Public Health, University of Texas Health Science Center at Houston-UTHealth, Austin; Department of Neurology (R.D.), University of Arkansas for Medical Sciences, Little Rock; Department of Neurology (C.W.C.), University of California San Francisco; Department of Neurology (C.S.), Leonard M. Miller School of Medicine, University of Miami, FL; Department of Neurology (F.C.), University of Pittsburgh, PA; and Department of Neurological Sciences (J.T.B.), Larner College of Medicine, University of Vermont, Burlington. Dr. Luo is currently with the Department of Biostatistics and Bioinformatics, Duke University, Durham, NC.

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http://dx.doi.org/10.1212/WNL.0000000000004572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664310PMC
October 2017

Clinical Impact of 123I-Ioflupane SPECT (DaTscan) in a Movement Disorder Center.

Neurodegener Dis 2017 10;17(1):38-43. Epub 2016 Sep 10.

Parkinson's Disease and Movement Disorders Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000447561DOI Listing
July 2017

Mitochondrial DNA mutations in Parkinson's disease brain.

Acta Neuropathol Commun 2017 04 29;5(1):33. Epub 2017 Apr 29.

Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave. Room CLS-638, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s40478-017-0433-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410101PMC
April 2017

Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.

Mov Disord 2017 03 24;32(3):319-324. Epub 2017 Feb 24.

Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.26913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359057PMC
March 2017

PLA2G6 mutations and Parkinsonism: Long-term follow-up of clinical features and neuropathology.

Mov Disord 2016 12 6;31(12):1927-1929. Epub 2016 Oct 6.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/mds.26814DOI Listing
December 2016

Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease: A randomized trial.

Neurology 2016 11 5;87(18):1907-1915. Epub 2016 Oct 5.

From the New York University School of Medicine (M.B., S.A., M.B., G.D., P.K., A.D.R.), Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, Department of Neurology, New York; Berenson-Allen Center for Noninvasive Brain Stimulation (M.D.F., Z.G., A.P.-L.), Division of Cognitive Neurology, and Parkinson's Disease and Movement Disorders Center (D.K.S., A.P.-L.), Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Department of Neurology (A.W.) and Ahmanson-Lovelace Brain Mapping Center (A.W.), University of California School of Medicine, Los Angeles; Cleveland Clinic (H.F.), Department of Neurology, OH; Toronto Western Research Institute (R.C.), University of Toronto, Ontario, Canada; University of Florida (A.W.S.), Department of Neurology, Gainesville; University of North Dakota School of Medicine (J.-S.L.), Department of Neurology, Grand Forks; and Center for Brain Health (E.P.), NYU School of Medicine, New York, NY.

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http://dx.doi.org/10.1212/WNL.0000000000003279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100715PMC
November 2016

CoQ10 in progressive supranuclear palsy: A randomized, placebo-controlled, double-blind trial.

Neurol Neuroimmunol Neuroinflamm 2016 Oct 2;3(5):e266. Epub 2016 Aug 2.

Department of Neurology (D.A., S.A.S.), Lahey Hospital & Medical Center, Burlington, MA; Department of Neurology and Neurobiology (D.G.S., T.A.Y.), University of Alabama Hospital, Birmingham; Department of Neurology (R.W.H.), University of Vermont College of Medicine, Burlington; Department of Neurology (D.K.S.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; and Research Design Center/Biostatistics Research Center (S.P., R.R.), Tufts Clinical & Translational Science Institute, Boston, MA.

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http://dx.doi.org/10.1212/NXI.0000000000000266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990260PMC
October 2016

Caffeine and Progression of Parkinson Disease: A Deleterious Interaction With Creatine.

Clin Neuropharmacol 2015 Sep-Oct;38(5):163-9

*Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; †Department of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; ‡Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; §Department of Neurology, University of California, San Francisco, CA; ∥Department of Clinical Pharmacy and Neurology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO; ¶Department of Neurology, University of South Florida, Tampa, FL; #Department of Pathology, Anatomy and Cell Biology, Parkinson's Disease Research Unit, Thomas Jefferson University, Philadelphia, PA; **Clinical Trials Coordination Center, University of Rochester Medical Center, Rochester, NY; ††Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL; ‡‡Parkinson's Disease Research Education and Clinical Center, San Francisco Veteran's Affairs Medical Center, San Francisco, CA; §§The Parkinson's and Movement Disorder Institute, Fountain Valley, CA; and ∥∥Singapore General Hospital, Singapore.

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http://pdfs.journals.lww.com/clinicalneuropharm/2015/09000/C
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WNF.0000000000000102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573899PMC
June 2016

Complicated spontaneous intracranial hypotension treated with intrathecal saline infusion.

Pract Neurol 2016 Apr 14;16(2):146-9. Epub 2015 Oct 14.

Department of Neurology, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/practneurol-2015-001231DOI Listing
April 2016

Head injury at early ages is associated with risk of Parkinson's disease.

Parkinsonism Relat Disord 2016 Feb 19;23:57-61. Epub 2015 Dec 19.

Department of Epidemiology and Environmental Health, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787263PMC
February 2016

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.

Neurotoxicol Teratol 2014 Nov-Dec;46:62-7

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08920362140017
Publisher Site
http://dx.doi.org/10.1016/j.ntt.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293310PMC
November 2015

Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.

Neurobiol Aging 2015 Nov 21;36(11):2972-2983. Epub 2015 Jul 21.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609600PMC
November 2015

Computationally simple estimation and improved efficiency for special cases of double truncation.

Lifetime Data Anal 2014 Jul 18;20(3):335-54. Epub 2013 Dec 18.

Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA,

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http://dx.doi.org/10.1007/s10985-013-9287-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058384PMC
July 2014

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.

Authors:
M Flint Beal David Oakes Ira Shoulson Claire Henchcliffe Wendy R Galpern Richard Haas Jorge L Juncos John G Nutt Tiffini Smith Voss Bernard Ravina Clifford M Shults Karen Helles Victoria Snively Mark F Lew Brian Griebner Arthur Watts Shan Gao Emmanuelle Pourcher Louisette Bond Katie Kompoliti Pinky Agarwal Cherissa Sia Mandar Jog Linda Cole Munira Sultana Roger Kurlan Irene Richard Cheryl Deeley Cheryl H Waters Angel Figueroa Ani Arkun Matthew Brodsky William G Ondo Christine B Hunter Joohi Jimenez-Shahed Alicia Palao Janis M Miyasaki Julie So James Tetrud Liza Reys Katharine Smith Carlos Singer Anita Blenke David S Russell Candace Cotto Joseph H Friedman Margaret Lannon Lin Zhang Edward Drasby Rajeev Kumar Thyagarajan Subramanian Donna Stuppy Ford David A Grimes Diane Cote Jennifer Conway Andrew D Siderowf Marian Leslie Evatt Barbara Sommerfeld Abraham N Lieberman Michael S Okun Ramon L Rodriguez Stacy Merritt Camille Louise Swartz W R Wayne Martin Pamela King Natividad Stover Stephanie Guthrie Ray L Watts Anwar Ahmed Hubert H Fernandez Adrienna Winters Zoltan Mari Ted M Dawson Becky Dunlop Andrew S Feigin Barbara Shannon Melissa Jill Nirenberg Mattson Ogg Samuel A Ellias Cathi-Ann Thomas Karen Frei Ivan Bodis-Wollner Sofya Glazman Thomas Mayer Robert A Hauser Rajesh Pahwa April Langhammer Ranjit Ranawaya Lorelei Derwent Kapil D Sethi Buff Farrow Rajan Prakash Irene Litvan Annette Robinson Alok Sahay Maureen Gartner Vanessa K Hinson Samuel Markind Melisa Pelikan Joel S Perlmutter Johanna Hartlein Eric Molho Sharon Evans Charles H Adler Amy Duffy Marlene Lind Lawrence Elmer Kathy Davis Julia Spears Stephanie Wilson Maureen A Leehey Neal Hermanowicz Shari Niswonger Holly A Shill Sanja Obradov Alex Rajput Marilyn Cowper Stephanie Lessig David Song Deborah Fontaine Cindy Zadikoff Karen Williams Karen A Blindauer Jo Bergholte Clara Schindler Propsom Mark A Stacy Joanne Field Dragos Mihaila Mark Chilton Ergun Y Uc Jeri Sieren David K Simon Lauren Kraics Althea Silver James T Boyd Robert W Hamill Christopher Ingvoldstad Jennifer Young Karen Thomas Sandra K Kostyk Joanne Wojcieszek Ronald F Pfeiffer Michel Panisset Monica Beland Stephen G Reich Michelle Cines Nancy Zappala Jean Rivest Richard Zweig L Pepper Lumina Colette Lynn Hilliard Stephen Grill Marye Kellermann Paul Tuite Susan Rolandelli Un Jung Kang Joan Young Jayaraman Rao Maureen M Cook Lawrence Severt Karyn Boyar

JAMA Neurol 2014 May;71(5):543-52

Department of Neurology, Beth Israel Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2014.131DOI Listing
May 2014

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation.

Hum Mol Genet 2014 Feb 18;23(3):637-47. Epub 2013 Sep 18.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/hmg/ddt450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888257PMC
February 2014

Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice.

Mitochondrion 2013 Jul 27;13(4):282-91. Epub 2013 Mar 27.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.mito.2013.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682692PMC
July 2013

The inverse association of cancer and Alzheimer's: a bioenergetic mechanism.

J R Soc Interface 2013 May 20;10(82):20130006. Epub 2013 Feb 20.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1098/rsif.2013.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627084PMC
May 2013

An inverse-Warburg effect and the origin of Alzheimer's disease.

Biogerontology 2012 Dec 20;13(6):583-94. Epub 2012 Oct 20.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s10522-012-9403-6DOI Listing
December 2012

Mitochondria and Parkinson's disease.

Parkinsons Dis 2011 29;2011:261791. Epub 2012 Aug 29.

Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Room CLS-638, Boston, MA 02215, USA.

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http://dx.doi.org/10.4061/2011/261791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437634PMC
September 2012

Singing in groups for Parkinson's disease (SING-PD): a pilot study of group singing therapy for PD-related voice/speech disorders.

Parkinsonism Relat Disord 2012 Jun 19;18(5):548-52. Epub 2012 Mar 19.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2012.02.009DOI Listing
June 2012

Do somatic mitochondrial DNA mutations contribute to Parkinson's disease?

Parkinsons Dis 2011 27;2011:659694. Epub 2011 Apr 27.

Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E/CLS-628, Boston, MA 02215, USA.

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http://dx.doi.org/10.4061/2011/659694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096076PMC
July 2011

Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease.

BMC Med Genet 2011 May 19;12:69. Epub 2011 May 19.

Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Room CLS-638, Boston, MA 02215, USA.

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http://dx.doi.org/10.1186/1471-2350-12-69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112073PMC
May 2011

Mitochondrial DNA deletions in mice in men: substantia nigra is much less affected in the mouse.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1159-62. Epub 2010 Apr 11.

Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.bbabio.2010.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891141PMC
January 2011

Association of cumulative lead exposure with Parkinson's disease.

Environ Health Perspect 2010 Nov;118(11):1609-13

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1289/ehp.1002339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974701PMC
November 2010

MELAS syndrome, cardiomyopathy, rhabdomyolysis, and autism associated with the A3260G mitochondrial DNA mutation.

Biochem Biophys Res Commun 2010 Nov 20;402(2):443-7. Epub 2010 Oct 20.

Department of Medicine, Hamilton Health Sciences, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.bbrc.2010.10.060DOI Listing
November 2010

Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice.

PLoS One 2010 Aug 23;5(8):e12333. Epub 2010 Aug 23.

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012333PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925900PMC
August 2010

Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease.

BMC Med Genet 2010 Apr 1;11:53. Epub 2010 Apr 1.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2350-11-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858137PMC
April 2010

Identification of ataxia-associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids.

Muscle Nerve 2009 Sep;40(3):381-94

Neurogenesis and Brain Repair Group M54, Institute for Biological Sciences, National Research Council Canada, 1200 Montreal Road, Ottawa, Ontario, K1A 0R6, Canada.

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http://dx.doi.org/10.1002/mus.21355DOI Listing
September 2009

Do mtDNA deletions drive premature aging in mtDNA mutator mice?

Aging Cell 2009 Aug 22;8(4):502-6. Epub 2009 Apr 22.

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00484.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137638PMC
August 2009

Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease.

Antioxid Redox Signal 2009 Mar;11(3):509-28

Beth Israel Deaconess Medical Center, Department of Neurology, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1089/ars.2008.2241DOI Listing
March 2009

Beating a dead horse: dopamine and Parkinson disease.

Neurology 2008 Nov;71(20):1651; author reply 1651-2

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http://dx.doi.org/10.1212/01.wnl.0000339368.54460.68DOI Listing
November 2008

Caffeine and progression of Parkinson disease.

Clin Neuropharmacol 2008 Jul-Aug;31(4):189-96

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/WNF.0b013e31815a3f03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056438PMC
October 2008

Noninvasive brain stimulation for Parkinson's disease and dystonia.

Neurotherapeutics 2008 Apr;5(2):345-61

Department of Neurology, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1016/j.nurt.2008.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270324PMC
April 2008

Mitochondrial complex I gene variant associated with early age at onset in spinocerebellar ataxia type 2.

Arch Neurol 2007 Jul;64(7):1042-4

Department of Neurology, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Room HIM-847, Boston, MA 02115, USA.

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http://dx.doi.org/10.1001/archneur.64.7.1042DOI Listing
July 2007

Dystonia.

N Engl J Med 2006 Aug;355(8):818-29

Department of Neurology, Parkinson's Disease and Movement Disorders Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMra055549DOI Listing
August 2006

Somatic mitochondrial DNA mutations in single neurons and glia.

Neurobiol Aging 2005 Nov-Dec;26(10):1343-55. Epub 2004 Dec 29.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.11.008DOI Listing
January 2006

No evidence for heritability of Parkinson disease in Swedish twins.

Neurology 2005 Mar;64(5):932; author reply 932

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http://dx.doi.org/10.1212/wnl.64.5.932DOI Listing
March 2005

Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome").

Mov Disord 2004 Jul;19(7):838-840

Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Neurology, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.20078DOI Listing
July 2004

Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease.

Mov Disord 2004 Jun;19(6):649-55

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/mds.20097DOI Listing
June 2004

Attenuation of free radical production and paracrystalline inclusions by creatine supplementation in a patient with a novel cytochrome b mutation.

Muscle Nerve 2004 Apr;29(4):537-47

Department of Medicine, McMaster University Medical Center, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1002/mus.20020DOI Listing
April 2004

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.

Neurobiol Aging 2004 Jan;25(1):71-81

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0197-4580(03)00037-xDOI Listing
January 2004

A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystonia.

Neurogenetics 2003 Aug 17;4(4):199-205. Epub 2003 May 17.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s10048-003-0150-3DOI Listing
August 2003

A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease.

Arch Neurol 2003 May;60(5):722-5

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1001/archneur.60.5.722DOI Listing
May 2003

Spongiform encephalopathy mimicking corticobasal degeneration.

Mov Disord 2002 May;17(3):606-7

Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1002/mds.10166DOI Listing
May 2002

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain.

Hum Mol Genet 2002 Jan;11(2):133-45

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1093/hmg/11.2.133DOI Listing
January 2002