David J Rawlings

David J Rawlings

UNVERIFIED PROFILE

Are you David J Rawlings?   Register this Author

Register author
David J Rawlings

David J Rawlings

Publications by authors named "David J Rawlings"

Are you David J Rawlings?   Register this Author

98Publications

2568Reads

38Profile Views

Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.

J Immunol 2019 Dec 13;203(12):3166-3178. Epub 2019 Nov 13.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1900848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904544PMC
December 2019

In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods.

Mol Ther Nucleic Acids 2019 Sep 7;17:277-288. Epub 2019 Jun 7.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, School of Medicine, Seattle, WA, USA; Department of Immunology, University of Washington, School of Medicine, Seattle, WA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtn.2019.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611979PMC
September 2019

TALEN-Mediated Gene Editing of in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.

Mol Ther Methods Clin Dev 2019 Mar 31;12:175-183. Epub 2018 Dec 31.

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtm.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348980PMC
March 2019

Generation of functional murine CD11c age-associated B cells in the absence of B cell T-bet expression.

Eur J Immunol 2019 01 5;49(1):170-178. Epub 2018 Nov 5.

Center for Immunity and Immunotherapy, Seattle Children's Research Institute, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201847641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779321PMC
January 2019

The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy.

Curr Opin Immunol 2018 12 1;55:81-88. Epub 2018 Nov 1.

Seattle Children's Research Institute, Seattle, WA, United States; Department of Pediatrics, University of Washington, School of Medicine, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09527915183004
Publisher Site
http://dx.doi.org/10.1016/j.coi.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289281PMC
December 2018

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.

J Autoimmun 2018 11 24;94:45-55. Epub 2018 Jul 24.

Centre for Inflammation Biology and Cancer Immunology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198113PMC
November 2018

TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.

Kidney Int 2018 10 12;94(4):728-740. Epub 2018 Jun 12.

Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151274PMC
October 2018

αv Integrins regulate germinal center B cell responses through noncanonical autophagy.

J Clin Invest 2018 08 20;128(9):4163-4178. Epub 2018 Aug 20.

Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI99597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118577PMC
August 2018

Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.

Eur J Immunol 2018 02 20;48(2):306-315. Epub 2017 Oct 20.

Academic Department of Rheumatology, Centre for Inflammation Biology and Cancer Immunology, Faculty of Life Sciences and Medicine, King's College London, London, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/eji.201747092
Publisher Site
http://dx.doi.org/10.1002/eji.201747092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859948PMC
February 2018

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.

Mol Ther 2018 02 22;26(2):456-467. Epub 2017 Nov 22.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835153PMC
February 2018

The Autoimmune Risk Variant C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.

J Immunol 2017 10 11;199(7):2249-2260. Epub 2017 Aug 11.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1700601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791366PMC
October 2017

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.

Autophagy 2017 Sep 8;13(9):1590-1601. Epub 2017 Aug 8.

a Division of Gastroenterology and Hepatology , University Hospital Zurich, University of Zurich , Zurich , Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15548627.2017.1341453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612532PMC
September 2017

Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.

J Allergy Clin Immunol 2017 08 16;140(2):616-619.e7. Epub 2017 Mar 16.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Wash; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Wash. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2017.02.017DOI Listing
August 2017

Altered B cell signalling in autoimmunity.

Nat Rev Immunol 2017 Jul 10;17(7):421-436. Epub 2017 Apr 10.

Seattle Children's Research Institute, 1900 9th Avenue, Seattle, Washington 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri.2017.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523822PMC
July 2017

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells.

Mol Ther 2017 03 28;25(3):570-579. Epub 2017 Jan 28.

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2016.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363191PMC
March 2017

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Mol Ther Methods Clin Dev 2017 Mar 18;4:1-16. Epub 2016 Dec 18.

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98105, USA; Department of Immunology, University of Washington, Seattle, WA 98105, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23290501163012
Publisher Site
http://dx.doi.org/10.1016/j.omtm.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363182PMC
March 2017

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.

Mol Ther Methods Clin Dev 2017 Mar 10;4:192-203. Epub 2017 Jan 10.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA; Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98101, USA; Department of Immunology, University of Washington, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtm.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363294PMC
March 2017

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

J Immunol 2016 12 11;197(12):4529-4534. Epub 2016 Nov 11.

Seattle Children's Research Institute, Seattle, WA 98101;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1601198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147509PMC
December 2016

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Mol Ther Nucleic Acids 2016 Aug 23;5(8):e352. Epub 2016 Aug 23.

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtna.2016.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023401PMC
August 2016

Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome.

Blood 2016 05 22;127(21):2513-22. Epub 2016 Feb 22.

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA; and Department of Pediatrics and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-11-683235DOI Listing
May 2016

Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.

J Immunol 2016 05 28;196(9):3525-31. Epub 2016 Mar 28.

Seattle Children's Research Institute, Seattle, WA 98101; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1600017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868625PMC
May 2016

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.

J Exp Med 2016 05 11;213(5):733-50. Epub 2016 Apr 11.

Seattle Children's Research Institute, Seattle, WA 98105 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20151724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854732PMC
May 2016

BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.

Curr Opin Immunol 2015 Dec;37:46-53

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States; Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States; Seattle Children's Research Institute, Seattle, WA, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679457PMC
December 2015

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.

J Exp Med 2015 Sep 14;212(10):1663-77. Epub 2015 Sep 14.

Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20150585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577851PMC
September 2015

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.

Sci Transl Med 2015 Sep;7(307):307ra156

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA. Department of Pediatrics, University of Washington, Seattle, WA 98101, USA. Department of Immunology, University of Washington, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aac5530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790757PMC
September 2015

Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine hemophilia A.

Mol Ther 2015 Apr 6;23(4):617-26. Epub 2015 Feb 6.

1] Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA [2] Department of Pediatrics, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15250016163008
Publisher Site
http://dx.doi.org/10.1038/mt.2015.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395783PMC
April 2015

B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production.

Curr Opin Immunol 2015 Apr 11;33:70-7. Epub 2015 Feb 11.

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States; Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States; Seattle Children's Research Institute, Seattle, WA, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09527915150001
Publisher Site
http://dx.doi.org/10.1016/j.coi.2015.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397155PMC
April 2015

The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.

J Immunol 2015 Apr;194(7):2977-84

Translational Research Program, Benaroya Research Institute, Seattle, WA 98101

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1403034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369788PMC
April 2015

Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial.

Biol Blood Marrow Transplant 2014 Dec 6;20(12):1996-2003. Epub 2014 Sep 6.

Fred Hutchinson Cancer Research Center, Seattle, Washington; University of Washington School of Medicine, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2014.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324724PMC
December 2014

CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.

J Immunol 2014 Oct 29;193(7):3492-502. Epub 2014 Aug 29.

Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195; and Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170672PMC
October 2014

Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Blood 2014 Jun 18;123(23):3578-84. Epub 2014 Mar 18.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-11-538926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047497PMC
June 2014

Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus.

Nucleic Acids Res 2014 Jun 25;42(10):6463-75. Epub 2014 Mar 25.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA Departments of Pediatrics and Immunology, University of Washington, Seattle, WA 98195, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gku224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041414PMC
June 2014

In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease.

Mol Ther Nucleic Acids 2014 Feb 4;3:e146. Epub 2014 Feb 4.

1] Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA [2] Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtna.2013.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951911PMC
February 2014

Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.

Nucleic Acids Res 2014 Jan 10;42(1):e4. Epub 2013 Oct 10.

Center of Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, 98101 Washington, USA, Program in Molecular and Cellular Biology, University of Washington, Seattle, 98195 Washington, USA, Department of Immunology, University of Washington, Seattle, 98195 Washington, USA and Department of Biochemistry, University of Washington, Seattle, 98195 Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874187PMC
January 2014

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.

Nat Immunol 2013 May 7;14(5):514-22. Epub 2013 Apr 7.

Centro de Investigaciones en Bioquímica Clínica e Inmunología, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ni.2569
Publisher Site
http://dx.doi.org/10.1038/ni.2569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631452PMC
May 2013

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

J Clin Invest 2013 May 24;123(5):2024-36. Epub 2013 Apr 24.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI66963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638909PMC
May 2013

A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.

Genes Dev 2013 Apr 18;27(8):955-69. Epub 2013 Apr 18.

Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.213827.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650231PMC
April 2013

Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation.

Mol Cell Biol 2013 Mar 7;33(6):1149-63. Epub 2013 Jan 7.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.06407-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592024PMC
March 2013

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.

J Immunol 2012 May 18;188(10):4792-800. Epub 2012 Apr 18.

Centro de Investigaciones en Bioquímica Clínica e Inmunología, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba CP 5000, Argentina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1102070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361506PMC
May 2012

Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.

J Immunol 2012 Mar 30;188(5):2065-9. Epub 2012 Jan 30.

Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1103282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288200PMC
March 2012

Integration of B cell responses through Toll-like receptors and antigen receptors.

Nat Rev Immunol 2012 Mar 16;12(4):282-94. Epub 2012 Mar 16.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri3190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437941PMC
March 2012

Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.

Front Biosci (Landmark Ed) 2012 Jan 1;17:1499-516. Epub 2012 Jan 1.

Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, D-30625 Germany.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601656PMC
http://dx.doi.org/10.2741/4000DOI Listing
January 2012

Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.

Front Biosci (Landmark Ed) 2012 Jan 1;17:1499-516. Epub 2012 Jan 1.

Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, D-30625 Germany.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601656PMC
http://dx.doi.org/10.2741/4000DOI Listing
January 2012

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.

J Exp Med 2011 Sep 29;208(10):2033-42. Epub 2011 Aug 29.

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA; Seattle Children’s Research Institute, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20110200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182055PMC
September 2011

Tracking genome engineering outcome at individual DNA breakpoints.

Nat Methods 2011 Jul 10;8(8):671-6. Epub 2011 Jul 10.

Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nmeth.1648
Publisher Site
http://dx.doi.org/10.1038/nmeth.1648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415300PMC
July 2011

Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.

Mol Ther 2011 Mar 7;19(3):515-25. Epub 2010 Dec 7.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2010.259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048182PMC
March 2011

MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.

Mol Cell Biol 2010 Feb 14;30(4):922-34. Epub 2009 Dec 14.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01129-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815576PMC
February 2010

CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.

Immunity 2010 Jan 14;32(1):129-40. Epub 2010 Jan 14.

Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2009.11.009DOI Listing
January 2010

Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.

J Immunol 2009 Dec 16;183(11):7362-70. Epub 2009 Nov 16.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0902438
Publisher Site
http://dx.doi.org/10.4049/jimmunol.0902438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433237PMC
December 2009

Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.

Exp Hematol 2009 Nov 3;37(11):1353-63. Epub 2009 Sep 3.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, Tenn., USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0301472X0900359
Publisher Site
http://dx.doi.org/10.1016/j.exphem.2009.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771582PMC
November 2009

Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.

Blood 2009 Nov 21;114(20):4373-82. Epub 2009 Sep 21.

Department of Pediatrics, Seattle Children's Research Institute and University of Washington, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-05-217315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777123PMC
November 2009

Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.

J Immunol 2009 Jun;182(12):7370-80

Department of Immunology, University of Washington School of Medicine and Seattle Children's Research Institute, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0804256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830893PMC
June 2009

Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.

J Immunol 2009 Mar;182(5):2868-78

Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0802368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694130PMC
March 2009

Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.

Clin Immunol 2009 Feb 25;130(2):162-74. Epub 2008 Oct 25.

Department of Pediatrics, University of Washington and Seattle Children's Hospital Research Institute, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S152166160800810
Publisher Site
http://dx.doi.org/10.1016/j.clim.2008.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727638PMC
February 2009

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.

Blood 2008 Sep 23;112(5):1662-72. Epub 2008 Jun 23.

Department of Pediatrics, Seattle Children's Hospital Research Institute and University of Washington, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-01-128413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518877PMC
September 2008

B cell autonomous TLR signaling and autoimmunity.

Autoimmun Rev 2008 Feb 8;7(4):313-6. Epub 2008 Jan 8.

Seattle Children's Hospital Research Institute, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2007.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763483PMC
February 2008

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.

J Exp Med 2008 Jan 7;205(1):155-68. Epub 2008 Jan 7.

Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20071088
Publisher Site
http://dx.doi.org/10.1084/jem.20071088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234381PMC
January 2008