David J Segal

David J Segal

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David J Segal

Publications by authors named "David J Segal"

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Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.

Nucleic Acids Res 2020 Jan 11. Epub 2020 Jan 11.

Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.

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http://dx.doi.org/10.1093/nar/gkz1214DOI Listing
January 2020

Versatile 3' Functionalization of CRISPR Single Guide RNA.

Chembiochem 2020 Jan 14. Epub 2020 Jan 14.

University of California Davis, Department of Chemistry, One Shields Ave, 95616, Davis, UNITED STATES.

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http://dx.doi.org/10.1002/cbic.201900736DOI Listing
January 2020

Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways.

Hum Mol Genet 2019 Nov;28(22):3842-3852

Medical Immunology and Microbiology, University of California (UC) Davis School of Medicine, Davis, CA 95616, USA.

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http://dx.doi.org/10.1093/hmg/ddz221DOI Listing
November 2019

The Right Tools for the Right Job: CRISPR-pass Could Offer Safe Gene Correction for Many Disorders.

Authors:
David J Segal

Mol Ther 2019 08 24;27(8):1346-1347. Epub 2019 Jun 24.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698281PMC
August 2019

In Vivo Applications of Cell-Penetrating Zinc-Finger Transcription Factors.

Methods Mol Biol 2018 ;1867:239-251

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.

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http://link.springer.com/10.1007/978-1-4939-8799-3_18
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http://dx.doi.org/10.1007/978-1-4939-8799-3_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296463PMC
July 2019

Live-Animal Epigenome Editing: Convergence of Novel Techniques.

Trends Genet 2019 Jul 22;35(7):527-541. Epub 2019 May 22.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2019.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608710PMC
July 2019

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.

Epigenetics Chromatin 2019 May 3;12(1):26. Epub 2019 May 3.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1186/s13072-019-0275-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498470PMC
May 2019

Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain.

Methods Mol Biol 2018 ;1767:227-239

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7774-1_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281562PMC
February 2019

UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease.

Front Mol Neurosci 2018 4;11:476. Epub 2019 Jan 4.

Department of Medical Immunology and Microbiology, University of California, Davis, Davis, CA, United States.

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http://dx.doi.org/10.3389/fnmol.2018.00476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338038PMC
January 2019

Pathogen-specific DNA sensing with engineered zinc finger proteins immobilized on a polymer chip.

Analyst 2018 Aug;143(17):4009-4016

Department of Chemistry, Western Kentucky University, Bowling Green, Kentucky 42101, USA.

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http://dx.doi.org/10.1039/c8an00395eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239418PMC
August 2018

Targeted DNA demethylation of the genome using the human TET1 catalytic domain.

Proc Natl Acad Sci U S A 2018 02 14;115(9):E2125-E2134. Epub 2018 Feb 14.

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095;

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http://dx.doi.org/10.1073/pnas.1716945115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834696PMC
February 2018

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

Sci Rep 2017 11 8;7(1):15044. Epub 2017 Nov 8.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1038/s41598-017-15407-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678142PMC
November 2017

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

Nucleic Acids Res 2017 Sep;45(17):9901-9916

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1093/nar/gkx578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622328PMC
September 2017

Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells.

Nucleic Acids Res 2016 05 6;44(9):4123-33. Epub 2016 Jan 6.

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA

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http://dx.doi.org/10.1093/nar/gkv1530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872074PMC
May 2016

Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain.

Mol Ther 2016 Mar 4;24(3):548-55. Epub 2016 Jan 4.

Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA.

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http://dx.doi.org/10.1038/mt.2015.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786922PMC
March 2016

Miz-1 activates gene expression via a novel consensus DNA binding motif.

PLoS One 2014 1;9(7):e101151. Epub 2014 Jul 1.

Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, California, United States of America; Genome Center, University of California Davis, Davis, California, United States of America; Comprehensive Cancer Center, University of California Davis, Sacramento, California, United States of America; Institute of Pediatric Regenerative Medicine, Shriners Hospital For Children Northern California, Sacramento, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077741PMC
December 2015

How specific is CRISPR/Cas9 really?

Curr Opin Chem Biol 2015 Dec 24;29:72-8. Epub 2015 Oct 24.

Genome Center, Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684463PMC
December 2015

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.

PLoS Genet 2015 Jul 31;11(7):e1005410. Epub 2015 Jul 31.

Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521702PMC
July 2015

Conformational elasticity can facilitate TALE-DNA recognition.

Adv Protein Chem Struct Biol 2014 ;94:347-64

UC Davis Genome Center and Department of Biomedical Engineering, One Shields Avenue, Davis, California, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-800168-4.00009-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334902PMC
April 2015

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.

Nucleic Acids Res 2015 Mar 20;43(6):3389-404. Epub 2015 Feb 20.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA

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http://dx.doi.org/10.1093/nar/gkv137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381059PMC
March 2015

Beyond the genome and into the clinic.

Authors:
David J Segal

Genome Med 2012 30;4(10):78. Epub 2012 Oct 30.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, 451 Health Sciences Drive, Davis, CA 95616, USA.

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http://dx.doi.org/10.1186/gm379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580447PMC
August 2014

Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology.

ACS Chem Biol 2014 Aug;9(8):1645-6

Department of Cancer Biology and Department of Molecular Therapeutics, The Scripps Research Institute , Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, United States.

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http://dx.doi.org/10.1021/cb5005993DOI Listing
August 2014

Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.

Angew Chem Int Ed Engl 2014 Jul 9;53(30):7848-52. Epub 2014 Jul 9.

School of Molecular Bioscience, University of Sydney, Sydney, N.S.W 2006 (Australia).

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http://dx.doi.org/10.1002/anie.201402980DOI Listing
July 2014

The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders.

BMC Neurosci 2014 Jun 19;15:76. Epub 2014 Jun 19.

Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1186/1471-2202-15-76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069279PMC
June 2014

The functional significance of common polymorphisms in zinc finger transcription factors.

G3 (Bethesda) 2014 Jun 26;4(9):1647-55. Epub 2014 Jun 26.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616

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http://dx.doi.org/10.1534/g3.114.012195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169156PMC
June 2014

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.

Nature 2014 03 22;507(7490):124-128. Epub 2014 Jan 22.

Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/nature12931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963826PMC
March 2014

Genome engineering at the dawn of the golden age.

Annu Rev Genomics Hum Genet 2013 20;14:135-58. Epub 2013 May 20.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616; email:

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http://dx.doi.org/10.1146/annurev-genom-091212-153435DOI Listing
December 2013

Transcription activator like effector (TALE)-directed piggyBac transposition in human cells.

Nucleic Acids Res 2013 Oct 5;41(19):9197-207. Epub 2013 Aug 5.

Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA, Genome Center, Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA and Manoa BioSciences, Honolulu, HI 96819, USA.

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http://dx.doi.org/10.1093/nar/gkt677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799441PMC
October 2013

Quantitative analysis of TALE-DNA interactions suggests polarity effects.

Nucleic Acids Res 2013 Apr 13;41(7):4118-28. Epub 2013 Feb 13.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1093/nar/gkt085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627578PMC
April 2013

Bacteria herald a new era of gene editing.

Authors:
David J Segal

Elife 2013 Jan 29;2:e00563. Epub 2013 Jan 29.

is at the Genome Center and the Department of Biochemistry and Molecular Medicine , University of California, Davis , United States

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http://dx.doi.org/10.7554/eLife.00563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557904PMC
January 2013

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.

J Am Chem Soc 2012 Oct 10;134(42):17814-22. Epub 2012 Oct 10.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/ja308888cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483022PMC
October 2012

Chimeric piggyBac transposases for genomic targeting in human cells.

Nucleic Acids Res 2012 Aug 9;40(14):6978-91. Epub 2012 Apr 9.

Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA.

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http://dx.doi.org/10.1093/nar/gks309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413120PMC
August 2012

Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA.

Angew Chem Int Ed Engl 2012 May 19;51(22):5371-5. Epub 2012 Apr 19.

School of Molecular Bioscience, University of Sydney, Sydney, N.S.W 2006, Australia.

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http://dx.doi.org/10.1002/anie.201200866DOI Listing
May 2012

Adding fingers to an engineered zinc finger nuclease can reduce activity.

Biochemistry 2011 Jun 11;50(22):5033-41. Epub 2011 May 11.

Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, United States.

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http://dx.doi.org/10.1021/bi200393gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110833PMC
June 2011

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications.

Nucleic Acids Res 2011 Mar 5;39(5):e29. Epub 2010 Dec 5.

Genome Center, Department of Pharmacology, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1093/nar/gkq1214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061069PMC
March 2011

The prospects for designer single-stranded RNA-binding proteins.

Nat Struct Mol Biol 2011 Mar 27;18(3):256-61. Epub 2011 Feb 27.

School of Molecular Bioscience, University of Sydney, New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1038/nsmb.2005DOI Listing
March 2011

Zinc-finger nucleases transition to the CoDA.

Authors:
David J Segal

Nat Methods 2011 Jan;8(1):53-5

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http://dx.doi.org/10.1038/nmeth0111-53DOI Listing
January 2011

The generation of zinc finger proteins by modular assembly.

Methods Mol Biol 2010 ;649:3-30

Department of Pharmacology, Genome Center, University of California at Davis, Davis, CA, USA.

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http://dx.doi.org/10.1007/978-1-60761-753-2_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323424PMC
December 2010

Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER).

Methods Mol Biol 2010 ;649:365-82

Department of Chemistry, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.1007/978-1-60761-753-2_23DOI Listing
December 2010

Toward a general approach for RNA-templated hierarchical assembly of split-proteins.

J Am Chem Soc 2010 Aug;132(33):11692-701

Department of Chemistry & Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1021/ja104395bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954892PMC
August 2010

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.

Nucleic Acids Res 2009 Dec;37(22):e151

Genome Center, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1093/nar/gkp802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794170PMC
December 2009

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker.

Bioorg Med Chem Lett 2009 Jul 3;19(14):3970-2. Epub 2009 Mar 3.

University of California, Davis, Genome Center and Department of Pharmacology, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709702PMC
July 2009

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA.

Bioorg Med Chem Lett 2009 Jul 5;19(14):3748-51. Epub 2009 May 5.

Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709697PMC
July 2009

The protein-binding potential of C2H2 zinc finger domains.

Cell Biochem Biophys 2008 20;51(1):9-19. Epub 2008 Feb 20.

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1007/s12013-008-9007-6DOI Listing
September 2008

Generation and functional analysis of zinc finger nucleases.

Methods Mol Biol 2008 ;434:277-90

Charité Medical School, Institute of Virology, Berlin, Germany.

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http://link.springer.com/10.1007/978-1-60327-248-3_17
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http://dx.doi.org/10.1007/978-1-60327-248-3_17DOI Listing
September 2008

Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains.

Cell Biochem Biophys 2008 6;50(3):111-31. Epub 2008 Feb 6.

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1007/s12013-008-9008-5DOI Listing
June 2008

Critical parameters for genome editing using zinc finger nucleases.

Mini Rev Med Chem 2008 Jun;8(7):669-76

University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.2174/138955708784567458DOI Listing
June 2008

Split beta-lactamase sensor for the sequence-specific detection of DNA methylation.

Anal Chem 2007 Sep 8;79(17):6702-8. Epub 2007 Aug 8.

Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1021/ac071163+DOI Listing
September 2007

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.

Nat Biotechnol 2007 Jul 1;25(7):786-93. Epub 2007 Jul 1.

Charité Medical School, Institute of Virology (CBF), 12203 Berlin, Germany.

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http://dx.doi.org/10.1038/nbt1317DOI Listing
July 2007

Active integration: new strategies for transgenesis.

Transgenic Res 2007 Jun 6;16(3):333-9. Epub 2007 Mar 6.

Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s11248-007-9077-zDOI Listing
June 2007

Design, construction and in vitro testing of zinc finger nucleases.

Nat Protoc 2006 ;1(3):1329-41

Department of Biochemistry, University of Utah School of Medicine, 15 N. Medical Drive East, Room 4100, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.1038/nprot.2006.231DOI Listing
June 2007

Uranyl acetate as a direct inhibitor of DNA-binding proteins.

Chem Res Toxicol 2007 May 14;20(5):784-9. Epub 2007 Apr 14.

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1021/tx600347kDOI Listing
May 2007

Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics.

Mol Biosyst 2006 Nov 28;2(11):551-60. Epub 2006 Sep 28.

Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1039/b611169fDOI Listing
November 2006

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

J Mol Biol 2006 Oct 11;363(2):405-21. Epub 2006 Aug 11.

UC Davis Genome Center and Department of Pharmacology, University of California, Davis, CA 95616, USA.

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http://escholarship.org/uc/item/7x34c3g6.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S002228360601028
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http://dx.doi.org/10.1016/j.jmb.2006.08.016DOI Listing
October 2006

Site-specific detection of DNA methylation utilizing mCpG-SEER.

J Am Chem Soc 2006 Aug;128(30):9761-5

Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1021/ja060681jDOI Listing
August 2006

Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA.

Biochemistry 2006 Mar;45(11):3620-5

Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1021/bi0517032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688710PMC
March 2006

Custom zinc-finger nucleases for use in human cells.

Mol Ther 2005 Oct;12(4):610-7

Institute of Virology, Charité Medical School, Campus Benjamin Franklin, Berlin, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S152500160500278
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http://dx.doi.org/10.1016/j.ymthe.2005.06.094DOI Listing
October 2005

Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction.

Trends Biotechnol 2005 Aug;23(8):399-406

Hannah Research Institute, Hannah Research Park, Ayr, UK, KA6 5HL.

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http://dx.doi.org/10.1016/j.tibtech.2005.06.005DOI Listing
August 2005

Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools.

Trends Biotechnol 2005 Aug;23(8):407-19

Department of Entomology, Texas A&M University, College Station, TX 77843, USA.

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http://dx.doi.org/10.1016/j.tibtech.2005.06.009DOI Listing
August 2005

DNA sequence-enabled reassembly of the green fluorescent protein.

J Am Chem Soc 2005 Aug;127(31):10782-3

Department of Chemistry and Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1021/ja051969wDOI Listing
August 2005

Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jun 1;61(Pt 6):573-6. Epub 2005 Jun 1.

Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1107/S1744309105014363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952332PMC
June 2005

Designing transcription factor architectures for drug discovery.

Mol Pharmacol 2004 Dec 31;66(6):1361-71. Epub 2004 Aug 31.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.104.00
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http://dx.doi.org/10.1124/mol.104.002758DOI Listing
December 2004

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

J Biol Chem 2004 Apr 20;279(15):14509-19. Epub 2004 Jan 20.

The Skaggs Institute for Chemical Biology and the Departments of Molecular Biology and Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M400349200
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http://dx.doi.org/10.1074/jbc.M400349200DOI Listing
April 2004

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites.

J Virol 2004 Feb;78(3):1301-13

Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321411PMC
http://dx.doi.org/10.1128/jvi.78.3.1301-1313.2004DOI Listing
February 2004

Zinc fingers and a green thumb: manipulating gene expression in plants.

Curr Opin Plant Biol 2003 Apr;6(2):163-8

The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/s1369-5266(03)00007-4DOI Listing
April 2003

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins.

Biochemistry 2003 Feb;42(7):2137-48

The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/bi026806oDOI Listing
February 2003

The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment.

Authors:
David J Segal

Methods 2002 Jan;26(1):76-83

The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/S1046-2023(02)00009-9DOI Listing
January 2002