David Housman

David Housman

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David Housman

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IKKβ slows Huntington's disease progression in R6/1 mice.

Proc Natl Acad Sci U S A 2019 May 14;116(22):10952-10961. Epub 2019 May 14.

Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1814246116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561205PMC
May 2019

Could antiretrovirals be treating EBV in MS? A case report.

Mult Scler Relat Disord 2018 May 27;22:19-21. Epub 2018 Feb 27.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2018.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100748PMC
May 2018

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models.

Sci Rep 2017 10 2;7(1):12556. Epub 2017 Oct 2.

UCL Huntington's Disease Centre, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-12897-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624871PMC
October 2017

Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists?

Nurs Res 2017 Mar/Apr;66(2):198-205

Jacquelyn Y. Taylor, PhD, PNP-BC, RN, FAHA, FAAN, is Associate Professor and Associate Dean of Diversity and Inclusion, School of Nursing, Yale University, Orange, Connecticut. Michelle L. Wright, PhD, RN, is Assistant Research Professor, School of Nursing, Emory University, Atlanta, Georgia. She was a Postdoctoral Associate, School of Nursing, Yale University, Orange, Connecticut, at the time this work was completed Kathleen T. Hickey, EdD, FNP, ANP, FAHA, FAAN, is Associate Professor, School of Nursing, Columbia University, New York, New York. David E. Housman, PhD, is Virginia and D. K. Ludwig Scholar for Cancer Research and Professor of Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge.

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http://dx.doi.org/10.1097/NNR.0000000000000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334658PMC
May 2017

Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.

Cell Rep 2017 05;19(7):1365-1377

Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; UCI MIND, University of California, Irvine, Irvine, CA 92697, USA; Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646270PMC
May 2017

Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.

Proc Natl Acad Sci U S A 2016 10 19;113(40):11318-11323. Epub 2016 Sep 19.

McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1613337113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056098PMC
October 2016

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Proc Natl Acad Sci U S A 2016 09 6;113(38):E5598-607. Epub 2016 Sep 6.

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912; Institute for Brain Science, Brown University, Providence, RI 02912; Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital and Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, East Providence, RI 02915;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035873PMC
http://dx.doi.org/10.1073/pnas.1609221113DOI Listing
September 2016

Lead toxicity and genetics in Flint, MI.

NPJ Genom Med 2016;1. Epub 2016 Jun 22.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/npjgenmed.2016.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936820PMC
June 2016

A perspective for sequencing familial hypercholesterolaemia in African Americans.

NPJ Genom Med 2016 11;1:16012. Epub 2016 May 11.

Department of Primary Care, School of Nursing, Yale University, Orange, CT, USA.

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http://dx.doi.org/10.1038/npjgenmed.2016.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685298PMC
May 2016

Surveying the landscape of Huntington's disease mechanisms, measurements, and medicines.

J Huntingtons Dis 2013 ;2(4):405-36

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.3233/JHD-130072DOI Listing
September 2014

In vivo identification of therapeutic constructs from pooled candidates in HD model mice.

J Huntingtons Dis 2013 ;2(4):437-41

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.3233/JHD-130073DOI Listing
September 2014

Aberrantly spliced HTT, a new player in Huntington's disease pathogenesis.

RNA Biol 2013 Nov 11;10(11):1647-52. Epub 2013 Oct 11.

Koch Institute for Integrative Cancer Research; Massachusetts Institute of Technology; Cambridge, MA USA.

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http://dx.doi.org/10.4161/rna.26706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907474PMC
November 2013

Systematic identification of combinatorial drivers and targets in cancer cell lines.

PLoS One 2013 5;8(4):e60339. Epub 2013 Apr 5.

Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060339PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618473PMC
October 2013

Targeting H3K4 trimethylation in Huntington disease.

Proc Natl Acad Sci U S A 2013 Aug 19;110(32):E3027-36. Epub 2013 Jul 19.

Department of Psychiatry and Human Behavior and UCI Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1073/pnas.1311323110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740882PMC
August 2013

Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Proc Natl Acad Sci U S A 2013 Feb 22;110(6):2354-9. Epub 2013 Jan 22.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.1221292110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568325PMC
February 2013

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice.

Proc Natl Acad Sci U S A 2012 May 23;109(19):7487-92. Epub 2012 Apr 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1204542109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358846PMC
May 2012

Rapid haplotype inference for nuclear families.

Genome Biol 2010 29;11(10):R108. Epub 2010 Oct 29.

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1186/gb-2010-11-10-r108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218664PMC
June 2011

Huntington's disease: can mice lead the way to treatment?

Neuron 2011 Feb;69(3):423-35

The David H. Koch Institute for Integrative Cancer Research at MIT, 500 Main Street, Building 76-553, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685469PMC
February 2011

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

Hum Mol Genet 2010 May 10;19(9):1756-65. Epub 2010 Feb 10.

McGovern Institute for Brain Research, MIT, 43 Vassar Street, Building 46-6133, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/hmg/ddq055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850620PMC
May 2010

Development of a method for the high-throughput quantification of cellular proteins.

Chembiochem 2009 Jul;10(10):1678-88

Novartis Institutes for Biomedical Research Basel, Novartis Pharma AG, Basel, Switzerland.

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http://doi.wiley.com/10.1002/cbic.200900131
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http://dx.doi.org/10.1002/cbic.200900131DOI Listing
July 2009

Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas.

Cancer Res 2009 Mar 10;69(6):2180-4. Epub 2009 Mar 10.

Molecular Oncology Research Institute and Department of Neurosurgery, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3351DOI Listing
March 2009

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2712-6. Epub 2009 Feb 5.

Molecular Oncology Research Institute, Department of Neurosurgery, Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

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http://dx.doi.org/10.1073/pnas.0813314106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650331PMC
February 2009

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.

Science 2008 Oct;322(5902):703-9

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1160058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701511PMC
October 2008

Effects of altered temperature and precipitation on desert protozoa associated with biological soil crusts.

J Eukaryot Microbiol 2006 Nov-Dec;53(6):507-14

Department of Earth, Ecological and Environmental Sciences, University of Toledo, Toledo, OH 43606 USA.

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http://dx.doi.org/10.1111/j.1550-7408.2006.00134.xDOI Listing
February 2008

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Proc Natl Acad Sci U S A 2007 Oct 9;104(42):16685-9. Epub 2007 Oct 9.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0707842104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034257PMC
October 2007

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

J Clin Invest 2007 Jun 10;117(6):1699-707. Epub 2007 May 10.

CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI30575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865026PMC
June 2007

Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.

Proc Natl Acad Sci U S A 2006 Nov 6;103(46):17278-83. Epub 2006 Nov 6.

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Meguro, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1073/pnas.0608357103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634838PMC
November 2006

New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions.

Cell Cycle 2006 Jul 17;5(14):1477-80. Epub 2006 Jul 17.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.4161/cc.5.14.2929DOI Listing
July 2006

Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study.

Atherosclerosis 2006 Mar 7;185(1):210-8. Epub 2005 Jul 7.

Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2005.06.008DOI Listing
March 2006

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Proc Natl Acad Sci U S A 2006 Mar 6;103(11):4246-51. Epub 2006 Mar 6.

Center for Cancer Research, Massachusetts Institute of Technology, Room E18-505, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0511256103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449678PMC
March 2006

Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study.

J Hypertens 2005 Dec;23(12):2193-200

Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1097/01.hjh.0000188728.66183.92DOI Listing
December 2005

Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study.

J Clin Endocrinol Metab 2005 Nov 6;90(11):6257-62. Epub 2005 Sep 6.

National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1210/jc.2005-0670DOI Listing
November 2005

Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.

Am J Hypertens 2005 Nov;18(11):1388-95

Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1016/j.amjhyper.2005.05.023DOI Listing
November 2005

Estrogen receptor alpha gene variation and the risk of stroke.

Stroke 2005 Oct 22;36(10):2281-2. Epub 2005 Sep 22.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1161/01.STR.0000181088.76518.ecDOI Listing
October 2005

Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level.

Hum Mol Genet 2005 Aug 13;14(16):2405-13. Epub 2005 Jul 13.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/hmg/ddi242DOI Listing
August 2005

Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.

Development 2005 Jan 2;132(1):165-76. Epub 2004 Dec 2.

Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17-227, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/dev.01551DOI Listing
January 2005

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.

Nat Med 2004 Sep 29;10(9):982-6. Epub 2004 Aug 29.

Department of Brain and Cognitive Sciences, and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25-618, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nm1098DOI Listing
September 2004

Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study.

J Bone Miner Res 2004 May 22;19(5):773-81. Epub 2003 Dec 22.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1359/JBMR.0301258DOI Listing
May 2004

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis.

Dev Biol 2004 Apr;268(2):429-40

Department of Medicine, The Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ydbio.2003.12.033DOI Listing
April 2004

Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome.

Nature 2004 Feb;427(6975):640-5

Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature02320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618873PMC
February 2004

Association between estrogen receptor alpha gene variation and cardiovascular disease.

JAMA 2003 Nov;290(17):2263-70

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA.

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http://dx.doi.org/10.1001/jama.290.17.2263DOI Listing
November 2003

Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).

Genes Chromosomes Cancer 2003 May;37(1):58-71

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1002/gcc.10207DOI Listing
May 2003

Digital genotyping and haplotyping with polymerase colonies.

Proc Natl Acad Sci U S A 2003 May 2;100(10):5926-31. Epub 2003 May 2.

Lipper Center for Computational Genetics and Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0936399100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156303PMC
May 2003

Role of the WT1 tumor suppressor in murine hematopoiesis.

Blood 2003 Apr 5;101(7):2570-4. Epub 2002 Dec 5.

Center for Cancer Research, the Department of Biology, and the Whitehead Institute, Massachusetts Institute of Technology, Cambridge, USA.

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http://dx.doi.org/10.1182/blood-2002-06-1656DOI Listing
April 2003

Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms.

Plant Physiol 2003 Mar;131(3):1294-301

Malaysia-MIT Biotechnology Partnership Programme, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA.

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http://dx.doi.org/10.1104/pp.012492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166889PMC
March 2003

Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.

Proc Natl Acad Sci U S A 2003 Feb 21;100(3):916-21. Epub 2003 Jan 21.

Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.242741799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298701PMC
February 2003

Architecture of coastal and desert Encelia farinosa (Asteraceae): consequences of plastic and heritable variation in leaf characters.

Am J Bot 2002 Aug;89(8):1303-10

Department of Biology, University of California, Riverside, California 92521 USA;

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http://dx.doi.org/10.3732/ajb.89.8.1303DOI Listing
August 2002

A mammal-specific exon of WT1 is not required for development or fertility.

Mol Cell Biol 2002 Jun;22(12):4433-8

Department of Medicine, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133868PMC
http://dx.doi.org/10.1128/mcb.22.12.4433-4438.2002DOI Listing
June 2002

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

Nat Genet 2002 Apr 25;30(4):367-76. Epub 2002 Mar 25.

Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/articles/ng864
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http://dx.doi.org/10.1038/ng864DOI Listing
April 2002

Genome complexity reduction for SNP genotyping analysis.

Proc Natl Acad Sci U S A 2002 Mar;99(5):2942-7

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.261710699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122452PMC
March 2002

Conducting and reporting research.

Prof Ethics 1995 Spring-Summer;4(3-4):127-54

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http://dx.doi.org/10.5840/profethics199543/415DOI Listing
February 1998