Publications by authors named "David J Stone"

75Publications

The clinical artificial intelligence department: a prerequisite for success.

BMJ Health Care Inform 2020 Jul;27(1)

Laboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA

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http://dx.doi.org/10.1136/bmjhci-2020-100183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368506PMC
July 2020

An awakening in medicine: the partnership of humanity and intelligent machines.

Lancet Digit Health 2019 Oct 26;1(6):e255-e257. Epub 2019 Sep 26.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA (LAC); Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA (LAC); Department of Diagnostic Imaging and Operational Analytics Lab, Trillium Health Partners, Mississauga, ON, Canada (BF); Department of Medical Imaging, University of Toronto, ON, Canada (BF); Departments of Anesthesiology and Neurosurgery and the Center for Advanced Data Analytics, University of Virginia, Charlottesville, USA (DJS).

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http://dx.doi.org/10.1016/s2589-7500(19)30127-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331949PMC
October 2019

Machine Learning for Pulmonary and Critical Care Medicine: A Narrative Review.

Pulm Ther 2020 Jun 5;6(1):67-77. Epub 2020 Feb 5.

MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1007/s41030-020-00110-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229087PMC
June 2020

Developing well-calibrated illness severity scores for decision support in the critically ill.

NPJ Digit Med 2019 15;2:76. Epub 2019 Aug 15.

1MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1038/s41746-019-0153-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695410PMC
August 2019

Critical Care, Critical Data.

Biomed Eng Comput Biol 2019 12;10:1179597219856564. Epub 2019 Jun 12.

MIT Critical Data, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1177/1179597219856564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563388PMC
June 2019

The authors reply.

Crit Care Med 2019 07;47(7):e612

Big Data Analytics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil, and Laboratory for Critical Care Research, Critical Care Department, Hospital Israelita Albert Einstein, São Paulo, Brazil, and MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA, and Departments of Anesthesiology and Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA; MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA, and Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA; MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA.

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http://dx.doi.org/10.1097/CCM.0000000000003786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673667PMC
July 2019

Oligogenic basis of sporadic ALS: The example of p.Ala90Val mutation.

Neurol Genet 2019 Jun 23;5(3):e335. Epub 2019 Apr 23.

Department of Clinical Genetics (L.K.), Helsinki University Hospital; Department of Medical Genetics (L.K.), University of Helsinki, Helsinki, Finland; Molecular Neurology (K.K., M.V., P.J.T.), Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland; Department of Medical Genetics (S.M.), University of Helsinki, Helsinki, Finland and Turku; University Hospital (S.M.), Laboratory Division, Genetics and Saske, Department of Medical Genetics, Turku, Finland; Department of Neurology (H.L.), Helsinki University Hospital, and Molecular Neurology, Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland; Neuromuscular Research Center (M.J., B.U.), Tampere University Hospital and University of Tampere, Tampere, Finland; Division of Clinical Neurosciences (M.J.), Turku University Hospital and University of Turku, Turku, Finland; Folkhälsan Research Center (B.U.), Biomedicum, University of Helsinki, Helsinki, Finland; Institute of Biomedicine (P.P., J.S.), University of Turku; Turku University Hospital (P.P., J.S.), Laboratory Division, Genetics and Saske, Department of Medical Genetics, Turku, Finland; Department of Pathology (A.P.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Laboratory of Neurogenetics (B.J.T.), National Institute on Aging, National Institutes of Health, Bethesda, MD; Merck & Co. (D.J.S.), Inc., West Point, PA; Department of Clinical Genetics (M.P.), Helsinki University Hospital; Department of Medical Genetics (M.P.), University of Helsinki, Helsinki, Finland; Department of Neurology (P.J.T.), Helsinki University Hospital; and Department of Pathology (L.M.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1212/NXG.0000000000000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481226PMC
June 2019

Counterintuitive results from observational data: a case study and discussion.

BMJ Open 2019 05 5;9(5):e026447. Epub 2019 May 5.

Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02644
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http://dx.doi.org/10.1136/bmjopen-2018-026447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502001PMC
May 2019

Heritability and genetic variance of dementia with Lewy bodies.

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.

Ann Neurol 2019 04 13;85(4):470-481. Epub 2019 Mar 13.

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/ana.25431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450729PMC
April 2019

Assessment of Intensive Care Unit Laboratory Values That Differ From Reference Ranges and Association With Patient Mortality and Length of Stay.

JAMA Netw Open 2018 11 2;1(7):e184521. Epub 2018 Nov 2.

Department of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.4521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324400PMC
November 2018

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

Applying machine learning to continuously monitored physiological data.

J Clin Monit Comput 2019 Oct 11;33(5):887-893. Epub 2018 Nov 11.

Departments of Anesthesiology and Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA, 22904, USA.

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http://link.springer.com/10.1007/s10877-018-0219-z
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http://dx.doi.org/10.1007/s10877-018-0219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511324PMC
October 2019

Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database.

Intensive Care Med 2018 06 28;44(6):884-892. Epub 2018 May 28.

Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, USA.

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http://dx.doi.org/10.1007/s00134-018-5208-7DOI Listing
June 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+).

Neurol Genet 2018 Feb 18;4(1):e211. Epub 2018 Jan 18.

Department of Pathology (M.M., A.E.P., M.T., L.M.), University of Helsinki, and Helsinki University Hospital, Finland; Molecular Neurology (K.K., M.V., T. Peuralinna, P.J.T.), Research Programs Unit, University of Helsinki, and Department of Neurology, Helsinki University Hospital, Finland; Institute of Neuroscience (T. Polvikoski), Newcastle University, United Kingdom; Laboratory of Neurogenetics (A.B.S., B.J.T.), National Institutes on Aging, NIH, Bethesda, MD; and Merck Research Laboratories (D.J.S.), Merck & Co., Inc., West Point, PA, USA.

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http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
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http://dx.doi.org/10.1212/NXG.0000000000000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773846PMC
February 2018

From Big Data to Artificial Intelligence: Harnessing Data Routinely Collected in the Process of Care.

Crit Care Med 2018 02;46(2):345-346

Division of Critical Care Medicine, St. Paul's Hospital; and Centre for Heart Lung Innovation (HLI), University of British Columbia, Vancouver, BC, Canada Departments of Anesthesiology and Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA; and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1097/CCM.0000000000002892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772897PMC
February 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

Severity of Illness Scores May Misclassify Critically Ill Obese Patients.

Crit Care Med 2018 03;46(3):394-400

Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA.

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http://dx.doi.org/10.1097/CCM.0000000000002868DOI Listing
March 2018

Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis.

Crit Care Med 2018 01;46(1):e81-e86

Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA.

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http://dx.doi.org/10.1097/CCM.0000000000002777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734994PMC
January 2018

The MIMIC Code Repository: enabling reproducibility in critical care research.

J Am Med Inform Assoc 2018 01;25(1):32-39

Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/jamia/ocx084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381763PMC
January 2018

Clinical Note Creation, Binning, and Artificial Intelligence.

JMIR Med Inform 2017 Aug 3;5(3):e24. Epub 2017 Aug 3.

Harvard - MIT, Division of Health Science and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://dx.doi.org/10.2196/medinform.7627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561387PMC
August 2017

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Proc Natl Acad Sci U S A 2017 02 13;114(9):2389-2394. Epub 2017 Feb 13.

Genetics, Genetics and Pharmacogenomics, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486;

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http://dx.doi.org/10.1073/pnas.1616332114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338534PMC
February 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

Actuating critical care therapeutics.

J Crit Care 2016 10 10;35:90-5. Epub 2016 May 10.

Huntington Medical Research Institutes, Pasadena, CA. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2016.05.002DOI Listing
October 2016

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.

Neurobiol Dis 2016 Oct 14;94:55-62. Epub 2016 Jun 14.

Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983488PMC
October 2016

A "datathon" model to support cross-disciplinary collaboration.

Sci Transl Med 2016 Apr;8(333):333ps8

Departments of Anesthesiology and Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Center for Wireless Health, University of Virginia School of Engineering and Applied Science, Charlottesville, VA 22904, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad9072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679209PMC
April 2016

Disrupting Electronic Health Records Systems: The Next Generation.

JMIR Med Inform 2015 Oct 23;3(4):e34. Epub 2015 Oct 23.

Beth Israel Deaconess Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Boston, MA, United States.

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http://dx.doi.org/10.2196/medinform.4192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704959PMC
October 2015

Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI).

Mov Disord 2016 Jan 13;31(1):79-85. Epub 2015 Aug 13.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mds.26374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724309PMC
January 2016

State of the art review: the data revolution in critical care.

Crit Care 2015 Mar 16;19:118. Epub 2015 Mar 16.

Departments of Anesthesiology and Neurological Surgery, and the Center for Wireless Health, University of Virginia, Charlottesville, USA.

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http://dx.doi.org/10.1186/s13054-015-0801-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361206PMC
March 2015

Preparing a New Generation of Clinicians for the Era of Big Data.

Harv Med Stud Rev 2015 Jan;2(1):24-27

Departments of Anesthesiology and Neurological Surgery, and the Center for Wireless Health, University of Virginia, Charlottesville, VA 22908, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327872PMC
January 2015

Engineering control into medicine.

J Crit Care 2015 Jun 30;30(3):652.e1-7. Epub 2015 Jan 30.

Huntington Medical Research Institutes, Pasadena, CA. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2015.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414787PMC
June 2015

Dynamic clinical data mining: search engine-based decision support.

JMIR Med Inform 2014 Jun 23;2(1):e13. Epub 2014 Jun 23.

Harvard-MIT Division of Health Science and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://dx.doi.org/10.2196/medinform.3110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288074PMC
June 2014

Making big data useful for health care: a summary of the inaugural mit critical data conference.

JMIR Med Inform 2014 Aug 22;2(2):e22. Epub 2014 Aug 22.

MIT Critical Data Conference 2014 Organizing Committee, Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://dx.doi.org/10.2196/medinform.3447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288071PMC
August 2014

Beyond open big data: addressing unreliable research.

J Med Internet Res 2014 Nov 11;16(11):e259. Epub 2014 Nov 11.

Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, United States.

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http://dx.doi.org/10.2196/jmir.3871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260008PMC
November 2014

Crowdsourcing knowledge discovery and innovations in medicine.

J Med Internet Res 2014 Sep 19;16(9):e216. Epub 2014 Sep 19.

Institute for Medical Engineering and Science, Laboratory of Computational Physiology, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://dx.doi.org/10.2196/jmir.3761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180345PMC
September 2014

Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.

Sleep 2014 Oct 1;37(10):1589-600. Epub 2014 Oct 1.

Center for Sleep and Circadian Neurobiology and Division of Sleep Medicine/Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.5665/sleep.4064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173916PMC
October 2014

Leveraging a critical care database: selective serotonin reuptake inhibitor use prior to ICU admission is associated with increased hospital mortality.

Chest 2014 Apr;145(4):745-752

Massachusetts Institute of Technology, Cambridge, MA; Beth Israel Deaconess Medical Center, Boston, MA. Electronic address:

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http://dx.doi.org/10.1378/chest.13-1722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971969PMC
April 2014

Systems biology approach for new target and biomarker identification.

Curr Top Microbiol Immunol 2013 ;363:169-99

Informatics and Analysis, Merck Research Laboratory, West Point, PA 19486, USA.

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http://link.springer.com/content/pdf/10.1007/82_2012_252.pdf
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http://link.springer.com/10.1007/82_2012_252
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http://dx.doi.org/10.1007/82_2012_252DOI Listing
April 2013

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging.

PLoS One 2011 28;6(12):e29610. Epub 2011 Dec 28.

Exploratory and Translational Sciences, Merck Research Laboratories, Merck Inc., West Point, Pennsylvania, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247273PMC
May 2012

Molecular profiling of a 6-hydroxydopamine model of Parkinson's disease.

Neurochem Res 2010 May 19;35(5):761-72. Epub 2010 Feb 19.

Department of Stroke, Merck Research Laboratories, P.O. Box 4, WP26A-2000, West Point, PA 19486-0004, USA.

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http://dx.doi.org/10.1007/s11064-010-0133-3DOI Listing
May 2010

High-throughput screening by RNA interference: control of two distinct types of variance.

Cell Cycle 2007 Apr 22;6(8):898-901. Epub 2007 Apr 22.

Departments of Molecular Profiling, Merck & Co., Inc., West Point, Pennsylvania 19486, USA.

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http://dx.doi.org/10.4161/cc.6.8.4184DOI Listing
April 2007

A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels.

Mol Cell Neurosci 2006 Nov 15;33(3):227-35. Epub 2006 Sep 15.

Department of Molecular and Cellular Technologies, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.mcn.2006.07.003DOI Listing
November 2006

Biosynthesis and characterization of deuterated polyhydroxyoctanoate.

Biomacromolecules 2006 Apr;7(4):1344-9

Bio/polymers Research Group and Centre for Advanced Macromolecular Design, School of Biotechnology & Biomolecular Sciences, and Nuclear Magnetic Resonance Facility, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1021/bm050969lDOI Listing
April 2006

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro.

Proc Natl Acad Sci U S A 2003 Aug 17;100(16):9608-13. Epub 2003 Jul 17.

CuraGen Corporation, 322 East Main Street, Branford, CT 06405, USA.

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http://dx.doi.org/10.1073/pnas.1632587100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170965PMC
August 2003

Aging and increased hypothalamic glial fibrillary acid protein (GFAP) mRNA in F344 female rats. Dissociation of GFAP inducibility from the luteinizing hormone surge.

Neuroendocrinology 2002 Aug;76(2):121-30

Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, Calif., USA.

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http://dx.doi.org/10.1159/000064429DOI Listing
August 2002

Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin.

Endocrinology 2002 Feb;143(2):636-46

Neurogerontology Division, Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089-0191, USA.

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http://dx.doi.org/10.1210/endo.143.2.8615DOI Listing
February 2002