David Holtzman

David Holtzman

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David Holtzman

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Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors.

Neuropsychopharmacology 2020 Jan 13;45(1):104-120. Epub 2019 Aug 13.

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41386-019-0478-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879647PMC
January 2020

Dementia is not synonymous with Alzheimer's disease.

Sci Transl Med 2019 Dec;11(522)

Clifford Jack is a Professor in the Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aav0511DOI Listing
December 2019

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.

J Alzheimers Dis 2018 ;66(3):1213-1221

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University, School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.3233/JAD-180564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330210PMC
November 2019

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.

J Exp Med 2019 Nov 10;216(11):2546-2561. Epub 2019 Oct 10.

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20190980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829593PMC
November 2019

Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease.

J Gerontol A Biol Sci Med Sci 2019 Nov 18. Epub 2019 Nov 18.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1093/gerona/glz262DOI Listing
November 2019

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis.

Neurology 2019 Oct 1;93(17):e1647-e1659. Epub 2019 Aug 1.

From the Department of Neurology (S.E.S., J.G.B., V.O., K.G.M., D.M.H., J.C.M., T.L.S.B., C.X., A.M.F., R.J.B.), Knight Alzheimer's Disease Research Center (S.E.S., B.A.G., D.M.H., J.C.M., T.L.S.B., C.X., A.M.F., R.J.B.), Division of Biostatistics (Y.L., C.X.), Mallinckrodt Institute of Radiology (B.A.G., T.L.S.B.), and Hope Center for Neurological Disorders (D.M.H., A.M.F., R.J.B.), Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000008081DOI Listing
October 2019

The microbiome: A target for Alzheimer disease?

Cell Res 2019 Oct;29(10):779-780

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41422-019-0227-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796832PMC
October 2019

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.

Cell 2019 Oct 26;179(2):312-339. Epub 2019 Sep 26.

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778042PMC
October 2019

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model.

Mol Neurodegener 2019 Oct 17;14(1):37. Epub 2019 Oct 17.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1186/s13024-019-0337-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796484PMC
October 2019

Targeting tauopathy with engineered tau-degrading intrabodies.

Mol Neurodegener 2019 Oct 22;14(1):38. Epub 2019 Oct 22.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-019-0340-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805661PMC
October 2019

Dietary salt promotes cognitive impairment through tau phosphorylation.

Nature 2019 Oct 23;574(7780):686-690. Epub 2019 Oct 23.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41586-019-1688-zDOI Listing
October 2019

TREM2 function impedes tau seeding in neuritic plaques.

Nat Neurosci 2019 08 24;22(8):1217-1222. Epub 2019 Jun 24.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-019-0433-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660358PMC
August 2019

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.

Alzheimers Res Ther 2019 Aug 9;11(1):71. Epub 2019 Aug 9.

Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 425 S. Euclid Ave, BJC Institute of Health, Office: 9607, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13195-019-0524-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689177PMC
August 2019

Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.

Ann Clin Transl Neurol 2019 Aug 9;6(8):1423-1434. Epub 2019 Jul 9.

Department of Neurology, Washington University School of Medicine, 510 S. Kingshighway Blvd, St. Louis, Missouri, 63110.

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http://dx.doi.org/10.1002/acn3.50837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689696PMC
August 2019

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.

Alzheimers Dement 2019 May 4;15(5):655-665. Epub 2019 Mar 4.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511459PMC
May 2019

Senescent glia spell trouble in Alzheimer's disease.

Nat Neurosci 2019 05;22(5):683-684

Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-019-0395-2DOI Listing
May 2019

Reply to "obstructive sleep apnea treatment and amyloid-β in cerebrospinal fluid".

Ann Neurol 2019 Mar 19;85(3):460-461. Epub 2019 Feb 19.

Department of Neurology, Washington University, Saint Louis, MO.

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http://dx.doi.org/10.1002/ana.25424DOI Listing
March 2019

Obstructive sleep apnea treatment, slow wave activity, and amyloid-β.

Ann Neurol 2019 Feb 17;85(2):291-295. Epub 2019 Jan 17.

Department of Neurology, Washington University, Saint Louis, MO.

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http://dx.doi.org/10.1002/ana.25408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396979PMC
February 2019

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.

Science 2019 02 24;363(6429):880-884. Epub 2019 Jan 24.

Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.aav2546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410369PMC
February 2019

Dural lymphatics regulate clearance of extracellular tau from the CNS.

Mol Neurodegener 2019 02 27;14(1):11. Epub 2019 Feb 27.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-019-0312-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391770PMC
February 2019

Multi-Modal Home Sleep Monitoring in Older Adults.

J Vis Exp 2019 01 26(143). Epub 2019 Jan 26.

Department of Neurology, Washington University School of Medicine; Hope Center for Neurological Disorders, Washington University School of Medicine;

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http://dx.doi.org/10.3791/58823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377867PMC
January 2019

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight.

Nat Rev Immunol 2018 12;18(12):759-772

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41577-018-0051-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425488PMC
December 2018

Amyloid-β 'seeds' in old vials of growth hormone.

Nature 2018 12;564(7736):354-355

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http://dx.doi.org/10.1038/d41586-018-07604-6DOI Listing
December 2018

New insights into the role of TREM2 in Alzheimer's disease.

Mol Neurodegener 2018 12 20;13(1):66. Epub 2018 Dec 20.

Department of Neurology, St. Louis, USA.

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http://dx.doi.org/10.1186/s13024-018-0298-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302500PMC
December 2018

Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.

Alzheimers Dement 2018 11 2;14(11):1460-1469. Epub 2018 Mar 2.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119652PMC
November 2018

High-affinity interactions and signal transduction between Aβ oligomers and TREM2.

EMBO Mol Med 2018 11;10(11)

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA

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http://dx.doi.org/10.15252/emmm.201809027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220267PMC
November 2018

Intercellular Spread of Protein Aggregates in Neurodegenerative Disease.

Annu Rev Cell Dev Biol 2018 10 25;34:545-568. Epub 2018 Jul 25.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-cellbio-10
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http://dx.doi.org/10.1146/annurev-cellbio-100617-062636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350082PMC
October 2018

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.

Neurology 2018 10 14;91(14):e1295-e1306. Epub 2018 Sep 14.

From the Department of Neurology (E.M., J.H., V.B., A.M.F., D.M.H., J.C.M., K.P., R.J.B.), Division of Biostatistics (G.W., C.X.), Department of Radiology (B.A.G., T.L.S.B., D.S.M.), and Department of Pathology (N.J.C.), Washington University School of Medicine, Saint Louis, MO; Department of Neuroscience (A.M.J.), Icahn School of Medicine at Mount Sinai, New York, NY; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) (R.A.), Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina; University of Pittsburgh School of Medicine (S.B.B., W.K.), PA; College of Physicians and Surgeons (J.N.), Columbia University, New York, NY; Department of Neurology (J.R.), Keck School of Medicine of University of Southern California, Los Angeles; Department of Neurology (B.G., M.F.), Indiana University, Indianapolis; Massachusetts General Hospital (R.A.S., J.C.), Harvard Medical School, Boston; Butler Hospital and Brown University (S.S.), Providence, RI; Department of Neurology (N.R.G.-R.), Mayo Clinic Jacksonville, FL; Neuroscience Research Australia (P.R.S.); School of Medical Sciences (P.R.S.), University of New South Wales, Sydney; The Florey Institute and the University of Melbourne (C.M.), Parkville, Australia; Dementia Research Centre, Institute of Neurology (M.N.R., N.C.F.), University College London, UK; German Center for Neurodegenerative Diseases (DZNE) Munich (J.L.); Department of Neurology (J.L.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) Tübingen (M.J.); and Hertie-Institute for Clinical Brain Research (M.J.), University of Tübingen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177272PMC
October 2018

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

Mol Neurodegener 2018 10 19;13(1):57. Epub 2018 Oct 19.

Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA.

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http://dx.doi.org/10.1186/s13024-018-0286-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194676PMC
October 2018

In Search of an Identity for Amyloid Plaques.

Trends Neurosci 2018 08;41(8):483-486

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2018.06.002DOI Listing
August 2018

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease.

Alzheimers Dement 2018 07 23;14(7):869-879. Epub 2018 Mar 23.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110083PMC
July 2018

Using the A/T/N Framework to Examine Driving in Preclinical AD.

Geriatrics (Basel) 2018 Jun 2;3(2). Epub 2018 May 2.

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.3390/geriatrics3020023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964600PMC
June 2018

Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers.

Alzheimers Dement 2018 05 10;14(5):610-616. Epub 2018 Jan 10.

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.jalz.2017.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938126PMC
May 2018

Dual therapy for Aβ amyloidosis in AD: A successful one-two combo.

J Exp Med 2018 05 23;215(5):1267-1268. Epub 2018 Apr 23.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20180494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940274PMC
May 2018

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model.

Mol Neurodegener 2018 05 15;13(1):22. Epub 2018 May 15.

Department of Neurology, Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-018-0256-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952376PMC
May 2018

Regulation of amyloid-β dynamics and pathology by the circadian clock.

J Exp Med 2018 04 30;215(4):1059-1068. Epub 2018 Jan 30.

Department of Neurology, Washington University School of Medicine, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20172347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881473PMC
April 2018

Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report.

J Alzheimers Dis 2017 ;58(3):675-680

Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.3233/JAD-170067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555740PMC
March 2018

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.

Nat Rev Neurol 2018 03 29;14(3):168-181. Epub 2018 Jan 29.

National Institute of Diabetes and Digestive and Kidney Diseases, 6707 Democracy Boulevard, Bethesda, Maryland 20817, USA. Diabetes Center and Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Bullfinch 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nrneurol.2017.185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098968PMC
March 2018

Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years.

Alzheimers Dement 2018 01 12;14(1):62-70. Epub 2017 Jul 12.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.06.2264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750131PMC
January 2018

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities.

Neurology 2017 Dec 8;89(23):2381-2391. Epub 2017 Nov 8.

From the National Institute of Neurological Disorders and Stroke (R.A.C., W.J.K., J.T.G., S.J., D.B., M.E., C.S.M., P.A.S., B.-A.S., M.L.S., C.L.T., A.K.G.), Bethesda, MD; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.C.), David Geffen School of Medicine, University of California, Los Angeles; The Association for Frontotemporal Degeneration (S.L.-J.D.), Radnor, PA; Department of Neuroscience (D.W.D.), Mayo Clinic, Jacksonville, FL; The Alzheimer's Drug Discovery Foundation (H.F.); Icahn School of Medicine at Mount Sinai (H.F.), New York, NY; Department of Neurology (S.M.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Eli Lilly and Company (M.L.H.), Lilly Research Centre, Erl Wood Manor, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.) and College of Physicians and Surgeons (K.S.M.), Columbia University, New York, NY; National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; Memory and Aging Center, Department of Neurology (W.W.S.), and Department of Pathology (W.W.S.), University of California San Francisco; Lewy Body Dementia Association (A.T.), Lilburn, GA; National Institute of Diabetes and Digestive and Kidney Diseases (S.P.W.), Bethesda, MD; and Knight Alzheimer's Disease Research Center (D.M.H.), Hope Center for Neurological Disorders (D.M.H.), and Department of Neurology (D.M.H.), Washington University in St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000004717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719928PMC
December 2017

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.

Neuron 2017 Dec;96(5):1013-1023.e4

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273173106
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http://dx.doi.org/10.1016/j.neuron.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728673PMC
December 2017

Pretreatment with Human Chorionic Gonadotropin Protects the Neonatal Brain against the Effects of Hypoxic-Ischemic Injury.

Front Pediatr 2017 3;5:232. Epub 2017 Nov 3.

Department of Neurology, Hope Center for Neurological Disorders, Washington University, St. Louis, MO, United States.

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http://dx.doi.org/10.3389/fped.2017.00232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675846PMC
November 2017

Antibody Therapeutics Targeting Aβ and Tau.

Cold Spring Harb Perspect Med 2017 Oct 3;7(10). Epub 2017 Oct 3.

Department of Neurology, Hope Center for Neurological Disorders, and Knight Alzheimer's Disease Research Center, Washington University, St. Louis, Missouri 63110.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a024331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500436PMC
October 2017

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.

Ann Clin Transl Neurol 2017 10 30;4(10):722-738. Epub 2017 Aug 30.

Department of Neurology Hope Center for Neurological Disorders Washington University St. Louis Missouri 63110.

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http://dx.doi.org/10.1002/acn3.450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634348PMC
October 2017

Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus.

PLoS One 2017 17;12(2):e0172353. Epub 2017 Feb 17.

Department of Neurological Surgery, Washington University in St. Louis, School of Medicine, Saint Louis, MO, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172353PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315300PMC
August 2017

Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease.

Neurobiol Aging 2017 08 14;56:25-32. Epub 2017 Apr 14.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505233PMC
August 2017

Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis.

Alzheimers Dement 2017 Aug 19;13(8):841-849. Epub 2017 Jul 19.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.06.2266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567785PMC
August 2017

Glial contributions to neurodegeneration in tauopathies.

Mol Neurodegener 2017 06 29;12(1):50. Epub 2017 Jun 29.

Department of Neurology, Washington University, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-017-0192-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492997PMC
June 2017

Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins.

J Lipid Res 2017 05 27;58(5):824-836. Epub 2017 Feb 27.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110

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http://dx.doi.org/10.1194/jlr.R075481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408619PMC
May 2017

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy.

J Exp Med 2017 05 17;214(5):1227-1238. Epub 2017 Apr 17.

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110

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http://dx.doi.org/10.1084/jem.20162125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413341PMC
May 2017

Diurnal oscillation of CSF Aβ and other AD biomarkers.

Mol Neurodegener 2017 05 8;12(1):36. Epub 2017 May 8.

Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-017-0161-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421331PMC
May 2017

Automated selective disruption of slow wave sleep.

J Neurosci Methods 2017 Apr 24;281:33-39. Epub 2017 Feb 24.

Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399676PMC
April 2017

Elucidating the Role of TREM2 in Alzheimer's Disease.

Neuron 2017 Apr;94(2):237-248

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.02.042DOI Listing
April 2017

Altered sleep and EEG power in the P301S Tau transgenic mouse model.

Ann Clin Transl Neurol 2017 Mar 15;4(3):180-190. Epub 2017 Feb 15.

Department of Neurology Hope Center for Neurological Disorders, and the Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri 63110.

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http://dx.doi.org/10.1002/acn3.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338139PMC
March 2017

Reply.

Ann Neurol 2017 02 27;81(2):322-323. Epub 2017 Jan 27.

Department of Neurology.

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http://dx.doi.org/10.1002/ana.24849DOI Listing
February 2017

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Mol Neurodegener 2017 01 12;12(1). Epub 2017 Jan 12.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1186/s13024-016-0147-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234150PMC
January 2017

Sleep in Alzheimer's Disease - Beyond Amyloid.

Neurobiol Sleep Circadian Rhythms 2017 Jan 10;2:4-14. Epub 2016 Aug 10.

Department of Neurology, Hope Center for Neurological Disorders, and the Knight Alzheimer's Disease Research Center, Washington University, 660 S. Euclid Ave, Box 8111, St. Louis, MO 63108.

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http://dx.doi.org/10.1016/j.nbscr.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312809PMC
January 2017

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Mol Neurodegener 2016 12 8;11(1):74. Epub 2016 Dec 8.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1186/s13024-016-0138-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146863PMC
December 2016

Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels.

Am J Geriatr Psychiatry 2016 11 19;24(11):1095-1104. Epub 2016 Apr 19.

Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO; Departments of Neurology, Washington University School of Medicine, St. Louis, MO.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069099PMC
http://dx.doi.org/10.1016/j.jagp.2016.04.004DOI Listing
November 2016

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.

J Neurosci 2016 11;36(46):11704-11715

Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University, St. Louis, Missouri 63110

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http://dx.doi.org/10.1523/JNEUROSCI.2119-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125227PMC
November 2016

Mechanisms linking circadian clocks, sleep, and neurodegeneration.

Science 2016 11;354(6315):1004-1008

Department of Neurology, Hope Center for Neurological Disorders, and Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.aah4968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219881PMC
November 2016

Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology.

JAMA Neurol 2016 Oct;73(10):1192-1200

Department of Radiology, Washington University, St Louis, Missouri2Knight Alzheimer's Disease Research Center, Washington University, St Louis, Missouri6Department of Neurological Surgery, Washington University, St Louis, Missouri.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2016.2642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237381PMC
October 2016

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.

Proc Natl Acad Sci U S A 2016 09 24;113(36):10186-91. Epub 2016 Aug 24.

Department of Neurobiology, School of Medicine, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1609896113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018780PMC
September 2016

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.

Ann Clin Transl Neurol 2016 06 6;3(6):434-42. Epub 2016 May 6.

Departments of Neurology Washington University School of Medicine St. Louis Missouri; Hope Center for Neurological Disorders Washington University School of Medicine St. Louis Missouri; Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri.

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http://dx.doi.org/10.1002/acn3.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891997PMC
June 2016