David J Rowlands

David J Rowlands

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David J Rowlands

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Career thoughts and recollections: 50 years of publishing in the .

Authors:
David J Rowlands

J Gen Virol 2019 Oct 27;100(10):1390-1392. Epub 2019 Aug 27.

School of Molecular and Cellular Biology & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1099/jgv.0.001311DOI Listing
October 2019

Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective.

Lab Chip 2019 Sep;19(19):3152-3161

Drug Metabolism and Pharmacokinetics, Theravance Biopharma US, Inc, South San Francisco, CA, USA.

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http://dx.doi.org/10.1039/c9lc00492kDOI Listing
September 2019

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Nat Microbiol 2019 03 10;4(3):414-419. Epub 2018 Dec 10.

Division of Structural Biology, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41564-018-0319-zDOI Listing
March 2019

Involvement of a Nonstructural Protein in Poliovirus Capsid Assembly.

J Virol 2019 Mar 19;93(5). Epub 2019 Feb 19.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom

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http://dx.doi.org/10.1128/JVI.01447-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384072PMC
March 2019

Recombinant Expression of Tandem-HBc Virus-Like Particles (VLPs).

Methods Mol Biol 2018 ;1776:97-123

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1007/978-1-4939-7808-3_7DOI Listing
February 2019

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.

PLoS Pathog 2017 Oct 2;13(10):e1006666. Epub 2017 Oct 2.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1006666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638621PMC
October 2017

Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.

J Virol 2017 02 31;91(4). Epub 2017 Jan 31.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom

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http://dx.doi.org/10.1128/JVI.01586-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286869PMC
February 2017

Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes.

PLoS Pathog 2017 02 6;13(2):e1006197. Epub 2017 Feb 6.

School of Molecular and Cellular Biology & Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1006197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325612PMC
February 2017

Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander?

Authors:
David J Rowlands

Pharmacol Ther 2016 10 1;166:96-105. Epub 2016 Jul 1.

Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.06.019DOI Listing
October 2016

miRNA-140-5p: new avenue for pulmonary arterial hypertension drug development?

Epigenomics 2016 10 7;8(10):1311-1313. Epub 2016 Sep 7.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.

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http://dx.doi.org/10.2217/epi-2016-0089DOI Listing
October 2016

Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.

J Virol 2016 08 11;90(15):6864-6883. Epub 2016 Jul 11.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom

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http://dx.doi.org/10.1128/JVI.00469-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944275PMC
August 2016

Human hepatitis A virus is united with a host of relations.

Authors:
David J Rowlands

Proc Natl Acad Sci U S A 2015 Dec 18;112(49):15010-1. Epub 2015 Nov 18.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom

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http://dx.doi.org/10.1073/pnas.1520121112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679024PMC
December 2015

Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers.

J Biol Chem 2015 Jun 7;290(26):16238-45. Epub 2015 May 7.

From the School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom and

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http://dx.doi.org/10.1074/jbc.M114.622035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481223PMC
June 2015

Revealing the density of encoded functions in a viral RNA.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):2227-32. Epub 2015 Feb 2.

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1420812112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343168PMC
February 2015

Hepatitis A virus and the origins of picornaviruses.

Nature 2015 Jan 19;517(7532):85-88. Epub 2014 Oct 19.

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, UK.

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http://dx.doi.org/10.1038/nature13806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773894PMC
January 2015

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.

J Gen Virol 2014 Dec 5;95(Pt 12):2649-57. Epub 2014 Aug 5.

School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK

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http://dx.doi.org/10.1099/vir.0.067751-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233629PMC
December 2014

NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.

J Gen Virol 2014 Nov 14;95(Pt 11):2427-41. Epub 2014 Jul 14.

Leeds Institute of Cancer & Pathology (LICAP), and Leeds CRUK Clinical Centre, Faculty of Medicine and Health, St James's University Hospital, University of Leeds, Beckett St., Leeds, West Yorkshire LS9 7TF, UK School of Molecular & Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Mount Preston Street, Leeds, West Yorkshire LS2 9JT, UK

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http://dx.doi.org/10.1099/vir.0.068932-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202265PMC
November 2014

Sex-dependent influence of endogenous estrogen in pulmonary hypertension.

Am J Respir Crit Care Med 2014 Aug;190(4):456-67

1 Institute of Cardiovascular and Medical Sciences, College of Medical and Veterinary Science, University of Glasgow, Glasgow, United Kingdom; and.

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http://dx.doi.org/10.1164/rccm.201403-0483OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214128PMC
August 2014

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.

Hepatology 2014 Feb 24;59(2):408-22. Epub 2013 Dec 24.

Leeds Institute of Cancer & Pathology & CRUK Clinical Centre, Faculty of Medicine and Health, St James' University Hospital, University of Leeds, Leeds, West Yorkshire, UK; School of Molecular & Cellular Biology & Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire, UK.

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http://dx.doi.org/10.1002/hep.26685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298801PMC
February 2014

A plate-based high-throughput assay for virus stability and vaccine formulation.

J Virol Methods 2012 Oct 26;185(1):166-70. Epub 2012 Jun 26.

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01660934120022
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http://dx.doi.org/10.1016/j.jviromet.2012.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470038PMC
October 2012

Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.

Nat Med 2012 Apr 15;18(5):759-65. Epub 2012 Apr 15.

Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.2736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727429PMC
April 2012

Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity.

J Virol 2012 Feb 7;86(4):2371-4. Epub 2011 Dec 7.

Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1128/JVI.05696-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302376PMC
February 2012

Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels.

J Clin Invest 2011 May 25;121(5):1986-99. Epub 2011 Apr 25.

Lung Biology Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI43839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083796PMC
May 2011

Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30.

Hypertension 2011 Apr 7;57(4):833-40. Epub 2011 Feb 7.

Cardiovascular Division, British Heart Foundation Centre for Research Excellence, School of Medicine, Franklin-Wilkins Building (Room 3.01), King's College London, 150 Stamford St, London SE1 9NH, UK.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.110.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.162198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086276PMC
April 2011

Picornaviruses.

Curr Top Microbiol Immunol 2010 ;343:43-89

Faculty of Biological Sciences, Institute for Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, West Yorkshire, LS2 9JT, UK.

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http://dx.doi.org/10.1007/82_2010_37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018333PMC
January 2011

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.

J Gen Virol 2010 Aug 28;91(Pt 8):1971-7. Epub 2010 Apr 28.

Division of Structural Biology and Oxford Protein Production Facility, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1099/vir.0.020420-0DOI Listing
August 2010

Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification.

J Virol 2010 Jun 7;84(12):6235-40. Epub 2010 Apr 7.

Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1128/JVI.02375-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876639PMC
June 2010

Foot-and-mouth disease virus assembly: processing of recombinant capsid precursor by exogenous protease induces self-assembly of pentamers in vitro in a myristoylation-dependent manner.

J Virol 2009 Nov 26;83(21):11275-82. Epub 2009 Aug 26.

Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01263-09
Publisher Site
http://dx.doi.org/10.1128/JVI.01263-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772760PMC
November 2009

Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

PLoS Pathog 2009 Oct 9;5(10):e1000620. Epub 2009 Oct 9.

Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1000620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752993PMC
October 2009

Fred Brown: 31 January 1925 - 20 February 2004.

Biogr Mem Fellows R Soc 2007 ;53:93-108

Institute of Molecular and Cellular Biology, Faculty of Biological Science, University of Leeds, Leeds.

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November 2008

Recombinant VP4 of human rhinovirus induces permeability in model membranes.

J Virol 2008 Apr 6;82(8):4169-74. Epub 2008 Feb 6.

Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01070-07
Publisher Site
http://dx.doi.org/10.1128/JVI.01070-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293005PMC
April 2008

Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system.

Antiviral Res 2007 Oct 4;76(1):48-58. Epub 2007 Jun 4.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1016/j.antiviral.2007.05.001DOI Listing
October 2007

Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression.

Cardiovasc Res 2007 Jul 6;75(2):261-74. Epub 2007 Apr 6.

Cardiovascular Division, School of Medicine, King's College London, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.cardiores.2007.04.004DOI Listing
July 2007

Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes.

Free Radic Biol Med 2007 Apr 8;42(7):909-25. Epub 2007 Jan 8.

Cardiovascular Division, School of Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.01.004DOI Listing
April 2007

Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.

RNA 2006 Nov 3;12(11):1970-9. Epub 2006 Oct 3.

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom.

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http://dx.doi.org/10.1261/rna.161006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1624902PMC
November 2006

Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells.

J Physiol 2006 Oct 27;576(Pt 2):585-94. Epub 2006 Jul 27.

2.38A, New Hunts Hose, King's College London, Guy's Hospital Campus, London Bridge, London SE1 1UL, UK.

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http://dx.doi.org/10.1113/jphysiol.2006.115998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890348PMC
October 2006

Tagging of NS5A expressed from a functional hepatitis C virus replicon.

J Gen Virol 2006 Mar;87(Pt 3):635-40

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1099/vir.0.81553-0DOI Listing
March 2006

A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.

J Gen Virol 2006 Jan;87(Pt 1):93-102

Institute of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, UK.

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http://dx.doi.org/10.1099/vir.0.81180-0DOI Listing
January 2006

Hepatitis B small surface antigen particles are octahedral.

Proc Natl Acad Sci U S A 2005 Oct 3;102(41):14783-8. Epub 2005 Oct 3.

Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0505062102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253561PMC
October 2005

Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system.

J Gen Virol 2004 Feb;85(Pt 2):429-39

Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.19676-0DOI Listing
February 2004

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.

J Gen Virol 2004 Feb;85(Pt 2):451-61

Astbury Centre of Molecular Biology, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1099/vir.0.19634-0DOI Listing
February 2004

Viral internal ribosome entry site structures segregate into two distinct morphologies.

J Virol 2003 Jun;77(11):6574-9

Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154988PMC
http://dx.doi.org/10.1128/jvi.77.11.6574-6579.2003DOI Listing
June 2003

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.

FEBS Lett 2003 Jan;535(1-3):34-8

School of Biochemistry and Molecular Biology, University of Leeds, Division of Microbiology Old Medical School, Thoresby Place, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1016/s0014-5793(02)03851-6DOI Listing
January 2003

Efficient delivery and regulable expression of hepatitis C virus full-length and minigenome constructs in hepatocyte-derived cell lines using baculovirus vectors.

J Gen Virol 2002 Feb;83(Pt 2):383-94

Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1099/0022-1317-83-2-383DOI Listing
February 2002