David J Adams

David J Adams

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David J Adams

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Malta (MYH9 Associated Elastin Aggregation) Syndrome: Germline Variants in MYH9 Cause Rare Sweat Duct Proliferations and Irregular Elastin Aggregations.

J Invest Dermatol 2019 Oct 22;139(10):2238-2241.e6. Epub 2019 May 22.

Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom; East Anglian Medical Genetics Service, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.03.1151DOI Listing
October 2019

α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement.

ACS Chem Neurosci 2019 Oct 9;10(10):4328-4336. Epub 2019 Sep 9.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy , Ocean University of China , 5 Yushan Road , Qingdao 266003 , China.

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http://dx.doi.org/10.1021/acschemneuro.9b00389DOI Listing
October 2019

Melanoma predisposition-A limited role for germline BRCA1 and BRCA2 variants.

Pigment Cell Melanoma Res 2019 Oct 14. Epub 2019 Oct 14.

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http://dx.doi.org/10.1111/pcmr.12833DOI Listing
October 2019

Bombesin receptors as potential targets for anticancer drug delivery and imaging.

Int J Biochem Cell Biol 2019 Sep 8;114:105567. Epub 2019 Jul 8.

School of Nano Sciences, Central University of Gujarat, Gandhinagar, 382030, Gujarat, India. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2019.105567DOI Listing
September 2019

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor.

Br J Pharmacol 2019 Aug 7;176(15):2750-2763. Epub 2019 Jun 7.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1111/bph.14698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609542PMC
August 2019

Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels.

Br J Pharmacol 2019 Jul 16;176(13):2264-2278. Epub 2019 May 16.

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.

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http://dx.doi.org/10.1111/bph.14676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555866PMC
July 2019

Derivation and maintenance of mouse haploid embryonic stem cells.

Nat Protoc 2019 Jul 3;14(7):1991-2014. Epub 2019 Jun 3.

UK Dementia Research Institute at University of Cambridge and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41596-019-0169-zDOI Listing
July 2019

VCF/Plotein: Visualisation and prioritisation of genomic variants from human exome sequencing projects.

Bioinformatics 2019 Jun 4. Epub 2019 Jun 4.

Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, Qro., Mexico.

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http://dx.doi.org/10.1093/bioinformatics/btz458DOI Listing
June 2019

ZMYM2 inhibits NANOG-mediated reprogramming.

Wellcome Open Res 2019 6;4:88. Epub 2019 Jun 6.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, Cambridgeshire, CB2 1QR, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.15250.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640293PMC
June 2019

Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities.

J Pathol 2019 Apr 15;247(5):539-551. Epub 2019 Feb 15.

Experimental Cancer Genetics, The Wellcome Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1002/path.5213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492003PMC
April 2019

A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma.

Pigment Cell Melanoma Res 2019 03 19;32(2):332-335. Epub 2018 Oct 19.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1111/pcmr.12737DOI Listing
March 2019

Collateral damage and CRISPR genome editing.

PLoS Genet 2019 03 14;15(3):e1007994. Epub 2019 Mar 14.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1007994
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http://dx.doi.org/10.1371/journal.pgen.1007994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417652PMC
March 2019

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis.

Nat Commun 2019 03 29;10(1):1425. Epub 2019 Mar 29.

Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-09321-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441055PMC
March 2019

Monoclonal Antibody-Conjugated Dendritic Nanostructures for siRNA Delivery.

Methods Mol Biol 2019 ;1974:195-201

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW, Australia.

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http://dx.doi.org/10.1007/978-1-4939-9220-1_14DOI Listing
January 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183030
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http://dx.doi.org/10.1016/j.chembiol.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505PMC
December 2018

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.

J Natl Cancer Inst 2018 12;110(12):1328-1341

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1093/jnci/djy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292796PMC
December 2018

Pulmonary metastatic colonisation and granulomas in NOX2-deficient mice.

J Pathol 2018 11 19;246(3):300-310. Epub 2018 Sep 19.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1002/path.5140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221033PMC
November 2018

Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers.

Clin Cancer Res 2018 10 27;24(20):5133-5142. Epub 2018 Jun 27.

Division of Pathology, Centre for Comparative Pathology, Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-3713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193541PMC
October 2018

Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma.

Clin Lymphoma Myeloma Leuk 2018 10 29;18(10):679-686. Epub 2018 Jul 29.

Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2018.07.285DOI Listing
October 2018

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB.

Biochem Pharmacol 2018 09 21;155:288-297. Epub 2018 Jul 21.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.07.007DOI Listing
September 2018

No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice.

PLoS Genet 2018 07 9;14(7):e1007503. Epub 2018 Jul 9.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057650PMC
July 2018

α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.

Br J Pharmacol 2018 06 11;175(11):1855-1868. Epub 2017 Jun 11.

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW, Australia.

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http://dx.doi.org/10.1111/bph.13852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979624PMC
June 2018

Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1.

Br J Pharmacol 2018 06 21;175(12):2284-2295. Epub 2017 Jul 21.

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.

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http://dx.doi.org/10.1111/bph.13910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980596PMC
June 2018

Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.

Br J Pharmacol 2018 06 13;175(12):2384-2398. Epub 2018 Feb 13.

Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, Australia.

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http://dx.doi.org/10.1111/bph.14115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980271PMC
June 2018

Contribution of membrane receptor signalling to chronic visceral pain.

Int J Biochem Cell Biol 2018 05 21;98:10-23. Epub 2018 Mar 21.

Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia; Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, SA, 5000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2018.02.017DOI Listing
May 2018

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype.

J Med Chem 2018 05 15;61(10):4628-4634. Epub 2018 May 15.

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong , Wollongong , New South Wales 2522 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00115DOI Listing
May 2018

Whole-exome sequencing of a meningeal melanocytic tumour reveals activating CYSLTR2 and EIF1AX hotspot mutations and similarities to uveal melanoma.

Brain Tumor Pathol 2018 04 23;35(2):127-130. Epub 2018 Feb 23.

Department of Neurosurgery, Radboud University Medical Center, P.O. Box 9101, IPC 633, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s10014-018-0308-1DOI Listing
April 2018

Widespread spontaneous hyperproliferation, melanosis and melanoma in Hgf-Cdk4R24C mice.

Melanoma Res 2018 02;28(1):76-78

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge.

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http://dx.doi.org/10.1097/CMR.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739287PMC
February 2018

Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons.

Neuropharmacology 2017 Dec 19;127:116-123. Epub 2017 May 19.

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, 2522, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.05.020DOI Listing
December 2017

In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens.

Neuropharmacology 2017 Dec 14;127:253-259. Epub 2017 Sep 14.

Marine Biochemical Sciences, Chemical Sciences Division, National Institute of Standards and Technology, 331 Fort Johnson Road, Charleston, SC 29412, USA; Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431-0991, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908173043
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http://dx.doi.org/10.1016/j.neuropharm.2017.09.020DOI Listing
December 2017

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.

Nat Protoc 2017 Dec 2;12(12):2465-2477. Epub 2017 Nov 2.

Experimental Cancer Genetics Group, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nprot.2017.118DOI Listing
December 2017

Neuropharmacology of venom peptides.

Neuropharmacology 2017 12 14;127:1-3. Epub 2017 Nov 14.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD Australia.

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http://dx.doi.org/10.1016/j.neuropharm.2017.11.025DOI Listing
December 2017

Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing.

Nat Commun 2017 12 11;8(1):2128. Epub 2017 Dec 11.

Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK.

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http://dx.doi.org/10.1038/s41467-017-02001-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723634PMC
December 2017

Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis.

Nat Commun 2017 12 11;8(1):2026. Epub 2017 Dec 11.

Department of Oncology, University of Cambridge, CRUK Cambridge institute, Cambridge, CB2 0RE, UK.

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http://dx.doi.org/10.1038/s41467-017-02245-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725450PMC
December 2017

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer.

J Biol Chem 2017 10 28;292(41):17101-17112. Epub 2017 Aug 28.

From the Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia and

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http://dx.doi.org/10.1074/jbc.M117.808386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641895PMC
October 2017

Sanger Institute series: uncovering the genetics of cancer: an interview with David Adams.

Authors:
David J Adams

Future Oncol 2017 Oct 6;13(24):2133-2135. Epub 2017 Oct 6.

Wellcome Trust Sanger Institute, Cambridge, UK, CB10 1SA.

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http://dx.doi.org/10.2217/fon-2017-0312DOI Listing
October 2017

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.

Sci Data 2017 09 12;4:170129. Epub 2017 Sep 12.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1038/sdata.2017.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827107PMC
September 2017

Role of Cys-Cys Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors.

ACS Omega 2017 Aug 17;2(8):4621-4631. Epub 2017 Aug 17.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

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http://dx.doi.org/10.1021/acsomega.7b00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044955PMC
August 2017

Melanoma: a global perspective.

Nat Rev Cancer 2017 07 28;17(7):393-394. Epub 2017 Apr 28.

Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro 76230, México.

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http://www.nature.com/articles/nrc.2017.43
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http://dx.doi.org/10.1038/nrc.2017.43DOI Listing
July 2017

Identifying transposon insertions and their effects from RNA-sequencing data.

Nucleic Acids Res 2017 Jul;45(12):7064-7077

Division of Molecular Pathology and Cancer Genomics Netherlands, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkx461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499543PMC
July 2017

Peptide grafted and self-assembled poly(γ-glutamic acid)-phenylalanine nanoparticles targeting camptothecin to glioma.

Nanomedicine (Lond) 2017 Jul 21;12(14):1661-1674. Epub 2017 Jun 21.

Health Innovations Research Institute, RMIT University, Melbourne, VIC 3083, Australia.

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http://dx.doi.org/10.2217/nnm-2017-0067DOI Listing
July 2017

A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA.

Mar Drugs 2017 Jun 5;15(6). Epub 2017 Jun 5.

Department of Central Laboratory, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

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http://dx.doi.org/10.3390/md15060164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484114PMC
June 2017

Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor.

Mar Drugs 2017 Jun 9;15(6). Epub 2017 Jun 9.

Department of Central Laboratory, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

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http://www.mdpi.com/1660-3397/15/6/170
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http://dx.doi.org/10.3390/md15060170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484120PMC
June 2017

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

J Pathol 2017 04 7;241(5):649-660. Epub 2017 Mar 7.

University of Edinburgh, Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1002/path.4869DOI Listing
April 2017

Synthetic lethality: emerging targets and opportunities in melanoma.

Pigment Cell Melanoma Res 2017 03 11;30(2):183-193. Epub 2017 Mar 11.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/pcmr.12573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396340PMC
March 2017

Revisiting olfactory receptors as putative drivers of cancer.

Wellcome Open Res 2017 Feb 10;2. Epub 2017 Feb 10.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.10646.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421569PMC
February 2017