David J Brooks

David J Brooks

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David J Brooks

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Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter.

Mol Imaging Biol 2019 Oct;21(5):935-944

Division of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s11307-019-01323-8DOI Listing
October 2019

Dynamic C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis.

J Nucl Med 2019 Oct 8;60(10):1452-1460. Epub 2019 Mar 8.

Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

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http://dx.doi.org/10.2967/jnumed.118.223834DOI Listing
October 2019

Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET.

J Alzheimers Dis 2018 ;64(s1):S339-S351

Department of Nuclear Medicine, Aarhus University, Denmark.

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http://dx.doi.org/10.3233/JAD-179929DOI Listing
June 2019

Widespread microglial activation in multiple system atrophy.

Mov Disord 2019 04 6;34(4):564-568. Epub 2019 Feb 6.

Departments of Nulcear Medicine and Geriatric Medicine, University Hospital Essen, Germany.

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http://dx.doi.org/10.1002/mds.27620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659386PMC
April 2019

Attenuation of dopamine-induced GABA release in problem gamblers.

Brain Behav 2019 03 20;9(3):e01239. Epub 2019 Feb 20.

Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1002/brb3.1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422713PMC
March 2019

Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume.

Neurology 2019 Mar 22;92(12):e1331-e1343. Epub 2019 Feb 22.

From the Department of Medicine (G.D.F., M.D., M.W., Z.F., V.C., R.A., D.J.B., P.E.), Imperial College London; Department of Psychology (T.E.), University of London, London; Wolfson Molecular Imaging Centre (R.H.), University of Manchester, UK; and Department of Nuclear Medicine (D.J.B.), Aarhus University, Denmark.

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http://dx.doi.org/10.1212/WNL.0000000000007133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511099PMC
March 2019

In vivo quantification of glial activation in minipigs overexpressing human α-synuclein.

Synapse 2018 12 12;72(12):e22060. Epub 2018 Aug 12.

Department of Nuclear Medicine and PET Center, Institute of Clinical Medicine, Aarhus University and Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1002/syn.22060DOI Listing
December 2018

Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study.

Neurobiol Dis 2018 09 11;117:211-216. Epub 2018 Jun 11.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark; Division of Neuroscience, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1016/j.nbd.2018.06.004DOI Listing
September 2018

Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease.

Brain 2018 09;141(9):2740-2754

Neurology Imaging Unit, Department of Medicine, Imperial College London, Hammersmith Hospital, UK.

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http://dx.doi.org/10.1093/brain/awy188DOI Listing
September 2018

Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder.

Neurobiol Dis 2018 07 6;115:9-16. Epub 2018 Mar 6.

Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Denmark; Division of Neuroscience, Newcastle University, England, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.02.017DOI Listing
July 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients.

Mov Disord 2018 07 24;33(6):1006-1010. Epub 2018 May 24.

Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.

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http://dx.doi.org/10.1002/mds.27411DOI Listing
July 2018

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study.

Lancet Neurol 2018 07 1;17(7):618-628. Epub 2018 Jun 1.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30162-5DOI Listing
July 2018

The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease.

Int J Alzheimers Dis 2018 30;2018:6852303. Epub 2018 Jul 30.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1155/2018/6852303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091362PMC
July 2018

MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([F]-AV-1451) Binding.

Mol Imaging Biol 2018 06;20(3):356-360

Department of Nuclear Medicine and PET-Centre, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, bld. 10G, DK-8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1007/s11307-017-1143-1DOI Listing
June 2018

Chronic exposure to dopamine agonists affects the integrity of striatal D receptors in Parkinson's patients.

Neuroimage Clin 2017 24;16:455-460. Epub 2017 Aug 24.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.nicl.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577411PMC
May 2018

Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs.

Exp Neurol 2018 05 8;303:142-152. Epub 2018 Feb 8.

Department of Nuclear Medicine and PET Center, Institute of Clinical Medicine, Aarhus University and Hospital, Denmark; Translational Neuropsychiatry Unit, Institute of Clinical Medicine, Aarhus University, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2018.02.005DOI Listing
May 2018

Observations on muscle activity in REM sleep behavior disorder assessed with a semi-automated scoring algorithm.

Clin Neurophysiol 2018 03 28;129(3):541-547. Epub 2017 Dec 28.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark; Department of Neurology, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1016/j.clinph.2017.12.029DOI Listing
March 2018

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Authors:
Willemijn J Jansen Rik Ossenkoppele Betty M Tijms Anne M Fagan Oskar Hansson William E Klunk Wiesje M van der Flier Victor L Villemagne Giovanni B Frisoni Adam S Fleisher Alberto Lleó Mark A Mintun Anders Wallin Sebastiaan Engelborghs Duk L Na Gäel Chételat José Luis Molinuevo Susan M Landau Niklas Mattsson Johannes Kornhuber Osama Sabri Christopher C Rowe Lucilla Parnetti Julius Popp Tormod Fladby William J Jagust Pauline Aalten Dong Young Lee Rik Vandenberghe Catarina Resende de Oliveira Elisabeth Kapaki Lutz Froelich Adrian Ivanoiu Tomasz Gabryelewicz Marcel M Verbeek Páscual Sanchez-Juan Helmut Hildebrandt Vincent Camus Marzena Zboch David J Brooks Alexander Drzezga Juha O Rinne Andrew Newberg Alexandre de Mendonça Marie Sarazin Gil D Rabinovici Karine Madsen Milica G Kramberger Agneta Nordberg Vincent Mok Barbara Mroczko David A Wolk Philipp T Meyer Magda Tsolaki Philip Scheltens Frans R J Verhey Pieter Jelle Visser Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kaj Blennow Mark A van Buchem Enrica Cavedo Kewei Chen Elena Chipi Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Olymbia Gkatzima Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Peter Johannsen Aleksandra Klimkowicz-Mrowiec Sebastian Köhler Norman Koglin Koen van Laere Mony de Leon Viviana Lisetti Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Arto Nordlund Gerald P Novak George P Paraskevas Gayan Perera Oliver Peters Inez H G B Ramakers Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Henrik Zetterberg

JAMA Psychiatry 2018 01;75(1):84-95

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156PMC
January 2018

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

The Future of Brain Imaging in Parkinson's Disease.

J Parkinsons Dis 2018 ;8(s1):S47-S51

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark, Division of Neuroscience, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.3233/JPD-181482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311365PMC
January 2018

Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study.

Lancet Neurol 2017 10 3;16(10):789-796. Epub 2017 Jul 3.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark; Institute of Neuroscience, Newcastle University, Newcastle, England. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30173-4DOI Listing
October 2017

In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography.

Mov Disord 2017 06 3;32(6):922-927. Epub 2017 Mar 3.

Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1002/mds.26961DOI Listing
June 2017

Imaging Parkinson's disease below the neck.

NPJ Parkinsons Dis 2017 25;3:15. Epub 2017 Apr 25.

Department of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41531-017-0017-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460119PMC
April 2017

Validation of an electronic image reader training programme for interpretation of [18F]flutemetamol β-amyloid PET brain images.

Nucl Med Commun 2017 Mar;38(3):234-241

aGE Healthcare, Amersham bClinical Ageing Research Unit, Newcastle University, Newcastle, Upon Tyne, UK cGE Healthcare, Princeton, New Jersey, USA dDepartment of Nuclear Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1097/MNM.0000000000000633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318150PMC
March 2017

Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment.

Hum Brain Mapp 2017 03 13;38(3):1702-1715. Epub 2017 Jan 13.

Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1002/hbm.23499DOI Listing
March 2017

An early and late peak in microglial activation in Alzheimer's disease trajectory.

Brain 2017 03;140(3):792-803

Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1093/brain/aww349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837520PMC
March 2017

Imaging of genetic and degenerative disorders primarily causing Parkinsonism.

Authors:
David J Brooks

Handb Clin Neurol 2016 ;135:493-505

Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-53485-9.00024-6DOI Listing
February 2017

Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients.

Mov Disord 2017 02 17;32(2):235-240. Epub 2016 Nov 17.

Centre for Neurodegeneration and Neuroinflammation, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1002/mds.26848DOI Listing
February 2017

Decreased intestinal acetylcholinesterase in early Parkinson disease: An C-donepezil PET study.

Neurology 2017 Feb 18;88(8):775-781. Epub 2017 Jan 18.

From the Department of Nuclear Medicine and PET-Centre (T.D.F., L.B.S., K.K., A.C.S., N.P., D.J.B., P.B.) and Department of Neurology (J.G.), Aarhus University Hospital, Denmark.

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http://dx.doi.org/10.1212/WNL.0000000000003633DOI Listing
February 2017

Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease.

Neurology 2016 Dec 2;87(23):2451-2456. Epub 2016 Nov 2.

From the Division of Brain Sciences (G.P., P.G.B., D.J.B., N.P.), Imperial College London; Imperial College NHS Trust (S.M.); Imanova Ltd (E.A.R.); National Parkinson Foundation International Centre of Excellence (E.A.R.), King's College London and National Institute for Health Research Biomedical Research Centre and King's College London; Institute of Neuroscience (D.J.B., N.P.), Newcastle University, UK; and Institute of Clinical Medicine (D.J.B., N.P.), University of Aarhus, Denmark.

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http://dx.doi.org/10.1212/WNL.0000000000003396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177673PMC
December 2016

Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein.

J Nucl Med 2016 Nov 3;57(11):1753-1759. Epub 2016 Jun 3.

Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, United Kingdom

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http://dx.doi.org/10.2967/jnumed.115.169078DOI Listing
November 2016

Molecular imaging of dopamine transporters.

Authors:
David J Brooks

Ageing Res Rev 2016 09 21;30:114-21. Epub 2016 Jan 21.

Dept. of Nuclear Medicine, Aarhus University, Denmark; Division of Neuroscience, Imperial College London, UK; Division of Neuroscience, Newcastle University, UK. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2015.12.009DOI Listing
September 2016

In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET.

Brain 2016 07 5;139(Pt 7):2039-49. Epub 2016 May 5.

1 Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Denmark

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http://dx.doi.org/10.1093/brain/aww098DOI Listing
July 2016

Exogenous dopamine reduces GABA receptor availability in the human brain.

Brain Behav 2016 07 5;6(7):e00484. Epub 2016 May 5.

CFIN and Pet Center Aarhus University Norregade 44 8000 Aarhus Denmark.

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http://dx.doi.org/10.1002/brb3.484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864053PMC
July 2016

Imaging synucleinopathies.

Mov Disord 2016 06 16;31(6):814-29. Epub 2016 Feb 16.

Dept of Neurology, Azienda Ospedaliera e Universitaria di Perugia, Perugia, Italy.

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http://dx.doi.org/10.1002/mds.26547DOI Listing
June 2016

Imaging Systemic Dysfunction in Parkinson's Disease.

Curr Neurol Neurosci Rep 2016 Jun;16(6):51

Department of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University Hospital, Norrebrogade 44, building 10, DK-8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1007/s11910-016-0655-4DOI Listing
June 2016

Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism.

Neuroimage 2016 05 11;132:1-7. Epub 2016 Feb 11.

Centre for Neuropsychopharmacology, Imperial College London, Du Cane Rd., London W12 0NN, United Kingdom; Psychopharmacology Unit, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom; MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.neuroimage.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862962PMC
May 2016

Age at onset and Parkinson disease phenotype.

Neurology 2016 Apr 10;86(15):1400-1407. Epub 2016 Feb 10.

From the Department of Medicine (G.P., D.J.B., N.P.), Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, UK; Department of Translational Medical Sciences (G.P., N.F.), Federico II University of Naples; Salvatore Maugeri Foundation (N.F.), IRCCS, Scientific Institute of Telese, Telese Terme (BN), Italy; and Department of Clinical Medicine-Center for Functionally Integrative Neuroscience (D.J.B., N.P.), Aarhus University, Denmark.

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http://www.neurology.org/content/early/2016/02/10/WNL.000000
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http://dx.doi.org/10.1212/WNL.0000000000002461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831034PMC
April 2016

Amyloid pathology and axonal injury after brain trauma.

Neurology 2016 Mar 3;86(9):821-8. Epub 2016 Feb 3.

From the Division of Brain Sciences (G.S., A.F.R., P.E., P.H., J.C., R.L., S.M.G., R.A.H., P.M.M., D.J.B., D.J.S.), Department of Medicine, Imperial College London; Institute of Psychiatry, Psychology & Neuroscience (P.H., M.V., F.E.T.), King's College London; Institute of Neurology (R.J.G.), University College London, UK; MedTech West at Sahlgrenska University Hospital (R.A.H.), University of Gothenburg, Sweden; and Institute of Clinical Medicine (D.J.B.), Aarhus University, Denmark.

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http://dx.doi.org/10.1212/WNL.0000000000002413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793784PMC
March 2016

Progression of nonmotor symptoms in subgroups of patients with non-dopamine-deficient Parkinsonism.

Mov Disord 2016 Mar 11;31(3):344-51. Epub 2016 Feb 11.

Division of Brain Sciences, Imperial College London, UK.

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http://dx.doi.org/10.1002/mds.26456DOI Listing
March 2016

Neuroimaging in Parkinson's disease: a future perspective.

Authors:
David J Brooks

Neurodegener Dis Manag 2015 ;5(2):105-8

Aarhus University, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.2217/nmt.14.56DOI Listing
January 2016

Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?

Mov Disord 2016 Jan 22;31(1):103-10. Epub 2015 Jul 22.

Institute of Neuroscience, Newcastle University, Newcastle, United Kingdom.

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http://dx.doi.org/10.1002/mds.26312DOI Listing
January 2016

Imaging biomarkers in tauopathies.

Parkinsonism Relat Disord 2016 Jan 14;22 Suppl 1:S26-8. Epub 2015 Aug 14.

Neurology Imaging Unit, Division of Neuroscience, Imperial College London, UK; Dept. of Nuclear Medicine, Institute of Clinical Medicine, Aarhus University, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.08.011DOI Listing
January 2016

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease.

Brain 2015 Dec 27;138(Pt 12):3685-98. Epub 2015 Oct 27.

1 Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

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http://dx.doi.org/10.1093/brain/awv288DOI Listing
December 2015

Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage.

J Neuroinflammation 2015 Dec 1;12:224. Epub 2015 Dec 1.

Division of Brain Sciences, Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, UK.

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http://dx.doi.org/10.1186/s12974-015-0445-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666189PMC
December 2015

Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions.

Alzheimers Dement 2015 Sep 15;11(9):1110-20. Epub 2014 Nov 15.

Neurology Imaging Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.08.105DOI Listing
September 2015

Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia.

Alzheimers Dement 2015 Jun 16;11(6):608-21.e7. Epub 2014 Sep 16.

Neurology Imaging Unit, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.06.016DOI Listing
June 2015

An exploratory efficacy study of the amyloid imaging agent [(18)F]flutemetamol in Japanese Subjects.

Ann Nucl Med 2015 Jun 10;29(5):391-9. Epub 2015 Feb 10.

Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan.

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http://dx.doi.org/10.1007/s12149-015-0957-7DOI Listing
June 2015

Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

J Nucl Med 2015 May 3;56(5):707-13. Epub 2015 Apr 3.

Neurology Imaging Unit, Imperial College London, Hammersmith Campus, London, United Kingdom MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom; and

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http://dx.doi.org/10.2967/jnumed.114.149443DOI Listing
May 2015

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Authors:
Willemijn J Jansen Rik Ossenkoppele Dirk L Knol Betty M Tijms Philip Scheltens Frans R J Verhey Pieter Jelle Visser Pauline Aalten Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kristen Bibeau Kaj Blennow David J Brooks Mark A van Buchem Vincent Camus Enrica Cavedo Kewei Chen Gael Chetelat Ann D Cohen Alexander Drzezga Sebastiaan Engelborghs Anne M Fagan Tormod Fladby Adam S Fleisher Wiesje M van der Flier Lisa Ford Stefan Förster Juan Fortea Nadia Foskett Kristian S Frederiksen Yvonne Freund-Levi Giovanni B Frisoni Lutz Froelich Tomasz Gabryelewicz Kiran Dip Gill Olymbia Gkatzima Estrella Gómez-Tortosa Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Helmut Hildebrandt Lianna Ishihara Adrian Ivanoiu William J Jagust Peter Johannsen Ramesh Kandimalla Elisabeth Kapaki Aleksandra Klimkowicz-Mrowiec William E Klunk Sebastian Köhler Norman Koglin Johannes Kornhuber Milica G Kramberger Koen Van Laere Susan M Landau Dong Young Lee Mony de Leon Viviana Lisetti Alberto Lleó Karine Madsen Wolfgang Maier Jan Marcusson Niklas Mattsson Alexandre de Mendonça Olga Meulenbroek Philipp T Meyer Mark A Mintun Vincent Mok José Luis Molinuevo Hanne M Møllergård John C Morris Barbara Mroczko Stefan Van der Mussele Duk L Na Andrew Newberg Agneta Nordberg Arto Nordlund Gerald P Novak George P Paraskevas Lucilla Parnetti Gayan Perera Oliver Peters Julius Popp Sudesh Prabhakar Gil D Rabinovici Inez H G B Ramakers Lorena Rami Catarina Resende de Oliveira Juha O Rinne Karen M Rodrigue Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Christopher C Rowe Eckart Rüther Osama Sabri Páscual Sanchez-Juan Isabel Santana Marie Sarazin Johannes Schröder Christin Schütte Sang W Seo Femke Soetewey Hilkka Soininen Luiza Spiru Hanne Struyfs Charlotte E Teunissen Magda Tsolaki Rik Vandenberghe Marcel M Verbeek Victor L Villemagne Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Anders Wallin Åsa K Wallin Jens Wiltfang David A Wolk Marzena Zboch Henrik Zetterberg

JAMA 2015 May;313(19):1924-38

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden87UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jama.2015.4668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486209PMC
May 2015

The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study.

Neurobiol Aging 2015 Apr 6;36(4):1736-1742. Epub 2015 Jan 6.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK; Neurodegeneration Imaging Group, Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.037DOI Listing
April 2015

The role of neuroinflammation in dementias.

Curr Neurol Neurosci Rep 2015 Apr;15(4):17

Division of Brain Sciences, Department of Medicine, Imperial College London, 1st Floor B Block, Du Cane Road, London, W12 0NN, UK.

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http://link.springer.com/content/pdf/10.1007/s11910-015-0531
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http://link.springer.com/10.1007/s11910-015-0531-7
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http://dx.doi.org/10.1007/s11910-015-0531-7DOI Listing
April 2015

Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.

Neuroimage 2014 Aug 13;97:151-62. Epub 2014 Apr 13.

Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK; MRC Clinical Sciences Centre Hammersmith Hospital, London, UK; Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK; Epilepsy Society, Chalfont St Peter, UK; Neurodis Foundation, CERMEP, Imagerie du Vivant, Lyon. France. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2014.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283194PMC
August 2014

Initial evaluation of 18F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors.

J Nucl Med 2014 Mar 13;55(3):423-30. Epub 2014 Feb 13.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.2967/jnumed.113.130641DOI Listing
March 2014

Ventral striatal dopamine synthesis capacity is associated with individual differences in behavioral disinhibition.

Front Behav Neurosci 2014 14;8:86. Epub 2014 Mar 14.

Division of Brain Sciences, Department of Medicine, Imperial College London, UK ; Department of Nuclear Medicine, PET Centre, Aarhus University Aarhus, Denmark.

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http://journal.frontiersin.org/article/10.3389/fnbeh.2014.00
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http://dx.doi.org/10.3389/fnbeh.2014.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954060PMC
March 2014

Health-related quality of life in early Parkinson's disease: the impact of nonmotor symptoms.

Mov Disord 2014 Feb 7;29(2):195-202. Epub 2013 Oct 7.

Institute for Ageing and Health, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1002/mds.25664DOI Listing
February 2014

Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART.

AIDS 2014 Jan;28(1):67-72

aDepartment of Medicine, Faculty of Medicine, Imperial College London, St Mary's Hospital Campus, Norfolk Place bDepartment of HIV and GU Medicine, Imperial College Healthcare NHS Trust cDivision of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1097/01.aids.0000432467.54003.f7DOI Listing
January 2014

Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study.

Neurology 2014 Jan 20;82(4):308-16. Epub 2013 Dec 20.

From the Institute for Ageing and Health (A.J.Y., G.W.D., M.J.F., D.J.B.), Industrial Statistics Research Unit (S.Y.C.), and Institute of Genetic Medicine (G.H., P.F.C.), Newcastle University; John van Geest Centre for Brain Repair (D.P.B., J.R.E., R.A.B.), Department of Clinical Neurosciences (C.N., S.W.-R., J.B.R.), Behavioural and Clinical Neuroscience Institute (C.N., S.W.-R., J.B.R., T.W.R.), MRC Cognition and Brain Sciences Unit (C.N., S.W.-R., J.B.R.), Departments of Psychiatry (J.T.O.) and Psychology (T.W.R.), University of Cambridge, UK; School of Medicine (T.K.K.), Griffith University, Australia; Paracelsus-Elena-Klinik (B.M.), Kassel, and Göttingen University; Institute for Neuropathology (N.K.), Prion and Dementia Research Unit, University Medical Centre Göttingen, Germany; Centre for Human Psychopharmacology (K.W.), Swinburne University, Melbourne, Australia; and Department of Medicine (D.J.W.), Imperial College London, UK.

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http://www.neurology.org/content/82/4/308.full.pdf
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http://dx.doi.org/10.1212/WNL.0000000000000066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929202PMC
January 2014

Reference region automatic extraction in dynamic [(11)C]PIB.

J Cereb Blood Flow Metab 2013 Nov 7;33(11):1725-31. Epub 2013 Aug 7.

Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.

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http://dx.doi.org/10.1038/jcbfm.2013.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824180PMC
November 2013

Benefits of putaminal GDNF infusion in Parkinson disease are maintained after GDNF cessation.

Neurology 2013 Sep 14;81(13):1176-8. Epub 2013 Aug 14.

From the Institute of Clinical Neurosciences (N.K.P., S.J., S.S.G.), Frenchay Hospital, Bristol; and Imperial College London (N.P., G.R.H., D.J.B.), Division of Brain Sciences, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1212/WNL.0b013e3182a55ea5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795600PMC
September 2013

Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia.

Neuropsychopharmacology 2013 May 6;38(6):938-49. Epub 2012 Dec 6.

Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/npp.2012.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629382PMC
May 2013

Diffusion-weighted imaging and its relationship to microglial activation in parkinsonian syndromes.

Parkinsonism Relat Disord 2013 May 18;19(5):527-32. Epub 2013 Feb 18.

Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.parkreldis.2013.01.017DOI Listing
May 2013

Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD.

Neurology 2013 May 17;80(20):1850-5. Epub 2013 Apr 17.

Department of Medicine, Division of Brain Sciences, Hammersmith Hospital, Imperial College London, UK.

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http://dx.doi.org/10.1212/WNL.0b013e318292a31dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908354PMC
May 2013

Ventral striatal dopamine synthesis capacity predicts financial extravagance in Parkinson's disease.

Front Psychol 2013 27;4:90. Epub 2013 Feb 27.

School of Psychology, Cardiff University Cardiff, UK.

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http://dx.doi.org/10.3389/fpsyg.2013.00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583186PMC
March 2013

Binary classification of ¹⁸F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI.

Neuroimage 2013 Jan 14;64:517-25. Epub 2012 Sep 14.

Laboratory for Cognitive Neurology, Experimental Neurology Section, Katholieke Universiteit Leuven, Belgium.

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http://dx.doi.org/10.1016/j.neuroimage.2012.09.015DOI Listing
January 2013

The spectrum of nonmotor symptoms in early Parkinson disease.

Neurology 2013 Jan;80(3):276-81

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1212/WNL.0b013e31827deb74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589180PMC
January 2013

Bad news for neuroprotective therapies in PD?

J Parkinsons Dis 2013 Jan;3(3):271-3

Lund University, Basal ganglia pathophysiology unit, Lund, Sweden.

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http://dx.doi.org/10.3233/JPD-139001DOI Listing
January 2013

The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study.

Brain 2012 Aug;135(Pt 8):2449-57

Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1093/brain/aws157DOI Listing
August 2012

Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts.

Sci Transl Med 2012 Apr;4(128):128ra41

Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK.

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http://dx.doi.org/10.1126/scitranslmed.3003391DOI Listing
April 2012