David H Gutmann

David H Gutmann

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David H Gutmann

Publications by authors named "David H Gutmann"

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Understanding a complicated Gal-1.

Neuro Oncol 2019 Nov;21(11):1341-1343

Department of Neurology, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1093/neuonc/noz165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827833PMC
November 2019

Microglia as Dynamic Cellular Mediators of Brain Function.

Trends Mol Med 2019 Nov 6;25(11):967-979. Epub 2019 Oct 6.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829057PMC
November 2019

NF1 glioblastoma clonal profiling reveals mutations as potential somatic oncogenic events.

Neurology 2019 Nov 5. Epub 2019 Nov 5.

From the Division of Hematology and Oncology (W.H.W., T.E.D.), Department of Pediatrics, Washington University School of Medicine; Edison Family Center for Genome Sciences and Systems Biology (W.H.W., T.E.D.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (L.J.), University of Michigan Health System, Ann Arbor; Department of Neurology (D.H.G.), Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000008623DOI Listing
November 2019

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology.

Neuron 2019 Nov;104(3):442-449

Cellular Neurosciences, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.08.028DOI Listing
November 2019

Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1.

Brain Behav Immun 2019 Oct 2;81:470-483. Epub 2019 Jul 2.

Cellular Neurosciences, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.06.047DOI Listing
October 2019

Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.

Bull Math Biol 2019 Sep 22;81(9):3655-3673. Epub 2018 Oct 22.

Math Department, Pomona College, Claremont, CA, 91711, USA.

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http://dx.doi.org/10.1007/s11538-018-0526-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476710PMC
September 2019

Neurofibromatosis 2 in children presenting during the first decade of life.

Neurology 2019 Sep 30;93(10):e964-e967. Epub 2019 Jul 30.

From the Department of Neurology (C.G., D.H.G.), Washington University School of Medicine, St. Louis, MO; Ann & Robert H. Lurie Children's Hospital of Chicago (R.L.), Feinberg School of Medicine, Northwestern University, IL; Division of Oncology (M.J.F., A.P.), Children's Hospital of Philadelphia, PA; and Department of Neurology (C.J.C.), Stanford University, Palo Alto, CA.

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http://dx.doi.org/10.1212/WNL.0000000000008065DOI Listing
September 2019

Neurofibromatosis type 1 (Nf1)-mutant mice exhibit increased sleep fragmentation.

J Sleep Res 2019 Aug 4;28(4):e12816. Epub 2019 Jan 4.

Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1111/jsr.12816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609510PMC
August 2019

Adaptive functioning in children with neurofibromatosis type 1: relationship to cognition, behavior, and magnetic resonance imaging.

Dev Med Child Neurol 2019 Aug 18;61(8):972-978. Epub 2019 Jan 18.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://doi.wiley.com/10.1111/dmcn.14144
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http://dx.doi.org/10.1111/dmcn.14144DOI Listing
August 2019

Pain symptomology, functional impact, and treatment of people with Neurofibromatosis type 1.

J Pain Res 2019 22;12:2555-2561. Epub 2019 Aug 22.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.2147/JPR.S209540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710538PMC
August 2019

Commentary: Identification of Mutation Regions on Responsible for High- and Low-Risk Development of Optic Pathway Glioma in Neurofibromatosis Type I.

Front Genet 2019 1;10:115. Epub 2019 Mar 1.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States.

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http://dx.doi.org/10.3389/fgene.2019.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405421PMC
March 2019

Insights into optic pathway glioma vision loss from mouse models of neurofibromatosis type 1.

J Neurosci Res 2019 Jan 28;97(1):45-56. Epub 2018 Apr 28.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

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http://doi.wiley.com/10.1002/jnr.24250
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http://dx.doi.org/10.1002/jnr.24250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766750PMC
January 2019

KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production.

Neoplasia 2019 01 30;21(1):52-60. Epub 2018 Nov 30.

Department of Neurology, Washington University, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277251PMC
January 2019

Clearing the Fog surrounding Chemobrain.

Authors:
David H Gutmann

Cell 2019 01;176(1-2):2-4

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.12.027DOI Listing
January 2019

Height Growth Impairment in Children With Neurofibromatosis Type 1 Is Characterized by Decreased Pubertal Growth Velocity in Both Sexes.

J Child Neurol 2018 10 16;33(12):762-766. Epub 2018 Jul 16.

1 Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1177/0883073818786807DOI Listing
October 2018

Neurofibromatosis type 1.

Handb Clin Neurol 2018 ;148:799-811

Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-64076-5.00051-XDOI Listing
August 2018

Independent mutations underlie café-au-lait macule development in a woman with segmental NF1.

Neurol Genet 2018 Aug 23;4(4):e261. Epub 2018 Jul 23.

Department of Neurology (M.E.F., C.A., D.H.G.), Washington University School of Medicine, Saint Louis, MO; and Harvard Medical School (M.E.F.), Boston, MA.

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http://dx.doi.org/10.1212/NXG.0000000000000261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066364PMC
August 2018

Increased prevalence of brain tumors classified as T2 hyperintensities in neurofibromatosis 1.

Neurol Clin Pract 2018 Aug;8(4):283-291

Departments of Neurology (JLG, SMM, JM, DHG) and Radiology (MSG, TH), Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/CPJ.0000000000000494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105062PMC
August 2018

Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights.

Pediatr Blood Cancer 2018 03 19;65(3). Epub 2017 Oct 19.

Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Washington, District of Columbia.

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http://dx.doi.org/10.1002/pbc.26838DOI Listing
March 2018

A Conserved Circadian Function for the Neurofibromatosis 1 Gene.

Cell Rep 2018 03;22(13):3416-3426

Penn Chronobiology, Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898822PMC
March 2018

A genotype-phenotype correlation for quantitative autistic trait burden in neurofibromatosis 1.

Neurology 2018 02 24;90(8):377-379. Epub 2018 Jan 24.

From Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000005000DOI Listing
February 2018

Human stem cell modeling in neurofibromatosis type 1 (NF1).

Exp Neurol 2018 01 6;299(Pt B):270-280. Epub 2017 Apr 6.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144886173009
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http://dx.doi.org/10.1016/j.expneurol.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630478PMC
January 2018

Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.

Autism Res 2018 01 26;11(1):44-58. Epub 2017 Aug 26.

Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri.

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http://dx.doi.org/10.1002/aur.1853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773379PMC
January 2018

Optic Pathway Gliomas in Neurofibromatosis Type 1.

J Child Neurol 2018 Jan;33(1):73-81

2 Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1177/0883073817739509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739070PMC
January 2018

Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.

Epilepsia 2017 12 12;58(12):2053-2063. Epub 2017 Oct 12.

Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, U.S.A.

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http://dx.doi.org/10.1111/epi.13923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716871PMC
December 2017

Neurodevelopmental disorders in children with neurofibromatosis type 1.

Dev Med Child Neurol 2017 11 27;59(11):1112-1116. Epub 2017 Aug 27.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1111/dmcn.13526DOI Listing
November 2017

Caddyshack therapeutics: overcoming glioblastoma adaptation.

Authors:
David H Gutmann

Neuro Oncol 2017 10;19(11):1429-1431

Department of Neurology, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1093/neuonc/nox096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737573PMC
October 2017

Children with 5'-end gene mutations are more likely to have glioma.

Neurol Genet 2017 Oct 22;3(5):e192. Epub 2017 Sep 22.

Department of Neurology (C.A., S.M.M., D.H.G.) and Department of Surgery (F.G.), Washington University in St. Louis, MO.

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http://dx.doi.org/10.1212/NXG.0000000000000192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610042PMC
October 2017

Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.

J Neuroophthalmol 2017 09;37 Suppl 1:S23-S32

Cancer and Blood Diseases Institute (PMKdB), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics (PMKdB), University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Oncology (MJF), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics (MJF), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Neuro-Ophthalmology Service (GTL, RAA), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurology and Ophthalmology (GTL, RAA), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Neurofibromatosis Center and Department of Neurology (DHG), Washington University, St. Louis, Missouri; Department of Pediatrics (RL), Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Neurofibromatosis Centre, Department of Neurology (REF), Guy's and St. Thomas' NHS Foundation Trust; and Department of Clinical Neuroscience (REF), King's College, London, United Kingdom.

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http://Insights.ovid.com/crossref?an=00041327-201709001-0000
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http://dx.doi.org/10.1097/WNO.0000000000000550DOI Listing
September 2017

Updated nomenclature for human and mouse neurofibromatosis type 1 genes.

Neurol Genet 2017 Aug 26;3(4):e169. Epub 2017 Jul 26.

Department of Neurology (C.A., D.H.G.), Washington University in St. Louis, MO; Department of Dermatology (L.Q.L.), University of Texas Southwestern Medical Center, Dallas; and Department of Genetics (R.A.K.), The University of Alabama at Birmingham.

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http://dx.doi.org/10.1212/NXG.0000000000000169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530422PMC
August 2017

The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.

Authors:
David H Gutmann

Cell 2017 08;170(5):821-822

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173093
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http://dx.doi.org/10.1016/j.cell.2017.08.011DOI Listing
August 2017

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.

Oncotarget 2017 Aug 18;8(32):52474-52487. Epub 2017 Apr 18.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.18632/oncotarget.17193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581044PMC
August 2017

Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.

J Natl Cancer Inst 2017 08;109(8)

Rare Tumor Initiative, Laboratory of Pathology, and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC; Department of Neurology, Johns Hopkins Hospital, Baltimore, MD; Neurofibromatosis Center, Department of Neurology Guy's Hospital London, London, UK; Department of Neurology, Washington University School of Medicine, St. Louis, MO; Department of Human Genetics, University of Leuven, Leuven, Belgium; Hunstman Cancer Institute, University of Utah, Salt Lake City, UT; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH; Bill and Melinda Gates Foundation, Seattle, WA; Children's Tumor Foundation, New York, NY; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

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http://dx.doi.org/10.1093/jnci/djx124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057517PMC
August 2017

KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.

Oncotarget 2017 Jul;8(29):47574-47585

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.18632/oncotarget.17736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564588PMC
July 2017

CNS Tumors in Neurofibromatosis.

J Clin Oncol 2017 Jul 22;35(21):2378-2385. Epub 2017 Jun 22.

All authors: Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1200/JCO.2016.71.7199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516481PMC
July 2017

Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction.

Neuro Oncol 2017 06;19(6):808-819

Department of Neurology, Washington University School of Medicine (WUSM), St Louis, Missouri, USA.

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http://dx.doi.org/10.1093/neuonc/now267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464459PMC
June 2017

The power of the few.

Genes Dev 2017 06;31(12):1177-1179

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gad.303453.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558920PMC
June 2017

Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma.

Cancer Res 2017 05 24;77(9):2266-2278. Epub 2017 Feb 24.

Department of Pediatrics and Aflac Cancer Center of Children's Health Care of Atlanta, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741820PMC
May 2017

Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer.

Cancer Cell 2017 05;31(5):609-611

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.008DOI Listing
May 2017

Oligodendroglial myelination requires astrocyte-derived lipids.

PLoS Biol 2017 05 26;15(5):e1002605. Epub 2017 May 26.

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pbio.1002605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446120PMC
May 2017

A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1.

Neurology 2017 Apr 22;88(16):1584-1589. Epub 2017 Mar 22.

From the Departments of Neurology (J.M., S.M.M., D.H.G.) and Radiology (R.C.M.), Washington University School of Medicine, St. Louis, MO; Division of Oncology (A.C.S., M.J.F.), Children's Hospital of Philadelphia, PA; Center for Neuroscience of Behavioral Medicine (A.S., R.J.P.), Children's National Medical Center, Washington, DC; Division of Academic General Pediatrics (R.L.), Feinberg School of Medicine, Northwestern University, Ann & Robert H. Lurie Children's Hospital of Chicago, IL; and Department of Pediatrics (M.J.F.), The Perelman School of Medicine at The University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000003881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395076PMC
April 2017

Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.

Biophys J 2017 Apr;112(8):1535-1538

Department of Biomedical Engineering, Washington University, St. Louis, Missouri; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, Missouri. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495173033
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http://dx.doi.org/10.1016/j.bpj.2017.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406378PMC
April 2017

Neurofibromatosis type 1.

Nat Rev Dis Primers 2017 Feb 23;3:17004. Epub 2017 Feb 23.

Master of Public Health Program, Brown School, St. Louis, Missouri, USA.

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http://www.nature.com/articles/nrdp20174
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http://dx.doi.org/10.1038/nrdp.2017.4DOI Listing
February 2017

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.

J Biol Chem 2017 01 9;292(4):1240-1250. Epub 2016 Dec 9.

From the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan,

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http://dx.doi.org/10.1074/jbc.M116.748871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270470PMC
January 2017

Dissecting Clinical Heterogeneity in Neurofibromatosis Type 1.

Annu Rev Pathol 2017 01;12:53-74

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110; email:

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http://dx.doi.org/10.1146/annurev-pathol-052016-100228DOI Listing
January 2017

Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1.

J Child Neurol 2016 12 31;31(14):1540-1545. Epub 2016 Aug 31.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA

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http://dx.doi.org/10.1177/0883073816664659DOI Listing
December 2016

Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT).

JAMA Psychiatry 2016 Dec;73(12):1276-1284

Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri12Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.2600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298203PMC
December 2016

Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1.

Neurology 2016 Dec 9;87(24):2575-2584. Epub 2016 Nov 9.

From the Murdoch Children's Research Institute (J.M.P., S.J.C.H., K.N.N.), Royal Children's Hospital; Department of Paediatrics (J.M.P., K.N.N.), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne; Children's Hospital Education Research Institute (B.B.), Children's Hospital at Westmead; Discipline of Paediatrics and Child Health (B.B.), University of Sydney, Australia; Department of Neurology (N.J.U., C.R.-C.), Boston Children's Hospital, MA; Department of Preventative Medicine (A.C.), School of Public Health (G.C.), Department of Psychology (J.D.A.), and Department of Genetics (B.K.), University of Alabama at Birmingham; Department of Neurology (T.R., S.H.O.), Children's Hospital of Los Angeles, CA; Center for Neuroscience and Behavioral Medicine (K.S.W., G.A.G., R.J.P., M.T.A.), Children's National Health System, Washington, DC; Pediatric Oncology Branch Center for Cancer Research (P.L.W.), National Cancer Institute, Bethesda, MD; Division of Neurology (J.T., S.J.H.), University of Chicago Medicine Comer Children's Hospital, IL; Human Genetics (E.S.) and Division of Neurology (A.W.B.), Cincinnati Children's Hospital Medical Center, OH; Department of Genetics (D.V.), University of Utah, Salt Lake City; Department of Pediatrics (L.K.), University of Texas Southwestern Medical Center, Dallas; Division of Oncology (M.F., C.L.A.), Children's Hospital of Philadelphia, PA; Department of Neurology (D.H.G., J.I.), Washington University School of Medicine in St Louis, MO; Gonda Neuroscience and Genetics Center (A.J.S.), University of California Los Angeles; Primary Children's Hospital (N.L.C.), Salt Lake City, UT; and University of Texas MD Anderson Cancer Center (P.L.S.), Houston.

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http://dx.doi.org/10.1212/WNL.0000000000003435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207004PMC
December 2016

Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma.

Front Oncol 2016 20;6:259. Epub 2016 Dec 20.

Children's Cancer Therapy Development Institute , Beaverton, OR , USA.

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http://dx.doi.org/10.3389/fonc.2016.00259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167692PMC
December 2016

Gliosarcomas lack BRAF mutation, but a subset exhibit β-catenin nuclear localization.

Neuropathology 2016 Oct 2;36(5):448-455. Epub 2016 Mar 2.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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http://doi.wiley.com/10.1111/neup.12293
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http://dx.doi.org/10.1111/neup.12293DOI Listing
October 2016

Contextual signaling in cancer.

Semin Cell Dev Biol 2016 10 3;58:118-26. Epub 2016 Jun 3.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028257PMC
October 2016

3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.

J Proteomics 2016 10 13;149:77-84. Epub 2016 Feb 13.

Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983271PMC
October 2016

Exploring the genetic basis for clinical variation in neurofibromatosis type 1.

Authors:
David H Gutmann

Expert Rev Neurother 2016 09 30;16(9):999-1001. Epub 2016 May 30.

a Department of Neurology , Washington University School of Medicine , St. Louis , MO , USA.

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http://dx.doi.org/10.1080/14737175.2016.1189329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998178PMC
September 2016

Neurofibromatosis type 1.

Handb Clin Neurol 2015 ;132:75-86

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-62702-5.00004-4DOI Listing
August 2016

Pediatric gliomas as neurodevelopmental disorders.

Glia 2016 Jun 6;64(6):879-95. Epub 2015 Dec 6.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1002/glia.22945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833573PMC
June 2016

Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1.

Cancer Epidemiol 2016 06 25;42:53-9. Epub 2016 Mar 25.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States.

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http://dx.doi.org/10.1016/j.canep.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899111PMC
June 2016

Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.

Genes Dev 2016 06;30(12):1383-8

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gad.279661.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926861PMC
June 2016

NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.

Hum Mol Genet 2016 05 16;25(9):1703-13. Epub 2016 Feb 16.

Department of Neurology, Washington University School of Medicine, PO Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA and

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http://dx.doi.org/10.1093/hmg/ddw039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986327PMC
May 2016

ABCG1 maintains high-grade glioma survival in vitro and in vivo.

Oncotarget 2016 Apr;7(17):23416-24

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.18632/oncotarget.8030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029636PMC
April 2016

De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging.

Radiol Case Rep 2016 Mar 2;11(1):33-5. Epub 2016 Feb 2.

Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.radcr.2015.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769616PMC
March 2016

The role of microglia and macrophages in glioma maintenance and progression.

Nat Neurosci 2016 Jan;19(1):20-7

Max Delbrück Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/nn.4185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876023PMC
January 2016

Racial/Ethnic Differences in Pediatric Brain Tumor Diagnoses in Patients with Neurofibromatosis Type 1.

J Pediatr 2015 Sep 28;167(3):613-20.e1-2. Epub 2015 May 28.

Brown School, Washington University, St. Louis, MO; Department of Pediatrics, School of Medicine, Washington University, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2015.04.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784699PMC
September 2015

Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.

Genes Dev 2015 Aug 13;29(16):1677-82. Epub 2015 Aug 13.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gad.261677.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561477PMC
August 2015

Parental age and Neurofibromatosis Type 1: a report from the NF1 Patient Registry Initiative.

Fam Cancer 2015 Jun;14(2):317-24

Brown School, Washington University in St. Louis, 237 Goldfarb Hall, One Brookings Drive, Campus Box 1196, St. Louis, MO, 63130, USA.

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http://dx.doi.org/10.1007/s10689-014-9774-8DOI Listing
June 2015

Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.

Neuro Oncol 2015 Jun 21;17(6):843-53. Epub 2014 Dec 21.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri (A.K., J.A.T., S.M.G., D.H.G.); Department of Pathology, Washington University School of Medicine, St. Louis, Missouri (P.J.C.).

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http://dx.doi.org/10.1093/neuonc/nou329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483119PMC
June 2015

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

Stem Cells 2015 Jun;33(6):1998-2010

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/stem.1990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889217PMC
June 2015

Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.

Neuro Oncol 2015 Apr 14;17(4):596-603. Epub 2014 Oct 14.

Division of Oncology, Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute, Cincinnati, Ohio (B.W., J.P.); Division of Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (E.S.); Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (A.V.); National Cancer Institute, Pediatric Oncology Branch, Bethesda, Maryland (B.C.W, E.D., P.W.); Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama (B.K.); Department of Preventitive Medicine, University of Alabama at Birmingham, Birmingham, Alabama (A.C.); Department of Neurology, Boston Children's Hospital, Boston, Massachusetts (N.U.); Department of Neurology, Washington University, St. Louis, Missouri (D.H.G.); Children's National Health System, Center for Neuroscience and Behavioral Medicine, Washington, DC (R.J.P.); Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (M.J.F.); Division of Genetics, Primary Children's Hospital, Salt Lake City, Utah (D.V.); Division of Neurology, The University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois (J.T.).

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http://dx.doi.org/10.1093/neuonc/nou235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483073PMC
April 2015

Improving outcomes for neurofibromatosis 1-associated brain tumors.

Expert Rev Anticancer Ther 2015 Apr 5;15(4):415-23. Epub 2015 Feb 5.

Department of Pediatrics, St. Louis Children's Hospital, St. Louis, MO, USA.

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http://dx.doi.org/10.1586/14737140.2015.1009043DOI Listing
April 2015

Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties.

Cell Rep 2015 Mar 12;10(11):1899-912. Epub 2015 Mar 12.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376586PMC
March 2015

Microglia in the tumor microenvironment: taking their TOLL on glioma biology.

Authors:
David H Gutmann

Neuro Oncol 2015 Feb 18;17(2):171-3. Epub 2014 Dec 18.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1093/neuonc/nou346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288529PMC
February 2015

A multidisciplinary approach in neurofibromatosis 1--authors' reply.

Lancet Neurol 2015 Jan;14(1):30-1

Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70298-4DOI Listing
January 2015

Validity of participant-reported diagnoses in an online patient registry: a report from the NF1 Patient Registry Initiative.

Contemp Clin Trials 2015 Jan 19;40:212-7. Epub 2014 Dec 19.

Brown School, Washington University, St. Louis, MO 63130, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15517144140019
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http://dx.doi.org/10.1016/j.cct.2014.12.006DOI Listing
January 2015

The taxonomy of brain cancer stem cells: what's in a name?

Authors:
David H Gutmann

Oncoscience 2014 31;1(3):241-7. Epub 2014 Mar 31.

Department of Neurology, Washington University School of Medicine, St. Louis MO.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278291PMC
http://dx.doi.org/10.18632/oncoscience.25DOI Listing
January 2015

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.

Nat Commun 2015 Jan 21;6:6122. Epub 2015 Jan 21.

1] Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA [2] Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ncomms7122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302765PMC
January 2015

NF GEMMs already! The power and promise of mouse tumor models.

Authors:
David H Gutmann

Cancer Cell 2014 Nov 10;26(5):596-9. Epub 2014 Nov 10.

Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, St. Louis MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.007DOI Listing
November 2014