Publications by authors named "David Hedley"

100Publications

Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, In or β-particle emitting, Lu.

EJNMMI Radiopharm Chem 2020 Nov 9;5(1):22. Epub 2020 Nov 9.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada.

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http://dx.doi.org/10.1186/s41181-020-00111-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652961PMC
November 2020

An Iodinated DAPI-Based Reagent for Mass Cytometry.

Chembiochem 2020 Sep 8. Epub 2020 Sep 8.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.

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http://dx.doi.org/10.1002/cbic.202000369DOI Listing
September 2020

Radioimmunotherapy of human pancreatic cancer xenografts in NOD-scid mice with [Cu]Cu-NOTA-panitumumab F(ab') alone or combined with radiosensitizing gemcitabine and the PARP inhibitor, rucaparib.

Nucl Med Biol 2020 May - Jun;84-85:46-54. Epub 2020 Feb 3.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute, Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2020.02.001DOI Listing
February 2020

Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy.

Sci Rep 2020 01 31;10(1):1638. Epub 2020 Jan 31.

Ontario Cancer Institute, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1038/s41598-019-57364-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994660PMC
January 2020

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201970107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350392PMC
October 2019

Skin platinum deposition in colorectal cancer patients following oxaliplatin-based therapy.

Cancer Chemother Pharmacol 2019 Dec 13;84(6):1195-1200. Epub 2019 Sep 13.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Room 7-824, 700 University Avenue, Toronto, ON, M5G 1X6, Canada.

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http://dx.doi.org/10.1007/s00280-019-03956-6DOI Listing
December 2019

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.

Cancer Cell 2019 02 24;35(2):267-282.e7. Epub 2019 Jan 24.

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada; Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, ON M5G 2M9, Canada; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183058
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http://dx.doi.org/10.1016/j.ccell.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398439PMC
February 2019

Mobilization of Leukemic Cells Using Plerixafor as Part of a Myeloablative Preparative Regimen for Patients with Acute Myelogenous Leukemia Undergoing Allografting: Assessment of Safety and Tolerability.

Biol Blood Marrow Transplant 2019 06 14;25(6):1158-1163. Epub 2019 Jan 14.

Messner Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2019.01.014DOI Listing
June 2019

Radioimmunotherapy of PANC-1 Human Pancreatic Cancer Xenografts in NRG Mice with Panitumumab Modified with Metal-Chelating Polymers Complexed to Lu.

Mol Pharm 2019 02 10;16(2):768-778. Epub 2019 Jan 10.

Department of Pharmaceutical Sciences , University of Toronto , 144 College Street , Toronto , Ontario M5S 3M2 , Canada.

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http://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01040
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01040DOI Listing
February 2019

Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients.

J Gastrointest Cancer 2019 Dec;50(4):801-807

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Room 5-719, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s12029-018-0153-9DOI Listing
December 2019

Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to In and Lu-An EGFR-Targeted Theranostic for Pancreatic Cancer.

Mol Pharm 2018 03 30;15(3):1150-1159. Epub 2018 Jan 30.

Department of Pharmaceutical Sciences , University of Toronto , 144 College Street , Toronto , ON M5S 3M2 , Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b01000DOI Listing
March 2018

Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.

Clin Colorectal Cancer 2018 03 23;17(1):73-79. Epub 2017 Oct 23.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.010DOI Listing
March 2018

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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http://doi.wiley.com/10.1002/eji.201646632
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http://dx.doi.org/10.1002/eji.201646632DOI Listing
October 2017

Staining of Frozen and Formalin-Fixed, Paraffin-Embedded Tissues with Metal-Labeled Antibodies for Imaging Mass Cytometry Analysis.

Curr Protoc Cytom 2017 Oct 2;82:12.47.1-12.47.8. Epub 2017 Oct 2.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpcy.29DOI Listing
October 2017

Mechanical CPR in a child: can one size fit all?

BMJ Case Rep 2017 Apr 24;2017. Epub 2017 Apr 24.

Emergency Department, Nobles Hospital, Braddan, Strang, Isle of Man.

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http://dx.doi.org/10.1136/bcr-2017-219728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534723PMC
April 2017

Imaging Mass Cytometry.

Cytometry A 2017 02 3;91(2):160-169. Epub 2017 Feb 3.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1002/cyto.a.23053DOI Listing
February 2017

Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.

PLoS One 2016 29;11(12):e0167272. Epub 2016 Dec 29.

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199060PMC
July 2017

Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.

Oncotarget 2017 Jan;8(2):3064-3071

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.13619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356865PMC
January 2017

Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts.

Oncotarget 2017 Jan;8(1):1392-1404

Ontario Cancer Institute/Princess Margaret Cancer Centre, University Health Network and Campbell Family Institute for Cancer Research, Toronto, Ontario, M5G2M9, Canada.

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http://www.oncotarget.com/fulltext/13625
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http://dx.doi.org/10.18632/oncotarget.13625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352063PMC
January 2017

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Br J Cancer 2017 01 22;116(1):50-57. Epub 2016 Nov 22.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario MG5 2M9, Canada.

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http://dx.doi.org/10.1038/bjc.2016.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220149PMC
January 2017

Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues.

Sci Rep 2016 11 4;6:36641. Epub 2016 Nov 4.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1038/srep36641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095658PMC
November 2016

Quantifying hypoxia in human cancers using static PET imaging.

Phys Med Biol 2016 11 25;61(22):7957-7974. Epub 2016 Oct 25.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Techna Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1088/0031-9155/61/22/7957DOI Listing
November 2016

Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.

Angew Chem Int Ed Engl 2016 10;55(42):13159-13163

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada.

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http://dx.doi.org/10.1002/anie.201607483DOI Listing
October 2016

Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study.

J Biomed Opt 2016 08;21(8):84002

University Health Network, Princess Margaret Cancer Center, 101 College Street, Toronto, Ontario M5G 1L7, CanadabUniversity of Toronto, Department of Medical Biophysics, 101 College Street, Toronto, Ontario M5G 1L7, CanadacPrincess Margaret Hospital, Department of Medical Oncology and Hematology, 610 University Avenue, Toronto, Ontario M5T 2M9, Canada.

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http://dx.doi.org/10.1117/1.JBO.21.8.084002DOI Listing
August 2016

FOLFIRINOX for advanced pancreatic cancer: the Princess Margaret Cancer Centre experience.

Br J Cancer 2016 09 28;115(6):649-54. Epub 2016 Jul 28.

Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, Toronto M5G 2M9, Canada.

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http://www.nature.com/articles/bjc2016222
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http://dx.doi.org/10.1038/bjc.2016.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023770PMC
September 2016

A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia.

Invest New Drugs 2016 10 12;34(5):614-24. Epub 2016 Jul 12.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s10637-016-0375-2DOI Listing
October 2016

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302.

Oncotarget 2016 Jun;7(23):33571-80

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.9654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085103PMC
June 2016

Cytokinetic effects of Wee1 disruption in pancreatic cancer.

Cell Cycle 2016 ;15(4):593-604

a Ontario Cancer Institute/Princess Margaret Cancer Center , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/15384101.2016.1138188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056606PMC
December 2016

Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake.

J Nucl Med 2016 Mar 14;57(3):361-6. Epub 2016 Jan 14.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

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http://dx.doi.org/10.2967/jnumed.115.167650DOI Listing
March 2016

Predictive and prognostic values of ERCC1 and XRCC1 in biliary tract cancers.

J Clin Pathol 2016 Aug 13;69(8):695-701. Epub 2016 Jan 13.

Department of Pathology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://jcp.bmj.com/content/early/2016/01/13/jclinpath-2015-2
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http://dx.doi.org/10.1136/jclinpath-2015-203397DOI Listing
August 2016

Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma.

J Clin Oncol 2015 Oct 4;33(28):3124-9. Epub 2015 May 4.

Spring Holter, Ayelet Borgida, Robert Grant, Kara Semotiuk, and Steven Gallinger, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital; Anna Dodd, David Hedley, Neesha Dhani, Malcolm Moore, and Steven Gallinger, McCain Pancreatic Cancer Centre, University Health Network; and Steven Narod and Mohammad Akbari, Women's College Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2014.59.7401DOI Listing
October 2015

Developing a prognostic micro-RNA signature for human cervical carcinoma.

PLoS One 2015 16;10(4):e0123946. Epub 2015 Apr 16.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399941PMC
May 2016

Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle.

J Control Release 2015 May 21;206:122-30. Epub 2015 Mar 21.

Drug Discovery Program, Ontario Institute for Cancer Research, 101 College Street, Suite 800, Toronto, Ontario M5G 0A3, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409566PMC
May 2015

The clinical significance of hypoxia in human cancers.

Semin Nucl Med 2015 Mar;45(2):110-21

Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.semnuclmed.2014.11.002DOI Listing
March 2015

Whole blood measurement of histone modifications linked to the epigenetic regulation of gene expression.

Curr Protoc Cytom 2015 Jan 5;71:6.36.1-6.36.9. Epub 2015 Jan 5.

Ontario Cancer Institute/Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/0471142956.cy0636s71DOI Listing
January 2015

MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using (64)Cu-NOTA-panitumumab F(ab')2 fragments.

Nucl Med Biol 2015 Feb 22;42(2):71-7. Epub 2014 Oct 22.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2014.10.009DOI Listing
February 2015

Identification of hypoxic cells using an organotellurium tag compatible with mass cytometry.

Angew Chem Int Ed Engl 2014 Oct 4;53(43):11473-7. Epub 2014 Sep 4.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6 (Canada).

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http://dx.doi.org/10.1002/anie.201405233DOI Listing
October 2014

Single-cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry.

Int J Cancer 2015 Mar 16;136(5):1202-9. Epub 2014 Jul 16.

Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.29074DOI Listing
March 2015

Assessment of hypoxia in the stroma of patient-derived pancreatic tumor xenografts.

Cancers (Basel) 2014 Feb 26;6(1):459-71. Epub 2014 Feb 26.

Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Center, University Health Network, 610 University Ave., Toronto, ON M5G2M9, Canada.

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http://dx.doi.org/10.3390/cancers6010459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980617PMC
February 2014

Outcome of adjuvant therapy in biliary tract cancers.

Am J Clin Oncol 2015 Aug;38(4):382-7

Departments of *Medical Oncology ∥Palliative Care Medicine #Radiation Oncology, Princess Margaret Hospital Departments of §Surgery ¶Pathology, Toronto General Hospital, Toronto, ON, Canada †Department of Gastroenterology, Edouard Herriot Hospital, Lyon, France ‡Department of Medical Oncology, Waterford Regional Hospital, Waterford, Ireland.

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http://dx.doi.org/10.1097/COC.0b013e31829e19fbDOI Listing
August 2015

The study of epigenetic mechanisms based on the analysis of histone modification patterns by flow cytometry.

Cytometry A 2014 Jan 26;85(1):78-87. Epub 2013 Aug 26.

Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1002/cyto.a.22344DOI Listing
January 2014

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Int J Cancer 2014 Oct 25;135(7):1692-9. Epub 2014 Apr 25.

Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.28403DOI Listing
October 2014

Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition.

Int J Cancer 2013 Jul 5;133(1):225-34. Epub 2013 Feb 5.

Ontario Cancer Institute/Princess Margaret Hospital, ON, Canada.

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http://dx.doi.org/10.1002/ijc.28006DOI Listing
July 2013

Emerging applications of flow cytometry in solid tumor biology.

Methods 2012 Jul 6;57(3):359-67. Epub 2012 Apr 6.

Research Division, Ontario Cancer Institute and Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

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https://linkinghub.elsevier.com/retrieve/pii/S10462023120008
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http://dx.doi.org/10.1016/j.ymeth.2012.03.027DOI Listing
July 2012

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation.

Cancer 2012 Jun 25;118(12):3105-15. Epub 2011 Oct 25.

Ontario Cancer Institute/Princess Margaret Hospital and The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.26635DOI Listing
June 2012

Orthotopic xenograft model of cervical cancer for studying microenvironmental effects on metastasis formation and response to drug treatment.

Curr Protoc Pharmacol 2011 Jun;Chapter 14:Unit 14.19

Ontario Cancer Institute/Princess Margaret Hospital, Campbell Family Institute for Cancer Research and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/0471141755.ph1419s53DOI Listing
June 2011

Cytometry of intracellular signaling: from laboratory bench to clinical application.

Methods Cell Biol 2011 ;103:203-20

Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/B978-0-12-385493-3.00009-7DOI Listing
November 2011

A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer.

Invest New Drugs 2012 Jun 28;30(3):1203-7. Epub 2011 Apr 28.

University Health Network-Princess Margaret Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10637-011-9673-xDOI Listing
June 2012

Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer.

Cancer Res 2011 Apr 22;71(8):3110-20. Epub 2011 Feb 22.

Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4049DOI Listing
April 2011

A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer.

Invest New Drugs 2012 Apr 18;30(2):779-86. Epub 2010 Dec 18.

Division of Medical Oncology and Hematology, Rm 5-708, Princess Margaret Hospital, 610 University Avenue, Toronto M5G2M9, Canada.

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http://dx.doi.org/10.1007/s10637-010-9611-3DOI Listing
April 2012

Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts.

BMC Cancer 2010 Sep 28;10:515. Epub 2010 Sep 28.

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-10-515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955043PMC
September 2010

SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinoma.

BMC Clin Pathol 2010 Feb 5;10. Epub 2010 Feb 5.

Department of Laboratory Medicine & Pathobiology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1472-6890-10-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829523PMC
February 2010

Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models.

Cancer Biol Ther 2009 Oct 6;8(20):1893-901. Epub 2009 Oct 6.

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.4161/cbt.8.20.9430DOI Listing
October 2009

Targeting focal adhesion kinase signaling in tumor growth and metastasis.

Expert Opin Ther Targets 2010 Jan;14(1):77-94

Princess Margaret Hospital/Ontario Cancer Institute (PMH/OCI), Toronto M5G 2M9, Ontario, Canada.

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http://dx.doi.org/10.1517/14728220903460340DOI Listing
January 2010

Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer.

Mol Pharmacol 2009 Nov 4;76(5):969-83. Epub 2009 Aug 4.

Department of Medical Biophysics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1124/mol.109.055277DOI Listing
November 2009

Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy.

BMC Cancer 2009 Apr 30;9:132. Epub 2009 Apr 30.

Division of Applied Molecular Oncology, University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2407-9-132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685435PMC
April 2009

Cancer stem cells, hypoxia and metastasis.

Semin Radiat Oncol 2009 Apr;19(2):106-11

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.semradonc.2008.12.002DOI Listing
April 2009

Heterogeneity and power in clinical biomarker studies.

J Clin Oncol 2009 Mar 9;27(9):1517-21. Epub 2009 Feb 9.

Department of Biostatistics, Radiation Medicine Program, and the Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Canada.

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http://dx.doi.org/10.1200/JCO.2008.18.7393DOI Listing
March 2009

Gene expression profiling of adenosine triphosphate-binding cassette transporters in response to K-ras activation and hypoxia in human pancreatic cancer cell cultures.

Pancreas 2009 Jan;38(1):85-93

Department of Cancer Genetics, British Columbia Cancer Agency, University of British Columbia,Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/mpa.0b013e318184aa8aDOI Listing
January 2009

Whole blood processing for measurement of signaling proteins by flow cytometry.

Curr Protoc Cytom 2008 Oct;Chapter 9:Unit 9.27

Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/0471142956.cy0927s46DOI Listing
October 2008

Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models.

Int J Cancer 2009 Jan;124(2):280-6

Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.23912DOI Listing
January 2009

Pharmacodynamic monitoring of molecular-targeted agents in the peripheral blood of leukemia patients using flow cytometry.

Toxicol Pathol 2008 Jan;36(1):133-9

Division of Applied Molecular Oncology, Ontario Cancer Institute, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/0192623307310952DOI Listing
January 2008

Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX.

Lab Invest 2007 Dec 1;87(12):1206-17. Epub 2007 Oct 1.

Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/labinvest.3700680DOI Listing
December 2007

Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.

Pancreas 2007 Oct;35(3):e16-26

Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://pdfs.journals.lww.com/pancreasjournal/2007/10000/Diss
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http://dx.doi.org/10.1097/mpa.0b013e318095a747DOI Listing
October 2007

Measurement of signaling pathway activities in solid tumor fine-needle biopsies by slide-based cytometry.

Diagn Mol Pathol 2007 Sep;16(3):130-40

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/PDM.0b013e31803df480DOI Listing
September 2007

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

Cancer Chemother Pharmacol 2008 Apr 20;61(4):669-81. Epub 2007 Jun 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 610 University Ave., 5th Floor, Rm 203, M5G 2M9, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00280-007-0522-8DOI Listing
April 2008

A Phase 2 study of perifosine in advanced or metastatic breast cancer.

Breast Cancer Res Treat 2008 Mar 26;108(1):87-92. Epub 2007 Apr 26.

Medical Oncology, Princess Margaret Hospital/University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10549-007-9584-xDOI Listing
March 2008

The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.

Hum Genet 2007 Jun 6;121(5):635-7. Epub 2007 Apr 6.

Sam Minuk Cancer Genetics and Biomarker Laboratories, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.

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http://link.springer.com/10.1007/s00439-007-0361-z
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http://dx.doi.org/10.1007/s00439-007-0361-zDOI Listing
June 2007

Quantitative image analysis of immunohistochemical stains using a CMYK color model.

Diagn Pathol 2007 Feb 27;2. Epub 2007 Feb 27.

Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.

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http://diagnosticpathology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/1746-1596-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810239PMC
February 2007

Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.

Cancer Res 2007 Feb;67(4):1735-43

Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital and University of Toronto, 610 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2722DOI Listing
February 2007

Concurrent gemcitabine and radiotherapy with and without neoadjuvant gemcitabine for locally advanced unresectable or resected pancreatic cancer: a phase I-II study.

Int J Radiat Oncol Biol Phys 2007 Mar 29;67(4):1027-36. Epub 2006 Dec 29.

Department of Radiation Oncology, University Health Network Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2006.10.015DOI Listing
March 2007

Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts.

Mol Cancer Ther 2006 Oct;5(10):2494-502

Division of Applied Molecular Oncology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0504DOI Listing
October 2006