Publications by authors named "David H Spencer"

32Publications

Deletions in BCP-ALL result in a TAD more FLT3.

Authors:
David H Spencer

Blood 2020 Aug;136(8):919-920

Washington University School of Medicine.

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http://dx.doi.org/10.1182/blood.2020006607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441166PMC
August 2020

Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells.

Leukemia 2020 May 12. Epub 2020 May 12.

Division of Oncology, Department of Medicine, Section of Stem Cell Biology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41375-020-0856-3DOI Listing
May 2020

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.

Exp Hematol 2019 12 5;80:36-41.e3. Epub 2019 Dec 5.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031927PMC
December 2019

Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.

JAMA 2018 Apr;319(14):1497-1498

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, The McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1001/jama.2018.2281DOI Listing
April 2018

DNMT3A-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A OCI-AML3 leukemia cell line.

Blood Cancer J 2018 04 4;8(4):38. Epub 2018 Apr 4.

Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41408-018-0072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884841PMC
April 2018

Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.

Exp Hematol 2017 11 28;55:19-33. Epub 2017 Jul 28.

The McDonnell Genome Institute, Washington University, St. Louis, MO; Department of Medicine, Washington University, St. Louis, MO; Siteman Cancer Center, Washington University, St. Louis, MO; Department of Biomedical Engineering, Washington University, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772960PMC
November 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell 2017 02 16;168(5):801-816.e13. Epub 2017 Feb 16.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328582PMC
February 2017

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.

Cancer Cell 2014 Apr 20;25(4):442-54. Epub 2014 Mar 20.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University, St. Louis, MO 63110, USA; The Genome Institute, Washington University, St. Louis, MO 63110, USA; Department of Genetics, Washington University, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018976PMC
April 2014

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Cancer Cell 2014 Mar 6;25(3):379-92. Epub 2014 Mar 6.

The Genome Institute, Washington University, St. Louis, MO 63110, USA; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983786PMC
March 2014

Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens.

J Mol Diagn 2013 Sep 26;15(5):623-33. Epub 2013 Jun 26.

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912568PMC
September 2013

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

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http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.

J Mol Diagn 2013 Jan 14;15(1):81-93. Epub 2012 Nov 14.

Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2012.08.001DOI Listing
January 2013

Validation and implementation of the GeneXpert MRSA/SA blood culture assay in a pediatric setting.

Am J Clin Pathol 2011 Nov;136(5):690-4

Departments of Pathology & Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1309/AJCP07UGYOKBVVNCDOI Listing
November 2011

Direct-to-consumer genetic testing: reliable or risky?

Clin Chem 2011 Dec 1;57(12):1641-4. Epub 2011 Sep 1.

Washington University/Barnes-Jewish Hospital, St. Louis, MO, USA.

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http://dx.doi.org/10.1373/clinchem.2011.167197DOI Listing
December 2011

Red cell transfusion decreases hemoglobin A1c in patients with diabetes.

Clin Chem 2011 Feb 8;57(2):344-6. Epub 2010 Nov 8.

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http://dx.doi.org/10.1373/clinchem.2010.157321DOI Listing
February 2011

Detecting disease-causing mutations in the human genome by haplotype matching.

Am J Hum Genet 2006 Nov 25;79(5):958-64. Epub 2006 Sep 25.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1086/508757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698563PMC
November 2006

Evidence for diversifying selection at the pyoverdine locus of Pseudomonas aeruginosa.

J Bacteriol 2005 Mar;187(6):2138-47

Program of Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1128/JB.187.6.2138-2147.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064051PMC
March 2005

Whole-genome sequence variation among multiple isolates of Pseudomonas aeruginosa.

J Bacteriol 2003 Feb;185(4):1316-25

The University of Washington Genome Center, Department of Medicine, University of Washington. Children's Hospital and Regional Medical Center, Seattle, Washington 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC142842PMC
http://dx.doi.org/10.1128/jb.185.4.1316-1325.2003DOI Listing
February 2003

Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa.

J Bacteriol 2002 Jul;184(13):3614-22

University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135118PMC
http://dx.doi.org/10.1128/jb.184.13.3614-3622.2002DOI Listing
July 2002