David Goulding

David Goulding

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David Goulding

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The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre.

Mol Microbiol 2019 12 9;112(6):1831-1846. Epub 2019 Oct 9.

Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, 3800, Australia.

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http://dx.doi.org/10.1111/mmi.14396DOI Listing
December 2019

Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.

Neurotox Res 2019 Oct 8;36(3):563-582. Epub 2019 Jul 8.

National Toxicology Program Laboratory, National Institute of Environmental Health Sciences (NIEHS), P.O. Box 12233, MD E1-07, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1007/s12640-019-00077-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745261PMC
October 2019

Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens.

J Vis Exp 2019 05 12(147). Epub 2019 May 12.

Wellcome Trust Sanger Institute; Department of Medicine, University of Cambridge.

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http://dx.doi.org/10.3791/59478DOI Listing
May 2019

Inter-α-inhibitor deficiency in the mouse is associated with alterations in anxiety-like behavior, exploration and social approach.

Genes Brain Behav 2019 01 6;18(1):e12505. Epub 2018 Aug 6.

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1111/gbb.12505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328341PMC
January 2019

Separating Bacteria by Capsule Amount Using a Discontinuous Density Gradient.

J Vis Exp 2019 01 7(143). Epub 2019 Jan 7.

Wellcome Sanger Institute, Wellcome Genome Campus; Department of Medicine, University of Cambridge;

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http://dx.doi.org/10.3791/58679DOI Listing
January 2019

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

Cell Stem Cell 2018 11 27;23(5):687-699.e8. Epub 2018 Sep 27.

Wellcome Sanger Institute, Hinxton CB10 1SA, UK; MRC Cancer Unit, University of Cambridge, Hutchison-MRC Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224607PMC
November 2018

The Capsule Regulatory Network of Defined by density-TraDISort.

mBio 2018 11 20;9(6). Epub 2018 Nov 20.

Wellcome Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

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http://dx.doi.org/10.1128/mBio.01863-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247091PMC
November 2018

Lysogenic conversion of atypical enteropathogenic Escherichia coli (aEPEC) from human, murine, and bovine origin with bacteriophage Φ3538 Δstx::cat proves their enterohemorrhagic E. coli (EHEC) progeny.

Int J Med Microbiol 2018 Oct 19;308(7):890-898. Epub 2018 Jun 19.

Institute for Microbiology and Epizootics, Freie Universität Berlin, Berlin, Germany; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2018.06.005DOI Listing
October 2018

Two-color bursting oscillations.

Sci Rep 2017 08 21;7(1):8414. Epub 2017 Aug 21.

National Research University of Information Technologies, Mechanics and Optics, Saint Petersburg, Russia.

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http://dx.doi.org/10.1038/s41598-017-08751-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566208PMC
August 2017

Evolution of complexity in the zebrafish synapse proteome.

Nat Commun 2017 03 2;8:14613. Epub 2017 Mar 2.

Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh EH16 4SB, UK.

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http://www.nature.com/doifinder/10.1038/ncomms14613
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http://dx.doi.org/10.1038/ncomms14613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337974PMC
March 2017

Gestational exposure to perfluorooctanoic acid (PFOA): Alterations in motor related behaviors.

Neurotoxicology 2017 01 22;58:110-119. Epub 2016 Nov 22.

Neurotoxicology Group, NTPL, DNTP, NIEHS, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345697PMC
January 2017

Evaluation of buprenorphine hydrochloride Pluronic(®) gel formulation in male C57BL/6NCrl mice.

Lab Anim (NY) 2016 Sep;45(10):370-9

Veterinary Medicine Section, Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1038/laban.1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116768PMC
September 2016

Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.

Nature 2016 05 4;533(7604):543-546. Epub 2016 May 4.

Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nature17645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890681PMC
May 2016

Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

PLoS One 2015 6;10(5):e0124307. Epub 2015 May 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124307PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422593PMC
February 2016

The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.

Sci Rep 2015 Jan 22;5:7947. Epub 2015 Jan 22.

1] The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom [3] The London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1038/srep07947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302301PMC
January 2015

Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss.

PLoS Genet 2014 Oct 30;10(10):e1004688. Epub 2014 Oct 30.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214598PMC
October 2014

Juno is the egg Izumo receptor and is essential for mammalian fertilization.

Nature 2014 Apr 16;508(7497):483-7. Epub 2014 Apr 16.

Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature13203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998876PMC
April 2014

The agr locus regulates virulence and colonization genes in Clostridium difficile 027.

J Bacteriol 2013 Aug 14;195(16):3672-81. Epub 2013 Jun 14.

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.

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http://dx.doi.org/10.1128/JB.00473-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754575PMC
August 2013

Permissive and restricted virus infection of murine embryonic stem cells.

J Gen Virol 2012 Oct 18;93(Pt 10):2118-2130. Epub 2012 Jul 18.

UCL/MRC Centre for Medical Molecular Virology, Department of Infection, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1099/vir.0.043406-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541792PMC
October 2012

Investigation of active filter using injection-locked slotted Fabry-Perot semiconductor laser.

Appl Opt 2012 Oct;51(30):7357-61

Physics Department, University College Cork, Cork, Ireland.

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http://dx.doi.org/10.1364/AO.51.007357DOI Listing
October 2012

Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.

Cell Host Microbe 2012 Aug;12(2):246-58

Malaria Programme, The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1016/j.chom.2012.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501726PMC
August 2012

Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy.

Lab Anim (NY) 2011 Mar;40(3):85-93

Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://www.nature.com/articles/laban0311-85
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http://dx.doi.org/10.1038/laban0311-85DOI Listing
March 2011

Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.

J Am Assoc Lab Anim Sci 2011 Mar;50(2):185-91

Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061418PMC
March 2011

Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.

J Cell Sci 2011 Feb 18;124(Pt 4):565-77. Epub 2011 Jan 18.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1242/jcs.071274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031369PMC
February 2011

Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens.

Appl Environ Microbiol 2010 Oct 27;76(20):6895-900. Epub 2010 Aug 27.

Microbial Pathogenesis Laboratory, Wellcome Trust, Hinxton, Cambridgeshire CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1128/AEM.00718-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953018PMC
October 2010

Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia.

Cerebellum 2010 Sep;9(3):310-23

Laboratory of Respiratory Biology, Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, Durham, NC 27709, USA.

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http://dx.doi.org/10.1007/s12311-010-0163-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928415PMC
September 2010

Refinement of the hamster model of Clostridium difficile disease.

Methods Mol Biol 2010 ;646:215-27

Division of Infection and Immunity, IBLS, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-60327-365-7_14DOI Listing
September 2010

The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer.

J Am Assoc Lab Anim Sci 2010 Jul;49(4):423-6

Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919181PMC
July 2010

Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1.

Infect Immun 2009 Dec 14;77(12):5478-85. Epub 2009 Sep 14.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1128/IAI.00551-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786451PMC
December 2009

The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.

PLoS Pathog 2009 Dec 11;5(12):e1000683. Epub 2009 Dec 11.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.ppat.1000683
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http://dx.doi.org/10.1371/journal.ppat.1000683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782363PMC
December 2009

A novel genetic switch controls phase variable expression of CwpV, a Clostridium difficile cell wall protein.

Mol Microbiol 2009 Nov 28;74(3):541-56. Epub 2009 Jul 28.

Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06812.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784873PMC
November 2009

Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.

J Bacteriol 2009 Sep 19;191(17):5377-86. Epub 2009 Jun 19.

Microbial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom.

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http://dx.doi.org/10.1128/JB.00597-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725610PMC
September 2009

Interaction of enteric bacterial pathogens with murine embryonic stem cells.

Infect Immun 2009 Feb 24;77(2):585-97. Epub 2008 Nov 24.

The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1128/IAI.01003-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632033PMC
February 2009

Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1.

J Bacteriol 2008 Apr 11;190(7):2580-7. Epub 2008 Jan 11.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1128/JB.01654-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293211PMC
April 2008

Phase-locked mutually coupled 1.3 microm quantum-dot lasers.

Opt Lett 2007 Nov;32(22):3245-7

Tyndall National Institute, Lee Maltings, Cork, Ireland.

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http://dx.doi.org/10.1364/ol.32.003245DOI Listing
November 2007

A generalized transducing phage for the murine pathogen Citrobacter rodentium.

Microbiology 2007 Sep;153(Pt 9):2984-2988

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1099/mic.0.2007/008888-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652034PMC
September 2007

TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation.

J Biol Chem 2006 Sep 11;281(37):27600-12. Epub 2006 Jul 11.

Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M602183200
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http://dx.doi.org/10.1074/jbc.M602183200DOI Listing
September 2006

Dramatic reorganisation of Trichomonas endomembranes during amoebal transformation: a possible role for G-proteins.

Mol Biochem Parasitol 2006 Jul 31;148(1):99-102. Epub 2006 Mar 31.

Department of Zoology, The Natural History Museum, South Kensington, London, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2006.02.022DOI Listing
July 2006

Trypanosoma brucei: TbRAB4 regulates membrane recycling and expression of surface proteins in procyclic forms.

Exp Parasitol 2005 Nov 13;111(3):160-71. Epub 2005 Sep 13.

Department of Biological Sciences, Imperial College, London SW7 2AY, UK.

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http://dx.doi.org/10.1016/j.exppara.2005.07.005DOI Listing
November 2005

Identification and characterization of genes required for competence in Neisseria meningitidis.

J Bacteriol 2005 May;187(9):3273-6

Centre for Molecular Microiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Armstrong Road, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1128/JB.187.9.3273-3276.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082832PMC
May 2005

Developmental variation in Rab11-dependent trafficking in Trypanosoma brucei.

Eukaryot Cell 2005 May;4(5):971-80

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom.

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http://dx.doi.org/10.1128/EC.4.5.971-980.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140102PMC
May 2005

Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes.

J Cell Sci 2005 Feb 1;118(Pt 4):831-41. Epub 2005 Feb 1.

Wellcome Trust Laboratories for Molecular Parasitology, Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1242/jcs.01624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705012PMC
February 2005

Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis.

Mol Biochem Parasitol 2004 Nov;138(1):67-77

Department of Biological Sciences, Imperial College, Exhibition Road, London SW7 2AY, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.07.007DOI Listing
November 2004

Rab4 is an essential regulator of lysosomal trafficking in trypanosomes.

J Biol Chem 2004 Oct 28;279(43):45047-56. Epub 2004 Jul 28.

Department of Biological Sciences, Imperial College, London SW7 2AY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M407271200DOI Listing
October 2004

TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei.

Mol Biochem Parasitol 2004 Oct;137(2):253-65

Department of Biological Sciences, Imperial College, London, SW7 2AY, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.06.007DOI Listing
October 2004

New approaches to the microscopic imaging of Trypanosoma brucei.

Microsc Microanal 2004 Oct;10(5):621-36

Wellcome Trust Laboratories for Molecular Parasitology, Department of Biological Sciences, Imperial College, Exhibition Road, London SW7 2AY, UK.

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http://dx.doi.org/10.1017/S1431927604040942DOI Listing
October 2004

Trichinella spiralis secretes a homologue of prosaposin.

Mol Biochem Parasitol 2004 May;135(1):49-56

Department of Biological Sciences, Biochemistry Building, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.01.005DOI Listing
May 2004