Publications by authors named "David Horst"

93Publications

Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient.

Authors:
Matthias Ochs Sara Timm Sefer Elezkurtaj David Horst Jenny Meinhardt Frank L Heppner Steffen Weber-Carstens Andreas C Hocke Martin Witzenrath

Eur Respir J 2021 Jan 14. Epub 2021 Jan 14.

German Center for Lung Research (DZL), Berlin, Germany.

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January 2021

B Cell Depletion and Signs of Sepsis Acquired Immunodeficiency in Bone Marrow and Spleen of COVID-19 Deceased.

Authors:
Jana Ihlow Edward Michaelis Selina Greuel Verena Heynol Annika Lehmann Helena Radbruch Jenny Meinhardt Florian Miller Hermann Herbst Victor Max Corman Jörg Westermann Lars Bullinger David Horst Ann-Christin von Brünneck Sefer Elezkurtaj

Int J Infect Dis 2021 Jan 2. Epub 2021 Jan 2.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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January 2021

Correction: EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer.

Authors:
Michael Rose Angela Maurer Julia Wirtz Andreas Bleilevens Tanja Waldmann Maximilian Wenz Marie Eyll Mirja Geelvink Melanie Gereitzig Nadine Rüchel Bernd Denecke Elke Eltze Edwin Herrmann Marieta Toma David Horst Tobias Grimm Stefan Denzinger Thorsten Ecke Thomas Alexander Vögeli Ruth Knuechel Jochen Maurer Nadine T Gaisa

Oncogene 2020 Dec 1. Epub 2020 Dec 1.

Institute of Pathology, RWTH Aachen University, Aachen, Germany.

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December 2020

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.

Authors:
Jenny Meinhardt Josefine Radke Carsten Dittmayer Jonas Franz Carolina Thomas Ronja Mothes Michael Laue Julia Schneider Sebastian Brünink Selina Greuel Malte Lehmann Olga Hassan Tom Aschman Elisa Schumann Robert Lorenz Chua Christian Conrad Roland Eils Werner Stenzel Marc Windgassen Larissa Rößler Hans-Hilmar Goebel Hans R Gelderblom Hubert Martin Andreas Nitsche Walter J Schulz-Schaeffer Samy Hakroush Martin S Winkler Björn Tampe Franziska Scheibe Péter Körtvélyessy Dirk Reinhold Britta Siegmund Anja A Kühl Sefer Elezkurtaj David Horst Lars Oesterhelweg Michael Tsokos Barbara Ingold-Heppner Christine Stadelmann Christian Drosten Victor Max Corman Helena Radbruch Frank L Heppner

Nat Neurosci 2020 Nov 30. Epub 2020 Nov 30.

Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

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November 2020

Correction to: The majority of β-catenin mutations in colorectal cancer is homozygous.

Authors:
Alexander Arnold Moritz Tronser Christine Sers Aysel Ahadova Volker Endris Soulafa Mamlouk David Horst Markus Möbs Philip Bischoff Matthias Kloor Hendrik Bläker

BMC Cancer 2020 Nov 26;20(1):1151. Epub 2020 Nov 26.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Virchoweg 15 / Charitéplatz 1, 10117, Berlin, Germany.

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November 2020

The majority of β-catenin mutations in colorectal cancer is homozygous.

Authors:
Alexander Arnold Moritz Tronser Christine Sers Aysel Ahadova Volker Endris Soulafa Mamlouk David Horst Markus Möbs Philip Bischoff Matthias Kloor Hendrik Bläker

BMC Cancer 2020 Oct 28;20(1):1038. Epub 2020 Oct 28.

Institute of Pathology, Charité - Universitätsmedizin Berlin, Virchoweg 15 / Charitéplatz 1, 10117, Berlin, Germany.

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October 2020

EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer.

Authors:
Michael Rose Angela Maurer Julia Wirtz Andreas Bleilevens Tanja Waldmann Maximilian Wenz Marie Eyll Mirja Geelvink Melanie Gereitzig Nadine Rüchel Bernd Denecke Elke Eltze Edwin Herrmann Marieta Toma David Horst Tobias Grimm Stefan Denzinger Thorsten Ecke Thomas Alexander Vögeli Ruth Knuechel Jochen Maurer Nadine T Gaisa

Oncogene 2020 10 25;39(44):6856-6870. Epub 2020 Sep 25.

Institute of Pathology, RWTH Aachen University, Aachen, Germany.

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October 2020

SFPQ Depletion Is Synthetically Lethal with BRAF in Colorectal Cancer Cells.

Authors:
Kathleen Klotz-Noack Bertram Klinger Maria Rivera Natalie Bublitz Florian Uhlitz Pamela Riemer Mareen Lüthen Thomas Sell Katharina Kasack Bastian Gastl Sylvia S S Ispasanie Tincy Simon Nicole Janssen Matthias Schwab Johannes Zuber David Horst Nils Blüthgen Reinhold Schäfer Markus Morkel Christine Sers

Cell Rep 2020 Sep;32(12):108184

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health. Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, 10117 Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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September 2020

Standardization of Reporting Criteria for Lung Pathology in SARS-CoV-2-infected Hamsters: What Matters?

Authors:
Achim D Gruber Nikolaus Osterrieder Luca D Bertzbach Daria Vladimirova Selina Greuel Jana Ihlow David Horst Jakob Trimpert Kristina Dietert

Am J Respir Cell Mol Biol 2020 12;63(6):856-859

Freie Universität Berlin Berlin, Germany and.

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December 2020

Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.

Authors:
Soulafa Mamlouk Tincy Simon Laura Tomás David C Wedge Alexander Arnold Andrea Menne David Horst David Capper Markus Morkel David Posada Christine Sers Hendrik Bläker

BMC Biol 2020 09 7;18(1):116. Epub 2020 Sep 7.

Department für Diagnostik, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Leipzig, Germany.

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September 2020

Age-dependent performance of BRAF mutation testing in Lynch syndrome diagnostics.

Authors:
Hendrik Bläker Saskia Haupt Monika Morak Elke Holinski-Feder Alexander Arnold David Horst Julia Sieber-Frank Florian Seidler Moritz von Winterfeld Elizabeth Alwers Jenny Chang-Claude Hermann Brenner Wilfried Roth Christoph Engel Markus Löffler Gabriela Möslein Hans-Konrad Schackert Jürgen Weitz Claudia Perne Stefan Aretz Robert Hüneburg Wolff Schmiegel Deepak Vangala Nils Rahner Verena Steinke-Lange Vincent Heuveline Magnus von Knebel Doeberitz Aysel Ahadova Michael Hoffmeister Matthias Kloor

Int J Cancer 2020 Nov 14;147(10):2801-2810. Epub 2020 Sep 14.

Department of Applied Tumor Biology, University Hospital Heidelberg, Cooperation Unit Applied Tumor Biology, German Cancer research Center (DKFZ), and Molecular Medicine Partnership Unit (MMPU), University Hospital Heidelberg, Heidelberg, Germany.

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November 2020

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.

Authors:
Honglin Jiang Robert J Torphy Katja Steiger Henry Hongo Alexa J Ritchie Mark Kriegsmann David Horst Sarah E Umetsu Nancy M Joseph Kimberly McGregor Michael J Pishvaian Edik M Blais Brian Lu Mingyu Li Michael Hollingsworth Connor Stashko Keith Volmar Jen Jen Yeh Valerie M Weaver Zhen J Wang Margaret A Tempero Wilko Weichert Eric A Collisson

J Clin Invest 2020 Sep;130(9):4704-4709

Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California, USA.

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September 2020

Discovery of Prognostic Markers for Early-Stage High-Grade Serous Ovarian Cancer by Maldi-Imaging.

Authors:
Hagen Kulbe Oliver Klein Zhiyang Wu Eliane T Taube Wanja Kassuhn David Horst Silvia Darb-Esfahani Paul Jank Salem Abobaker Frauke Ringel Andreas du Bois Florian Heitz Jalid Sehouli Elena I Braicu

Cancers (Basel) 2020 Jul 22;12(8). Epub 2020 Jul 22.

Tumorbank Ovarian Cancer Network, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

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July 2020

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe.

Authors:
Bastian Gastl Kathleen Klotz-Noack Bertram Klinger Sylvia Ispasanie Krenoula Hani Fouad Salib Johannes Zuber Soulafa Mamlouk Natalie Bublitz Nils Blüthgen David Horst Markus Morkel Reinhold Schäfer Christine Sers

Cell Death Dis 2020 07 1;11(7):499. Epub 2020 Jul 1.

Institute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

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July 2020

Measles virus and rinderpest virus divergence dated to the sixth century BCE.

Authors:
Ariane Düx Sebastian Lequime Livia Victoria Patrono Bram Vrancken Sengül Boral Jan F Gogarten Antonia Hilbig David Horst Kevin Merkel Baptiste Prepoint Sabine Santibanez Jasmin Schlotterbeck Marc A Suchard Markus Ulrich Navena Widulin Annette Mankertz Fabian H Leendertz Kyle Harper Thomas Schnalke Philippe Lemey Sébastien Calvignac-Spencer

Science 2020 06;368(6497):1367-1370

Epidemiology of Highly Pathogenic Microorganisms Project Group, Robert Koch Institute, Berlin, Germany.

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June 2020

NTRK testing: First results of the QuiP-EQA scheme and a comprehensive map of NTRK fusion variants and their diagnostic coverage by targeted RNA-based NGS assays.

Authors:
Martina Kirchner Julia Glade Ulrich Lehmann Sabine Merkelbach-Bruse Michael Hummel Annika Lehmann Marcel Trautmann Jörg Kumbrink Andreas Jung Wolfgang Dietmaier Volker Endris Daniel Kazdal Carolin Ploeger Matthias Evert David Horst Hans Kreipe Thomas Kirchner Eva Wardelmann Reinhard Büttner Wilko Weichert Manfred Dietel Peter Schirmacher Albrecht Stenzinger Nicole Pfarr

Genes Chromosomes Cancer 2020 08 9;59(8):445-453. Epub 2020 May 9.

Institute of Pathology, Technical University Munich (TUM), Munich, Germany.

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August 2020

Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer.

Authors:
Xiaolong Shi Markus Kaller Matjaz Rokavec Thomas Kirchner David Horst Heiko Hermeking

Cell Mol Gastroenterol Hepatol 2020 15;10(2):391-418. Epub 2020 Apr 15.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium, Partner site Munich, Munich, Germany; German Cancer Research Center, Heidelberg, Germany. Electronic address:

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April 2020

Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study.

Authors:
Albrecht Stenzinger Volker Endris Jan Budczies Sabine Merkelbach-Bruse Daniel Kazdal Wolfgang Dietmaier Nicole Pfarr Udo Siebolts Michael Hummel Sylvia Herold Johanna Andreas Martin Zoche Lars Tögel Eugen Rempel Jörg Maas Diana Merino Mark Stewart Karim Zaoui Matthias Schlesner Hanno Glimm Stefan Fröhling Jeff Allen David Horst Gustavo Baretton Claudia Wickenhauser Markus Tiemann Matthias Evert Holger Moch Thomas Kirchner Reinhard Büttner Peter Schirmacher Andreas Jung Florian Haller Wilko Weichert Manfred Dietel

J Thorac Oncol 2020 07 29;15(7):1177-1189. Epub 2020 Feb 29.

Quality in Pathology (QuIP), Berlin, Germany.

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July 2020

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis.

Authors:
Simon Hohenester Veronika Kanitz Andreas E Kremer Coen C Paulusma Ralf Wimmer Helen Kuehn Gerald Denk David Horst Ronald Oude Elferink Ulrich Beuers

Cells 2020 01 23;9(2). Epub 2020 Jan 23.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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January 2020

Clinical Evidence on the Interaction Between MLK4, KRAS and Microsatellite Instability to Determine the Prognosis of Early-Stage Colorectal Carcinoma.

Authors:
Lydia Brandl David Horst Thomas G P Grünewald Julia Mayerle Andrea Sendelhofert Jens Neumann Thomas Kirchner Enrico N De Toni

Cell Physiol Biochem 2019 ;53(5):820-831

Department of Medicine 2, University Hospital Grosshadern, University of Munich, Munich, Germany,

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November 2019

Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy.

Authors:
Iryna Trotsyuk Halina Sparschuh Alice Josephine Müller Konrad Neumann Martin Kruschewski David Horst Sefer Elezkurtaj

BMC Cancer 2019 Nov 1;19(1):1033. Epub 2019 Nov 1.

Institut für Pathologie, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.

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November 2019

Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer.

Authors:
Steve Z Martin Daniel C Wagner Nina Hörner David Horst Hauke Lang Katrin E Tagscherer Wilfried Roth

BMC Cancer 2019 Nov 1;19(1):1030. Epub 2019 Nov 1.

Institute of Pathology, University Medical Center Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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November 2019

Testing NTRK testing: Wet-lab and in silico comparison of RNA-based targeted sequencing assays.

Authors:
Nicole Pfarr Martina Kirchner Ulrich Lehmann Jonas Leichsenring Sabine Merkelbach-Bruse Julia Glade Michael Hummel Fabian Stögbauer Annika Lehmann Marcel Trautmann Jörg Kumbrink Andreas Jung Wolfgang Dietmaier Volker Endris Daniel Kazdal Matthias Evert David Horst Hans Kreipe Thomas Kirchner Eva Wardelmann Ulrik Lassen Reinhard Büttner Wilko Weichert Manfred Dietel Peter Schirmacher Albrecht Stenzinger

Genes Chromosomes Cancer 2020 03 18;59(3):178-188. Epub 2019 Nov 18.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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March 2020

Next generation sequencing of lung adenocarcinoma subtypes with intestinal differentiation reveals distinct molecular signatures associated with histomorphology and therapeutic options.

Authors:
Philipp Jurmeister Claudia Vollbrecht Anke Behnke Nikolaj Frost Alexander Arnold Denise Treue Jens-Carsten Rückert Jens Neudecker Leonille Schweizer Frederick Klauschen David Horst Michael Hummel Manfred Dietel Maximilian von Laffert

Lung Cancer 2019 12 11;138:43-51. Epub 2019 Oct 11.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Pathology, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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December 2019

RBP7 is a clinically prognostic biomarker and linked to tumor invasion and EMT in colon cancer.

Authors:
Manal Elmasry Lydia Brandl Jutta Engel Andreas Jung Thomas Kirchner David Horst

J Cancer 2019 27;10(20):4883-4891. Epub 2019 Aug 27.

German Cancer Consortium (DKTK), Heidelberg, Germany.

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August 2019

Papillary vs clear cell renal cell carcinoma. Differentiation and grading by iodine concentration using DECT-correlation with microvascular density.

Authors:
Julian Marcon Anno Graser David Horst Jozefina Casuscelli Annabel Spek Christian G Stief Maximilian F Reiser Johannes Rübenthaler Alexander Buchner Michael Staehler

Eur Radiol 2020 Jan 5;30(1):1-10. Epub 2019 Jul 5.

Department of Urology, Ludwig-Maximilians-Universität München, Munich, Germany.

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January 2020

Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer.

Authors:
Gerald B Schulz Tobias Grimm Christine Sers Pamela Riemer Manal Elmasry Thomas Kirchner Christian G Stief Alexander Karl David Horst

Urol Oncol 2019 08 5;37(8):530.e9-530.e18. Epub 2019 Jun 5.

Department of Pathology, Charité Universitätsmedizin, Berlin, Germany. Electronic address:

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August 2019

In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer.

Authors:
Christoph Spartalis Eva Marina Schmidt Manal Elmasry Gerald Bastian Schulz Thomas Kirchner David Horst

Cancer Sci 2019 Aug 17;110(8):2529-2539. Epub 2019 Jun 17.

Institute of Pathology, Ludwig-Maximilians-Universität Munich, Munich, Germany.

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August 2019

The efficacy of treatment options for patients with gastric cancer and peritoneal metastasis.

Authors:
Beate Rau Andreas Brandl Peter Thuss-Patience Fabian Bergner Wieland Raue Alexander Arnold David Horst Johann Pratschke Matthias Biebl

Gastric Cancer 2019 11 7;22(6):1226-1237. Epub 2019 May 7.

Department of Surgery, Campus Virchow-Klinikum and Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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November 2019

Urinary Calprotectin loses specificity as tumour marker due to sterile leukocyturia associated with bladder cancer.

Authors:
Kathrin Bausch Elisa Roth Stefan Heinz David Horst Susanne Mathia Tatjana Vlajnic Lukas Bubendorf Timm Westhoff Christian Wetterauer Hans Helge Seifert Jan Ebbing

PLoS One 2019 14;14(3):e0213549. Epub 2019 Mar 14.

Urological University-Clinic Basel-Liestal, University Hospital Basel, Basel, Switzerland.

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December 2019

DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer.

Authors:
Philipp Jurmeister Anne Schöler Alexander Arnold Frederick Klauschen Dido Lenze Michael Hummel Leonille Schweizer Hendrik Bläker Berit Maria Pfitzner Soulafa Mamlouk Christine Sers Carsten Denkert Damian Stichel Nikolaj Frost David Horst Maximilian von Laffert David Capper

Mod Pathol 2019 06 5;32(6):855-865. Epub 2019 Feb 5.

Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

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June 2019

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.

Authors:
Stephanie Jaeckel Markus Kaller Rene Jackstadt Ursula Götz Susanna Müller Sophie Boos David Horst Peter Jung Heiko Hermeking

Nat Commun 2018 09 3;9(1):3573. Epub 2018 Sep 3.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, D-80337, Munich, Germany.

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September 2018

Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

Authors:
Meryem Gülfem Öner Matjaz Rokavec Markus Kaller Nassim Bouznad David Horst Thomas Kirchner Heiko Hermeking

Gastroenterology 2018 12 10;155(6):1868-1882. Epub 2018 Aug 10.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany. Electronic address:

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December 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Authors:
Paul K Ziegler Julia Bollrath Charles K Pallangyo Takaji Matsutani Özge Canli Tiago De Oliveira Michaela A Diamanti Nina Müller Jaba Gamrekelashvili Tracy Putoczki David Horst Arun K Mankan Meryem G Öner Susanna Müller Josef Müller-Höcker Thomas Kirchner Julia Slotta-Huspenina M Mark Taketo Thomas Reinheckel Stefan Dröse Andrew C Larner Winfried S Wels Matthias Ernst Tim F Greten Melek C Arkan Thomas Korn Dagmar Wirth Florian R Greten

Cell 2018 06 14;174(1):88-101.e16. Epub 2018 Jun 14.

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt am, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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June 2018

Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer.

Authors:
Eva Marina Schmidt Sebastian Lamprecht Cristina Blaj Christian Schaaf Stefan Krebs Helmut Blum Heiko Hermeking Andreas Jung Thomas Kirchner David Horst

J Exp Med 2018 06 16;215(6):1693-1708. Epub 2018 May 16.

Pathologisches Institut, Ludwig-Maximilians-Universität München, Munich, Germany.

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June 2018

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.

Authors:
Joachim Pircher Thomas Czermak Andreas Ehrlich Clemens Eberle Erik Gaitzsch Andreas Margraf Jochen Grommes Prakash Saha Anna Titova Hellen Ishikawa-Ankerhold Konstantin Stark Tobias Petzold Thomas Stocker Ludwig T Weckbach Julia Novotny Markus Sperandio Bernhard Nieswandt Alberto Smith Hanna Mannell Barbara Walzog David Horst Oliver Soehnlein Steffen Massberg Christian Schulz

Nat Commun 2018 04 18;9(1):1523. Epub 2018 Apr 18.

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-University, 81377, Munich, Germany.

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April 2018

Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications.

Authors:
Isabella Barth Ursula Schneider Tobias Grimm Alexander Karl David Horst Nadine T Gaisa Ruth Knüchel Stefan Garczyk

Virchows Arch 2018 May 13;472(5):749-758. Epub 2018 Apr 13.

Institute of Pathology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.

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May 2018

PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer.

Authors:
Sebastian Lamprecht Markus Kaller Eva Marina Schmidt Cristina Blaj Tobias S Schiergens Jutta Engel Andreas Jung Heiko Hermeking Thomas G P Grünewald Thomas Kirchner David Horst

Clin Cancer Res 2018 04 1;24(8):1974-1986. Epub 2018 Feb 1.

Pathologisches Institut, Ludwig-Maximilians-Universität München, Germany.

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April 2018

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.

Authors:
Özge Canli Adele M Nicolas Jalaj Gupta Fabian Finkelmeier Olga Goncharova Marina Pesic Tobias Neumann David Horst Martin Löwer Ugur Sahin Florian R Greten

Cancer Cell 2017 Dec;32(6):869-883.e5

Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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December 2017

Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer.

Authors:
Sebastian Lamprecht Eva Marina Schmidt Cristina Blaj Heiko Hermeking Andreas Jung Thomas Kirchner David Horst

Nat Commun 2017 11 10;8(1):1406. Epub 2017 Nov 10.

Pathologisches Institut, Ludwig-Maximilians-Universität München, Thalkirchner Str. 36, 80337, München, Germany.

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November 2017

Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression.

Authors:
Matjaz Rokavec Markus Kaller David Horst Heiko Hermeking

Sci Rep 2017 07 5;7(1):4687. Epub 2017 Jul 5.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany.

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July 2017

Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.

Authors:
Huihui Li Matjaz Rokavec Longchang Jiang David Horst Heiko Hermeking

Gastroenterology 2017 08 20;153(2):505-520. Epub 2017 Apr 20.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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August 2017

Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations.

Authors:
Cristina Blaj Eva Marina Schmidt Sebastian Lamprecht Heiko Hermeking Andreas Jung Thomas Kirchner David Horst

Cancer Res 2017 04 15;77(7):1763-1774. Epub 2017 Feb 15.

Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany.

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April 2017

Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis.

Authors:
Matjaz Rokavec David Horst Heiko Hermeking

Cancer Res 2017 04 27;77(8):1854-1867. Epub 2017 Jan 27.

Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany.

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April 2017

ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer.

Authors:
Cristina Blaj Agnes Bringmann Eva Marina Schmidt Manuela Urbischek Sebastian Lamprecht Thomas Fröhlich Georg J Arnold Stefan Krebs Helmut Blum Heiko Hermeking Andreas Jung Thomas Kirchner David Horst

Clin Cancer Res 2017 Jun 30;23(11):2769-2780. Epub 2016 Nov 30.

Pathologisches Institut, Ludwig-Maximilians-Universität München, Germany.

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June 2017

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.

Authors:
Paloma Cejas Alessia Cavazza C N Yandava Victor Moreno David Horst Juan Moreno-Rubio Emilio Burgos Marta Mendiola Len Taing Ajay Goel Jaime Feliu Ramesh A Shivdasani

Cancer Res 2017 02 29;77(3):766-779. Epub 2016 Nov 29.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.

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February 2017

Identification of recurrent mutational events in anorectal melanoma.

Authors:
Hui Min Yang Susan J Hsiao David F Schaeffer Chi Lai Helen E Remotti David Horst Mahesh M Mansukhani Basil A Horst

Mod Pathol 2017 02 14;30(2):286-296. Epub 2016 Oct 14.

Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.

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February 2017

In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.

Authors:
Christine Woischke Christian W Schaaf Hui-Min Yang Michael Vieth Lothar Veits Helene Geddert Bruno Märkl Peter Stömmer David F Schaeffer Matthias Frölich Helmut Blum Sebastian Vosberg Philipp A Greif Andreas Jung Thomas Kirchner David Horst

Mod Pathol 2017 01 2;30(1):95-103. Epub 2016 Sep 2.

Pathologisches Institut der Ludwig-Maximilians-Universität (LMU), München, Germany.

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January 2017

CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer.

Authors:
Christine Woischke Cristina Blaj Eva Marina Schmidt Sebastian Lamprecht Jutta Engel Heiko Hermeking Thomas Kirchner David Horst

Oncotarget 2016 May;7(21):31350-60

Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Germany.

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May 2016

Pancreatic CSCs and microenvironment.

Authors:
Matthias Ilmer David Horst

Genes Cancer 2015 Sep;6(9-10):365-6

Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Hospital of the University of Munich, Ludwig-Maximilians-University (LMU) Munich (Germany).

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September 2015

Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.

Authors:
Steffen Ormanns Annelore Altendorf-Hofmann Rene Jackstadt David Horst Gerald Assmann Yue Zhao Christiane Bruns Thomas Kirchner Thomas Knösel

Br J Cancer 2015 Nov 15;113(10):1460-6. Epub 2015 Oct 15.

Institute of Pathology, Ludwig-Maximilians-University, Thalkirchner Strasse 36, Munich 80337, Germany.

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November 2015

ITF-2B protein levels are correlated with favorable prognosis in patients with colorectal carcinomas.

Authors:
Lydia Brandl David Horst Enrico de Toni Thomas Kirchner Andreas Herbst Frank T Kolligs

Am J Cancer Res 2015 15;5(7):2241-8. Epub 2015 Jun 15.

Department of Medicine II, University of Munich D-81377 Munich, Germany ; German Cancer Consortium (DKTK) Im Neuenheimer Feld 280, 69120 Heidelberg, Germany ; German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280, 69120 Heidelberg, Germany ; Department of Internal Medicine and Gastroenterology, HELIOS Klinikum Berlin-Buch D-13125 Berlin, Germany.

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September 2015

Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Authors:
Matjaz Rokavec Meryem Gülfem Öner Huihui Li Rene Jackstadt Longchang Jiang Dmitri Lodygin Markus Kaller David Horst Paul K Ziegler Sarah Schwitalla Julia Slotta-Huspenina Franz G Bader Florian R Greten Heiko Hermeking

J Clin Invest 2015 Mar 2;125(3):1362. Epub 2015 Mar 2.

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March 2015

Colorectal cancers mimic structural organization of normal colonic crypts.

Authors:
Laura Cernat Cristina Blaj Rene Jackstadt Lydia Brandl Jutta Engel Heiko Hermeking Andreas Jung Thomas Kirchner David Horst

PLoS One 2014 11;9(8):e104284. Epub 2014 Aug 11.

Pathologisches Institut, Ludwig-Maximilians-Universität, München, Germany.

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April 2015

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling.

Authors:
Steffen Ormanns Jens Neumann David Horst Thomas Kirchner Andreas Jung

Oncotarget 2014 May;5(10):2999-3011

Institute of Pathology, Ludwig Maximilians Universität, Munich, Germany.

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May 2014

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.

Authors:
Serkan I Göktuna Ozge Canli Julia Bollrath Alexander A Fingerle David Horst Michaela A Diamanti Charles Pallangyo Moritz Bennecke Tim Nebelsiek Arun K Mankan Roland Lang David Artis Yinling Hu Thomas Patzelt Jürgen Ruland Thomas Kirchner M Mark Taketo Alain Chariot Melek C Arkan Florian R Greten

Cell Rep 2014 Jun 29;7(6):1914-25. Epub 2014 May 29.

Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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June 2014

Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men.

Authors:
Marlon R Schneider Felix Hiltwein Jessica Grill Helmut Blum Stefan Krebs Andrea Klanner Stefan Bauersachs Christiane Bruns Thomas Longerich David Horst Lydia Brandl Enrico de Toni Andreas Herbst Frank T Kolligs

Carcinogenesis 2014 Aug 19;35(8):1855-62. Epub 2014 May 19.

Department of Internal Medicine II and German Cancer Consortium (DKTK) and the German Cancer Research Center, Heidelberg, Germany

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August 2014

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Authors:
Matjaz Rokavec Meryem Gülfem Öner Huihui Li Rene Jackstadt Longchang Jiang Dmitri Lodygin Markus Kaller David Horst Paul K Ziegler Sarah Schwitalla Julia Slotta-Huspenina Franz G Bader Florian R Greten Heiko Hermeking

J Clin Invest 2014 Apr 18;124(4):1853-67. Epub 2014 Mar 18.

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April 2014

Large-scale mitochondrial DNA analysis in Southeast Asia reveals evolutionary effects of cultural isolation in the multi-ethnic population of Myanmar.

Authors:
Monika Summerer Jürgen Horst Gertraud Erhart Hansi Weißensteiner Sebastian Schönherr Dominic Pacher Lukas Forer David Horst Angelika Manhart Basil Horst Torpong Sanguansermsri Anita Kloss-Brandstätter

BMC Evol Biol 2014 Jan 28;14:17. Epub 2014 Jan 28.

Division of Genetic Epidemiology, Innsbruck Medical University, Schöpfstraße 41, 6020 Innsbruck, Austria.

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January 2014

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

Authors:
Tracy L Putoczki Stefan Thiem Andrea Loving Rita A Busuttil Nicholas J Wilson Paul K Ziegler Paul M Nguyen Adele Preaudet Ryan Farid Kirsten M Edwards Yeliz Boglev Rodney B Luwor Andrew Jarnicki David Horst Alex Boussioutas Joan K Heath Oliver M Sieber Irina Pleines Benjamin T Kile Andrew Nash Florian R Greten Brent S McKenzie Matthias Ernst

Cancer Cell 2013 Aug;24(2):257-71

Ludwig Institute for Cancer Research, Melbourne, VIC 3050, Australia.

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August 2013

AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer.

Authors:
Rene Jackstadt Simone Röh Jens Neumann Peter Jung Reinhard Hoffmann David Horst Christian Berens Georg W Bornkamm Thomas Kirchner Antje Menssen Heiko Hermeking

J Exp Med 2013 Jul 10;210(7):1331-50. Epub 2013 Jun 10.

Experimental and Molecular Pathology, Ludwig-Maximilians University of Munich, Germany.

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July 2013

Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.

Authors:
Lydia Kriegl Andreas Jung David Horst Antonia Rizzani Rene Jackstadt Heiko Hermeking Eike Gallmeier Alexander L Gerbes Thomas Kirchner Burkhard Göke Enrico N De Toni

PLoS One 2012 20;7(12):e51654. Epub 2012 Dec 20.

Institute of Pathology, University of Munich, Munich, Germany.

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June 2013

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.

Authors:
Sarah Schwitalla Paul K Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G Bader Olivia Prazeres da Costa Markus F Neurath Alexander Meining Thomas Kirchner Florian R Greten

Cancer Cell 2013 Jan 27;23(1):93-106. Epub 2012 Dec 27.

Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.

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January 2013

Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer.

Authors:
Helge Siemens Jens Neumann Rene Jackstadt Ulrich Mansmann David Horst Thomas Kirchner Heiko Hermeking

Clin Cancer Res 2013 Feb 14;19(3):710-20. Epub 2012 Dec 14.

Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.

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February 2013

Mold attacks a beating heart.

Authors:
Thomas Weig Michael Irlbeck Claus Neurohr Hauke Winter Rene Schramm Thomas Knösel David Horst

Respiration 2013 13;85(1):64-5. Epub 2012 Nov 13.

Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany.

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May 2013

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling.

Authors:
Kohichi Takada Di Zhu Gregory H Bird Kumar Sukhdeo Jian-Jun Zhao Mala Mani Madeleine Lemieux Daniel E Carrasco Jeremy Ryan David Horst Mariateresa Fulciniti Nikhil C Munshi Wenqing Xu Andrew L Kung Ramesh A Shivdasani Loren D Walensky Daniel Ruben Carrasco

Sci Transl Med 2012 Aug;4(148):148ra117

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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August 2012

Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone.

Authors:
Jutta M Nagel Brenda M Geiger Apostolos K A Karagiannis Beatriz Gras-Miralles David Horst Robert M Najarian Dimitrios C Ziogas Xinhua Chen Efi Kokkotou

PLoS One 2012 27;7(7):e41914. Epub 2012 Jul 27.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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January 2013

Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling.

Authors:
David Horst Justina Chen Teppei Morikawa Shuji Ogino Thomas Kirchner Ramesh A Shivdasani

Cancer Res 2012 Mar 8;72(6):1547-56. Epub 2012 Feb 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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March 2012

A simple immunohistochemical algorithm predicts the risk of distant metastases in right-sided colon cancer.

Authors:
Jens Neumann David Horst Lydia Kriegl Susanne Maatz Jutta Engel Andreas Jung Thomas Kirchner

Histopathology 2012 Feb;60(3):416-26

Pathologisches Institut der Ludwig-Maximilians-Universität München, Germany.

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February 2012

SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer.

Authors:
Jens Neumann Fiorina Bahr David Horst Lydia Kriegl Jutta Engel Raquel Mejias Luque Markus Gerhard Thomas Kirchner Andreas Jung

BMC Cancer 2011 Dec 14;11:518. Epub 2011 Dec 14.

Pathologisches Institut, Ludwig-Maximilians-Universität München, Munich, Germany.

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December 2011

Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer.

Authors:
Abdelhamid Beji David Horst Jutta Engel Thomas Kirchner Axel Ullrich

Clin Cancer Res 2012 Feb 5;18(4):956-68. Epub 2011 Dec 5.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Munich, Germany.

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February 2012

The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors.

Authors:
Tobias Vogler Lydia Kriegl David Horst Jutta Engel Sabine Sagebiel Achim J Schäffauer Thomas Kirchner Andreas Jung

Exp Mol Pathol 2012 Feb 10;92(1):111-7. Epub 2011 Nov 10.

Pathologisches Institut der Ludwig-Maximilians-Universität München, Thalkirchner Straße 36, D-80337 München, Germany.

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February 2012

Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice.

Authors:
Jutta M Nagel Jürgen Staffa Ingrid Renner-Müller David Horst Michael Vogeser Markus Langkamp Andreas Hoeflich Burkhard Göke Frank T Kolligs Christos S Mantzoros

Horm Cancer 2010 Dec;1(6):320-30

Department of Medicine II, Klinikum Grosshadern, Ludwig-Maximilians University of Munich, 81377 Munich, Germany.

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December 2010

Southeast Asian diversity: first insights into the complex mtDNA structure of Laos.

Authors:
Martin Bodner Bettina Zimmermann Alexander Röck Anita Kloss-Brandstätter David Horst Basil Horst Sourideth Sengchanh Torpong Sanguansermsri Jürgen Horst Tanja Krämer Peter M Schneider Walther Parson

BMC Evol Biol 2011 Feb 18;11:49. Epub 2011 Feb 18.

Institute of Legal Medicine, Innsbruck Medical University, Austria.

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February 2011

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation.

Authors:
Marlon R Schneider Maik Dahlhoff David Horst Benjamin Hirschi Konrad Trülzsch Josef Müller-Höcker Roger Vogelmann Michael Allgäuer Markus Gerhard Sylvia Steininger Eckhard Wolf Frank T Kolligs

PLoS One 2010 Dec 14;5(12):e14325. Epub 2010 Dec 14.

Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, University of Munich, Munich, Germany.

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December 2010

LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer.

Authors:
Lydia Kriegl David Horst Jana A Reiche Jutta Engel Thomas Kirchner Andreas Jung

J Transl Med 2010 Nov 22;8:123. Epub 2010 Nov 22.

Department of Pathology, Ludwig-Maximilians-Universität (LMU), Thalkirchnerstr, 36, 80337, Munich, Germany.

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November 2010

Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs.

Authors:
Barbara Stoll David A Horst Liwei Cui Xiaoyan Chang Kenneth J Ellis Darryl L Hadsell Agus Suryawan Ashish Kurundkar Akhil Maheshwari Teresa A Davis Douglas G Burrin

J Nutr 2010 Dec 27;140(12):2193-200. Epub 2010 Oct 27.

USDA/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.

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December 2010

Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.

Authors:
David Horst Xuesong Gu Manoj Bhasin Quanli Yang Michael Verzi Dongxu Lin Marie Joseph Xiaobo Zhang Wei Chen Yi-Ping Li Ramesh A Shivdasani Towia A Libermann

J Biol Chem 2010 Nov 26;285(45):35047-55. Epub 2010 Aug 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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November 2010

γ-Catenin is an independent prognostic marker in early stage colorectal cancer.

Authors:
Jutta Maria Nagel Lydia Kriegl David Horst Jutta Engel Shiva Gautam Christos S Mantzoros Thomas Kirchner Burkhard Göke Frank Thomas Kolligs

Int J Colorectal Dis 2010 Nov 25;25(11):1301-9. Epub 2010 Aug 25.

Department of Medicine II, University of Munich, Marchioninistrasse 15, Munich, Germany.

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November 2010

Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma.

Authors:
Markus Reschke Ingvar Ferby Ewa Stepniak Nina Seitzer David Horst Erwin F Wagner Axel Ullrich

Hepatology 2010 Apr;51(4):1383-90

Max-Planck Institute of Biochemistry, Department of Molecular Biology, Martinsried, Germany.

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April 2010

Forensic and phylogeographic characterization of mtDNA lineages from northern Thailand (Chiang Mai).

Authors:
Bettina Zimmermann Martin Bodner Sylvain Amory Liane Fendt Alexander Röck David Horst Basil Horst Torpong Sanguansermsri Walther Parson Anita Brandstätter

Int J Legal Med 2009 Nov;123(6):495-501

Institute of Legal Medicine, Innsbruck Medical University, Müllerstrasse 44, Innsbruck, Austria.

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November 2009

Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer.

Authors:
David Horst Jan Budczies Thomas Brabletz Thomas Kirchner Falk Hlubek

Cancer 2009 Nov;115(21):4946-58

Pathologisches Institut der Ludwig-Maximilians-Universität München, Munich, Germany.

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November 2009

Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer.

Authors:
David Horst Lydia Kriegl Jutta Engel Thomas Kirchner Andreas Jung

Cancer Invest 2009 Oct;27(8):844-50

Pathologisches Institut, Ludwig-Maximilians-Universitat Munchen, Germany.

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October 2009

The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer.

Authors:
David Horst Silvio K Scheel Sibylle Liebmann Jens Neumann Susanne Maatz Thomas Kirchner Andreas Jung

J Pathol 2009 Dec;219(4):427-34

Pathologisches Institut der Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, 80337 München, Germany.

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December 2009

CD133 and nuclear beta-catenin: the marker combination to detect high risk cases of low stage colorectal cancer.

Authors:
David Horst Lydia Kriegl Jutta Engel Andreas Jung Thomas Kirchner

Eur J Cancer 2009 Jul 4;45(11):2034-40. Epub 2009 May 4.

Pathologisches Institut der Ludwig-Maximilians-Universität München, Germany.

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July 2009

The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer.

Authors:
David Horst Simone Reu Lydia Kriegl Jutta Engel Thomas Kirchner Andreas Jung

Cancer 2009 May;115(10):2063-70

Pathologisches Institut der Ludwig-Maximilians-Universität, Munich, Germany.

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May 2009

p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.

Authors:
Stella Wassermann Silvio K Scheel Elke Hiendlmeyer Richard Palmqvist David Horst Falk Hlubek Angela Haynl Lydia Kriegl Simone Reu Susanne Merkel Thomas Brabletz Thomas Kirchner Andreas Jung

Gastroenterology 2009 Jan 20;136(1):196-205.e2. Epub 2008 Sep 20.

Pathologisch-Anatomisches Institut der Universität Erlangen-Nürnberg, Erlangen, Germany.

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January 2009

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice.

Authors:
Maik Dahlhoff David Horst Markus Gerhard Frank T Kolligs Eckhard Wolf Marlon R Schneider

FEBS Lett 2008 Aug 24;582(19):2911-5. Epub 2008 Jul 24.

Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor-Lynen-Strasse 25, Munich, Germany.

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August 2008

Comparative expression analysis of Pax3 and Pax7 during mouse myogenesis.

Authors:
David Horst Svetlana Ustanina Consolato Sergi Gregor Mikuz Herbert Juergens Thomas Braun Eugene Vorobyov

Int J Dev Biol 2006 ;50(1):47-54

Klinik und Poliklinik für pädiatrische Hämatologie/Onkologie, Universitätsklinikum Münster, Germany.

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April 2006

High frequency of alpha-thalassemia in the So ethnic group of South Laos.

Authors:
Sourideth Sengchanh Torpong Sanguansermsri David Horst Jurgen Horst Gebhard Flatz

Acta Haematol 2005 ;114(3):164-6

Department of Pediatrics, Faculty of Medical Sciences, National University of Lao, Vientiane, Lao PDR.

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November 2005

Nasopharyngeal surfactant administration to prevent neonatal respiratory distress syndrome.

Authors:
Caraciolo J Fernandes David A Horst Donough J O'Donovan

J Perinatol 2005 May;25(5):361-2; author reply 363

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May 2005

The Southeast Asian 12.5 KB (delta-beta) degrees-deletion: a common beta-thalassemia in Mon-Khmer groups (Lao Theung) of South Laos.

Authors:
Torpong Sanguansermsri Sourideth Sengchanh David Horst Antonin Eigel Gebhard Flatz Jürgen Horst

Haematologica 2004 Aug;89(8):ECR29

Department of Pediatrics, Chiangmai University Hospital, Chiangmai, Thailand.

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August 2004

The 'hot-spot' of Hb E [beta26(B8)Glu-->Lys] in Southeast Asia: beta-globin anomalies in the Lao Theung population of southern Laos.

Authors:
Gebhard Flatz Torpong Sanguansermsri Sourideth Sengchanh David Horst Jürgen Horst

Hemoglobin 2004 Aug;28(3):197-204

Medizinische Hochschule Hannover, Hannover, Germany.

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August 2004