David Hardisson

David Hardisson

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David Hardisson

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[Recommendations for biomarker testing in epithelial ovarian cancer. A national consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology].

Rev Esp Patol 2018 Apr - Jun;51(2):84-96. Epub 2018 Jan 17.

Departamento de Anatomía Patológica, Hospital Universitario Ramón y Cajal, IRYCIS y Universidad de Alcalá, CIBERONC, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.patol.2017.11.002DOI Listing
March 2019

Intratumoral activating GNAS (R201C) mutation in two unrelated patients with virilizing ovarian Leydig cell tumors.

Endocrinol Diabetes Nutr 2017 Jun - Jul;64(6):335-337. Epub 2017 May 11.

Endocrinology and Nutrition Department, La Paz University Hospital, IdiPAZ, Autonomous University of Madrid, Castellana 261, 28046 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.endinu.2017.03.007DOI Listing
December 2018

Frequent and Rare HABP2 Variants Are Not Associated with Increased Susceptibility to Familial Nonmedullary Thyroid Carcinoma in the Spanish Population.

Horm Res Paediatr 2018 12;89(6):397-407. Epub 2018 Jun 12.

Thyroid Molecular Laboratory, Institute for Medical and Molecular Genetics (INGEMM), IdiPAZ, La Paz University Hospital, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1159/000487395DOI Listing
November 2018

[Hospital tumor registry in the Hospital La Paz (Spain)].

Rev Esp Patol 2019 Apr - Jun;52(2):72-75. Epub 2018 Aug 1.

Registro de Tumores, Hospital Universitario La Paz, Madrid, España.

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http://dx.doi.org/10.1016/j.patol.2018.06.004DOI Listing
August 2018

High-throughput 3-dimensional culture of epithelial ovarian cancer cells as preclinical model of disease.

Oncotarget 2018 Apr 24;9(31):21893-21903. Epub 2018 Apr 24.

Molecular Pathology and Therapeutic Targets Research Lab, Instituto de Investigación del Hospital Universitario La Paz, IdiPAZ, Hospital Universitario La Paz, HULP, Madrid 28046, Spain.

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http://dx.doi.org/10.18632/oncotarget.25098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955171PMC
April 2018

Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review.

Int J Surg Pathol 2017 Jun 23;25(4):339-343. Epub 2016 Nov 23.

1 Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.

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http://journals.sagepub.com/doi/10.1177/1066896916679888
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http://dx.doi.org/10.1177/1066896916679888DOI Listing
June 2017

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.

EBioMedicine 2016 Nov 1;13:132-145. Epub 2016 Oct 1.

Departamento de Biología Molecular, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Universidad Autónoma de Madrid, 28049 Madrid, Spain; Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264252PMC
November 2016

One-step nucleic acid amplification (OSNA) for the detection of sentinel lymph node metastasis in endometrial cancer.

Gynecol Oncol 2016 10 3;143(1):54-59. Epub 2016 Aug 3.

Department of Pathology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain; Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain; Molecular Pathology and Therapeutic Targets Group, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.07.106DOI Listing
October 2016

The PTEN/NRF2 axis promotes human carcinogenesis.

Antioxid Redox Signal 2014 Dec 31;21(18):2498-514. Epub 2014 Jul 31.

1 Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid , and Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Madrid, Spain .

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http://dx.doi.org/10.1089/ars.2014.5843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245871PMC
December 2014

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.

Authors:
Roger L Milne Barbara Burwinkel Kyriaki Michailidou Jose-Ignacio Arias-Perez M Pilar Zamora Primitiva Menéndez-Rodríguez David Hardisson Marta Mendiola Anna González-Neira Guillermo Pita M Rosario Alonso Joe Dennis Qin Wang Manjeet K Bolla Anthony Swerdlow Alan Ashworth Nick Orr Minouk Schoemaker Yon-Dschun Ko Hiltrud Brauch Ute Hamann Irene L Andrulis Julia A Knight Gord Glendon Sandrine Tchatchou Keitaro Matsuo Hidemi Ito Hiroji Iwata Kazuo Tajima Jingmei Li Judith S Brand Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Diether Lambrechts Gilian Peuteman Marie-Rose Christiaens Ann Smeets Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katazyna Durda Mikael Hartman Miao Hui Wei Yen Lim Ching Wan Chan Federick Marme Rongxi Yang Peter Bugert Annika Lindblom Sara Margolin Montserrat García-Closas Stephen J Chanock Jolanta Lissowska Jonine D Figueroa Stig E Bojesen Børge G Nordestgaard Henrik Flyger Maartje J Hooning Mieke Kriege Ans M W van den Ouweland Linetta B Koppert Olivia Fletcher Nichola Johnson Isabel dos-Santos-Silva Julian Peto Wei Zheng Sandra Deming-Halverson Martha J Shrubsole Jirong Long Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Angela Cox Simon S Cross Malcolm W R Reed Marjanka K Schmidt Annegien Broeks Sten Cornelissen Linde Braaf Daehee Kang Ji-Yeob Choi Sue K Park Dong-Young Noh Jacques Simard Martine Dumont Mark S Goldberg France Labrèche Peter A Fasching Alexander Hein Arif B Ekici Matthias W Beckmann Paolo Radice Paolo Peterlongo Jacopo Azzollini Monica Barile Elinor Sawyer Ian Tomlinson Michael Kerin Nicola Miller John L Hopper Daniel F Schmidt Enes Makalic Melissa C Southey Soo Hwang Teo Cheng Har Yip Kavitta Sivanandan Wan-Ting Tay Chen-Yang Shen Chia-Ni Hsiung Jyh-Cherng Yu Ming-Feng Hou Pascal Guénel Therese Truong Marie Sanchez Claire Mulot William Blot Qiuyin Cai Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Anna H Wu Chiu-Chen Tseng David Van Den Berg Daniel O Stram Natalia Bogdanova Thilo Dörk Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Xiao-Ou Shu Wei Lu Yu-Tang Gao Ben Zhang Fergus J Couch Amanda E Toland Drakoulis Yannoukakos Suleeporn Sangrajrang James McKay Xianshu Wang Janet E Olson Celine Vachon Kristen Purrington Gianluca Severi Laura Baglietto Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Kamila Czene Mikael Eriksson Keith Humphreys Hatef Darabi Shahana Ahmed Mitul Shah Paul D P Pharoah Per Hall Graham G Giles Javier Benítez Alison M Dunning Georgia Chenevix-Trench Douglas F Easton

Hum Mol Genet 2014 Nov 18;23(22):6096-111. Epub 2014 Jun 18.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

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http://hmg.oxfordjournals.org/content/early/2014/07/04/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu311
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http://dx.doi.org/10.1093/hmg/ddu311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204770PMC
November 2014

Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients.

Breast Cancer Res Treat 2014 Sep 28;147(2):371-80. Epub 2014 Aug 28.

Breast Surgical Oncology Unit, Hospital Universitario Vall d´Hebron, Universitat Autònoma de Barcelona, 119, 08035, Barcelona, Spain,

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http://dx.doi.org/10.1007/s10549-014-3108-2DOI Listing
September 2014

NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer.

J Clin Endocrinol Metab 2014 Jul 7;99(7):E1199-208. Epub 2014 Apr 7.

Instituto de Investigaciones Biomédicas (G.R.-E., S.G.L., M.A.E.-C., P.S.), Consejo Superior de Investigaciones Científicas (CSIC-UAM) 28029 Madrid, Spain; Servicio de Endocrinología y Nutrición (G.R-E.), Departamento de Anatomía Patologica (M.M., D.H.), and Servicio de Oncología Medica (A.R.), Hospital Universitario La Paz, IdPAZ, 28046, Madrid, Spain; and Unidad de Patología Mamaria (M.I.G.) and Unidad de Tumores Endocrinos (A.D.l.V.), Unidad Funcional de Investigación en Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, 28220, Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1210/jc.2013-4249DOI Listing
July 2014

Reproducibility of current classifications of endometrial endometrioid glandular proliferations: further evidence supporting a simplified classification.

Histopathology 2014 Jan 20;64(2):284-92. Epub 2013 Sep 20.

Department of Pathology, CRESIB (Centre de Recerca en Salut Internacional de Barcelona), Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/his.12249DOI Listing
January 2014

An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer.

BMC Cancer 2010 Jun 28;10:336. Epub 2010 Jun 28.

Unidad de Investigación, Instituto de Investigación Sanitaria IdIPAZ, Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid 28046, Spain.

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http://dx.doi.org/10.1186/1471-2407-10-336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906483PMC
June 2010

Angiogenesis and ovarian cancer.

Clin Transl Oncol 2009 Sep;11(9):564-71

Department of Clinical Oncology, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain.

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September 2009

Signet-ring stromal tumor of the ovary: report of a case and review of the literature.

Pathol Oncol Res 2008 Sep 29;14(3):333-6. Epub 2008 Aug 29.

Department of Pathology, University Hospital La Paz, Autonomous University of Madrid, Madrid, Spain.

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http://dx.doi.org/10.1007/s12253-008-9080-6DOI Listing
September 2008

Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.

Mod Pathol 2008 Aug 23;21(8):925-36. Epub 2008 May 23.

Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/modpathol.2008.49DOI Listing
August 2008

Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.

Cancer Res 2008 Jun;68(12):4541-50

Departamento de Bioquímica, Instituto de Investigaciones Biomédicas "Alberto Sols" Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6345DOI Listing
June 2008

Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype.

Cancer Res 2008 Feb;68(4):989-97

Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2017DOI Listing
February 2008

Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas.

J Clin Pathol 2007 Sep 14;60(9):1006-12. Epub 2006 Nov 14.

Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1136/jcp.2006.042143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972443PMC
September 2007

Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer.

Mod Pathol 2007 Apr 2;20(4):474-81. Epub 2007 Mar 2.

Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/modpathol.3800760DOI Listing
April 2007

Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.

Cancer Res 2007 Mar;67(5):1927-34

Breast and Gynecological Cancer Group, Tumor Suppression Group, Spanish National Cancer Center (CNIO), 3 Melchior Fernandez Almagro Street, Madrid E-28029, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2687DOI Listing
March 2007

Caveolin-1 expression is associated with a basal-like phenotype in sporadic and hereditary breast cancer.

Breast Cancer Res Treat 2006 Sep 16;99(1):85-90. Epub 2006 Mar 16.

Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://link.springer.com/10.1007/s10549-006-9184-1
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http://dx.doi.org/10.1007/s10549-006-9184-1DOI Listing
September 2006

Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas.

Hum Pathol 2006 Aug 2;37(8):1042-9. Epub 2006 Jun 2.

Molecular Pathology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.humpath.2006.03.003DOI Listing
August 2006

Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas.

Breast Cancer Res Treat 2006 Jul 15;98(1):71-9. Epub 2006 Mar 15.

Breast and Gynaecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://link.springer.com/10.1007/s10549-005-9133-4
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http://dx.doi.org/10.1007/s10549-005-9133-4DOI Listing
July 2006

Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas.

Clin Cancer Res 2006 Mar;12(5):1533-9

Breast and Gynecological Cancer Group, Molecular Pathology Programme and Department of Human Genetics, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-05-2281DOI Listing
March 2006

Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis.

Carcinogenesis 2005 Dec 20;26(12):2095-104. Epub 2005 Jul 20.

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgi188DOI Listing
December 2005

Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.

Int J Cancer 2004 Dec;112(6):959-66

Programa de Patología Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1002/ijc.20524DOI Listing
December 2004

Molecular alterations associated with cyclin D1 overexpression in endometrial cancer.

Int J Cancer 2004 Jun;110(2):194-200

Laboratory of Breast and Gynecologic Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1002/ijc.20130DOI Listing
June 2004

Numerical aberrations of chromosomes 8, 9, 11, and 17 in squamous cell carcinoma of the pharynx and larynx: a fluorescence in situ hybridization and DNA flow cytometric analysis of 50 cases.

Oral Oncol 2004 Apr;40(4):409-17

Department of Pathology, Hospital Universitario La Paz, Autonomous University of Madrid, Paseo de la Castellana 261, E-28046 Madrid, Spain.

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http://dx.doi.org/10.1016/j.oraloncology.2003.09.008DOI Listing
April 2004

Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma.

J Pathol 2003 Dec;201(4):589-95

Laboratory of Breast and Gynaecological Cancer, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1002/path.1474DOI Listing
December 2003

Molecular pathogenesis of head and neck squamous cell carcinoma.

Authors:
David Hardisson

Eur Arch Otorhinolaryngol 2003 Oct 8;260(9):502-8. Epub 2003 May 8.

Department of Pathology, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Paseo de la Castellana 261, 28046 Madrid, Spain.

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http://dx.doi.org/10.1007/s00405-003-0581-3DOI Listing
October 2003

Cyclin D1 gene (CCND1) mutations in endometrial cancer.

Oncogene 2003 Sep;22(38):6115-8

Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://www.nature.com/articles/1206868
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http://dx.doi.org/10.1038/sj.onc.1206868DOI Listing
September 2003

Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability.

Int J Cancer 2003 Aug;106(2):208-15

Laboratory of Breast and Gynecological Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1002/ijc.11197DOI Listing
August 2003

Fine needle aspiration cytology of solid papillary carcinoma of the breast. A report of four cases.

Acta Cytol 2003 Mar-Apr;47(2):259-64

Departamento de Anatomia Patologica, Hospital Universitario La Paz, Paseo de la Castellana, 261, E-28046 Madrid, Spain.

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http://dx.doi.org/10.1159/000326513DOI Listing
May 2003

Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia.

J Pathol 2003 Apr;199(4):471-8

Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/path.1310DOI Listing
April 2003

Multiple pulmonary leiomyomatous hamartomas associated with a bronchogenic cyst in a man.

Arch Pathol Lab Med 2003 Apr;127(4):e194-6

Department of Pathology, University Hospital La Paz, Autonomous University of Madrid, Spain.

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http://dx.doi.org/10.1043/0003-9985(2003)1272.0.CO;2DOI Listing
April 2003

Abnormalities of the APC/beta-catenin pathway in endometrial cancer.

Oncogene 2002 Nov;21(52):7981-90

Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/sj.onc.1205924DOI Listing
November 2002

Kaposiform hemangioendothelioma of the external auditory canal in an adult.

Head Neck 2002 Jun;24(6):614-7

Departamento de Anatomia Patologica, Hospital Universitario La Paz, Paseo de la Castellana, 261, E-28046 Madrid, Spain.

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http://dx.doi.org/10.1002/hed.10074DOI Listing
June 2002

Solitary fibrous tumor of the skin.

J Am Acad Dermatol 2002 Feb;46(2 Suppl Case Reports):S37-40

Department of Pathology, University General Hospital of Guadalajara, Alcalá University, Spain.

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February 2002

Eccrine porocarcinoma (malignant eccrine poroma).

Am J Surg Pathol 2002 Feb;26(2):272-4

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February 2002