Publications by authors named "David H Sherman"

100Publications

Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.

J Am Chem Soc 2020 Oct 8;142(42):17981-17988. Epub 2020 Oct 8.

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/jacs.0c04388DOI Listing
October 2020

Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis.

Tetrahedron Lett 2020 Jan 2;61(5). Epub 2019 Dec 2.

UM Natural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1016/j.tetlet.2019.151469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453842PMC
January 2020

Structure and Function of NzeB, a Versatile C-C and C-N Bond-Forming Diketopiperazine Dimerase.

J Am Chem Soc 2020 Oct 30;142(41):17413-17424. Epub 2020 Sep 30.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/jacs.0c06312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572911PMC
October 2020

Exploring the molecular basis for selective C-H functionalization in plant P450s.

Synth Syst Biotechnol 2020 Jun 9;5(2):97-98. Epub 2020 Jun 9.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, United States.

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http://dx.doi.org/10.1016/j.synbio.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292896PMC
June 2020

Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases.

Angew Chem Int Ed Engl 2020 08 5;59(32):13575-13580. Epub 2020 Jun 5.

Life Sciences Institute, The University of Michigan (USA), 210 Washtenaw Avenue, Ann Arbor, MI, 48109-2216, USA.

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http://dx.doi.org/10.1002/anie.202004991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395861PMC
August 2020

Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids.

ACS Synth Biol 2020 06 7;9(6):1349-1360. Epub 2020 May 7.

New England Biolabs, Inc., Ipswich, Massachusetts 01938, United States.

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http://dx.doi.org/10.1021/acssynbio.0c00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323787PMC
June 2020

Enzyme evolution in fungal indole alkaloid biosynthesis.

FEBS J 2020 Apr;287(7):1381-1402

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1111/febs.15270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317620PMC
April 2020

Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases.

Angew Chem Int Ed Engl 2020 05 19;59(21):8166-8172. Epub 2020 Mar 19.

Life Sciences Institute, Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109-2216n, USA.

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http://dx.doi.org/10.1002/anie.201913686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274885PMC
May 2020

Stereoselective Synthesis of Baulamycin A.

J Org Chem 2020 Mar 7;85(5):3812-3823. Epub 2020 Feb 7.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.

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http://dx.doi.org/10.1021/acs.joc.9b03443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271067PMC
March 2020

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs.

ACS Chem Biol 2020 02 3;15(2):524-532. Epub 2020 Feb 3.

Department of Internal Medicine, Henry Ford Cancer Institute , Henry Ford Health System , Detroit , Michigan 48202 , United States.

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http://dx.doi.org/10.1021/acschembio.9b00998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094870PMC
February 2020

Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway.

J Am Chem Soc 2020 02 16;142(5):2244-2252. Epub 2020 Jan 16.

Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , United States.

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http://dx.doi.org/10.1021/jacs.9b09070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065246PMC
February 2020

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.

Structure 2020 01 27;28(1):63-74.e4. Epub 2019 Nov 27.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949403PMC
January 2020

DDAP: docking domain affinity and biosynthetic pathway prediction tool for type I polyketide synthases.

Bioinformatics 2020 02;36(3):942-944

Department of Computational Medicine and Bioinformatics, MI, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz677DOI Listing
February 2020

Engineered Production of Hapalindole Alkaloids in the Cyanobacterium sp. UTEX 2973.

ACS Synth Biol 2019 08 19;8(8):1941-1951. Epub 2019 Jul 19.

Department of Biology , Washington University , St. Louis , Missouri 63130 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724726PMC
August 2019

Isolation of a new indoxyl alkaloid, Amoenamide B, from NRRL 35600: biosynthetic implications and correction of the structure of Speramide B.

Tetrahedron Lett 2018 Nov 20;50(48):4236-4240. Epub 2018 Oct 20.

Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.tetlet.2018.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370310PMC
November 2018

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

J Am Chem Soc 2019 02 24;141(5):1961-1969. Epub 2019 Jan 24.

Department of Chemistry , NC State University , Raleigh , North Carolina 27695 , United States.

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http://dx.doi.org/10.1021/jacs.8b10521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556384PMC
February 2019

Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.

Methods Enzymol 2018 9;604:207-236. Epub 2018 Apr 9.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Chemistry, University of Michigan, Ann Arbor, MI, United States; Life Sciences Institute, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00766879183004
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http://dx.doi.org/10.1016/bs.mie.2018.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327954PMC
April 2019

Halogenase engineering and its utility in medicinal chemistry.

Bioorg Med Chem Lett 2018 06 30;28(11):1992-1999. Epub 2018 Apr 30.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, United States; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.04.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964047PMC
June 2018

Isolation of amoenamide A and five antipodal prenylated alkaloids from NRRL 35600.

Tetrahedron Lett 2017 Jul 18;58(29):2797-2800. Epub 2017 May 18.

Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.tetlet.2017.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881583PMC
July 2017

Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.

Tetrahedron Lett 2016 Dec 19;57(52):5919-5923. Epub 2016 Nov 19.

Shandong Provincial Key Laboratory of Synthetic Biology, and CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China.

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http://dx.doi.org/10.1016/j.tetlet.2016.11.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628624PMC
December 2016

Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.

J Am Chem Soc 2017 09 19;139(38):13450-13455. Epub 2017 Sep 19.

Life Sciences Institute, ‡Department of Medicinal Chemistry, §Cancer Biology Graduate Program, ⊥Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/jacs.7b06432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617803PMC
September 2017

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

J Am Chem Soc 2017 09 19;139(38):13456-13465. Epub 2017 Sep 19.

Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja , 26006 Logroño, La Rioja, Spain.

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http://dx.doi.org/10.1021/jacs.7b06436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617804PMC
September 2017

High-quality draft genome sequence of a biofilm forming lignocellulolytic strain ATCC 10864.

Stand Genomic Sci 2017 17;12:37. Epub 2017 Jul 17.

Laboratorio de Micología y Biotecnología, Universidad Nacional Agraria La Molina, Av. La Molina s/n, 12 Lima, Peru.

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http://dx.doi.org/10.1186/s40793-017-0254-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514509PMC
July 2017

Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

J Am Chem Soc 2017 06 19;139(25):8570-8578. Epub 2017 Jun 19.

Department of Chemistry, †Life Sciences Institute, §Department of Medicinal Chemistry, ‡Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/jacs.7b03198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553906PMC
June 2017

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

J Am Chem Soc 2017 06 5;139(23):7913-7920. Epub 2017 Jun 5.

Life Sciences Institute, ‡Department of Medicinal Chemistry, §Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/jacs.7b02875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532807PMC
June 2017

Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

Biochemistry 2017 05 16;56(21):2701-2714. Epub 2017 May 16.

Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109-2216, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520640PMC
May 2017

Insights from the genome of a high alkaline cellulase producing Aspergillus fumigatus strain obtained from Peruvian Amazon rainforest.

J Biotechnol 2017 Jun 12;251:53-58. Epub 2017 Apr 12.

Laboratorio de Micología y Biotecnología, Universidad Nacional Agraria La Molina, Av. La Molina s/n, Lima 12, Peru.

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https://linkinghub.elsevier.com/retrieve/pii/S01681656173016
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http://dx.doi.org/10.1016/j.jbiotec.2017.04.010DOI Listing
June 2017

Complete elucidation of the late steps of bafilomycin biosynthesis in .

J Biol Chem 2017 04 14;292(17):7095-7104. Epub 2017 Mar 14.

From the Shandong Provincial Key Laboratory of Synthetic Biology, and CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101,

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http://dx.doi.org/10.1074/jbc.M116.751255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409476PMC
April 2017

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.

Nat Chem Biol 2017 05 13;13(5):467-469. Epub 2017 Mar 13.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/nchembio.2327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391265PMC
May 2017

Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

J Am Chem Soc 2016 12 30;138(49):16024-16036. Epub 2016 Nov 30.

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/jacs.6b09748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590676PMC
December 2016

Environmental Pseudomonads Inhibit Cystic Fibrosis Patient-Derived Pseudomonas aeruginosa.

Appl Environ Microbiol 2017 01 30;83(2). Epub 2016 Dec 30.

Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, USA

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http://dx.doi.org/10.1128/AEM.02701-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203635PMC
January 2017

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

ACS Chem Biol 2016 12 18;11(12):3319-3327. Epub 2016 Oct 18.

Life Sciences Institute, University of Michigan , Ann Arbor, Michigan, United States.

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http://dx.doi.org/10.1021/acschembio.6b00759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224524PMC
December 2016

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.

Proc Natl Acad Sci U S A 2016 09 29;113(37):10316-21. Epub 2016 Aug 29.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109

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http://dx.doi.org/10.1073/pnas.1607210113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027445PMC
September 2016

OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30.

J Am Chem Soc 2016 09 24;138(35):11176-84. Epub 2016 Aug 24.

Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/jacs.6b04915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014723PMC
September 2016

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

ACS Chem Biol 2016 09 5;11(9):2642-54. Epub 2016 Aug 5.

Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acschembio.6b00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026600PMC
September 2016

Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.

J Ind Microbiol Biotechnol 2016 08 9;43(8):1189-93. Epub 2016 Jun 9.

Department of Biological Engineering, Inha University, Incheon, 402-751, Korea.

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http://dx.doi.org/10.1007/s10295-016-1790-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939285PMC
August 2016

The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide.

Chembiochem 2016 Jan 23;17(2):164-73. Epub 2015 Dec 23.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0212, La Jolla, CA, 92093, USA) address.

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http://dx.doi.org/10.1002/cbic.201500467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878910PMC
January 2016

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity.

Nat Prod Rep 2016 Feb;33(2):348-64

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, USA. and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, USA.

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http://dx.doi.org/10.1039/c5np00097aDOI Listing
February 2016

Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404).

Angew Chem Int Ed Engl 2016 Jan 8;55(3):1128-32. Epub 2015 Dec 8.

Graduated School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

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http://dx.doi.org/10.1002/anie.201509462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960981PMC
January 2016

Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.

J Am Chem Soc 2015 Dec 2;137(49):15366-9. Epub 2015 Dec 2.

Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.

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http://dx.doi.org/10.1021/jacs.5b10136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681624PMC
December 2015

Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

ACS Med Chem Lett 2015 Nov 8;6(11):1122-7. Epub 2015 Sep 8.

Carmen and Ann Adams Department of Pediatrics, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Department of Otolaryngology, Wayne State University and Karmanos Cancer Institute , Detroit, Michigan 48201, United States ; Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute , Detroit, Michigan 48201, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645248PMC
November 2015

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.

Structure 2015 Dec 29;23(12):2213-2223. Epub 2015 Oct 29.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA; Department Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-0600, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670573PMC
December 2015

Natural Diels-Alderases: Elusive and Irresistable.

J Org Chem 2015 Dec;80(23):11672-85

Department of Chemistry, Colorado State University , Fort Collins, Colorado 80524, United States.

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http://dx.doi.org/10.1021/acs.joc.5b01951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806863PMC
December 2015

Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.

ACS Med Chem Lett 2015 Aug 6;6(8):877-81. Epub 2015 Jul 6.

Center for Chemical Genomics, Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109-2216, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538430PMC
August 2015

Minimum Information about a Biosynthetic Gene cluster.

Authors:
Marnix H Medema Renzo Kottmann Pelin Yilmaz Matthew Cummings John B Biggins Kai Blin Irene de Bruijn Yit Heng Chooi Jan Claesen R Cameron Coates Pablo Cruz-Morales Srikanth Duddela Stephanie Düsterhus Daniel J Edwards David P Fewer Neha Garg Christoph Geiger Juan Pablo Gomez-Escribano Anja Greule Michalis Hadjithomas Anthony S Haines Eric J N Helfrich Matthew L Hillwig Keishi Ishida Adam C Jones Carla S Jones Katrin Jungmann Carsten Kegler Hyun Uk Kim Peter Kötter Daniel Krug Joleen Masschelein Alexey V Melnik Simone M Mantovani Emily A Monroe Marcus Moore Nathan Moss Hans-Wilhelm Nützmann Guohui Pan Amrita Pati Daniel Petras F Jerry Reen Federico Rosconi Zhe Rui Zhenhua Tian Nicholas J Tobias Yuta Tsunematsu Philipp Wiemann Elizabeth Wyckoff Xiaohui Yan Grace Yim Fengan Yu Yunchang Xie Bertrand Aigle Alexander K Apel Carl J Balibar Emily P Balskus Francisco Barona-Gómez Andreas Bechthold Helge B Bode Rainer Borriss Sean F Brady Axel A Brakhage Patrick Caffrey Yi-Qiang Cheng Jon Clardy Russell J Cox René De Mot Stefano Donadio Mohamed S Donia Wilfred A van der Donk Pieter C Dorrestein Sean Doyle Arnold J M Driessen Monika Ehling-Schulz Karl-Dieter Entian Michael A Fischbach Lena Gerwick William H Gerwick Harald Gross Bertolt Gust Christian Hertweck Monica Höfte Susan E Jensen Jianhua Ju Leonard Katz Leonard Kaysser Jonathan L Klassen Nancy P Keller Jan Kormanec Oscar P Kuipers Tomohisa Kuzuyama Nikos C Kyrpides Hyung-Jin Kwon Sylvie Lautru Rob Lavigne Chia Y Lee Bai Linquan Xinyu Liu Wen Liu Andriy Luzhetskyy Taifo Mahmud Yvonne Mast Carmen Méndez Mikko Metsä-Ketelä Jason Micklefield Douglas A Mitchell Bradley S Moore Leonilde M Moreira Rolf Müller Brett A Neilan Markus Nett Jens Nielsen Fergal O'Gara Hideaki Oikawa Anne Osbourn Marcia S Osburne Bohdan Ostash Shelley M Payne Jean-Luc Pernodet Miroslav Petricek Jörn Piel Olivier Ploux Jos M Raaijmakers José A Salas Esther K Schmitt Barry Scott Ryan F Seipke Ben Shen David H Sherman Kaarina Sivonen Michael J Smanski Margherita Sosio Evi Stegmann Roderich D Süssmuth Kapil Tahlan Christopher M Thomas Yi Tang Andrew W Truman Muriel Viaud Jonathan D Walton Christopher T Walsh Tilmann Weber Gilles P van Wezel Barrie Wilkinson Joanne M Willey Wolfgang Wohlleben Gerard D Wright Nadine Ziemert Changsheng Zhang Sergey B Zotchev Rainer Breitling Eriko Takano Frank Oliver Glöckner

Nat Chem Biol 2015 Sep;11(9):625-31

1] Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, Bremen, Germany. [2] Jacobs University Bremen gGmbH, Bremen, Germany.

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http://orbit.dtu.dk/files/115504295/Minimum_Information_abou
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http://www.nature.com/doifinder/10.1038/nchembio.1890
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http://dx.doi.org/10.1038/nchembio.1890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714517PMC
September 2015

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.

J Am Chem Soc 2015 Aug 13;137(33):10603-9. Epub 2015 Aug 13.

Sequoia Sciences, Inc. , 1912 Innerbelt Business Center Drive, Saint Louis, Missouri 63114, United States.

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http://dx.doi.org/10.1021/jacs.5b04842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666801PMC
August 2015

Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.

PLoS One 2015 29;10(7):e0133297. Epub 2015 Jul 29.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, 92093, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, 92093, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133297PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519256PMC
May 2016

Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations.

Nat Chem 2015 Aug 29;7(8):653-60. Epub 2015 Jun 29.

1] Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA [3] Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA [4] Department of Microbiology &Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nchem.2285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518477PMC
August 2015

ORGANIC SYNTHESIS. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence".

Science 2015 Jul 9;349(6244):149. Epub 2015 Jul 9.

Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA. The University of Colorado Cancer Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/science.aaa9349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499860PMC
July 2015

Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries.

Chem Biol Drug Des 2015 Dec 25;86(6):1331-8. Epub 2015 Jul 25.

Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI, 48109-2216, USA.

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http://dx.doi.org/10.1111/cbdd.12614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888872PMC
December 2015

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743.

Environ Microbiol 2015 Oct 21;17(10):3964-75. Epub 2015 Jul 21.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1111/1462-2920.12908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618771PMC
October 2015

Architecture of the polyketide synthase module: surprises from electron cryo-microscopy.

Curr Opin Struct Biol 2015 Apr 16;31:9-19. Epub 2015 Mar 16.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0959440X150002
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http://dx.doi.org/10.1016/j.sbi.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476912PMC
April 2015

Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungus Aspergillus amoenus: biogenetic implications.

Org Lett 2015 Feb 23;17(3):700-3. Epub 2015 Jan 23.

Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

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http://dx.doi.org/10.1021/ol5037198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456087PMC
February 2015

The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products.

J Biomol Screen 2015 Jun 30;20(5):673-80. Epub 2014 Dec 30.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA

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http://dx.doi.org/10.1177/1087057114564868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439314PMC
June 2015

Uncovering the cultivable microbial diversity of costa rican beetles and its ability to break down plant cell wall components.

PLoS One 2014 20;9(11):e113303. Epub 2014 Nov 20.

Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Costa Rica; Escuela de Química & Centro de Investigación en Productos Naturales (CIPRONA), Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239062PMC
January 2016

Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.

Mol Pharmacol 2014 Oct 1;86(4):406-16. Epub 2014 Aug 1.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (A.R., P.J.S., D.H.S.); Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan (L.A., R.R.N., B.S.); Department of Pharmacology (C.C.), Department of Medicinal Chemistry (D.H.S.), Department of Microbiology and Immunology (D.H.S.), Department of Chemistry (D.H.S.), Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (D.H.S.); Unidad Estrategica de Bioprospección, Instituto Nacional de Biodiversidad, Santo Domingo de Heredia, Costa Rica & CIPRONA, Escuela de Química, Universidad de Costa Rica, San Pedro, Costa Rica (G.T-C.); Harvard Medical School, Boston, Massachusetts (S.C., J.C.); and University of Hawaii Cancer Center, Honolulu, Hawaii (S.C.)

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http://dx.doi.org/10.1124/mol.114.092403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067637PMC
October 2014

Structural rearrangements of a polyketide synthase module during its catalytic cycle.

Nature 2014 Jun 18;510(7506):560-4. Epub 2014 Jun 18.

1] Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/nature13409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074775PMC
June 2014

Structure of a modular polyketide synthase.

Nature 2014 Jun 18;510(7506):512-7. Epub 2014 Jun 18.

1] Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.nature.com/articles/nature13423
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http://dx.doi.org/10.1038/nature13423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278352PMC
June 2014

Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism.

Chembiochem 2014 May 25;15(8):1079-81. Epub 2014 Apr 25.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA).

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http://dx.doi.org/10.1002/cbic.201402095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122295PMC
May 2014

High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.

Chem Biol Drug Des 2014 Apr;83(4):440-9

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109-2216, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109-2216, USA.

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http://dx.doi.org/10.1111/cbdd.12259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068144PMC
April 2014

Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation.

J Am Chem Soc 2014 Apr 21;136(13):4901-4. Epub 2014 Mar 21.

Department of Medicinal Chemistry, §Life Sciences Institute, ⊥Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/ja5016052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012894PMC
April 2014

New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.

J Am Chem Soc 2014 Mar 25;136(9):3640-6. Epub 2014 Feb 25.

CAS Key Laboratory of Biofuels, and Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao, Shandong 266101, China.

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http://dx.doi.org/10.1021/ja4130302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985502PMC
March 2014

Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways.

PLoS One 2014 27;9(1):e85140. Epub 2014 Jan 27.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903477PMC
November 2014

The role of HTS in drug discovery at the University of Michigan.

Comb Chem High Throughput Screen 2014 Mar;17(3):210-30

Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166557PMC
http://dx.doi.org/10.2174/1386207317666140109121546DOI Listing
March 2014

Discovery of potent broad spectrum antivirals derived from marine actinobacteria.

PLoS One 2013 5;8(12):e82318. Epub 2013 Dec 5.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America ; Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857800PMC
October 2014

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

Chem Biol 2013 Nov 31;20(11):1340-51. Epub 2013 Oct 31.

Chemical Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870462PMC
November 2013

Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis.

Curr Opin Biotechnol 2013 Dec 31;24(6):1151-8. Epub 2013 May 31.

Life Sciences Institute and Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.copbio.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797859PMC
December 2013

Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Chembiochem 2013 Feb 29;14(3):301-6. Epub 2013 Jan 29.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101, PR China.

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http://dx.doi.org/10.1002/cbic.201200743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771327PMC
February 2013

Chemistry. Re-engineering nature's catalysts.

Science 2013 Jan;339(6117):283-4

Life Sciences Institute and Department of Medical Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/science.1233324DOI Listing
January 2013