David J Conway

David J Conway

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David J Conway

David J Conway

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An expanded global inventory of allelic variation in the most extremely polymorphic region of Plasmodium falciparum merozoite surface protein 1 provided by short read sequence data.

Malar J 2018 Oct 1;17(1):345. Epub 2018 Oct 1.

Pathogen Molecular Biology Department, School of Hygiene and Tropical Medicine London, Keppel St, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1186/s12936-018-2475-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167803PMC
October 2018

Genome-wide mosaicism in divergence between zoonotic malaria parasite subpopulations with separate sympatric transmission cycles.

Mol Ecol 2018 02 13;27(4):860-870. Epub 2018 Feb 13.

Faculty of Medicine and Health Sciences, Malaria Research Centre, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia.

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http://dx.doi.org/10.1111/mec.14477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918592PMC
February 2018

Multiplication rate variation in the human malaria parasite Plasmodium falciparum.

Sci Rep 2017 07 25;7(1):6436. Epub 2017 Jul 25.

Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-06295-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527095PMC
July 2017

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.

Mol Ecol 2017 Jun 15;26(11):2880-2894. Epub 2017 Mar 15.

Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1111/mec.14066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485074PMC
June 2017

Assessing the impact of differences in malaria transmission intensity on clinical and haematological indices in children with malaria.

Malar J 2017 03 1;16(1):96. Epub 2017 Mar 1.

West African Centre for Cell Biology of Infectious Pathogens and Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Volta Road, Legon, P. O. Box LG 54, Accra, Ghana.

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http://dx.doi.org/10.1186/s12936-017-1745-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333465PMC
March 2017

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Elife 2017 01 9;6. Epub 2017 Jan 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.15085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222559PMC
January 2017

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.

Sci Rep 2017 01 24;7:41303. Epub 2017 Jan 24.

London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1038/srep41303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259787PMC
January 2017

Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi.

Infect Genet Evol 2016 06 14;40:243-252. Epub 2016 Mar 14.

Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2016.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844884PMC
June 2016

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).

Trends Parasitol 2016 Apr 23;32(4):274-283. Epub 2015 Dec 23.

Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1016/j.pt.2015.11.009DOI Listing
April 2016

Widespread distribution of Plasmodium vivax malaria in Mauritania on the interface of the Maghreb and West Africa.

Malar J 2016 Feb 9;15:80. Epub 2016 Feb 9.

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1186/s12936-016-1118-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748559PMC
February 2016

Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana.

J Infect Dis 2015 Oct 2;212(8):1288-97. Epub 2015 Apr 2.

West African Center for Cell Biology of Infectious Pathogens Department of Biochemistry, Cell and Molecular Biology Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.

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http://dx.doi.org/10.1093/infdis/jiv207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577045PMC
October 2015

Serology describes a profile of declining malaria transmission in Farafenni, The Gambia.

Malar J 2015 Oct 22;14:416. Epub 2015 Oct 22.

Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1186/s12936-015-0939-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618886PMC
October 2015

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

PLoS Pathog 2015 Sep 25;11(9):e1005119. Epub 2015 Sep 25.

Laboratory of Malaria and Vector Research, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583463PMC
September 2015

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.

BMC Genomics 2015 Jul 16;16:527. Epub 2015 Jul 16.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Box LG 54, Volta Road, Legon, Accra, Ghana.

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http://dx.doi.org/10.1186/s12864-015-1746-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502944PMC
July 2015

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species.

PLoS Pathog 2015 May 28;11(5):e1004888. Epub 2015 May 28.

Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom; Malaria Research Centre, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Kuching, Sarawak, Malaysia.

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http://dx.doi.org/10.1371/journal.ppat.1004888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447398PMC
May 2015

Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.

Immunity 2015 Mar;42(3):580-90

The Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Melbourne, VIC 3004, Australia; Department of Microbiology, Monash University, Clayton, VIC 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372259PMC
March 2015

Paths to a malaria vaccine illuminated by parasite genomics.

Authors:
David J Conway

Trends Genet 2015 Feb 22;31(2):97-107. Epub 2015 Jan 22.

Pathogen Molecular Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359294PMC
February 2015

Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone.

Malar J 2015 Jan 21;14. Epub 2015 Jan 21.

Dipartimento di Sanità Pubblica e Malattie Infettive, Istituto Pasteur-Fondazione Cenci-Bolognetti, Università "Sapienza", Piazzale Aldo Moro 5, Rome, 00185, Italy.

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http://dx.doi.org/10.1186/s12936-014-0522-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308935PMC
January 2015

Dynamics of the antibody response to Plasmodium falciparum infection in African children.

J Infect Dis 2014 Oct 8;210(7):1115-22. Epub 2014 Apr 8.

Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London.

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http://dx.doi.org/10.1093/infdis/jiu219DOI Listing
October 2014

Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.

Hum Immunol 2014 Aug 11;75(8):816-21. Epub 2014 Jun 11.

Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2014.06.002DOI Listing
August 2014

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Mol Biol Evol 2014 Jun 18;31(6):1490-9. Epub 2014 Mar 18.

Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, United KingdomMedical Research Council Unit, Fajara, Banjul, The Gambia

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http://dx.doi.org/10.1093/molbev/msu106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032133PMC
June 2014

PfHPRT: a new biomarker candidate of acute Plasmodium falciparum infection.

J Proteome Res 2013 Mar 12;12(3):1211-22. Epub 2013 Feb 12.

Wellcome Trust Centre for Human Genetics and Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1021/pr300858gDOI Listing
March 2013

A polyvalent hybrid protein elicits antibodies against the diverse allelic types of block 2 in Plasmodium falciparum merozoite surface protein 1.

Vaccine 2011 Oct 4;29(44):7811-7. Epub 2011 Aug 4.

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1016/j.vaccine.2011.07.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195258PMC
October 2011

Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques.

PLoS Pathog 2011 Apr 7;7(4):e1002015. Epub 2011 Apr 7.

Malaria Research Centre, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Kuching, Sarawak, Malaysia.

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http://core.ac.uk/download/pdf/18423999.pdf
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http://dx.plos.org/10.1371/journal.ppat.1002015
Publisher Site
http://dx.doi.org/10.1371/journal.ppat.1002015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072369PMC
April 2011

The "far-west" of Anopheles gambiae molecular forms.

PLoS One 2011 Feb 15;6(2):e16415. Epub 2011 Feb 15.

Istituto Pasteur-Fondazione Cenci-Bolognetti, Dipartimento di Sanità Pubblica e Malattie Infettive, Università di Roma Sapienza, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039643PMC
February 2011

Detecting signatures of balancing selection to identify targets of anti-parasite immunity.

Trends Parasitol 2010 Jul 11;26(7):363-9. Epub 2010 May 11.

School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, UK, L69 7ZB.

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http://dx.doi.org/10.1016/j.pt.2010.04.002DOI Listing
July 2010

Erythrocyte invasion and merozoite ligand gene expression in severe and mild Plasmodium falciparum malaria.

J Infect Dis 2010 Feb;201(3):444-52

Medical Research Council Laboratories, Fajara, Banjul, The Gambia; 2London School of Hygiene and Tropical Medicine London, United Kingdom.

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http://dx.doi.org/10.1086/649902DOI Listing
February 2010

Heritability of antibody isotype and subclass responses to Plasmodium falciparum antigens.

PLoS One 2009 Oct 8;4(10):e7381. Epub 2009 Oct 8.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007381PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753646PMC
October 2009

Prospective identification of malaria parasite genes under balancing selection.

PLoS One 2009 15;4(5):e5568. Epub 2009 May 15.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679211PMC
August 2009

Gene copy number variation throughout the Plasmodium falciparum genome.

BMC Genomics 2009 Aug 4;10:353. Epub 2009 Aug 4.

Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1186/1471-2164-10-353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732925PMC
August 2009

Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria.

PLoS One 2009 6;4(5):e5454. Epub 2009 May 6.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005454PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674215PMC
June 2009

Quantitative detection of Plasmodium falciparum DNA in saliva, blood, and urine.

J Infect Dis 2009 Jun;199(11):1567-74

Medical Research Council (United Kingdom) Laboratories, Fajara, Banjul, The Gambia.

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http://dx.doi.org/10.1086/598856DOI Listing
June 2009

Genome-wide and fine-resolution association analysis of malaria in West Africa.

Nat Genet 2009 Jun 24;41(6):657-65. Epub 2009 May 24.

MRC Laboratories, Fajara, Banjul, Gambia.

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http://dx.doi.org/10.1038/ng.388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889040PMC
June 2009

Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission.

Eur J Immunol 2009 May;39(5):1288-300

Malaria Programme, MRC Laboratories, Fajara, Banjul, The Gambia.

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http://doi.wiley.com/10.1002/eji.200839112
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http://dx.doi.org/10.1002/eji.200839112DOI Listing
May 2009

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum.

Infect Immun 2009 Apr 9;77(4):1689-99. Epub 2009 Feb 9.

The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia.

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http://dx.doi.org/10.1128/IAI.01331-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663147PMC
April 2009

Anopheles gambiae complex along The Gambia river, with particular reference to the molecular forms of An. gambiae s.s.

Malar J 2008 Sep 22;7:182. Epub 2008 Sep 22.

Istituto Pasteur-Fondazione Cenci-Bolognetti, Dipartimento di Scienze di Sanità Pubblica, Università La Sapienza, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1186/1475-2875-7-182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569043PMC
September 2008

Dry season ecology of Anopheles gambiae complex mosquitoes in The Gambia.

Malar J 2008 Aug 18;7:156. Epub 2008 Aug 18.

Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia.

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http://dx.doi.org/10.1186/1475-2875-7-156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533673PMC
August 2008

Gene-specific signatures of elevated non-synonymous substitution rates correlate poorly across the Plasmodium genus.

PLoS One 2008 May 28;3(5):e2281. Epub 2008 May 28.

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002281PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2384006PMC
May 2008

Risk factors for house-entry by malaria vectors in a rural town and satellite villages in The Gambia.

Malar J 2008 Jan 7;7. Epub 2008 Jan 7.

School of Biological and Biomedical Sciences, Durham University, Science Laboratories, South Road, Durham DH1 3LE, UK.

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http://dx.doi.org/10.1186/1475-2875-7-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267476PMC
January 2008