David I Watkins

David I Watkins

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David I Watkins

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Vaccine protection against SIVmac239 acquisition.

Proc Natl Acad Sci U S A 2019 01 14;116(5):1739-1744. Epub 2019 Jan 14.

Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136;

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http://dx.doi.org/10.1073/pnas.1814584116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358712PMC
January 2019

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Rigorous Simian Immunodeficiency Virus Vaccine Trials Can Be Instructive.

Cold Spring Harb Perspect Biol 2018 04 2;10(4). Epub 2018 Apr 2.

Department of Pathology, University of Miami, Miami, Florida 33136.

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http://dx.doi.org/10.1101/cshperspect.a029504DOI Listing
April 2018

The role of MHC class I gene products in SIV infection of macaques.

Immunogenetics 2017 08 10;69(8-9):511-519. Epub 2017 Jul 10.

Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1007/s00251-017-0997-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537376PMC
August 2017

Genomic epidemiology reveals multiple introductions of Zika virus into the United States.

Nature 2017 06 24;546(7658):401-405. Epub 2017 May 24.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature22400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536180PMC
June 2017

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.

J Virol 2015 Oct 12;89(20):10625-36. Epub 2015 Aug 12.

Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA

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http://dx.doi.org/10.1128/JVI.01699-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580207PMC
October 2015

Improved genetic stability of recombinant yellow fever 17D virus expressing a lentiviral Gag gene fragment.

Virology 2014 Mar 8;452-453:202-11. Epub 2014 Feb 8.

Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955954PMC
March 2014

Protection against high-dose highly pathogenic mucosal SIV challenge at very low serum neutralizing titers of the antibody-like molecule CD4-IgG2.

PLoS One 2012 27;7(7):e42209. Epub 2012 Jul 27.

Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042209PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407103PMC
January 2013

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo.

Proc Natl Acad Sci U S A 2012 Nov 25;109(46):18921-5. Epub 2012 Oct 25.

Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1214785109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503218PMC
November 2012

Update on progress in HIV vaccine development.

Authors:
David I Watkins

Top Antivir Med 2012 Jun-Jul;20(2):30-1

University of Miami Miller School of Medicine, FL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148867PMC
October 2012

Escape from CD8(+) T cell responses in Mamu-B*00801(+) macaques differentiates progressors from elite controllers.

J Immunol 2012 Apr 2;188(7):3364-70. Epub 2012 Mar 2.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.

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http://dx.doi.org/10.4049/jimmunol.1102470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883130PMC
April 2012

Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques.

Immunogenetics 2012 Feb 1;64(2):111-21. Epub 2011 Sep 1.

Microbiology Doctoral Training Program, University of Wisconsin-Madison, 1326 Microbial Sciences, 1550 Linden Drive, Madison, WI 53706, USA.

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http://dx.doi.org/10.1007/s00251-011-0566-0DOI Listing
February 2012

HIV vaccine development.

Authors:
David I Watkins

Top Antivir Med 2011 May-Jun;19(2):36-7

Department of Pathology, University of Wisconsin-Madison, Madison, WI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148951PMC
January 2012

CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission.

J Virol 2011 Dec 28;85(23):12804-10. Epub 2011 Sep 28.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 555 Science Dr., Madison, WI 53711, USA.

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http://dx.doi.org/10.1128/JVI.05841-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209381PMC
December 2011

Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.

J Virol 2011 Jul 18;85(14):7454-9. Epub 2011 May 18.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 555 Science Dr., Madison, WI 53711, USA.

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http://dx.doi.org/10.1128/JVI.00738-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126606PMC
July 2011

Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses.

Curr Opin HIV AIDS 2011 May;6(3):197-201

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1097/COH.0b013e3283453e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789597PMC
May 2011

CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection.

J Virol 2010 Nov 25;84(21):11569-74. Epub 2010 Aug 25.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.

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http://dx.doi.org/10.1128/JVI.01419-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953171PMC
November 2010

Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection.

J Virol 2010 Oct 4;84(20):10907-12. Epub 2010 Aug 4.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01357-10
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http://dx.doi.org/10.1128/JVI.01357-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950557PMC
October 2010

Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid.

Immunogenetics 2010 Oct 2;62(10):701-7. Epub 2010 Sep 2.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.

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http://dx.doi.org/10.1007/s00251-010-0473-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018234PMC
October 2010

HIV vaccine development.

Authors:
David I Watkins

Top HIV Med 2010 Apr-May;18(2):35-6

Department of Pathology, University of Wisconsin Madison, Madison, WI, USA.

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August 2010

T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge.

J Virol 2010 May 17;84(9):4352-65. Epub 2010 Feb 17.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 555 Science Dr., Madison, WI 53711, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02365-09
Publisher Site
http://dx.doi.org/10.1128/JVI.02365-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863752PMC
May 2010

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L.

J Virol 2010 Feb 11;84(3):1302-13. Epub 2009 Nov 11.

Department of Immunology and Microbial Science and the International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/JVI.01272-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812338PMC
February 2010

Synchronous infection of SIV and HIV in vitro for virology, immunology and vaccine-related studies.

Nat Protoc 2010 Feb 21;5(2):239-46. Epub 2010 Jan 21.

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1038/nprot.2009.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936483PMC
February 2010

Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Basic HIV vaccine development.

Authors:
David I Watkins

Top HIV Med 2008 Apr-May;16(1):7-8

Department of Pathology, AIDS Vaccine Research Laboratory, University of Wisconsin Madison, Madison, WI, USA.

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January 2010

Is an HIV vaccine possible?

Braz J Infect Dis 2009 Aug;13(4):304-10

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Wisconsin 53711, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893404PMC
August 2009

HIV Vaccine Development.

Authors:
David I Watkins

Top HIV Med 2009 Apr-May;17(2):35-6

Department of Pathology, University of Wisconsin Madison, Madison, WI, USA.

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July 2009

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers.

PLoS Pathog 2009 May 15;5(5):e1000433. Epub 2009 May 15.

Department of Immunology and Microbial Science, and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674935PMC
May 2009

Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.

J Exp Med 2009 Apr 6;206(4):923-36. Epub 2009 Apr 6.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20081127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715115PMC
April 2009

Relevance of studying T cell responses in SIV-infected rhesus macaques.

Trends Microbiol 2008 Dec 27;16(12):605-11. Epub 2008 Oct 27.

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, 53711 USA.

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http://dx.doi.org/10.1016/j.tim.2008.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963024PMC
December 2008

The vaccine search goes on.

Authors:
David I Watkins

Sci Am 2008 Nov;299(5):69-74, 76

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http://dx.doi.org/10.1038/scientificamerican1108-69DOI Listing
November 2008

Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

Nat Rev Immunol 2008 Aug;8(8):619-30

Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK.

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http://dx.doi.org/10.1038/nri2357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963026PMC
August 2008

HIV vaccine research: the way forward.

Science 2008 Jul;321(5888):530-2

National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.1161000DOI Listing
July 2008

Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans.

Nat Med 2008 Jun;14(6):617-21

Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, Wisconsin 53715, USA.

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http://dx.doi.org/10.1038/nm.f.1759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697853PMC
June 2008

Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus.

Curr Opin HIV AIDS 2008 May;3(3):393-8

Wisconsin National Primate Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1097/COH.0b013e3282faa461DOI Listing
May 2008

The hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a review.

Authors:
David I Watkins

Mem Inst Oswaldo Cruz 2008 Mar;103(2):119-29

Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997999PMC
http://dx.doi.org/10.1590/s0074-02762008000200001DOI Listing
March 2008

Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences.

J Virol 2008 Jan 24;82(1):575-81. Epub 2007 Oct 24.

Wisconsin National Primate Research Center, Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1128/JVI.00275-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224389PMC
January 2008

Molecular typing of major histocompatibility complex class I alleles in the Indian rhesus macaque which restrict SIV CD8+ T cell epitopes.

Immunogenetics 2007 Sep 20;59(9):693-703. Epub 2007 Jul 20.

Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.

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http://dx.doi.org/10.1007/s00251-007-0233-7DOI Listing
September 2007

Mamu-B*08-positive macaques control simian immunodeficiency virus replication.

J Virol 2007 Aug 30;81(16):8827-32. Epub 2007 May 30.

Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.

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http://dx.doi.org/10.1128/JVI.00895-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951344PMC
August 2007

Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine.

J Virol 2007 May 7;81(10):5202-11. Epub 2007 Mar 7.

International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1128/JVI.02881-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900223PMC
May 2007

Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil.

Braz J Infect Dis 2007 Feb;11(1):27-30

Advanced Public Health Laboratory, Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, BA, Brazil.

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February 2007