Publications by authors named "David Horst"

93Publications

Correction to: The majority of β-catenin mutations in colorectal cancer is homozygous.

BMC Cancer 2020 Nov 26;20(1):1151. Epub 2020 Nov 26.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Virchoweg 15 / Charitéplatz 1, 10117, Berlin, Germany.

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November 2020

The majority of β-catenin mutations in colorectal cancer is homozygous.

BMC Cancer 2020 Oct 28;20(1):1038. Epub 2020 Oct 28.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Virchoweg 15 / Charitéplatz 1, 10117, Berlin, Germany.

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October 2020

SFPQ Depletion Is Synthetically Lethal with BRAF in Colorectal Cancer Cells.

Cell Rep 2020 Sep;32(12):108184

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health. Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, 10117 Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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September 2020

Discovery of Prognostic Markers for Early-Stage High-Grade Serous Ovarian Cancer by Maldi-Imaging.

Cancers (Basel) 2020 Jul 22;12(8). Epub 2020 Jul 22.

Tumorbank Ovarian Cancer Network, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

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July 2020

Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer.

Cell Mol Gastroenterol Hepatol 2020 15;10(2):391-418. Epub 2020 Apr 15.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium, Partner site Munich, Munich, Germany; German Cancer Research Center, Heidelberg, Germany. Electronic address:

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April 2020

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis.

Cells 2020 01 23;9(2). Epub 2020 Jan 23.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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January 2020

Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy.

BMC Cancer 2019 Nov 1;19(1):1033. Epub 2019 Nov 1.

Institut für Pathologie, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.

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November 2019

Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer.

BMC Cancer 2019 Nov 1;19(1):1030. Epub 2019 Nov 1.

Institute of Pathology, University Medical Center Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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November 2019

Next generation sequencing of lung adenocarcinoma subtypes with intestinal differentiation reveals distinct molecular signatures associated with histomorphology and therapeutic options.

Lung Cancer 2019 12 11;138:43-51. Epub 2019 Oct 11.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Pathology, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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December 2019

In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer.

Cancer Sci 2019 Aug 17;110(8):2529-2539. Epub 2019 Jun 17.

Institute of Pathology, Ludwig-Maximilians-Universität Munich, Munich, Germany.

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August 2019

The efficacy of treatment options for patients with gastric cancer and peritoneal metastasis.

Gastric Cancer 2019 11 7;22(6):1226-1237. Epub 2019 May 7.

Department of Surgery, Campus Virchow-Klinikum and Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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November 2019

DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer.

Mod Pathol 2019 06 5;32(6):855-865. Epub 2019 Feb 5.

Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

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June 2019

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.

Nat Commun 2018 09 3;9(1):3573. Epub 2018 Sep 3.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, D-80337, Munich, Germany.

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September 2018

Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

Gastroenterology 2018 12 10;155(6):1868-1882. Epub 2018 Aug 10.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany. Electronic address:

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December 2018

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.

Cancer Cell 2017 Dec;32(6):869-883.e5

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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December 2017

Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer.

Nat Commun 2017 11 10;8(1):1406. Epub 2017 Nov 10.

Pathologisches Institut, Ludwig-Maximilians-Universität München, Thalkirchner Str. 36, 80337, München, Germany.

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November 2017

Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression.

Sci Rep 2017 07 5;7(1):4687. Epub 2017 Jul 5.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany.

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July 2017

Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.

Gastroenterology 2017 08 20;153(2):505-520. Epub 2017 Apr 20.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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August 2017

Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis.

Cancer Res 2017 04 27;77(8):1854-1867. Epub 2017 Jan 27.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany.

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April 2017

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.

Cancer Res 2017 02 29;77(3):766-779. Epub 2016 Nov 29.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.

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February 2017

Identification of recurrent mutational events in anorectal melanoma.

Mod Pathol 2017 02 14;30(2):286-296. Epub 2016 Oct 14.

Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.

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February 2017

Pancreatic CSCs and microenvironment.

Genes Cancer 2015 Sep;6(9-10):365-6

Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Hospital of the University of Munich, Ludwig-Maximilians-University (LMU) Munich (Germany).

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September 2015

Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.

Br J Cancer 2015 Nov 15;113(10):1460-6. Epub 2015 Oct 15.

Institute of Pathology, Ludwig-Maximilians-University, Thalkirchner Strasse 36, Munich 80337, Germany.

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November 2015

ITF-2B protein levels are correlated with favorable prognosis in patients with colorectal carcinomas.

Am J Cancer Res 2015 15;5(7):2241-8. Epub 2015 Jun 15.

Department of Medicine II, University of Munich D-81377 Munich, Germany ; German Cancer Consortium (DKTK) Im Neuenheimer Feld 280, 69120 Heidelberg, Germany ; German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280, 69120 Heidelberg, Germany ; Department of Internal Medicine and Gastroenterology, HELIOS Klinikum Berlin-Buch D-13125 Berlin, Germany.

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September 2015

Colorectal cancers mimic structural organization of normal colonic crypts.

PLoS One 2014 11;9(8):e104284. Epub 2014 Aug 11.

Pathologisches Institut, Ludwig-Maximilians-Universität, München, Germany.

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April 2015

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.

Cell Rep 2014 Jun 29;7(6):1914-25. Epub 2014 May 29.

Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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June 2014

Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men.

Carcinogenesis 2014 Aug 19;35(8):1855-62. Epub 2014 May 19.

Department of Internal Medicine II and German Cancer Consortium (DKTK) and the German Cancer Research Center, Heidelberg, Germany

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August 2014

Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer.

Clin Cancer Res 2013 Feb 14;19(3):710-20. Epub 2012 Dec 14.

Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.

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February 2013

Mold attacks a beating heart.

Respiration 2013 13;85(1):64-5. Epub 2012 Nov 13.

Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany.

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May 2013

Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone.

PLoS One 2012 27;7(7):e41914. Epub 2012 Jul 27.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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January 2013

Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling.

Cancer Res 2012 Mar 8;72(6):1547-56. Epub 2012 Feb 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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March 2012

Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer.

Clin Cancer Res 2012 Feb 5;18(4):956-68. Epub 2011 Dec 5.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Munich, Germany.

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February 2012

The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors.

Exp Mol Pathol 2012 Feb 10;92(1):111-7. Epub 2011 Nov 10.

Pathologisches Institut der Ludwig-Maximilians-Universität München, Thalkirchner Straße 36, D-80337 München, Germany.

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February 2012

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation.

PLoS One 2010 Dec 14;5(12):e14325. Epub 2010 Dec 14.

Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, University of Munich, Munich, Germany.

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December 2010

LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer.

J Transl Med 2010 Nov 22;8:123. Epub 2010 Nov 22.

Department of Pathology, Ludwig-Maximilians-Universität (LMU), Thalkirchnerstr, 36, 80337, Munich, Germany.

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November 2010

Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs.

J Nutr 2010 Dec 27;140(12):2193-200. Epub 2010 Oct 27.

USDA/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.

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December 2010

Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.

J Biol Chem 2010 Nov 26;285(45):35047-55. Epub 2010 Aug 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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November 2010

γ-Catenin is an independent prognostic marker in early stage colorectal cancer.

Int J Colorectal Dis 2010 Nov 25;25(11):1301-9. Epub 2010 Aug 25.

Department of Medicine II, University of Munich, Marchioninistrasse 15, Munich, Germany.

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November 2010

Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer.

Cancer 2009 Nov;115(21):4946-58

Pathologisches Institut der Ludwig-Maximilians-Universität München, Munich, Germany.

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November 2009

Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer.

Cancer Invest 2009 Oct;27(8):844-50

Pathologisches Institut, Ludwig-Maximilians-Universitat Munchen, Germany.

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October 2009

The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer.

J Pathol 2009 Dec;219(4):427-34

Pathologisches Institut der Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, 80337 München, Germany.

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December 2009

CD133 and nuclear beta-catenin: the marker combination to detect high risk cases of low stage colorectal cancer.

Eur J Cancer 2009 Jul 4;45(11):2034-40. Epub 2009 May 4.

Pathologisches Institut der Ludwig-Maximilians-Universität München, Germany.

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July 2009

The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer.

Cancer 2009 May;115(10):2063-70

Pathologisches Institut der Ludwig-Maximilians-Universität, Munich, Germany.

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May 2009

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice.

FEBS Lett 2008 Aug 24;582(19):2911-5. Epub 2008 Jul 24.

Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor-Lynen-Strasse 25, Munich, Germany.

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August 2008

Comparative expression analysis of Pax3 and Pax7 during mouse myogenesis.

Int J Dev Biol 2006 ;50(1):47-54

Klinik und Poliklinik für pädiatrische Hämatologie/Onkologie, Universitätsklinikum Münster, Germany.

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April 2006

High frequency of alpha-thalassemia in the So ethnic group of South Laos.

Acta Haematol 2005 ;114(3):164-6

Department of Pediatrics, Faculty of Medical Sciences, National University of Lao, Vientiane, Lao PDR.

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November 2005