David H Farb

David H Farb

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David H Farb

David H Farb

Publications by authors named "David H Farb"

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Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders.

Front Endocrinol (Lausanne) 2019 9;10:169. Epub 2019 Apr 9.

Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.

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http://dx.doi.org/10.3389/fendo.2019.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465949PMC
April 2019

Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus.

Hippocampus 2015 Dec 14;25(12):1541-55. Epub 2015 Jul 14.

Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1002/hipo.22474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633399PMC
December 2015

A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.

Mol Pharmacol 2014 Oct 23;86(4):390-8. Epub 2014 Jul 23.

Laboratory of Molecular Neurobiology (C.C.S., S.C.M., K.S., T.T.G., D.H.F.), Department of Pharmacology & Experimental Therapeutics, Laboratory of Translational Epilepsy (S.J.R.), Boston University School of Medicine, Boston, Massachusetts

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http://dx.doi.org/10.1124/mol.114.094128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164982PMC
October 2014

Targeting the modulation of neural circuitry for the treatment of anxiety disorders.

Pharmacol Rev 2014 Oct;66(4):1002-32

Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1124/pr.114.009126DOI Listing
October 2014

Pregnenolone sulfate as a modulator of synaptic plasticity.

Psychopharmacology (Berl) 2014 Sep 6;231(17):3537-56. Epub 2014 Jul 6.

Laboratory of Molecular Neurobiology, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, 72 East Concord St., Boston, MA, 02118, USA.

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http://dx.doi.org/10.1007/s00213-014-3643-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625978PMC
September 2014

Younger age at onset of sporadic Parkinson's disease among subjects occupationally exposed to metals and pesticides.

Interdiscip Toxicol 2014 Sep 30;7(3):123-33. Epub 2014 Dec 30.

Department of Neurology, Boston University School of Medicine, Boston, USA.

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http://dx.doi.org/10.2478/intox-2014-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434105PMC
September 2014

GABA-induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor.

J Neurosci Res 2014 Aug 10;92(8):1054-61. Epub 2014 Apr 10.

Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1002/jnr.23387DOI Listing
August 2014

The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.

Mol Pharmacol 2013 Aug 28;84(2):261-74. Epub 2013 May 28.

Laboratory of Molecular Neurobiology, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1124/mol.113.085696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716320PMC
August 2013

An interview with David H Farb, Section Editor for Basic Pharmacology.

Authors:
David H Farb

BMC Pharmacol Toxicol 2013 Aug 30;14:42. Epub 2013 Aug 30.

Department of Pharmacology and Experimental Therapeutics, Laboratory of Molecular Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1186/2050-6511-14-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846662PMC
August 2013

Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity.

BMC Pharmacol Toxicol 2013 Jul 23;14:37. Epub 2013 Jul 23.

Department of Pharmacology & Experimental Therapeutics, Laboratory of Translational Epilepsy, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1186/2050-6511-14-37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734045PMC
July 2013

Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons.

J Neurochem 2012 Jan 28;120(2):210-9. Epub 2011 Nov 28.

Laboratory of Translational Epilepsy, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07555.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116917PMC
January 2012

A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.

J Neurochem 2011 Nov 28;119(3):486-96. Epub 2011 Sep 28.

Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07442.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360518PMC
November 2011

Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.

J Neurochem 2008 Oct 14;107(2):510-21. Epub 2008 Aug 14.

Laboratory of Molecular Neurobiology, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05627.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752276PMC
October 2008

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.

BMC Pharmacol 2008 Jun 13;8:11. Epub 2008 Jun 13.

Laboratory of Molecular Neurobiology, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, 715 Albany St., Boston, MA 02118, USA.

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http://dx.doi.org/10.1186/1471-2210-8-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529273PMC
June 2008

Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor.

J Biol Chem 2008 Apr 7;283(14):9328-40. Epub 2008 Jan 7.

Laboratory of Translational Epilepsy, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1074/jbc.M705110200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431045PMC
April 2008

Sulfated steroids as endogenous neuromodulators.

Pharmacol Biochem Behav 2006 Aug 4;84(4):555-67. Epub 2006 Oct 4.

Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, United States.

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http://dx.doi.org/10.1016/j.pbb.2006.07.031DOI Listing
August 2006

Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.

Br J Pharmacol 2005 Aug;145(7):894-906

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA.

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http://dx.doi.org/10.1038/sj.bjp.0706251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576208PMC
August 2005

GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons.

J Biol Chem 2005 Jun 1;280(22):20954-60. Epub 2005 Apr 1.

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1074/jbc.M500131200DOI Listing
June 2005

cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.

J Neurosci 2004 Jul;24(27):6115-26

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1200-04.2004DOI Listing
July 2004

Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons.

J Comp Neurol 2004 May;473(1):16-29

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA.

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http://dx.doi.org/10.1002/cne.20094DOI Listing
May 2004

A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity.

Proc Natl Acad Sci U S A 2004 May 18;101(21):8198-203. Epub 2004 May 18.

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1073/pnas.0401838101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419580PMC
May 2004

Effects of prenatal malnutrition on GABAA receptor alpha1, alpha3 and beta2 mRNA levels.

Neuroreport 2003 Sep;14(13):1731-5

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1097/01.wnr.0000087730.58565.60DOI Listing
September 2003

Prenatal protein malnutrition reduces beta(2), beta(3) and gamma(2L) GABA(A) receptor subunit mRNAs in the adult septum.

Eur J Pharmacol 2002 Jun;446(1-3):201-2

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/s0014-2999(02)01815-0DOI Listing
June 2002

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.

Br J Pharmacol 2002 Feb;135(4):901-9

Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts, MA 02118, USA.

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http://dx.doi.org/10.1038/sj.bjp.0704543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573207PMC
February 2002