David J Lythgoe

David J Lythgoe

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David J Lythgoe

David J Lythgoe

Publications by authors named "David J Lythgoe"

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Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task.

Eur Neuropsychopharmacol 2019 12 14;29(2):222-234. Epub 2018 Dec 14.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom.

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http://dx.doi.org/10.1016/j.euroneuro.2018.12.005DOI Listing
December 2019

Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior.

Cortex 2019 Sep 19;121:135-146. Epub 2019 Sep 19.

Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, the Netherlands; Radboud University, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00109452193030
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http://dx.doi.org/10.1016/j.cortex.2019.08.017DOI Listing
September 2019

Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety.

Cortex 2019 Aug 7;117:53-63. Epub 2019 Mar 7.

Department of Psychology, University of Roehampton, London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Combined Universities Brain Imaging Centre, London, UK.

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http://dx.doi.org/10.1016/j.cortex.2019.02.021DOI Listing
August 2019

Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study.

Sci Rep 2019 Jul 2;9(1):8685. Epub 2019 Jul 2.

Psychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.

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http://dx.doi.org/10.1038/s41598-019-45018-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606579PMC
July 2019

Neurochemical effects of oxytocin in people at clinical high risk for psychosis.

Eur Neuropsychopharmacol 2019 May 28;29(5):601-615. Epub 2019 Mar 28.

Early Psychosis: Interventions & Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AF, UK; National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Outreach and Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2019.03.008DOI Listing
May 2019

Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder.

Biol Psychiatry 2019 04 21;85(7):584-595. Epub 2018 Dec 21.

Institute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, California; Keck School of Medicine, University of Southern California, Los Angeles, California.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183209
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http://dx.doi.org/10.1016/j.biopsych.2018.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420395PMC
April 2019

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis.

Neuropsychopharmacology 2018 12 30;43(13):2652-2659. Epub 2018 Jan 30.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1038/s41386-017-0004-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955214PMC
December 2018

Effects of N-acetylcysteine on brain glutamate levels and resting perfusion in schizophrenia.

Psychopharmacology (Berl) 2018 Oct 23;235(10):3045-3054. Epub 2018 Aug 23.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.

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http://link.springer.com/10.1007/s00213-018-4997-2
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http://dx.doi.org/10.1007/s00213-018-4997-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182588PMC
October 2018

Neuroanatomical changes in people with high schizotypy: relationship to glutamate levels.

Psychol Med 2018 08 4;48(11):1880-1889. Epub 2017 Dec 4.

Department of Neuroimaging,Institute of Psychiatry, Psychology & Neuroscience, King's College London,London,UK.

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http://dx.doi.org/10.1017/S0033291717003403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884418PMC
August 2018

Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase.

J Affect Disord 2018 07 27;234:214-219. Epub 2018 Feb 27.

Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327173114
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http://dx.doi.org/10.1016/j.jad.2018.02.059DOI Listing
July 2018

The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders.

Mol Autism 2017 23;8:24. Epub 2017 Jun 23.

Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s13229-017-0146-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481887PMC
March 2018

Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control.

Eur Neuropsychopharmacol 2018 03 1;28(3):381-391. Epub 2018 Feb 1.

Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2018.01.002DOI Listing
March 2018

Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder.

Eur Neuropsychopharmacol 2018 01 21;28(1):118-129. Epub 2017 Nov 21.

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, P.O Box 9101, 6500 HB Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2017.11.010DOI Listing
January 2018

Multi-modal imaging investigation of anterior cingulate cortex cytoarchitecture in neurodevelopment.

Eur Neuropsychopharmacol 2018 01 7;28(1):13-23. Epub 2017 Dec 7.

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.euroneuro.2017.11.021DOI Listing
January 2018

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.

Neuroimage Clin 2017 16;13:16-23. Epub 2016 Nov 16.

Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.nicl.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124361PMC
November 2017

Making use of longitudinal information in pattern recognition.

Hum Brain Mapp 2016 12 25;37(12):4385-4404. Epub 2016 Jul 25.

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1002/hbm.23317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111621PMC
December 2016

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.

Neuroimage Clin 2017 16;13:16-23. Epub 2016 Nov 16.

Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.nicl.2016.11.013DOI Listing
November 2016

COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes.

BMC Psychiatry 2016 10 26;16(1):361. Epub 2016 Oct 26.

Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, EZ, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12888-016-1072-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080712PMC
October 2016

Glutamatergic medication in the treatment of obsessive compulsive disorder (OCD) and autism spectrum disorder (ASD) - study protocol for a randomised controlled trial.

Trials 2016 Mar 17;17(1):141. Epub 2016 Mar 17.

Paediatric Psychopharmacology, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, PO Box 12 21 20, 68072, Mannheim, Germany.

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http://dx.doi.org/10.1186/s13063-016-1266-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794817PMC
March 2016

Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero.

Eur Neuropsychopharmacol 2015 Dec 21;25(12):2210-20. Epub 2015 Oct 21.

King's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychosis Studies, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.022DOI Listing
December 2015

Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: a review of magnetic resonance spectroscopy studies.

Neurosci Biobehav Rev 2015 May 21;52:74-88. Epub 2015 Feb 21.

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Geert Grooteplein Noord 10 (huispost 126), 6525 EZ Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2015.02.009DOI Listing
May 2015

Preventing visual field deficits from neurosurgery.

Neurology 2014 Aug 11;83(7):604-11. Epub 2014 Jul 11.

From the Epilepsy Society MRI Unit, Department of Clinical and Experimental Epilepsy (G.P.W., J.S., M.K.S., M.R.S., J.S.D.), and the Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation (M.J.W., C.M., L.M., J.T. , T.A.Y.), UCL Institute of Neurology; the UCL Centre for Medical Image Computing (P.D., M.M., S.O.); the Lysholm Department of Neuroradiology (M.J.W., C.M., L.M., J.T., T.A.Y.) and the Department of Neurosurgery (A.M., A.W.M.), National Hospital for Neurology and Neurosurgery; and Kings College London (D.J.L.), Institute of Psychiatry, Centre for Neuroimaging Sciences, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000000685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141993PMC
August 2014

Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophrenia.

Neuropsychopharmacology 2012 Oct 4;37(11):2515-21. Epub 2012 Jul 4.

Department of Psychosis Studies, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.

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http://dx.doi.org/10.1038/npp.2012.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442346PMC
October 2012

The response to rapid infusion of fentanyl in the human brain measured using pulsed arterial spin labelling.

MAGMA 2012 Apr 24;25(2):163-75. Epub 2011 Nov 24.

Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1007/s10334-011-0293-4DOI Listing
April 2012

Pulsed arterial spin labeling perfusion imaging at 3 T: estimating the number of subjects required in common designs of clinical trials.

Magn Reson Imaging 2011 Dec 5;29(10):1382-9. Epub 2011 May 5.

Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, CF10 3AT Cardiff, UK.

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http://dx.doi.org/10.1016/j.mri.2011.02.030DOI Listing
December 2011

Optimal MRI methods for direct stereotactic targeting of the subthalamic nucleus and globus pallidus.

Eur Radiol 2011 Jan 21;21(1):130-6. Epub 2010 Jul 21.

Department of Neuroradiology, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.

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http://dx.doi.org/10.1007/s00330-010-1885-5DOI Listing
January 2011

Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume.

Biol Psychiatry 2009 Sep 25;66(6):533-9. Epub 2009 Jun 25.

Institute of Psychiatry, King's College London, University College London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2009.05.006DOI Listing
September 2009