David H Spencer

David H Spencer

UNVERIFIED PROFILE

Are you David H Spencer?   Register this Author

Register author
David H Spencer

David H Spencer

Publications by authors named "David H Spencer"

Are you David H Spencer?   Register this Author

27Publications

911Reads

14Profile Views

DNMT3A-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A OCI-AML3 leukemia cell line.

Blood Cancer J 2018 04 4;8(4):38. Epub 2018 Apr 4.

Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41408-018-0072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884841PMC
April 2018

Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.

JAMA 2018 Apr;319(14):1497-1498

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, The McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2018.2281DOI Listing
April 2018

Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.

Exp Hematol 2017 11 28;55:19-33. Epub 2017 Jul 28.

The McDonnell Genome Institute, Washington University, St. Louis, MO; Department of Medicine, Washington University, St. Louis, MO; Siteman Cancer Center, Washington University, St. Louis, MO; Department of Biomedical Engineering, Washington University, St. Louis, MO. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772960PMC
November 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell 2017 02 16;168(5):801-816.e13. Epub 2017 Feb 16.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328582PMC
February 2017

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.

Cancer Cell 2014 Apr 20;25(4):442-54. Epub 2014 Mar 20.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University, St. Louis, MO 63110, USA; The Genome Institute, Washington University, St. Louis, MO 63110, USA; Department of Genetics, Washington University, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018976PMC
April 2014

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Cancer Cell 2014 Mar 6;25(3):379-92. Epub 2014 Mar 6.

The Genome Institute, Washington University, St. Louis, MO 63110, USA; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983786PMC
March 2014

Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens.

J Mol Diagn 2013 Sep 26;15(5):623-33. Epub 2013 Jun 26.

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912568PMC
September 2013

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.

J Mol Diagn 2013 Jan 14;15(1):81-93. Epub 2012 Nov 14.

Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2012.08.001DOI Listing
January 2013

Direct-to-consumer genetic testing: reliable or risky?

Clin Chem 2011 Dec 1;57(12):1641-4. Epub 2011 Sep 1.

Washington University/Barnes-Jewish Hospital, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2011.167197DOI Listing
December 2011

Validation and implementation of the GeneXpert MRSA/SA blood culture assay in a pediatric setting.

Am J Clin Pathol 2011 Nov;136(5):690-4

Departments of Pathology & Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1309/AJCP07UGYOKBVVNCDOI Listing
November 2011

Red cell transfusion decreases hemoglobin A1c in patients with diabetes.

Clin Chem 2011 Feb 8;57(2):344-6. Epub 2010 Nov 8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2010.157321DOI Listing
February 2011

Detecting disease-causing mutations in the human genome by haplotype matching.

Am J Hum Genet 2006 Nov 25;79(5):958-64. Epub 2006 Sep 25.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/508757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698563PMC
November 2006

Evidence for diversifying selection at the pyoverdine locus of Pseudomonas aeruginosa.

J Bacteriol 2005 Mar;187(6):2138-47

Program of Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.187.6.2138-2147.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064051PMC
March 2005

Whole-genome sequence variation among multiple isolates of Pseudomonas aeruginosa.

J Bacteriol 2003 Feb;185(4):1316-25

The University of Washington Genome Center, Department of Medicine, University of Washington. Children's Hospital and Regional Medical Center, Seattle, Washington 98195, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC142842PMC
http://dx.doi.org/10.1128/jb.185.4.1316-1325.2003DOI Listing
February 2003

Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa.

J Bacteriol 2002 Jul;184(13):3614-22

University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135118PMC
http://dx.doi.org/10.1128/jb.184.13.3614-3622.2002DOI Listing
July 2002