David J Hughes

David J Hughes

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David J Hughes

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Analysis of Paramyxovirus Transcription and Replication by High-Throughput Sequencing.

J Virol 2019 Sep 13;93(17). Epub 2019 Aug 13.

School of Biology, Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife, United Kingdom

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http://dx.doi.org/10.1128/JVI.00571-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694822PMC
September 2019

Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients.

Eur J Clin Microbiol Infect Dis 2019 Jul 31. Epub 2019 Jul 31.

Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, D04 V1W8, Ireland.

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http://dx.doi.org/10.1007/s10096-019-03649-1DOI Listing
July 2019

Lifestyle and dietary environmental factors in colorectal cancer susceptibility.

Mol Aspects Med 2019 Jun 28. Epub 2019 Jun 28.

International Agency for Research on Cancer (IARC-WHO), Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.06.005DOI Listing
June 2019

A conceptual replication of emotional intelligence as a second-stratum factor of intelligence.

Emotion 2019 Feb 7. Epub 2019 Feb 7.

School of Psychological, Social and Behavioural Sciences.

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http://dx.doi.org/10.1037/emo0000569DOI Listing
February 2019

Relationship between , inflammatory mediators and microRNAs in colorectal carcinogenesis.

World J Gastroenterol 2018 Dec;24(47):5351-5365

Department of Biology, UNESP, Univ. Estadual Paulista, Campus of São José do Rio Preto, São José do Rio Preto, São Paulo 15054-000, Brazil.

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http://dx.doi.org/10.3748/wjg.v24.i47.5351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305535PMC
December 2018

Phase separation in amorphous hydrophobically modified starch-sucrose blends: Glass transition, matrix dynamics and phase behavior.

Carbohydr Polym 2018 Nov 18;199:1-10. Epub 2018 Jun 18.

Food Science and Nutrition Department, California Polytechnic State University, 1 Grand Ave., San Luis Obispo, CA 93407, United States; H. H. Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, United Kingdom; Food Concept & Physical Design "The Mill", Mühlweg 10, CH-4112 Flüh, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2018.06.056DOI Listing
November 2018

Roadmaps and Detours: Active Chlorophyll- a Assessments of Primary Productivity Across Marine and Freshwater Systems.

Environ Sci Technol 2018 11 5;52(21):12039-12054. Epub 2018 Oct 5.

Climate Change Cluster , University of Technology Sydney , Ultimo, Sydney 2007 , New South Wales , Australia.

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http://pubs.acs.org/doi/10.1021/acs.est.8b03488
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http://dx.doi.org/10.1021/acs.est.8b03488DOI Listing
November 2018

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.

Nutrients 2018 Nov 21;10(11). Epub 2018 Nov 21.

Biomedical Centre, Medical and Teaching School Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic.

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http://www.mdpi.com/2072-6643/10/11/1812
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http://dx.doi.org/10.3390/nu10111812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266908PMC
November 2018

Putting 'Emotional Intelligences' in Their Place: Introducing the Integrated Model of Affect-Related Individual Differences.

Front Psychol 2018 14;9:2155. Epub 2018 Nov 14.

School of Psychological, Social and Behavioural Sciences, Coventry University, Coventry, United Kingdom.

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http://dx.doi.org/10.3389/fpsyg.2018.02155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246631PMC
November 2018

Contribution of the KSHV and EBV lytic cycles to tumourigenesis.

Curr Opin Virol 2018 10 28;32:60-70. Epub 2018 Sep 28.

School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom; Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom; Department of Biochemistry & Microbiology, Rhodes University, Grahamstown, 6140, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2018.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259586PMC
October 2018

Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection.

Sci Signal 2017 Nov 14;10(505). Epub 2017 Nov 14.

School of Molecular and Cellular Biology, Faculty of Biological Science, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1126/scisignal.aan0868DOI Listing
November 2017

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems.

Exp Biol Med (Maywood) 2017 10 15;242(16):1593-1604. Epub 2017 May 15.

CN Bio Innovations Limited, Welwyn Garden City AL73AX, UK.

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http://dx.doi.org/10.1177/1535370217708976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661768PMC
October 2017

Leader dark traits, workplace bullying, and employee depression: Exploring mediation and the role of the dark core.

J Abnorm Psychol 2017 Oct;126(7):911-920

Alliance Manchester Business School, The University of Manchester.

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http://dx.doi.org/10.1037/abn0000299DOI Listing
October 2017

The missing link? The potential role of selenium in the development of liver cancer and significance for the general population.

Expert Rev Gastroenterol Hepatol 2017 08 21;11(8):707-709. Epub 2017 Apr 21.

b Department of Physiology and Centre for Systems Medicine , Royal College of Surgeons in Ireland , Dublin , Ireland.

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http://dx.doi.org/10.1080/17474124.2017.1320219DOI Listing
August 2017

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.

Drug Metab Dispos 2017 07 27;45(7):855-866. Epub 2017 Apr 27.

Departments of Biological Engineering (U.S., K.C.R., C.L.Y., D.R.-B., J.Y., M.C., J.S.W., D.A.L., L.G.G., S.R.T.) and Chemistry (S.R.T.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations Ltd., Welwyn Garden City, Hertfordshire, United Kingdom (E.L., D.J.H.)

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.116.0740
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http://dx.doi.org/10.1124/dmd.116.074005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469400PMC
July 2017

Ecosystem uptake and transfer of Sellafield-derived radiocarbon (C) part 2: The West of Scotland.

Mar Pollut Bull 2017 Feb 26;115(1-2):57-66. Epub 2016 Nov 26.

Scottish Universities Environmental Research Centre, Rankine Avenue, Scottish Enterprise Technology Park, East Kilbride, G75 0QF, Scotland, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S0025326X163091
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http://dx.doi.org/10.1016/j.marpolbul.2016.11.014DOI Listing
February 2017

Ecosystem uptake and transfer of Sellafield-derived radiocarbon (C). Part 1. The Irish Sea.

Mar Pollut Bull 2017 Jan 10;114(2):792-804. Epub 2016 Nov 10.

Scottish Universities Environmental Research Centre, Rankine Avenue, Scottish Enterprise Technology Park, East Kilbride, G75 0QF, Scotland, UK.

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http://dx.doi.org/10.1016/j.marpolbul.2016.10.072DOI Listing
January 2017

Three-dimensional perfused human model of non-alcoholic fatty liver disease.

World J Gastroenterol 2017 Jan;23(2):204-215

Tomasz Kostrzewski, Terri Cornforth, Sophie A Snow, Larissa Ouro-Gnao, Cliff Rowe, Emma M Large, David J Hughes, CN Bio Innovations Limited, Welwyn Garden City AL7 3AX, United Kingdom.

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http://www.wjgnet.com/1007-9327/full/v23/i2/204.htm
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http://dx.doi.org/10.3748/wjg.v23.i2.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236500PMC
January 2017

ARID3B: a Novel Regulator of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle.

J Virol 2016 10 29;90(20):9543-55. Epub 2016 Sep 29.

Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, United Kingdom

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http://dx.doi.org/10.1128/JVI.03262-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044832PMC
October 2016

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease.

Gene 2015 Oct 26;571(1):1-8. Epub 2015 Jul 26.

Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2015.07.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544754PMC
October 2015

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.

Drug Metab Dispos 2015 Jul 29;43(7):1091-9. Epub 2015 Apr 29.

Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.063495
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http://dx.doi.org/10.1124/dmd.115.063495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468434PMC
July 2015

Ecological impacts of large-scale disposal of mining waste in the deep sea.

Sci Rep 2015 May 5;5:9985. Epub 2015 May 5.

Scottish Association for Marine Science, Oban, Argyll PA37 1QA, United Kingdom.

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http://dx.doi.org/10.1038/srep09985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419517PMC
May 2015

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.

BMC Cancer 2015 Apr 30;15:329. Epub 2015 Apr 30.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.

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http://dx.doi.org/10.1186/s12885-015-1327-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417244PMC
April 2015

Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology.

Vet Microbiol 2015 Mar 30;176(1-2):109-19. Epub 2014 Dec 30.

Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; College of Veterinary Medicine, Northwest A&F University, Yangling, China; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.vetmic.2014.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414928PMC
March 2015

NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target.

PLoS Pathog 2015 Mar 20;11(3):e1004771. Epub 2015 Mar 20.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1004771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368050PMC
March 2015

Utilising proteomic approaches to understand oncogenic human herpesviruses (Review).

Mol Clin Oncol 2014 Nov 9;2(6):891-903. Epub 2014 Jul 9.

School of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

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http://dx.doi.org/10.3892/mco.2014.341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179824PMC
November 2014

Exploratory structural equation modeling of personality data.

Assessment 2014 Jun 28;21(3):260-71. Epub 2014 Mar 28.

University of Manchester, Manchester, UK Coventry University, Coventry, UK.

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http://journals.sagepub.com/doi/10.1177/1073191114528029
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http://dx.doi.org/10.1177/1073191114528029DOI Listing
June 2014

Bioreactor technologies to support liver function in vitro.

Adv Drug Deliv Rev 2014 Apr 5;69-70:132-57. Epub 2014 Mar 5.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Gynepathology Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X140003
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http://dx.doi.org/10.1016/j.addr.2014.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144187PMC
April 2014

Experimental infection of laboratory-bred bank voles (Myodes glareolus) with murid herpesvirus 4.

Arch Virol 2012 Nov 11;157(11):2207-12. Epub 2012 Jul 11.

Department of Infection Biology, University of Liverpool, Liverpool L69 7ZJ, UK.

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http://dx.doi.org/10.1007/s00705-012-1397-5DOI Listing
November 2012

CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements.

Virus Genes 2012 Oct 16;45(2):265-73. Epub 2012 Jun 16.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.

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http://dx.doi.org/10.1007/s11262-012-0769-yDOI Listing
October 2012

Contributions of CTCF and DNA methyltransferases DNMT1 and DNMT3B to Epstein-Barr virus restricted latency.

J Virol 2012 Jan 9;86(2):1034-45. Epub 2011 Nov 9.

Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, and Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1128/JVI.05923-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255836PMC
January 2012

trans-Repression of protein expression dependent on the Epstein-Barr virus promoter Wp during latency.

J Virol 2011 Nov 24;85(21):11435-47. Epub 2011 Aug 24.

Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr., Hershey, PA 17033, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.05158-11
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http://dx.doi.org/10.1128/JVI.05158-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194970PMC
November 2011

Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.

J Gastrointest Cancer 2011 Sep;42(3):149-54

Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide and Meath Hospital, Dublin 24, Ireland.

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http://dx.doi.org/10.1007/s12029-010-9168-6DOI Listing
September 2011

Effects of disease control by fungicides on greenhouse gas emissions by U.K. arable crop production.

Pest Manag Sci 2011 Sep 14;67(9):1082-92. Epub 2011 Apr 14.

Rothamsted Research, Harpenden, Herts, UK.

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http://dx.doi.org/10.1002/ps.2151DOI Listing
September 2011

Common variation in the vitamin D receptor gene and risk of inflammatory bowel disease in an Irish case-control study.

Eur J Gastroenterol Hepatol 2011 Sep;23(9):807-12

Department of Clinical Medicine, Adelaide and Meath Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1097/MEG.0b013e328349283eDOI Listing
September 2011

Altered host response to murine gammaherpesvirus 68 infection in mice lacking the tachykinin 1 gene and the receptor for substance P.

Neuropeptides 2011 Feb 23;45(1):49-53. Epub 2010 Nov 23.

Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/j.npep.2010.10.004DOI Listing
February 2011

Genetic variants in selenoprotein genes increase risk of colorectal cancer.

Carcinogenesis 2010 Jun 8;31(6):1074-9. Epub 2010 Apr 8.

Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgq076DOI Listing
June 2010

Pathogenesis of a model gammaherpesvirus in a natural host.

J Virol 2010 Apr 3;84(8):3949-61. Epub 2010 Feb 3.

School of Infection and Host Defence, The University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, United Kingdom.

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http://dx.doi.org/10.1128/JVI.02085-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849519PMC
April 2010

Myristylation and palmitylation of HSV-1 UL11 are not essential for its function.

Virology 2010 Feb 26;397(1):80-8. Epub 2009 Nov 26.

Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.virol.2009.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813933PMC
February 2010

Investigation of Van Gogh-like 2 mRNA regulation and localisation in response to nociception in the brain of adult common carp (Cyprinus carpio).

Neurosci Lett 2009 Nov 23;465(3):290-4. Epub 2009 Sep 23.

University of Liverpool, School of Biological Sciences, The BioScience Building, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.1016/j.neulet.2009.09.037DOI Listing
November 2009

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Anticancer Res 2009 Nov;29(11):4337-43

Department of Medical and Molecular Genetics, University of Birmingham, Institute of Biomedical Research, Edgbaston, Birmingham, B15 2TT, UK.

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November 2009

Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4.

Eur J Gastroenterol Hepatol 2009 Jun;21(6):630-5

Cancer Prevention Fellowship Program, Office of Preventive Oncology and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/MEG.0b013e3283140eeaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802816PMC
June 2009

Synthesis of glucose derivatives modified at the 4-OH as potential chain-terminators of cellulose biosynthesis; herbicidal activity of simple monosaccharide derivatives.

Org Biomol Chem 2009 Mar 30;7(6):1097-105. Epub 2009 Jan 30.

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK OX1 3TA.

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http://dx.doi.org/10.1039/b820830aDOI Listing
March 2009

Use of association studies to define genetic modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers.

Authors:
David J Hughes

Fam Cancer 2008 19;7(3):233-44. Epub 2008 Feb 19.

Department of Clinical Medicine, Trinity College Dublin, AMNCH Hospital, Dublin 24, Ireland.

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http://dx.doi.org/10.1007/s10689-008-9181-0DOI Listing
January 2009

RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.

Am J Hum Genet 2007 Dec 16;81(6):1186-200. Epub 2007 Oct 16.

Cancer Research UK, Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970763768
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http://dx.doi.org/10.1086/522611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276351PMC
December 2007

Membrane fouling by cell-protein mixtures: in situ characterisation using multi-photon microscopy.

Biotechnol Bioeng 2007 Apr;96(6):1083-91

Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK.

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http://dx.doi.org/10.1002/bit.21113DOI Listing
April 2007

In situ three-dimensional characterization of membrane fouling by protein suspensions using multiphoton microscopy.

Langmuir 2006 Jul;22(14):6266-72

Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK.

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http://dx.doi.org/10.1021/la053388qDOI Listing
July 2006

In vivo function of a gammaherpesvirus virion glycoprotein: influence on B-cell infection and mononucleosis.

J Virol 2004 Oct;78(19):10449-59

Centre for Comparative Infectious Diseases, Department of Medical Microbiology, University of Liverpool, Duncan Building, Daulby St., Liverpool L69 3GA, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.78.19.10449-10459.200
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http://dx.doi.org/10.1128/JVI.78.19.10449-10459.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516434PMC
October 2004

Modular control of lectin function: redox-switchable agglutination.

Angew Chem Int Ed Engl 2004 Jun;43(23):3025-9

Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK.

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http://dx.doi.org/10.1002/anie.200353320DOI Listing
June 2004