David J Kwiatkowski

David J Kwiatkowski

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David J Kwiatkowski

Publications by authors named "David J Kwiatkowski"

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Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.

Mol Ther Methods Clin Dev 2019 Dec 16;15:18-26. Epub 2019 Aug 16.

Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, and Neurodiscovery Center, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1016/j.omtm.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745533PMC
December 2019

Phenotypic distinctions between mosaic forms of tuberous sclerosis complex.

Genet Med 2019 Nov 22;21(11):2594-2604. Epub 2019 May 22.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41436-019-0520-3DOI Listing
November 2019

Low-level mosaicism in tuberous sclerosis complex: prevalence, clinical features, and risk of disease transmission.

Genet Med 2019 Nov 4;21(11):2639-2643. Epub 2019 Jun 4.

Cancer Genetics Laboratory, Division of Pulmonary and Critical Care Medicine and of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41436-019-0562-6DOI Listing
November 2019

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

J Exp Med 2019 Nov 10;216(11):2635-2652. Epub 2019 Sep 10.

Cancer Genetics Laboratory, Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1084/jem.20190251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829598PMC
November 2019

MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium.

J Thorac Oncol 2019 Sep 20;14(9):1666-1671. Epub 2019 Jun 20.

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1016/j.jtho.2019.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708730PMC
September 2019

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex.

Annu Rev Genomics Hum Genet 2019 Aug 24;20:217-240. Epub 2019 Apr 24.

F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

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http://dx.doi.org/10.1146/annurev-genom-083118-015354DOI Listing
August 2019

A novel mouse model of hemangiopericytoma due to loss of Tsc2.

Hum Mol Genet 2018 12;27(24):4169-4175

Division of Pulmonary Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/hmg/ddy289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276833PMC
December 2018

Comprehensive Genomic Profiling of Metastatic Tumors in a Phase 2 Biomarker Study of Everolimus in Advanced Renal Cell Carcinoma.

Clin Genitourin Cancer 2018 10 25;16(5):341-348. Epub 2018 Apr 25.

Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175670PMC
October 2018

Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma.

Proc Natl Acad Sci U S A 2018 07 11;115(27):E6274-E6282. Epub 2018 Jun 11.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1710849115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142242PMC
July 2018

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.

Clin Cancer Res 2018 05 9;24(9):2182-2193. Epub 2018 Feb 9.

Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932236PMC
May 2018

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.

Hum Mol Genet 2018 05;27(9):1654-1663

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddy073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905583PMC
May 2018

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology.

Arch Pathol Lab Med 2018 Mar 22;142(3):321-346. Epub 2018 Jan 22.

From the Departments of Pathology (Drs Lindeman and Sholl) and Medicine (Dr Kwiatkowski), Brigham and Women's Hospital, Boston, Massachusetts; the Cancer Center (Dr Bernicker) and the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Dr Cagle); the Department of Pathology, University of Colorado School of Medicine, Denver (Dr Aisner); the Diagnostic and Molecular Pathology Laboratory (Dr Arcila) and the Molecular Diagnostics Service (Dr Ladanyi), Memorial Sloan Kettering Cancer Center, New York, New York; the Department of Pathology & Medicine, Pulmonary, Critical Care and Sleep Medicine, New York, New York (Dr Beasley); the Pathology and Laboratory Quality Center, College of American Pathologists, Northfield, Illinois (Mss Colasacco and Ventura); the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (Dr Dacic); the Department of Medicine and Pathology, University of Colorado, Denver (Dr Hirsch); the Department of Pathology, University of Aberdeen, Aberdeen, Scotland (Dr Kerr); the Department of Molecular Pathology, Roswell Park Cancer Institute, Buffalo, New York (Dr Nowak); the Clinical and Scientific Affairs Division, Association for Molecular Pathology, Bethesda, Maryland (Dr Temple-Smolkin); the Molecular Therapeutics and Biomarkers Laboratory, Peter Maccallum Cancer Center, Melbourne, Australia (Dr Solomon); the Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands (Dr Thunnissen); the Department of Laboratory Medicine and Pathobiology, Princess Margaret Cancer Center, Toronto, Ontario, Canada (Dr Tsao); Scientific Affairs, International Association for the Study of Lung Cancer, Aurora, Colorado (Dr Wynes); and the Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan (Dr Yatabe). Dr Souter is in private practice in Wellanport, Ontario, Canada.

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http://dx.doi.org/10.5858/arpa.2017-0388-CPDOI Listing
March 2018

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.

Cell Rep 2017 12;21(13):3754-3766

Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752134PMC
December 2017

Notch transactivates Rheb to maintain the multipotency of TSC-null cells.

Nat Commun 2017 11 29;8(1):1848. Epub 2017 Nov 29.

Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, 1718 Pine Street, Abilene, TX, 79601, USA.

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http://dx.doi.org/10.1038/s41467-017-01845-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705704PMC
November 2017

Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex.

PLoS One 2016 1;11(12):e0167384. Epub 2016 Dec 1.

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167384PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132223PMC
July 2017

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

Pancreatic PEComa is a novel member of the family of tuberous sclerosis complex-associated tumors: case report and review of the literature.

Virchows Arch 2016 Dec 18;469(6):707-710. Epub 2016 Oct 18.

Department of Pathology, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH, 03756, USA.

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http://dx.doi.org/10.1007/s00428-016-2032-8DOI Listing
December 2016

Seizures in tuberous sclerosis complex: hitting the target.

Lancet 2016 10 6;388(10056):2062-2064. Epub 2016 Sep 6.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)31576-8DOI Listing
October 2016

Targeting molecular aberrations in urothelial carcinoma: are we almost there?

Am Soc Clin Oncol Educ Book 2013 :195-9

From the Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; the Translational Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/EdBook_AM.2013.33.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776417PMC
April 2016

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

Cell Rep 2016 Mar 3;14(10):2476-89. Epub 2016 Mar 3.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794376PMC
March 2016

Nipple Angiofibromas with Loss of TSC2 Are Associated with Tuberous Sclerosis Complex.

J Invest Dermatol 2016 Feb 10;136(2):535-538. Epub 2015 Dec 10.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2015.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733881PMC
February 2016

Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload.

Cardiovasc Pathol 2015 Mar-Apr;24(2):80-93. Epub 2014 Nov 7.

Pulmonary, Critical Care & Sleep Division, Department of Medicine, Tupper Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.carpath.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344870PMC
November 2015

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.

Neurobiol Dis 2015 Oct 24;82:22-31. Epub 2015 May 24.

Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070799PMC
http://dx.doi.org/10.1016/j.nbd.2015.04.018DOI Listing
October 2015

Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.

J Biol Chem 2015 Oct 20;290(42):25756-65. Epub 2015 Aug 20.

From the State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China,

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http://dx.doi.org/10.1074/jbc.M115.665208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646217PMC
October 2015

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise.

Clin Cancer Res 2015 Oct;21(20):4514-24

The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610178PMC
October 2015

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.

Nat Genet 2015 Sep 10;47(9):1067-72. Epub 2015 Aug 10.

Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/ng.3378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594173PMC
September 2015

Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.

Ann Neurol 2015 Apr 26;77(4):720-5. Epub 2015 Feb 26.

Division of Genetics and Genomics, Department of Medicine, Manton Center for Orphan Disease Research and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA.

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http://dx.doi.org/10.1002/ana.24357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471336PMC
April 2015

Molecular biology of bladder cancer.

Hematol Oncol Clin North Am 2015 Apr 31;29(2):191-203, vii. Epub 2015 Jan 31.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2014.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385194PMC
April 2015

A vascular model of Tsc1 deficiency accelerates renal tumor formation with accompanying hemangiosarcomas.

Mol Cancer Res 2015 Mar 29;13(3):548-55. Epub 2014 Dec 29.

Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369160PMC
March 2015

Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.

Mol Cancer Ther 2015 Jan 27;14(1):174-82. Epub 2014 Oct 27.

Translational Medicine Division, Department of Medicine, Brigham and Women Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0622-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297264PMC
January 2015

mTOR Inhibitors in Cancer: What Can We Learn from Exceptional Responses?

EBioMedicine 2015 Jan 26;2(1):2-4. Epub 2014 Dec 26.

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States ; Dana Farber Cancer Institute, Boston, MA 02115, United States ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States.

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http://dx.doi.org/10.1016/j.ebiom.2014.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484506PMC
January 2015

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.

J Exp Med 2014 Oct 6;211(11):2249-63. Epub 2014 Oct 6.

Institut Necker-Enfants Malades, CS 61431, Paris, France Institut National de la Santé et de la Recherche Médicale, U1151, F-75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France

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http://dx.doi.org/10.1084/jem.20140341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203941PMC
October 2014

Response and acquired resistance to everolimus in anaplastic thyroid cancer.

N Engl J Med 2014 Oct;371(15):1426-33

From the Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School (N.W., E.M.V.A., N.G., R.I.H., D.J.K., P.A.J., L.A.G., J.H.L.), the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (N.W., E.M.V.A., Y.G., R.I.H., D.J.K., P.A.J., L.A.G., J.H.L.), the Departments of Pathology (J.A.B.) and Surgery (S.J.S., D.T.R.), Brigham and Women's Hospital, the Department of Medicine, Beth Israel Deaconess Medical Center (G.J.H.), and Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute (P.A.J.) - all in Boston; and Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard (N.W., E.M.V.A., A.A.-M., A.T.-W., M.R., G.G., D.J.K., S.L.C., D.M.S., L.A.G.), Whitehead Institute for Biomedical Research and the MIT Department of Biology (B.C.G., D.M.S.), and Howard Hughes Medical Institute, MIT (B.C.G., D.M.S.) - all in Cambridge, MA.

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http://dx.doi.org/10.1056/NEJMoa1403352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564868PMC
October 2014

Coordinated regulation of protein synthesis and degradation by mTORC1.

Nature 2014 Sep 13;513(7518):440-3. Epub 2014 Jul 13.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402229PMC
September 2014

Molecular basis of giant cells in tuberous sclerosis complex.

N Engl J Med 2014 Aug;371(8):778-80

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http://dx.doi.org/10.1056/NEJMcibr1406613DOI Listing
August 2014

Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.

Hum Mol Genet 2014 Jul 5;23(14):3865-74. Epub 2014 Mar 5.

The F.M. Kirby Neurobiology Center, Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA,

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http://dx.doi.org/10.1093/hmg/ddu101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065158PMC
July 2014

Renal cell carcinoma in tuberous sclerosis complex.

Am J Surg Pathol 2014 Jul;38(7):895-909

Departments of *Pathology **Urology ††Carol and James Herscot Center for Tuberous Sclerosis Complex, Massachusetts General Hospital ‡‡Division of Translational Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston ∥Department of Pathology, University of Massachusetts Medical School, Worcester, MA †Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou §Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, PR China ‡Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN #Department of Medicine, Division of Genomic Medicine, Institute for Human Genetics, University of California, San Francisco, CA ¶Department of Neurology and Epileptology, The Children's Memorial Health Institute, Warsaw, Poland.

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http://dx.doi.org/10.1097/PAS.0000000000000237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139167PMC
July 2014

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

Clin Cancer Res 2014 Apr 31;20(7):1873-83. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Biostatistics and Computational Biology, and Medical Oncology; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Department of Biostatistics, Harvard School of Public Health; Department of Pathology; Translational Medicine Division, Brigham and Women's Hospital, Boston; Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Sidney Kimmel Cancer Center; Department of Pathology, Johns Hopkins University, Baltimore, Maryland; Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York; and Hospital del Mar Research Institute-IMIM, Barcelona; and Hospital Parc Tauli, Sabadell, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975677PMC
April 2014

Stochastic model of Tsc1 lesions in mouse brain.

PLoS One 2013 16;8(5):e64224. Epub 2013 May 16.

Molecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Massachusetts General Hospital, and Program in Neuroscience, Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064224PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655945PMC
December 2013

Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis.

Mol Cancer Res 2013 May 5;11(5):467-73. Epub 2013 Feb 5.

Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657392PMC
May 2013

TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.

J Pathol 2013 May 21;230(1):17-27. Epub 2013 Mar 21.

Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4176DOI Listing
May 2013

Molecular dissection of AKT activation in lung cancer cell lines.

Mol Cancer Res 2013 Mar 14;11(3):282-93. Epub 2013 Jan 14.

Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606262PMC
March 2013

Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.

Behav Genet 2013 Jan 12;43(1):51-9. Epub 2012 Dec 12.

Department of Neurology, The F.M. Kirby Neurobiology Center, Boston Children's Hospital, 300 Longwood Avenue CLS13074, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s10519-012-9571-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554236PMC
January 2013