Publications by authors named "David J Baylink"

100Publications

The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19.

J Transl Med 2020 08 26;18(1):322. Epub 2020 Aug 26.

Division of Hematology and Oncology, Department of Medicine, Loma Linda University, Loma Linda, California, USA.

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August 2020

Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient's bone marrow.

J Hematol Oncol 2020 06 3;13(1):63. Epub 2020 Jun 3.

Division of Hematology and Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA.

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June 2020

Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We?

Int J Mol Sci 2020 Apr 28;21(9). Epub 2020 Apr 28.

Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA.

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April 2020

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction.

J Vis Exp 2020 01 22(155). Epub 2020 Jan 22.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University; Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University;

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January 2020

Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model.

Bone Rep 2020 Jun 11;12:100236. Epub 2019 Dec 11.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, California, USA.

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June 2020

Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis.

BMC Infect Dis 2019 Dec 2;19(1):1020. Epub 2019 Dec 2.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, California, USA.

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December 2019

Towards Clinical Translation of CD8 Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules.

Int J Mol Sci 2019 Sep 28;20(19). Epub 2019 Sep 28.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, CA 92354, USA.

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September 2019

1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites.

JCI Insight 2018 09 6;3(17). Epub 2018 Sep 6.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University, Loma Linda, California, USA.

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September 2018

Detection of dinitrosyl iron complexes by ozone-based chemiluminescence.

Nitric Oxide 2018 09 27;79:57-67. Epub 2018 Jul 27.

Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA; Lawrence D. Longo Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA. Electronic address:

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September 2018

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein.

J Vis Exp 2017 12 20(130). Epub 2017 Dec 20.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University;

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December 2017

Unique Regenerative Mechanism to Replace Bone Lost During Dietary Bone Depletion in Weanling Mice.

Endocrinology 2017 04;158(4):714-729

Regenerative Medicine Division, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California.

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April 2017

Effect of aging on stem cells.

World J Exp Med 2017 Feb 20;7(1):1-10. Epub 2017 Feb 20.

Abu Shufian Ishtiaq Ahmed, Matilda HC Sheng, Samiksha Wasnik, David J Baylink, Kin-Hing William Lau, Regenerative Medicine Unit, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, United States.

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February 2017

Application of vitamin D and vitamin D analogs in acute myelogenous leukemia.

Exp Hematol 2017 06 4;50:1-12. Epub 2017 Feb 4.

Division of Hematology/Oncology, Loma Linda University School of Medicine, Loma Linda, CA, USA.

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June 2017

Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis.

Sci Rep 2016 10 31;6:36064. Epub 2016 Oct 31.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, California, USA.

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October 2016

Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice.

Bone 2016 11 9;92:18-28. Epub 2016 Aug 9.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address:

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November 2016

Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration.

Biomaterials 2015 Dec 11;73:51-9. Epub 2015 Sep 11.

Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109, USA; Macromolecular Science and Engineering Center, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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December 2015

PDGFB-based stem cell gene therapy increases bone strength in the mouse.

Proc Natl Acad Sci U S A 2015 Jul 6;112(29):E3893-900. Epub 2015 Jul 6.

Department of Medicine, Loma Linda University, Loma Linda, CA 92354;

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July 2015

Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming.

Curr Stem Cell Res Ther 2016 ;11(2):114-21

Division of Regenerative Medicine, Department of Medicine, Loma Linda University. 11234 Anderson Street, MC1528, Loma Linda, CA 92350, USA.

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October 2016

Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in mice.

PLoS One 2015 30;10(1):e0115897. Epub 2015 Jan 30.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United States of America.

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October 2015

Targeted 25-hydroxyvitamin D3 1α-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice.

Mol Ther 2015 Feb 20;23(2):339-51. Epub 2014 Oct 20.

1] Department of Medicine, Loma Linda University, Loma Linda, California, USA [2] Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Affairs Medical Center, Loma Linda, California, USA.

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February 2015

Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone.

J Bone Metab 2014 Feb 28;21(1):41-54. Epub 2014 Feb 28.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA.

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February 2014

ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size.

Physiol Genomics 2013 Dec 22;45(24):1222-8. Epub 2013 Oct 22.

Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, California;

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December 2013

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.

Am J Physiol Endocrinol Metab 2013 Jul 28;305(2):E271-81. Epub 2013 May 28.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

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July 2013

Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy: studies in a mouse model of multiple fractures.

Bone 2013 Apr 11;53(2):369-81. Epub 2013 Jan 11.

Division of Regenerative Medicine, Loma Linda University School of Medicine, Department of Medicine, Loma Linda, CA92350, USA.

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April 2013

Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice.

Bone 2013 Jan 29;52(1):133-44. Epub 2012 Sep 29.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

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January 2013

Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation.

PLoS One 2012 18;7(5):e37569. Epub 2012 May 18.

Division of Regenerative Medicine, Department of Medicine, Loma Linda University, Loma Linda, California, United States of America.

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December 2012

Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.

PLoS One 2012 20;7(4):e35280. Epub 2012 Apr 20.

Regenerative Medicine Division, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United States of America.

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August 2012

Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone.

Mol Ther 2012 Feb 22;20(2):408-16. Epub 2011 Nov 22.

Division of Regenerative Medicine MC1528B, Department of Medicine, Loma Linda University, Loma Linda, California 92350, USA.

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February 2012

Prevention of colorectal cancer with vitamin D.

Scand J Gastroenterol 2010 Aug;45(7-8):775-84

Department of Gastroenterology, Loma Linda University Medical Center, Loma Linda 92354, USA.

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August 2010

Mapping of the chromosome 17 BMD QTL in the F(2) male mice of MRL/MpJ x SJL/J.

Genetica 2009 Jan 11;135(1):59-66. Epub 2008 Mar 11.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA.

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January 2009

A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways.

Bone 2008 Feb 28;42(2):388-95. Epub 2007 Oct 28.

Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA 92357, USA.

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February 2008

Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: congenic analysis and fine mapping.

Wound Repair Regen 2007 Nov-Dec;15(6):922-7

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA.

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March 2008

Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion.

Endocrinology 2007 Dec 23;148(12):5706-15. Epub 2007 Aug 23.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

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December 2007

Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.

Bone 2007 Aug 27;41(2):223-30. Epub 2007 Apr 27.

Musculoskeletal Disease Center, Jerry L. Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

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August 2007

Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice.

Physiol Genomics 2007 Aug 22;30(3):354-62. Epub 2007 May 22.

Jerry L. Pettis Veterans Affairs Medical Center and Loma Linda University, Loma Linda, California 92357, USA.

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August 2007

Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells.

J Biol Chem 2007 Jul 17;282(30):22052-61. Epub 2007 May 17.

Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, CA 92357, USA.

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July 2007

Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene.

Genome Res 2007 May 6;17(5):577-85. Epub 2007 Apr 6.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, and Department of Medicine and Biochemistry, Loma Linda University, California 92357, USA.

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May 2007

A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2.

Arch Biochem Biophys 2007 Jul 15;463(1):47-59. Epub 2007 Mar 15.

The Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

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July 2007

Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice.

Wound Repair Regen 2007 Mar-Apr;15(2):275-84

Musculoskeletal Disease Center, JL Pettis VA Medical Center, Molecular Genetics Division, Loma Linda, CA 92357, USA.

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June 2007

The selective cyclooxygenase-2 inhibitor celecoxib reduces bone resorption, but not bone formation, in ovariectomized mice in vivo.

Tohoku J Exp Med 2007 Mar;211(3):275-83

Division of Orthopedic Surgery, Department of Neuro and Locomotor Science, Akita University School of Medicine, Japan.

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March 2007

Modifications of the fibroblast growth factor-2 gene led to a marked enhancement in secretion and stability of the recombinant fibroblast growth factor-2 protein.

J Cell Biochem 2007 Apr;100(6):1493-508

The Gene Therapy Division, Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial V.A. Medical Center, Loma Linda, California 92357, USA.

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April 2007

An improved mouse Sca-1+ cell-based bone marrow transplantation model for use in gene- and cell-based therapeutic studies.

Acta Haematol 2007 8;117(1):24-33. Epub 2006 Nov 8.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, Calif. 92357, USA.

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February 2007

Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo.

Endocrinology 2006 Dec 31;147(12):5653-61. Epub 2006 Aug 31.

Musculoskeletal Disease Center, J. L. Pettis Veterans Affairs Medical Center (151), 11201 Benton Street, and Department of Medicine, Loma Linda University, California 92357, USA.

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December 2006

Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation.

Am J Physiol Endocrinol Metab 2006 Jul 7;291(1):E128-36. Epub 2006 Feb 7.

Musculoskeletal Disease Center (151 Jerry L. Pettis Memorial Veterans Affairs Medical Center, 11201 Benton St., Loma Linda, CA 92357, USA.

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July 2006

Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background.

J Bone Miner Res 2006 Jan 17;21(1):97-104. Epub 2005 Oct 17.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA.

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January 2006

Mapping the dominant wound healing and soft tissue regeneration QTL in MRL x CAST.

Mamm Genome 2005 Dec 8;16(12):918-24. Epub 2005 Dec 8.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA.

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December 2005

Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation.

Am J Physiol Cell Physiol 2006 Mar 2;290(3):C900-6. Epub 2005 Nov 2.

Musculoskeletal Disease Center, PO Box 151, Jerry L. Pettis Veterans Affairs Medical Center, 11201 Benton St., Loma Linda, CA 92357, USA.

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March 2006

An osteoclastic protein-tyrosine phosphatase is a potential positive regulator of the c-Src protein-tyrosine kinase activity: a mediator of osteoclast activity.

J Cell Biochem 2006 Apr;97(5):940-55

Department of Medicine and Biochemistry, Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA.

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April 2006

Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice.

J Lipid Res 2006 Jan 27;47(1):123-33. Epub 2005 Oct 27.

Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA 92357, USA.

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January 2006

New quantitative trait loci that regulate wound healing in an intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of mice.

Funct Integr Genomics 2006 Apr 6;6(2):157-63. Epub 2005 Oct 6.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, Loma Linda, CA 92357, USA.

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April 2006

Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism.

J Biol Chem 2005 Nov 22;280(45):37782-9. Epub 2005 Aug 22.

Musculoskeletal Disease Center, JL Pettis Memorial Veterans Affairs Medical Center, CA 92357, USA.

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November 2005

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains.

J Appl Physiol (1985) 2005 Nov 14;99(5):1951-7. Epub 2005 Jul 14.

Musculoskeletal Disease Center, Veterans Affairs Loma Linda Healthcare System, Loma Linda, CA 92357, USA.

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November 2005

Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation.

J Bone Miner Res 2005 Aug 14;20(8):1430-9. Epub 2005 Mar 14.

Musculoskeletal Disease Center, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA.

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August 2005

Clinical use of serum and urine bone markers in the management of osteoporosis.

Curr Med Res Opin 2005 Jul;21(7):1015-26

Musculoskeletal Disease Center, VA Loma Linda Healthcare System, and Department of Medicine, Loma Linda University, Loma Linda, CA 92357, USA.

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July 2005

Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size.

J Bone Miner Res 2005 Jun 27;20(6):1041-50. Epub 2004 Dec 27.

Musculoskeletal Disease Center, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA.

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June 2005

Bayesian shrinkage estimation of quantitative trait loci parameters.

Genetics 2005 May 21;170(1):465-80. Epub 2005 Mar 21.

Department of Botany and Plant Sciences, University of California, Riverside, 92521, USA.

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May 2005

Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice.

Biochem Biophys Res Commun 2005 Apr;330(1):117-22

Musculoskeletal Disease Center, JL Pettis VA Medical Center, Loma Linda, CA 92357, USA.

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April 2005

Fluid shear stress synergizes with insulin-like growth factor-I (IGF-I) on osteoblast proliferation through integrin-dependent activation of IGF-I mitogenic signaling pathway.

J Biol Chem 2005 May 18;280(20):20163-70. Epub 2005 Mar 18.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Affairs Medical Center, Loma Linda, California 92357, USA.

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May 2005

Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density.

Bone 2005 Jan 24;36(1):111-22. Epub 2004 Nov 24.

Musculoskeletal Disease Center, J.L. Pettis Memorial V. A. Medical Center and Department of Medicine, Loma Linda University, Loma Linda, CA 92357, USA.

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January 2005

The multi-functional role of insulin-like growth factor binding proteins in bone.

Pediatr Nephrol 2005 Mar 11;20(3):261-8. Epub 2004 Nov 11.

Musculoskeletal Disease Center, Jerry L. Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

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March 2005

An osteoclastic protein-tyrosine phosphatase may play a role in differentiation and activity of human monocytic U-937 cell-derived, osteoclast-like cells.

Am J Physiol Cell Physiol 2004 Oct;287(4):C874-84

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, 11201 Benton St., Loma Linda, CA 92357, USA.

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October 2004

In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells.

Bone 2004 Sep;35(3):711-9

Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Medical Center, Loma Linda, CA 92357, USA.

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September 2004

Effects of secreted frizzled-related protein 3 on osteoblasts in vitro.

J Bone Miner Res 2004 Sep 3;19(9):1395-402. Epub 2004 May 3.

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.

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September 2004

Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation.

Bone 2004 Aug;35(2):525-34

Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial V.A. Medical Center, Loma Linda University, Loma Linda, CA 92357, USA.

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August 2004

Progress toward skeletal gene therapy.

Crit Rev Eukaryot Gene Expr 2004 ;14(1-2):89-136

Departments of Medicine and Biochemistry, Loma Linda University and the Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

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November 2004

Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice.

J Gene Med 2004 Jan;6(1):4-15

Department of Medicine, Loma Linda University, and Gene Therapy Division, Musculoskeletal Disease Center (151), VA Loma Linda Healthcare Network, Loma Linda, CA 92357, USA.

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January 2004

Osteoblastic tartrate-resistant acid phosphatase: its potential role in the molecular mechanism of osteogenic action of fluoride.

J Bone Miner Res 2003 Oct;18(10):1897-900

Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA.

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October 2003

Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice.

Endocrinology 2003 Nov 7;144(11):4682-9. Epub 2003 Aug 7.

Musculoskeletal Disease Center, J. L. Petttis Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California 92357, USA.

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November 2003

Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driven by an alternative intronic, cell type-specific promoter.

J Biol Chem 2003 Nov 29;278(45):44273-80. Epub 2003 Aug 29.

Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Affairs Medical Center, Loma Linda University, Loma Linda, California 92357, USA.

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November 2003

Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: studies in GH-deficient lit/lit mice.

Endocrinology 2003 Sep;144(9):3950-7

Musculoskeletal Disease Center, Jerry L. Pettis Veterans Affairs Medical Center, Loma Linda, California 92357, USA.

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September 2003