David J Balding

David J Balding

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David J Balding

Publications by authors named "David J Balding"

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Summary statistic analyses can mistake confounding bias for heritability.

Genet Epidemiol 2019 Sep 20. Epub 2019 Sep 20.

Melbourne Integrative Genomics, School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1002/gepi.22259DOI Listing
September 2019

SumHer better estimates the SNP heritability of complex traits from summary statistics.

Nat Genet 2019 02 3;51(2):277-284. Epub 2018 Dec 3.

UCL Genetics Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0279-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485398PMC
February 2019

Y-profile evidence: Close paternal relatives and mixtures.

Forensic Sci Int Genet 2019 01 10;38:48-53. Epub 2018 Oct 10.

Melbourne Integrative Genomics, School of BioSciences and School of Mathematics & Statistics, University of Melbourne, Building 184, Royal Parade, Parkville 3010, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2018.10.004DOI Listing
January 2019

How many individuals share a mitochondrial genome?

PLoS Genet 2018 11 1;14(11):e1007774. Epub 2018 Nov 1.

Melbourne Integrative Genomics, University of Melbourne, Victoria, Australia.

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http://dx.plos.org/10.1371/journal.pgen.1007774
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http://dx.doi.org/10.1371/journal.pgen.1007774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233927PMC
November 2018

How convincing is a matching Y-chromosome profile?

PLoS Genet 2017 Nov 3;13(11):e1007028. Epub 2017 Nov 3.

Centre for Systems Genomics, Royal Parade, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1007028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669422PMC
November 2017

Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation.

Genome Res 2017 10 1;27(10):1715-1729. Epub 2017 Sep 1.

Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1101/gr.226589.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630035PMC
October 2017

Reevaluation of SNP heritability in complex human traits.

Nat Genet 2017 Jul 22;49(7):986-992. Epub 2017 May 22.

UCL Genetics Institute, University College London, London, UK.

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http://dx.doi.org/10.1038/ng.3865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493198PMC
July 2017

Erratum to 'Encoding of low-quality DNA profiles as genotype probability matrices for improved profile comparisons, relatedness evalation and database searches'. Forensic Science International: Genetics (2016) 227-239.

Forensic Sci Int Genet 2017 03 9;27:189-190. Epub 2016 Dec 9.

UCL Genetics Institute, University College, London WC1E 6BT, United Kingdom; Centre for Systems Genomics, School of BioSciences and School of Mathematics and Statistics, University of Melbourne, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2016.11.003DOI Listing
March 2017

Encoding of low-quality DNA profiles as genotype probability matrices for improved profile comparisons, relatedness evaluation and database searches.

Forensic Sci Int Genet 2016 11 21;25:227-239. Epub 2016 Sep 21.

UCL Genetics Institute, University College, London WC1E 6BT, United Kingdom; Centre for Systems Genomics, School of BioSciences and School of Mathematics and Statistics, University of Melbourne, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2016.09.004DOI Listing
November 2016

Evaluation of low-template DNA profiles using peak heights.

Stat Appl Genet Mol Biol 2016 10;15(5):431-445

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http://dx.doi.org/10.1515/sagmb-2016-0038DOI Listing
October 2016

Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics.

Pharmacogenet Genomics 2015 May;25(5):231-8

aUniversity College London Genetics Institute bUniversity College London, Statistical Science Department, London, UK.

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http://dx.doi.org/10.1097/FPC.0000000000000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387202PMC
May 2015

Bayesian models for syndrome- and gene-specific probabilities of novel variant pathogenicity.

Genome Med 2015 28;7(1). Epub 2015 Jan 28.

NIHR Biomedical Research Unit in Cardiovascular Disease at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK ; National Heart and Lung Institute, Imperial College, London, UK ; National Heart Centre, Singapore, Singapore ; Duke-National University, Singapore, Singapore.

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http://genomemedicine.com/content/7/1/5
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http://dx.doi.org/10.1186/s13073-014-0120-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308924PMC
February 2015

Relatedness in the post-genomic era: is it still useful?

Nat Rev Genet 2015 Jan 18;16(1):33-44. Epub 2014 Nov 18.

1] UCL Genetics Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. [2] Department of Genetics and Department of Mathematics and Statistics, University of Melbourne, Parkville VIC 3010, Australia.

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http://dx.doi.org/10.1038/nrg3821DOI Listing
January 2015

Choice of population database for forensic DNA profile analysis.

Sci Justice 2014 Dec 7;54(6):487-93. Epub 2014 Nov 7.

UCL Genetics Institute, Darwin Building, Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.scijus.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275602PMC
December 2014

Verifying likelihoods for low template DNA profiles using multiple replicates.

Forensic Sci Int Genet 2014 Nov 10;13:82-9. Epub 2014 Jul 10.

UCL Genetics Institute, Darwin Building, Gower Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.fsigen.2014.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234080PMC
November 2014

Worldwide F(ST) estimates relative to five continental-scale populations.

Ann Hum Genet 2014 Nov;78(6):468-77

UCL Genetics Institute, Darwin Building Gower Street, London, WC1E 6BT, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223938PMC
http://dx.doi.org/10.1111/ahg.12081DOI Listing
November 2014

Describing the genetic architecture of epilepsy through heritability analysis.

Brain 2014 Oct 26;137(Pt 10):2680-9. Epub 2014 Jul 26.

7 Division of Brain Sciences, Imperial College London, London W6 8RF, UK

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http://dx.doi.org/10.1093/brain/awu206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163034PMC
October 2014

MultiBLUP: improved SNP-based prediction for complex traits.

Genome Res 2014 Sep 24;24(9):1550-7. Epub 2014 Jun 24.

UCL Genetics Institute, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1101/gr.169375.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158754PMC
September 2014

Multiple quantitative trait analysis using bayesian networks.

Genetics 2014 Sep;198(1):129-37

National Institute of Agricultural Botany (NIAB), Cambridge CB3 0LE, United Kingdom.

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http://dx.doi.org/10.1534/genetics.114.165704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174925PMC
September 2014

Understanding complex traits: from farmers to pharmas.

Genome Med 2012 27;4(7):59. Epub 2012 Jul 27.

UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1186/gm360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580415PMC
August 2014

Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.

PLoS One 2013 8;8(10):e74821. Epub 2013 Oct 8.

Department of Epidemiology and Biostatistics, Imperial College London, MRC-HPA Centre for Environment and Health, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074821PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792967PMC
June 2014

Response to Lee et al.: SNP-based heritability analysis with dense data.

Am J Hum Genet 2013 Dec;93(6):1155-7

UCL Genetics Institute, University College London, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852920PMC
December 2013

Evaluation of mixed-source, low-template DNA profiles in forensic science.

Authors:
David J Balding

Proc Natl Acad Sci U S A 2013 Jul 1;110(30):12241-6. Epub 2013 Jul 1.

University College London Genetics Institute, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1219739110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725068PMC
July 2013

Multiple single nucleotide polymorphism analysis using penalized regression in nonlinear mixed-effect pharmacokinetic models.

Pharmacogenet Genomics 2013 Mar;23(3):167-74

Genetics Institute, University College London Genetics Institute, London, UK.

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http://dx.doi.org/10.1097/FPC.0b013e32835dd22cDOI Listing
March 2013

Decision-making in familial database searching: KI alone or not alone?

Forensic Sci Int Genet 2013 Jan 29;7(1):52-4. Epub 2012 Jun 29.

Institute of Genetics, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.fsigen.2012.06.001DOI Listing
January 2013

Improved heritability estimation from genome-wide SNPs.

Am J Hum Genet 2012 Dec;91(6):1011-21

University College London Genetics Institute, University College London, London WC1E 6BT, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297120053
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http://dx.doi.org/10.1016/j.ajhg.2012.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516604PMC
December 2012

Using penalised logistic regression to fine map HLA variants for rheumatoid arthritis.

Ann Hum Genet 2011 Nov 1;75(6):655-64. Epub 2011 Sep 1.

Department of Epidemiology and Public Health, Imperial College London, UK.

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http://dx.doi.org/10.1111/j.1469-1809.2011.00670.xDOI Listing
November 2011

Admixture provides new insights into recombination.

Nat Genet 2011 Aug 29;43(9):819-20. Epub 2011 Aug 29.

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http://dx.doi.org/10.1038/ng.918DOI Listing
August 2011

Epigenome-wide association studies for common human diseases.

Nat Rev Genet 2011 Jul 12;12(8):529-41. Epub 2011 Jul 12.

Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.

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http://www.cell.com/trends/molecular-medicine/pdf/S1471-4914
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http://www.nature.com/doifinder/10.1038/nrg3000
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http://dx.doi.org/10.1038/nrg3000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508712PMC
July 2011

On optimal selection of summary statistics for approximate Bayesian computation.

Stat Appl Genet Mol Biol 2010 6;9:Article34. Epub 2010 Sep 6.

Lancaster University.

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http://dx.doi.org/10.2202/1544-6115.1576DOI Listing
March 2011

A genome-wide association study of the metabolic syndrome in Indian Asian men.

PLoS One 2010 Aug 4;5(8):e11961. Epub 2010 Aug 4.

Department of Epidemiology and Public Health, Imperial College London, London, UK.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915922PMC
August 2010

cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs.

Nat Methods 2010 Jul 30;7(7):541-6. Epub 2010 May 30.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Hospital, London, UK.

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http://dx.doi.org/10.1038/nmeth.1466DOI Listing
July 2010

Inferring combined CNV/SNP haplotypes from genotype data.

Bioinformatics 2010 Jun 20;26(11):1437-45. Epub 2010 Apr 20.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London W2 1PG, UK.

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http://dx.doi.org/10.1093/bioinformatics/btq157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913665PMC
June 2010

Interpreting low template DNA profiles.

Forensic Sci Int Genet 2009 Dec 2;4(1):1-10. Epub 2009 May 2.

Department of Epidemiology and Public Health, Imperial College, St Mary's Campus, Norfolk Place, London W21PG, UK.

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http://dx.doi.org/10.1016/j.fsigen.2009.03.003DOI Listing
December 2009

Bayesian statistical methods for genetic association studies.

Nat Rev Genet 2009 Oct;10(10):681-90

Departments of Statistics and Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://www.nature.com/articles/nrg2615
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http://dx.doi.org/10.1038/nrg2615DOI Listing
October 2009

Inferring population history with DIY ABC: a user-friendly approach to approximate Bayesian computation.

Bioinformatics 2008 Dec 7;24(23):2713-9. Epub 2008 Oct 7.

Department of Epidemiology and Public Health, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1093/bioinformatics/btn514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639274PMC
December 2008

Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions.

BMC Bioinformatics 2008 Dec 1;9:513. Epub 2008 Dec 1.

Department of Epidemiology and Public Health, Imperial College, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/1471-2105-9-513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647950PMC
December 2008

Fregene: simulation of realistic sequence-level data in populations and ascertained samples.

BMC Bioinformatics 2008 Sep 8;9:364. Epub 2008 Sep 8.

Department of Epidemiology and Public Health, Imperial College, St Mary's Campus, Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/1471-2105-9-364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542380PMC
September 2008

Confounding between recombination and selection, and the Ped/Pop method for detecting selection.

Genome Res 2008 Aug 10;18(8):1304-13. Epub 2008 Jul 10.

Department of Epidemiology and Public Health, Imperial College London, UK.

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http://dx.doi.org/10.1101/gr.067181.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493435PMC
August 2008

Functional constraint and small insertions and deletions in the ENCODE regions of the human genome.

Genome Biol 2007 ;8(9):R180

Department of Epidemiology and Public Health, Imperial College, Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/gb-2007-8-9-r180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375018PMC
May 2008

Population structure and inbreeding from pedigree analysis of purebred dogs.

Genetics 2008 May;179(1):593-601

Department of Epidemiology and Public Health, Imperial College, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1534/genetics.107.084954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390636PMC
May 2008

Disease association tests by inferring ancestral haplotypes using a hidden markov model.

Bioinformatics 2008 Apr 23;24(7):972-8. Epub 2008 Feb 23.

Department of Epidemiology and Public Health, Imperial College, London W2 1PG, UK.

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http://dx.doi.org/10.1093/bioinformatics/btn071DOI Listing
April 2008

Genome-wide significance for dense SNP and resequencing data.

Genet Epidemiol 2008 Feb;32(2):179-85

Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London, UK.

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http://dx.doi.org/10.1002/gepi.20292DOI Listing
February 2008

Variation in estimated recombination rates across human populations.

Hum Genet 2007 Nov 3;122(3-4):301-10. Epub 2007 Jul 3.

Department of Statistics and Operations Research, Universitat Politècnica de Catalunya, Avinguda Diagonal 647, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1007/s00439-007-0391-6DOI Listing
November 2007

Sequence-level population simulations over large genomic regions.

Genetics 2007 Nov 18;177(3):1725-31. Epub 2007 Oct 18.

Department of Epidemiology and Public Health, Imperial College, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1534/genetics.106.069088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147962PMC
November 2007

Family-based association analysis with ordered categorical phenotypes, covariates and interactions.

Genet Epidemiol 2007 Jan;31(1):1-8

Section of Applied Statistics, The University of Reading, Reading, UK.

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http://dx.doi.org/10.1002/gepi.20183DOI Listing
January 2007

A tutorial on statistical methods for population association studies.

Authors:
David J Balding

Nat Rev Genet 2006 Oct;7(10):781-91

Department of Epidemiology and Public Health, Imperial College, St Marys Campus, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nrg1916DOI Listing
October 2006

Discrimination of half-siblings when maternal genotypes are known.

Forensic Sci Int 2006 Jun 8;159(2-3):141-7. Epub 2005 Sep 8.

Department of Epidemiology and Public Health, Imperial College, St. Mary's Campus, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1016/j.forsciint.2005.07.007DOI Listing
June 2006

Logistic regression protects against population structure in genetic association studies.

Genome Res 2006 Feb 14;16(2):290-6. Epub 2005 Dec 14.

Department of Epidemiology and Public Health, Imperial College, St. Mary's Campus, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1101/gr.4346306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361725PMC
February 2006

Paternity index calculations when some individuals share common ancestry.

Forensic Sci Int 2005 Jun 8;151(1):101-3. Epub 2004 Dec 8.

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http://dx.doi.org/10.1016/j.forsciint.2004.10.007DOI Listing
June 2005

Clustering of protein domains in the human genome.

J Mol Biol 2004 Jul;340(5):991-1004

Department of Epidemiology and Public Health, Imperial College, St Mary's Campus, London W2 1PG, UK.

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http://dx.doi.org/10.1016/j.jmb.2004.05.036DOI Listing
July 2004

Identifying adaptive genetic divergence among populations from genome scans.

Mol Ecol 2004 Apr;13(4):969-80

School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK.

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http://dx.doi.org/10.1111/j.1365-294x.2004.02125.xDOI Listing
April 2004

Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity.

Proc Natl Acad Sci U S A 2003 Nov 3;100(23):13442-6. Epub 2003 Nov 3.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.2235031100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263833PMC
November 2003

Likelihood-based inference for genetic correlation coefficients.

Authors:
David J Balding

Theor Popul Biol 2003 May;63(3):221-30

Department of Epidemiology and Public Health, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

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May 2003

Approximate Bayesian computation in population genetics.

Genetics 2002 Dec;162(4):2025-35

School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462356PMC
December 2002

Implications for DNA identification arising from an analysis of Australian forensic databases.

Forensic Sci Int 2002 Sep;129(2):90-8

School of Applied Statistics, The University of Reading, P.O. Box 240, Earley Gate, UK.

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http://dx.doi.org/10.1016/s0379-0738(02)00232-3DOI Listing
September 2002

The DNA database search controversy.

Authors:
David J Balding

Biometrics 2002 Mar;58(1):241-4

Department of Applied Statistics, University of Reading, UK.

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March 2002