David J Sullivan

David J Sullivan

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David J Sullivan

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Human Plasmodium vivax mosquito experimental transmission.

J Clin Invest 2020 Apr 27. Epub 2020 Apr 27.

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http://dx.doi.org/10.1172/JCI135794DOI Listing
April 2020

Changes in mammalian copper homeostasis during microbial infection.

Metallomics 2020 03;12(3):416-426

The Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1039/c9mt00294dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122220PMC
March 2020

HRP2: Transforming Malaria Diagnosis, but with Caveats.

Trends Parasitol 2020 Feb 14;36(2):112-126. Epub 2019 Dec 14.

Medical Sciences Division, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2019.12.004DOI Listing
February 2020

Superior Pyronaridine Single-Dose Pharmacodynamics Compared to Artesunate, Chloroquine, and Amodiaquine in a Murine Malaria Luciferase Model.

Antimicrob Agents Chemother 2018 09 27;62(9). Epub 2018 Aug 27.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.00394-18
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http://dx.doi.org/10.1128/AAC.00394-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125524PMC
September 2018

Abundance and Dynamics of Anopheles (Diptera: Culicidae) Larvae in a Malaria Endemic Area of Bangladesh.

J Med Entomol 2018 02;55(2):382-391

Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

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http://dx.doi.org/10.1093/jme/tjx196DOI Listing
February 2018

Quinolines block every step of malaria heme crystal growth.

Authors:
David J Sullivan

Proc Natl Acad Sci U S A 2017 07 10;114(29):7483-7485. Epub 2017 Jul 10.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205;

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http://dx.doi.org/10.1073/pnas.1708153114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530708PMC
July 2017

Impact of Extended Duration of Artesunate Treatment on Parasitological Outcome in a Cytocidal Murine Malaria Model.

Antimicrob Agents Chemother 2017 04 24;61(4). Epub 2017 Mar 24.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.02499-16
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http://dx.doi.org/10.1128/AAC.02499-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365722PMC
April 2017

Quantitative characterization of hemozoin in Plasmodium berghei and vivax.

Int J Parasitol Drugs Drug Resist 2017 04 8;7(1):110-119. Epub 2017 Feb 8.

Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205-2179, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342986PMC
April 2017

Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding SO interactions.

Chem Commun (Camb) 2017 Apr;53(28):3964-3966

Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada.

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http://dx.doi.org/10.1039/c7cc00907kDOI Listing
April 2017

Nanoparticle-Based Histidine-Rich Protein-2 Assay for the Detection of the Malaria Parasite Plasmodium falciparum.

Am J Trop Med Hyg 2016 08 16;95(2):354-7. Epub 2016 May 16.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland. Institute for Nanobiotechnology Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.4269/ajtmh.15-0772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973181PMC
August 2016

Subclinical Plasmodium falciparum infections act as year-round reservoir for malaria in the hypoendemic Chittagong Hill districts of Bangladesh.

Int J Infect Dis 2016 Aug 24;49:161-9. Epub 2016 Jun 24.

Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615N. Wolfe St, Rm W4612, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2016.06.019DOI Listing
August 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity.

PLoS One 2015 7;10(5):e0125593. Epub 2015 May 7.

Gradient Biomodeling LLC, Park City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125593PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423929PMC
February 2016

Dynamic control of hepatic Plasmodium numbers by hepcidin despite elevated liver iron during iron supplementation.

Microbes Infect 2016 Jan 15;18(1):48-56. Epub 2015 Sep 15.

The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.micinf.2015.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715950PMC
January 2016

Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity.

PLoS One 2014 26;9(8):e105817. Epub 2014 Aug 26.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144897PMC
December 2015

A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments.

Authors:
David J Sullivan

mBio 2015 Nov 17;6(6):e01818-15. Epub 2015 Nov 17.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/mBio.01818-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659477PMC
November 2015

Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh.

Am J Trop Med Hyg 2015 Aug 22;93(2):281-6. Epub 2015 Jun 22.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Centre for Population, Urbanization and Climate Change, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh; Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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http://dx.doi.org/10.4269/ajtmh.14-0623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530748PMC
August 2015

Asymptomatic Plasmodium falciparum malaria in pregnant women in the Chittagong Hill Districts of Bangladesh.

PLoS One 2014 23;9(5):e98442. Epub 2014 May 23.

Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098442PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032281PMC
June 2015

Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition.

Antimicrob Agents Chemother 2015 Mar 15;59(3):1418-26. Epub 2014 Dec 15.

The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.04642-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325789PMC
March 2015

Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

Bioorg Med Chem Lett 2015 Jan 27;25(2):245-8. Epub 2014 Nov 27.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.11.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277730PMC
January 2015

Erythrocyte lysis and Xenopus laevis oocyte rupture by recombinant Plasmodium falciparum hemolysin III.

Eukaryot Cell 2014 Oct 22;13(10):1337-45. Epub 2014 Aug 22.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/EC.00088-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187644PMC
October 2014

In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains.

Am J Trop Med Hyg 2014 Oct 2;91(4):824-32. Epub 2014 Sep 2.

The Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland

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http://www.ajtmh.org/content/early/2014/08/28/ajtmh.13-0565.
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http://www.ajtmh.org/cgi/doi/10.4269/ajtmh.13-0565
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http://dx.doi.org/10.4269/ajtmh.13-0565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183413PMC
October 2014

Antimalarial efficacy of hydroxyethylapoquinine (SN-119) and its derivatives.

Antimicrob Agents Chemother 2014 18;58(2):820-7. Epub 2013 Nov 18.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.01704-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910808PMC
September 2014

Quantification of Plasmodium falciparum histidine-rich protein-2 in cerebrospinal spinal fluid from cerebral malaria patients.

Am J Trop Med Hyg 2014 Sep 30;91(3):486-92. Epub 2014 Jun 30.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia; Royal Darwin Hospital, Darwin Australia; Duke University and Veterans Administration Medical Centers, Durham, North Carolina; Hubert Kairuki Memorial University, Dar es Salaam, Tanzania; University of Utah School of Medicine and Veterans Administration Medical Center, Salt Lake City, Utah

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.14-0210
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http://dx.doi.org/10.4269/ajtmh.14-0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155548PMC
September 2014

The practice of jhum cultivation and its relationship to Plasmodium falciparum infection in the Chittagong Hill Districts of Bangladesh.

Am J Trop Med Hyg 2014 Aug 12;91(2):374-83. Epub 2014 May 12.

Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Centre for Population, Urbanization and Climate Change, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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http://dx.doi.org/10.4269/ajtmh.13-0592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125265PMC
August 2014

A new visually improved and sensitive loop mediated isothermal amplification (LAMP) for diagnosis of symptomatic falciparum malaria.

Acta Trop 2014 Jun 5;134:52-7. Epub 2014 Mar 5.

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh. Electronic address:

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http://dx.doi.org/10.1016/j.actatropica.2014.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117200PMC
June 2014

Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Bioorg Med Chem Lett 2014 Jun 16;24(11):2440-3. Epub 2014 Apr 16.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074917PMC
June 2014

Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites.

J Med Chem 2014 Jun 19;57(11):4521-31. Epub 2014 May 19.

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health , 615 North Wolfe Street, Baltimore, Maryland 21205 ( United States ).

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http://dx.doi.org/10.1021/jm401675aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059259PMC
June 2014

The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

Bioorg Med Chem Lett 2014 Mar 30;24(5):1285-9. Epub 2014 Jan 30.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.01.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943161PMC
March 2014

Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria.

Proc Natl Acad Sci U S A 2014 Jan 30;111(3):900-5. Epub 2013 Dec 30.

Department of Biochemistry and Cell Biology, Rice University Animal Facility, and Department of Physics and Astronomy, Rice University, Houston, TX 77005-1892.

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http://dx.doi.org/10.1073/pnas.1316253111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903264PMC
January 2014

Quantitative assessment of the proliferation of the protozoan parasite Perkinsus marinus using a bioluminescence assay for ATP content.

Int J Parasitol Drugs Drug Resist 2013 Dec 13;3:85-92. Epub 2013 Apr 13.

Department of Microbiology and Immunology, University of Maryland Baltimore, School of Medicine, Institute of Marine and Environmental Technology, 701 East Pratt Street, Baltimore, MD 21202-3101, USA.

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http://dx.doi.org/10.1016/j.ijpddr.2013.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862420PMC
December 2013

Model system to define pharmacokinetic requirements for antimalarial drug efficacy.

Sci Transl Med 2013 Oct;5(205):205ra135

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845824PMC
October 2013

Plasmodium drug targets outside the genetic control of the parasite.

Authors:
David J Sullivan

Curr Pharm Des 2013 ;19(2):282-9

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263254PMC
July 2013

Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

J Med Chem 2013 Mar 7;56(6):2630-41. Epub 2013 Mar 7.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA.

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http://dx.doi.org/10.1021/jm400058jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630999PMC
March 2013

Timing is everything for artemisinin action.

Authors:
David J Sullivan

Proc Natl Acad Sci U S A 2013 Mar 14;110(13):4866-7. Epub 2013 Mar 14.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1301607110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612629PMC
March 2013

Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model.

PLoS One 2012 21;7(5):e37171. Epub 2012 May 21.

The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037171PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357340PMC
December 2012

Trinuclear Mn(II) complex with paramagnetic bridging 1,2,3-dithiazolyl ligands.

Chem Commun (Camb) 2012 Nov;48(89):10963-5

Department of Chemistry, University of Guelph, Guelph, ON N1G 2W1, Canada.

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http://dx.doi.org/10.1039/c2cc35869gDOI Listing
November 2012

Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

J Med Chem 2012 Sep 27;55(17):7892-9. Epub 2012 Aug 27.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jm3009986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460521PMC
September 2012

Contributions of polyclonal malaria, gametocytemia, and pneumonia to infant severe anemia incidence in malaria hyperendemic Pemba, Tanzania.

Am J Trop Med Hyg 2012 Jun;86(6):925-30

Department of International Health, and Department of Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.4269/ajtmh.2012.11-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366534PMC
June 2012

Multiplex 5' nuclease-quantitative PCR for diagnosis of relapsing fever in a large Tanzanian cohort.

J Clin Microbiol 2011 Sep 20;49(9):3245-9. Epub 2011 Jul 20.

Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1128/JCM.00940-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165610PMC
September 2011

Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation.

Malar J 2011 Sep 20;10:274. Epub 2011 Sep 20.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1186/1475-2875-10-274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206494PMC
September 2011

Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression.

J Gen Virol 2011 Feb 24;92(Pt 2):247-68. Epub 2010 Nov 24.

The George Washington School of Medicine and Health Sciences, Washington, DC, USA.

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http://dx.doi.org/10.1099/vir.0.027102-0DOI Listing
February 2011

An update on the rapid advances in malaria parasite cell biology.

Trends Parasitol 2010 Jun 9;26(6):305-10. Epub 2010 Apr 9.

Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.pt.2010.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883679PMC
June 2010

Malaria incidence and prevalence on Pemba island before the onset of the successful control intervention on the Zanzibar archipelago.

Malar J 2010 Jan 25;9:32. Epub 2010 Jan 25.

Department of Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA.

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http://dx.doi.org/10.1186/1475-2875-9-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835718PMC
January 2010

Ingestion of the malaria pigment hemozoin renders human macrophages less permissive to HIV-1 infection.

Virology 2009 Dec 3;395(1):56-66. Epub 2009 Oct 3.

Centre de Recherche en Infectiologie, Centre Hospitalier de l'Université Laval, and Faculté de Médecine, Université Laval, 2705 Boulevard Laurier, Québec, QC, Canada.

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http://dx.doi.org/10.1016/j.virol.2009.09.010DOI Listing
December 2009

Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium.

Blood 2009 Nov 27;114(19):4243-52. Epub 2009 Aug 27.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-06-22
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http://dx.doi.org/10.1182/blood-2009-06-226415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925626PMC
November 2009

In vitro activity of pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis using radiolabelled thymidine incorporation and an SYBR Green I-based fluorescence assay.

J Antimicrob Chemother 2009 Oct 18;64(4):751-4. Epub 2009 Aug 18.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/jac/dkp296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766825PMC
October 2009

Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.

Antimicrob Agents Chemother 2008 Sep 30;52(9):3106-12. Epub 2008 Jun 30.

Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1128/AAC.00207-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533469PMC
September 2008

New uses for old drugs.

Nature 2007 Aug;448(7154):645-6

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/448645aDOI Listing
August 2007

Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers.

J Infect Dis 2007 Apr 21;195(7):942-50. Epub 2007 Feb 21.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1086/512083DOI Listing
April 2007

Inhibition of angiogenesis by the antifungal drug itraconazole.

ACS Chem Biol 2007 Apr;2(4):263-70

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1021/cb600362dDOI Listing
April 2007

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.

Biochem J 2007 Feb;402(1):197-204

Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1042/BJ20060986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783988PMC
February 2007

PCR detection of Plasmodium falciparum in human urine and saliva samples.

Malar J 2006 Nov 8;5:103. Epub 2006 Nov 8.

The Malaria Institute at Macha, P.O. Box 630166, Choma, Zambia.

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http://dx.doi.org/10.1186/1475-2875-5-103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1654175PMC
November 2006

Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity.

Proc Natl Acad Sci U S A 2006 Sep 18;103(39):14548-53. Epub 2006 Sep 18.

Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0604101103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599997PMC
September 2006

A clinical drug library screen identifies astemizole as an antimalarial agent.

Nat Chem Biol 2006 Aug 2;2(8):415-6. Epub 2006 Jul 2.

Department of Pharmacology and Molecular Sciences. The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nchembio806DOI Listing
August 2006

Plasmodium falciparum-infected erythrocytes increase intercellular adhesion molecule 1 expression on brain endothelium through NF-kappaB.

Infect Immun 2006 Jun;74(6):3262-70

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 720 Rutland Avenue, Ross 1170, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1128/IAI.01625-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479273PMC
June 2006

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target.

J Med Chem 2006 May;49(9):2677-80

Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1021/jm051225tDOI Listing
May 2006

Detection of Plasmodium falciparum in pregnancy by laser desorption mass spectrometry.

Am J Trop Med Hyg 2005 Sep;73(3):485-90

Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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September 2005

Nosocomial malaria and saline flush.

Emerg Infect Dis 2005 Jul;11(7):1097-9

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA.

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http://wwwnc.cdc.gov/eid/article/11/7/05-0092_article.htm
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371795PMC
http://dx.doi.org/10.3201/eid1107.050092DOI Listing
July 2005

Rapid detection of malaria infection in vivo by laser desorption mass spectrometry.

Am J Trop Med Hyg 2004 Nov;71(5):546-51

M. S. Eisenhower Research and Technology Development Center, Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723-6099, USA.

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November 2004

Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase.

Biochem J 2004 Aug;381(Pt 3):803-11

The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1042/BJ20040335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133890PMC
August 2004

Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparum.

Mol Med 2003 May-Aug;9(5-8):175-82

The W Harry Feinstone Department of Molecular Microbiology and Immunology, Department of International Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205,USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430826PMC
http://dx.doi.org/10.2119/2003-00010.sullivanDOI Listing
June 2004

The shape and size of hemozoin crystals distinguishes diverse Plasmodium species.

Mol Biochem Parasitol 2003 Aug;130(2):91-9

The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/s0166-6851(03)00163-4DOI Listing
August 2003

Theories on malarial pigment formation and quinoline action.

Authors:
David J Sullivan

Int J Parasitol 2002 Dec;32(13):1645-53

The Malaria Research Institute, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/s0020-7519(02)00193-5DOI Listing
December 2002

Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine.

Infect Immun 2002 Jul;70(7):3939-43

Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128057PMC
http://dx.doi.org/10.1128/iai.70.7.3939-3943.2002DOI Listing
July 2002

An (17)O-NMR Study of the Exchange of Water on AlOH(H(2)O)(5)(2+)(aq).

Inorg Chem 1998 Sep;37(19):4760-4763

Department of Land, Air and Water Resources; Chemical Engineering and Materials Science; and Department of Geology, University of California, Davis, California 95616.

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http://dx.doi.org/10.1021/ic980333lDOI Listing
September 1998