David J Beebe

David J Beebe

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David J Beebe

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Versatile exclusion-based sample preparation platform for integrated rare cell isolation and analyte extraction.

Lab Chip 2018 11;18(22):3446-3458

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.

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http://xlink.rsc.org/?DOI=C8LC00620B
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http://dx.doi.org/10.1039/c8lc00620bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402328PMC
November 2018

Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations.

EBioMedicine 2018 Nov 26;37:144-157. Epub 2018 Oct 26.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA; The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA; Department of Pathology & Laboratory Medicine, University of Wisconsin, MAdison, WI,USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284542PMC
November 2018

Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to .

Blood 2018 Oct 24;132(17):1818-1828. Epub 2018 Aug 24.

Department of Medical Microbiology and Immunology.

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http://dx.doi.org/10.1182/blood-2018-05-848465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202912PMC
October 2018

Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis.

Lab Chip 2018 09;18(18):2710-2719

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1039/c8lc00584bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402335PMC
September 2018

Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems.

Lab Chip 2018 09;18(19):3011-3017

Department of Medicine, Carbone Cancer Center, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.

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http://xlink.rsc.org/?DOI=C8LC00431E
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http://dx.doi.org/10.1039/c8lc00431eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178814PMC
September 2018

Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing.

ACS Appl Mater Interfaces 2018 May 8;10(20):17065-17070. Epub 2018 May 8.

Carbone Cancer Center , University of Wisconsin-Madison , Madison , Wisconsin 53792 , United States.

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http://pubs.acs.org/doi/10.1021/acsami.8b03627
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http://dx.doi.org/10.1021/acsami.8b03627DOI Listing
May 2018

miFAST: A novel and rapid microRNA target capture method.

Mol Carcinog 2018 04 12;57(4):559-566. Epub 2018 Feb 12.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/mc.22780DOI Listing
April 2018

Integration of Magnetic Bead-Based Cell Selection into Complex Isolations.

ACS Omega 2018 Apr 6;3(4):3908-3917. Epub 2018 Apr 6.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, United States.

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http://dx.doi.org/10.1021/acsomega.7b01427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928489PMC
April 2018

A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment.

Methods Mol Biol 2016 ;1458:59-69

Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, The US Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1007/978-1-4939-3801-8_5DOI Listing
January 2018

An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium.

Adv Healthc Mater 2018 01 7;7(2). Epub 2017 Aug 7.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, WIMR I Room 6028, 1111 Highland Ave, Madison, WI, 53705, USA.

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http://dx.doi.org/10.1002/adhm.201700497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402823PMC
January 2018

Adaptation of a Simple Microfluidic Platform for High-Dimensional Quantitative Morphological Analysis of Human Mesenchymal Stromal Cells on Polystyrene-Based Substrates.

SLAS Technol 2017 12 21;22(6):646-661. Epub 2017 Aug 21.

1 Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1177/2472630317726050DOI Listing
December 2017

RNA-mediated TILDA for improved cell capacity and enhanced detection of multiply-spliced HIV RNA.

Integr Biol (Camb) 2017 Nov;9(11):876-884

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1039/c7ib00112fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733636PMC
November 2017

Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.

Proc Natl Acad Sci U S A 2017 10 9;114(43):E9076-E9085. Epub 2017 Oct 9.

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53706;

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http://dx.doi.org/10.1073/pnas.1712018114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664542PMC
October 2017

Multikingdom microscale models.

PLoS Pathog 2017 08 24;13(8):e1006424. Epub 2017 Aug 24.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570211PMC
August 2017

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.

Cell Rep 2017 05;19(8):1572-1585

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505660PMC
May 2017

The Influence of Biomaterials on Cytokine Production in 3D Cultures.

Biomacromolecules 2017 03 16;18(3):709-718. Epub 2017 Feb 16.

Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, The U.S. Food and Drug Administration , Silver Spring, Maryland 20993, United States.

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http://dx.doi.org/10.1021/acs.biomac.6b01469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672812PMC
March 2017

Magnetic System for Automated Manipulation of Paramagnetic Particles.

Anal Chem 2016 Oct 3;88(20):9902-9907. Epub 2016 Oct 3.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison , 1111 Highland Avenue, Madison, Wisconsin 53705, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.6b02257
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http://dx.doi.org/10.1021/acs.analchem.6b02257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378678PMC
October 2016

Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement.

Pharmacol Ther 2016 09 21;165:79-92. Epub 2016 May 21.

Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; Department of Oncology, University of Wisconsin-Madison, Madison, WI, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439438PMC
September 2016

The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps.

PLoS Pathog 2016 09 13;12(9):e1005884. Epub 2016 Sep 13.

Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021349PMC
September 2016

High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.

Mol Biol Cell 2016 07 4;27(13):1981-9. Epub 2016 May 4.

Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705 Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705

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http://dx.doi.org/10.1091/mbc.E15-10-0747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927272PMC
July 2016

Progress towards understanding heterotypic interactions in multi-culture models of breast cancer.

Integr Biol (Camb) 2016 06 21;8(6):684-92. Epub 2016 Apr 21.

Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1039/c6ib00001kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993016PMC
June 2016

AirJump: Using Interfaces to Instantly Perform Simultaneous Extractions.

ACS Appl Mater Interfaces 2016 Jun 10;8(24):15040-5. Epub 2016 Jun 10.

Department of Biomedical Engineering, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058634PMC
http://dx.doi.org/10.1021/acsami.6b02555DOI Listing
June 2016

Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination.

Integr Biol (Camb) 2016 05 30;8(5):603-15. Epub 2016 Mar 30.

Department of Biomedical Engineering, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI 53705, USA.

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http://dx.doi.org/10.1039/c6ib00012fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868663PMC
May 2016

Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels.

Acta Biomater 2016 Apr 2;35:32-41. Epub 2016 Mar 2.

Department of Biomedical Engineering, University of Wisconsin-Madison, WI, USA; Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829480PMC
April 2016

Microbial metabolomics in open microscale platforms.

Nat Commun 2016 Feb 4;7:10610. Epub 2016 Feb 4.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1038/ncomms10610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742997PMC
February 2016

Development of a Highly Sensitive Cell-Based Assay for Detecting Botulinum Neurotoxin Type A through Neural Culture Media Optimization.

J Biomol Screen 2016 Jan 29;21(1):65-73. Epub 2015 Sep 29.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA Wisconsin Institute for Medical Research and University of Wisconsin Carbone Cancer Center, Madison, WI, USA

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http://dx.doi.org/10.1177/1087057115608103DOI Listing
January 2016

LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels.

Adv Healthc Mater 2016 Jan 26;5(2):198-204. Epub 2015 Nov 26.

Microtechnology, Medicine and Biology Lab, Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI, 53705, USA.

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http://dx.doi.org/10.1002/adhm.201500608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776323PMC
January 2016

Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices.

Lab Chip 2015 Jun;15(11):2364-78

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, USA.

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http://xlink.rsc.org/?DOI=C5LC00234F
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http://dx.doi.org/10.1039/c5lc00234fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439323PMC
June 2015

High-density self-contained microfluidic KOALA kits for use by everyone.

J Lab Autom 2015 Apr 25;20(2):146-53. Epub 2014 Nov 25.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, USA

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http://dx.doi.org/10.1177/2211068214560609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707655PMC
April 2015

Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis.

Anal Chem 2015 Mar 26;87(6):3239-46. Epub 2015 Feb 26.

†Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

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http://dx.doi.org/10.1021/ac503700fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405103PMC
March 2015

Phosphodiesterase 4D inhibitors limit prostate cancer growth potential.

Mol Cancer Res 2015 Jan 22;13(1):149-60. Epub 2014 Aug 22.

Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312503PMC
January 2015

Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges.

Cell Mol Life Sci 2015 Jan 2;72(2):237-49. Epub 2014 Oct 2.

Materials Science Program, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1007/s00018-014-1738-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629475PMC
January 2015

Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure.

BMC Cancer 2015 Jan 21;15:12. Epub 2015 Jan 21.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.1186/s12885-015-1007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305264PMC
January 2015

Microfluidic 3D models of cancer.

Adv Drug Deliv Rev 2014 Dec 10;79-80:68-78. Epub 2014 Jul 10.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA; Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258433PMC
December 2014

The importance of being a lumen.

FASEB J 2014 Nov 30;28(11):4583-90. Epub 2014 Jul 30.

Department of Biomedical Engineering, University of Wisconsin Carbone Comprehensive Cancer Center, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, Wisconsin, USA

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http://dx.doi.org/10.1096/fj.13-243733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200326PMC
November 2014

A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.

Curr Biol 2014 Nov 23;24(22):2687-92. Epub 2014 Oct 23.

Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA; Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.09.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254593PMC
November 2014

Cellular microenvironment dictates androgen production by murine fetal Leydig cells in primary culture.

Biol Reprod 2014 Oct 20;91(4):85. Epub 2014 Aug 20.

Department of Comparative Bioscience, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, Wisconsin

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http://dx.doi.org/10.1095/biolreprod.114.118570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435030PMC
October 2014

Fluorescence-based assessment of plasma-induced hydrophilicity in microfluidic devices via Nile Red adsorption and depletion.

Anal Chem 2014 Aug 17;86(15):7258-63. Epub 2014 Jul 17.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison , 1111 Highland Avenue, Madison, Wisconsin 53705, United States.

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http://dx.doi.org/10.1021/ac501259nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144722PMC
August 2014

Efficient sample preparation from complex biological samples using a sliding lid for immobilized droplet extractions.

Anal Chem 2014 Jul 13;86(13):6355-62. Epub 2014 Jun 13.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin , Madison, Wisconsin 53705, United States.

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http://dx.doi.org/10.1021/ac500574tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079323PMC
July 2014

A Combined Fabrication and Instrumentation Platform for Sample Preparation.

J Lab Autom 2014 Jun 8;19(3):267-74. Epub 2014 Jan 8.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1177/2211068213518312DOI Listing
June 2014

A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells.

Integr Biol (Camb) 2014 Jun;6(6):627-635

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.1039/c3ib40240aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077588PMC
June 2014

Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models.

PLoS One 2013 4;8(10):e76373. Epub 2013 Oct 4.

Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, United States of America ; Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin, United States of America ; Laboratory of Optical and Computational Instrumentation, University of Wisconsin, Madison, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076373PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790689PMC
May 2014

HIV viral RNA extraction in wax immiscible filtration assisted by surface tension (IFAST) devices.

J Mol Diagn 2014 May 6;16(3):297-304. Epub 2014 Mar 6.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.

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http://dx.doi.org/10.1016/j.jmoldx.2014.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715211PMC
May 2014

Characterizing asthma from a drop of blood using neutrophil chemotaxis.

Proc Natl Acad Sci U S A 2014 Apr 7;111(16):5813-8. Epub 2014 Apr 7.

Materials Science Program, Department of Biomedical Engineering, Wisconsin Institute for Medical Research, Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and Departments of Biostatistics and Medical Informatics and Pediatrics, University of Wisconsin-Madison, Madison, WI 53705.

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http://dx.doi.org/10.1073/pnas.1324043111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000787PMC
April 2014

The present and future role of microfluidics in biomedical research.

Nature 2014 Mar;507(7491):181-9

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Room 6009, Madison, Wisconsin 53705-2275, USA.

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http://dx.doi.org/10.1038/nature13118DOI Listing
March 2014

Streamlining gene expression analysis: integration of co-culture and mRNA purification.

Integr Biol (Camb) 2014 Feb;6(2):224-31

Departments of Biomedical Engineering, University of Wisconsin-Madison, 1111 Highland Ave., Madison, WI 53705, USA.

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http://dx.doi.org/10.1039/c3ib40136gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956049PMC
February 2014

Paired diagnostic and pharmacodynamic analysis of rare non-small cell lung cancer cells enabled by the VerIFAST platform.

Lab Chip 2014 Jan;14(1):99-105

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave., Madison, WI, USA.

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http://dx.doi.org/10.1039/c3lc50912eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897162PMC
January 2014

Lab on a chip and circulating tumor cells.

Lab Chip 2014 Jan;14(1):12-3

Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, FL 32611-6250, USA.

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http://dx.doi.org/10.1039/c3lc90125dDOI Listing
January 2014

Circulating Tumor Cells in Metastatic Breast Cancer: A Prognostic and Predictive Marker.

J Patient Cent Res Rev 2014 ;1(2):85-92

Department of Biomedical Engineering, University of Wisconsin, Madison, WI ; University of Wisconsin Carbone Cancer Center, Madison, WI.

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http://dx.doi.org/10.17294/2330-0698.1017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405902PMC
January 2014

Selective nucleic acid removal via exclusion (SNARE): capturing mRNA and DNA from a single sample.

Anal Chem 2013 Oct 26;85(20):9764-70. Epub 2013 Sep 26.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison , 1111 Highland Avenue, Madison, Wisconsin53706, United States.

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http://dx.doi.org/10.1021/ac402162rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897163PMC
October 2013

Organs on Chips 2013.

Lab Chip 2013 Sep;13(18):3447-8

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http://dx.doi.org/10.1039/c3lc90080kDOI Listing
September 2013

Nucleic acid sample preparation using spontaneous biphasic plug flow.

Anal Chem 2013 Sep 4;85(18):8641-6. Epub 2013 Sep 4.

Department of Biomedical Engineering and Wisconsin Institute for Medical Research, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.

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http://pubs.acs.org/doi/10.1021/ac4012914
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http://dx.doi.org/10.1021/ac4012914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858960PMC
September 2013

A microscale neuron and Schwann cell coculture model for increasing detection sensitivity of botulinum neurotoxin type A.

Toxicol Sci 2013 Jul 5;134(1):64-72. Epub 2013 Apr 5.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.1093/toxsci/kft082DOI Listing
July 2013

Automated operation of immiscible filtration assisted by surface tension (IFAST) arrays for streamlined analyte isolation.

J Lab Autom 2013 Jun 26;18(3):206-11. Epub 2012 Sep 26.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1177/2211068212462023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633642PMC
June 2013

Functional screen of paracrine signals in breast carcinoma fibroblasts.

PLoS One 2012 8;7(10):e46685. Epub 2012 Oct 8.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046685PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466317PMC
May 2013

Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging.

Lab Chip 2013 May;13(9):1732-6

Department of Biomedical Engineering, Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1039/c3lc50099cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446983PMC
May 2013

Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity.

Integr Biol (Camb) 2013 May;5(5):807-16

University of Wisconsin-Madison Carbone Comprehensive Cancer Center, Madison, WI 53705, USA.

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http://dx.doi.org/10.1039/c3ib20265hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648339PMC
May 2013

High-content adhesion assay to address limited cell samples.

Integr Biol (Camb) 2013 Apr 21;5(4):720-7. Epub 2013 Feb 21.

Biomedical Engineering, University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.1039/c3ib20224kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832292PMC
April 2013

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels.

Biomaterials 2013 Feb 26;34(5):1471-7. Epub 2012 Nov 26.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2012.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529167PMC
February 2013

The VerIFAST: an integrated method for cell isolation and extracellular/intracellular staining.

Lab Chip 2013 Feb;13(3):391-6

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1039/c2lc41136aDOI Listing
February 2013

Kit-On-A-Lid-Assays for accessible self-contained cell assays.

Lab Chip 2013 Feb;13(3):424-31

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.

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http://xlink.rsc.org/?DOI=C2LC41019B
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http://dx.doi.org/10.1039/c2lc41019bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562598PMC
February 2013

Effect of microculture on cell metabolism and biochemistry: do cells get stressed in microchannels?

Anal Chem 2013 Feb 17;85(3):1562-70. Epub 2013 Jan 17.

Department of Biomedical Engineering, University of Wisconsin-Madison, Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, Wisconsin 53705, United States.

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http://dx.doi.org/10.1021/ac3027228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565071PMC
February 2013

Assessment of enhanced autofluorescence and impact on cell microscopy for microfabricated thermoplastic devices.

Anal Chem 2013 Jan 18;85(1):44-9. Epub 2012 Dec 18.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 53705, United States.

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http://pubs.acs.org/doi/10.1021/ac3034773
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http://dx.doi.org/10.1021/ac3034773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017339PMC
January 2013

Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension).

Analyst 2012 Sep 20;137(17):4023-8. Epub 2012 Jul 20.

Department of Biomedical Engineering, University of Wisconsin-Madison, 1111 Highland Ave., Madison, WI 53705, USA.

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http://dx.doi.org/10.1039/c2an35506jDOI Listing
September 2012

Induced hydrophobic recovery of oxygen plasma-treated surfaces.

Lab Chip 2012 Jul 16;12(13):2317-21. Epub 2012 May 16.

Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1039/c2lc21052eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018413PMC
July 2012

Streamlining immunoassays with immiscible filtrations assisted by surface tension.

Anal Chem 2012 Jul 19;84(13):5518-23. Epub 2012 Jun 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

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http://pubs.acs.org/doi/10.1021/ac300085m
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July 2012

The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.

J Biol Chem 2012 Jul 7;287(30):25466-77. Epub 2012 Jun 7.

Departments of Pediatrics and Medical Microbiology and Immunology, 4205 Microbial Sciences Building, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M112.364562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408136PMC
July 2012

Circulating tumor cells: getting more from less.

Sci Transl Med 2012 Jul;4(141):141ps13

Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004261DOI Listing
July 2012

An inertia enhanced passive pumping mechanism for fluid flow in microfluidic devices.

Lab Chip 2012 Jun 23;12(12):2221-8. Epub 2012 Mar 23.

Materials Science Program, University of Wisconsin, Madison, WI 53706, USA.

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June 2012

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

J Biol Chem 2012 May 20;287(20):16454-66. Epub 2012 Mar 20.

McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M112.362137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351289PMC
May 2012

Quantification of kinase activity in cell lysates via photopatterned macroporous poly(ethylene glycol) hydrogel arrays in microfluidic channels.

Biomed Microdevices 2012 Apr;14(2):247-57

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI 53706, USA.

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http://dx.doi.org/10.1007/s10544-011-9602-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299890PMC
April 2012

A practical method for patterning lumens through ECM hydrogels via viscous finger patterning.

J Lab Autom 2012 Apr 24;17(2):96-103. Epub 2012 Jan 24.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53705-2275, USA.

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http://dx.doi.org/10.1177/2211068211426694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397721PMC
April 2012

Microscale functional cytomics for studying hematologic cancers.

Blood 2012 Mar 18;119(10):e76-85. Epub 2012 Jan 18.

Department of Biomedical Engineering, University of Wisconsin-Madison, 53705, USA.

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http://dx.doi.org/10.1182/blood-2011-10-384347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311264PMC
March 2012

Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth.

Integr Biol (Camb) 2012 Feb 11;4(2):142-52. Epub 2012 Jan 11.

Department of Biomedical Engineering and Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1039/c1ib00104cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335396PMC
February 2012

Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST).

Biomed Microdevices 2011 Dec;13(6):1033-42

Department of Biomedical Engineering, University of Wisconsin-Madison, 1111 Highland Ave., Madison, WI 53705, USA.

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http://dx.doi.org/10.1007/s10544-011-9573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314424PMC
December 2011

Micro- and nanoengineering for stem cell biology: the promise with a caution.

Trends Biotechnol 2011 Aug 5;29(8):399-408. Epub 2011 May 5.

Department of Biomedical Engineering, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.tibtech.2011.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726268PMC
August 2011

Automation of three-dimensional cell culture in arrayed microfluidic devices.

J Lab Autom 2011 Jun 16;16(3):171-85. Epub 2011 May 16.

Materials Science Program, University of Wisconsin-Madison, Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.jala.2011.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104941PMC
June 2011