David Ginsburg

David Ginsburg

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David Ginsburg

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Genome Editing and Hematologic Malignancy.

Annu Rev Med 2019 Aug 30. Epub 2019 Aug 30.

Departments of Internal Medicine, Human Genetics, and Pediatrics, Life Sciences Institute, and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; email:

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http://dx.doi.org/10.1146/annurev-med-052318-100741DOI Listing
August 2019

A diagnosis of discernment: Identifying a novel ATRX mutation in myelodysplastic syndrome with acquired α-thalassemia.

Cancer Genet 2019 02 9;231-232:36-40. Epub 2019 Jan 9.

Department of Internal Medicine, University of Michigan, 1524 Basic Science Research Building, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391734PMC
February 2019

Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.

Circulation 2019 01;139(5):620-635

Department of Epidemiology, (A.P.R., B.M.P., N.L.S.), University of Washington, Seattle.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438386PMC
January 2019

On the antioxidant activity of eumelanin biopigments: a quantitative comparison between free radical scavenging and redox properties.

Nat Prod Res 2019 Jan 2:1-9. Epub 2019 Jan 2.

c Department of Engineering Physics , Polytechnique Montreal , Montreal , Quebec , Canada.

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http://dx.doi.org/10.1080/14786419.2018.1542391DOI Listing
January 2019

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.

PLoS Genet 2018 09 6;14(9):e1007658. Epub 2018 Sep 6.

Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143275PMC
September 2018

Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo.

Blood Adv 2018 05;2(9):1014-1021

Genomic Medicine Institute, Lerner Research Institute of Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1182/bloodadvances.2018018317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942004PMC
May 2018

Dimeric sorting code for concentrative cargo selection by the COPII coat.

Proc Natl Acad Sci U S A 2018 04 19;115(14):E3155-E3162. Epub 2018 Mar 19.

State Key Laboratory of Membrane Biology, Peking University, Beijing 100871, China;

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http://dx.doi.org/10.1073/pnas.1704639115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889621PMC
April 2018

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.

Cell Rep 2017 06;19(13):2645-2656

Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Division of Hematology/Oncology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539946PMC
June 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
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http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

Von Willebrand Factor and ADAMTS13: Too Much or Too Little of a Good Thing?

Arterioscler Thromb Vasc Biol 2016 12;36(12):2281-2282

From the Department of Internal Medicine (B.T.E., D.G.), Life Sciences Institute, Department of Human Genetics, Howard Hughes Medical Institute (D.G.), and Department of Pediatrics and Communicable Disease (D.G., K.C.D.), University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1161/ATVBAHA.116.308531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127281PMC
December 2016

Probing ADAMTS13 substrate specificity using phage display.

PLoS One 2015 7;10(4):e0122931. Epub 2015 Apr 7.

Howard Hughes Medical Institute, Ann Arbor, Michigan, United States of America; Department of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122931PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388381PMC
March 2016

Food Resource Management Education With SNAP Participation Improves Food Security.

J Nutr Educ Behav 2015 Jul-Aug;47(4):374-8.e1. Epub 2015 Apr 3.

University of California CalFresh (SNAP-Ed) Nutrition Education Program, Davis, CA.

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http://dx.doi.org/10.1016/j.jneb.2015.01.012DOI Listing
February 2016

Diagnosis of acute cholecystitis: why do patients get multiple studies?

Emerg Radiol 2016 Feb 31;23(1):49-55. Epub 2015 Oct 31.

Department of Radiology, Montefiore Medical Center, Bronx, NY, USA.

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http://dx.doi.org/10.1007/s10140-015-1358-xDOI Listing
February 2016

Introduction of Francis S. Collins.

Authors:
David Ginsburg

J Clin Invest 2015 Sep 17;125(9):3321-7. Epub 2015 Aug 17.

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http://dx.doi.org/10.1172/JCI83698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588279PMC
September 2015

Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII.

Blood 2015 Aug 11;126(8):939-42. Epub 2015 Jun 11.

Life Sciences Institute, Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI.

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http://dx.doi.org/10.1182/blood-2015-04-641696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543228PMC
August 2015

Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9328-33. Epub 2015 Jul 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109; Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109

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http://dx.doi.org/10.1073/pnas.1511328112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522773PMC
July 2015

Characterization of large structural genetic mosaicism in human autosomes.

Authors:
Mitchell J Machiela Weiyin Zhou Joshua N Sampson Michael C Dean Kevin B Jacobs Amanda Black Louise A Brinton I-Shou Chang Chu Chen Constance Chen Kexin Chen Linda S Cook Marta Crous Bou Immaculata De Vivo Jennifer Doherty Christine M Friedenreich Mia M Gaudet Christopher A Haiman Susan E Hankinson Patricia Hartge Brian E Henderson Yun-Chul Hong H Dean Hosgood Chao A Hsiung Wei Hu David J Hunter Lea Jessop Hee Nam Kim Yeul Hong Kim Young Tae Kim Robert Klein Peter Kraft Qing Lan Dongxin Lin Jianjun Liu Loic Le Marchand Xiaolin Liang Jolanta Lissowska Lingeng Lu Anthony M Magliocco Keitaro Matsuo Sara H Olson Irene Orlow Jae Yong Park Loreall Pooler Jennifer Prescott Radhai Rastogi Harvey A Risch Fredrick Schumacher Adeline Seow Veronica Wendy Setiawan Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu David VanDen Berg Jiu-Cun Wang Nicolas Wentzensen Maria Pik Wong Chen Wu Tangchun Wu Yi-Long Wu Lucy Xia Hannah P Yang Pan-Chyr Yang Wei Zheng Baosen Zhou Christian C Abnet Demetrius Albanes Melinda C Aldrich Christopher Amos Laufey T Amundadottir Sonja I Berndt William J Blot Cathryn H Bock Paige M Bracci Laurie Burdett Julie E Buring Mary A Butler Tania Carreón Nilanjan Chatterjee Charles C Chung Michael B Cook Michael Cullen Faith G Davis Ti Ding Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Neal D Freedman Charles S Fuchs Yu-Tang Gao Susan M Gapstur Ana Patiño-Garcia Montserrat Garcia-Closas J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Mark H Greene Goran Hallmans Curtis C Harris Roger Henriksson Elizabeth A Holly Robert N Hoover Nan Hu Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Vittorio Krogh Robert C Kurtz Andrea LaCroix Annelie Landgren Maria Teresa Landi Donghui Li Linda M Liao Nuria Malats Katherine A McGlynn Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Beata Peplonska Ulrike Peters Gloria M Petersen Ludmila Prokunina-Olsson Mark Purdue You-Lin Qiao Kari G Rabe Preetha Rajaraman Francisco X Real Elio Riboli Benjamín Rodríguez-Santiago Nathaniel Rothman Avima M Ruder Sharon A Savage Ann G Schwartz Kendra L Schwartz Howard D Sesso Gianluca Severi Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias Kala Viswanathan Sholom Wacholder Zhaoming Wang Stephanie J Weinstein William Wheeler Emily White John K Wiencke Brian M Wolpin Xifeng Wu Jay S Wunder Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Regina G Ziegler Mariza de Andrade Kathleen C Barnes Terri H Beaty Laura J Bierut Karl C Desch Kimberly F Doheny Bjarke Feenstra David Ginsburg John A Heit Jae H Kang Cecilia A Laurie Jun Z Li William L Lowe Mary L Marazita Mads Melbye Daniel B Mirel Jeffrey C Murray Sarah C Nelson Louis R Pasquale Kenneth Rice Janey L Wiggs Anastasia Wise Margaret Tucker Luis A Pérez-Jurado Cathy C Laurie Neil E Caporaso Meredith Yeager Stephen J Chanock

Am J Hum Genet 2015 Mar;96(3):487-97

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375431PMC
March 2015

Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Krüppel-like Factor 9.

J Clin Endocrinol Metab 2015 Jan;100(1):166-74

Department of Physiology and Biophysics (J.M.P.P., F.A.S., R.C.M.S.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; and Department of Obstetrics and Gynecology (D.Z., D.S.G.), Crozer-Chester Medical Center, Upland, Pennsylvania 19013.

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http://dx.doi.org/10.1210/jc.2014-2846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283014PMC
January 2015

Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B.

Mol Cell Biol 2014 Oct 28;34(19):3721-34. Epub 2014 Jul 28.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/MCB.00287-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187739PMC
October 2014

A von Willebrand factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor VIII in mice.

Blood 2014 Jul 21;124(3):445-52. Epub 2014 May 21.

Life Sciences Institute, University of Michigan, Department of Pediatrics, Howard Hughes Medical Institute, Department of Internal Medicine, and Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI.

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http://www.bloodjournal.org/content/early/2014/05/21/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-11-54
Publisher Site
http://dx.doi.org/10.1182/blood-2013-11-540534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102715PMC
July 2014

Murine coagulation factor VIII is synthesized in endothelial cells.

Blood 2014 Jun 9;123(24):3697-705. Epub 2014 Apr 9.

Howard Hughes Medical Institute, Chevy Chase, MD; and Departments of Internal Medicine, Human Genetics, and Pediatrics, University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1182/blood-2014-02-554501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055920PMC
June 2014

Functional display of platelet-binding VWF fragments on filamentous bacteriophage.

PLoS One 2013 3;8(9):e73518. Epub 2013 Sep 3.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073518PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760814PMC
May 2014

Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents.

Bioorg Med Chem Lett 2014 Mar 7;24(6):1538-44. Epub 2014 Feb 7.

Vahlteich Medicinal Chemistry Core, Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.01.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005860PMC
March 2014

Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism.

Arterioscler Thromb Vasc Biol 2013 Nov 19;33(11):2674-81. Epub 2013 Sep 19.

From the Department of Clinical Hematology, University of Alberta, Edmonton, Alberta, Canada (C.W.); Departments of Medicine (D.J.D., J.I.W., C.K., P.C.L.), Department of Medical Sciences (L.P., Z.L.), Department of Pathology and Molecular Medicine (J.W.), and Oncology (J.J.), Thrombosis and Atherosclerosis Research Institute (D.J.D., L.P., Z.L., J.I.W., P.C.L.), McMaster University, Hamilton, Ontario, Canada; and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan (K.D., D.G.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115806PMC
November 2013

Disruption of the Sec24d gene results in early embryonic lethality in the mouse.

PLoS One 2013 15;8(4):e61114. Epub 2013 Apr 15.

Johns Hopkins Bayview Internal Medicine Residency Program, The Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061114PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626607PMC
October 2013

Development and use of an evaluation tool for taste-testing activities by school-aged children.

J Acad Nutr Diet 2012 Dec 11;112(12):2028-34. Epub 2012 Oct 11.

Department of Nutrition, University of California at Davis, One Shields Ave, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.jand.2012.07.006DOI Listing
December 2012

The COPII pathway and hematologic disease.

Blood 2012 Jul 14;120(1):31-8. Epub 2012 May 14.

Department of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1182/blood-2012-01-292086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390960PMC
July 2012

SEC23B is required for the maintenance of murine professional secretory tissues.

Proc Natl Acad Sci U S A 2012 Jul 28;109(29):E2001-9. Epub 2012 Jun 28.

Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1073/pnas.1209207109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406820PMC
July 2012

Detectable clonal mosaicism from birth to old age and its relationship to cancer.

Nat Genet 2012 May 6;44(6):642-50. Epub 2012 May 6.

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

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http://www.nature.com/articles/ng.2271
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http://dx.doi.org/10.1038/ng.2271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366033PMC
May 2012

Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice.

Proc Natl Acad Sci U S A 2012 Feb 13;109(9):3469-74. Epub 2012 Feb 13.

Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO 65212, USA.

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http://dx.doi.org/10.1073/pnas.1201031109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295313PMC
February 2012

Genetics and genomics to the clinic: a long road ahead.

Authors:
David Ginsburg

Cell 2011 Sep;147(1):17-9

Howard Hughes Medical Institute, Department of Internal Medicine, and the Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.cell.2011.09.013DOI Listing
September 2011

Treatment as prevention: preparing the way.

J Int AIDS Soc 2011 Jul 6;14 Suppl 1:S6. Epub 2011 Jul 6.

South African Centre for Epidemiological Modelling and Analysis (SACEMA), Stellenbosch, South Africa.

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http://doi.wiley.com/10.1186/1758-2652-14-S1-S6
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http://dx.doi.org/10.1186/1758-2652-14-S1-S6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194151PMC
July 2011

Exocyst function is regulated by effector phosphorylation.

Nat Cell Biol 2011 May 24;13(5):580-8. Epub 2011 Apr 24.

Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/ncb2226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904505PMC
May 2011

Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):16904-9. Epub 2010 Sep 13.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1012050107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947888PMC
September 2010

Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice.

Blood 2009 Dec 29;114(26):5368-74. Epub 2009 Sep 29.

Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1182/blood-2009-07-233213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796139PMC
December 2009

Genetic risk factors for arterial thrombosis and inflammation.

Authors:
David Ginsburg

Hematology Am Soc Hematol Educ Program 2005 :442-4

Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109-2216, USA.

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http://dx.doi.org/10.1182/asheducation-2005.1.442DOI Listing
November 2009

Physical activity promotion: a local and state health department perspective.

Prev Med 2009 Oct 21;49(4):297-8. Epub 2009 Jun 21.

Division of Chronic Disease and Injury Prevention, Los Angeles County Department of Public Health, Los Angeles, CA 90010, USA.

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http://dx.doi.org/10.1016/j.ypmed.2009.06.006DOI Listing
October 2009

Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant.

Thromb Res 2009 Mar 5;123(5):785-92. Epub 2008 Sep 5.

Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States.

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http://dx.doi.org/10.1016/j.thromres.2008.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670886PMC
March 2009

Reduced thrombin generation increases host susceptibility to group A streptococcal infection.

Blood 2009 Feb 3;113(6):1358-64. Epub 2008 Dec 3.

Department of Internal Medicine, University of Missouri-Columbia, USA.

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http://dx.doi.org/10.1182/blood-2008-07-170506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637198PMC
February 2009

What a polyclonal antibody sees in von Willebrand factor.

Thromb Res 2008 5;121(4):519-26. Epub 2007 Jul 5.

Department of Internal Medicine, Life Science Institute, Howard Hughes Medical Institute, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.thromres.2007.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258224PMC
April 2008

The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.

Blood 2008 Apr 14;111(7):3452-7. Epub 2007 Dec 14.

CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2007-08-108571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275014PMC
April 2008

The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.

Mamm Genome 2008 Jan 11;19(1):32-40. Epub 2008 Jan 11.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 48109-2216, USA.

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http://dx.doi.org/10.1007/s00335-007-9079-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226002PMC
January 2008

Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase.

Blood 2007 Jun 27;109(12):5270-5. Epub 2007 Feb 27.

Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1182/blood-2006-12-064188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890832PMC
June 2007

Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene.

Blood 2006 Nov 27;108(9):3061-7. Epub 2006 Jul 27.

Howard Hughes Medical Institute, University of Michigan, 210 Washtenaw, Life Sciences Institute, Rm 5028, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1182/blood-2006-04-014688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895519PMC
November 2006

Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.

Traffic 2006 Nov 1;7(11):1473-81. Epub 2006 Oct 1.

Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00483.xDOI Listing
November 2006

Trigger for group A streptococcal M1T1 invasive disease.

FASEB J 2006 Aug 21;20(10):1745-7. Epub 2006 Jun 21.

School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, 2522, Australia.

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http://dx.doi.org/10.1096/fj.06-5804fjeDOI Listing
August 2006

Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs.

Hum Mol Genet 2006 Jul 24;15(13):2098-105. Epub 2006 May 24.

Department of Human Genetics, Howard Hughes Medical Institute, USA.

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http://dx.doi.org/10.1093/hmg/ddl133DOI Listing
July 2006

Impact of Cyp1a2 or Ahr gene knockout in mice: implications for biomonitoring studies.

Toxicol Lett 2006 Apr 26;162(2-3):246-9. Epub 2005 Oct 26.

The Department of Environmental Health, The University of Cincinnati School of Medicine, 3223 Eden Ave, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1016/j.toxlet.2005.09.020DOI Listing
April 2006

Systemic antithrombotic effects of ADAMTS13.

J Exp Med 2006 Mar 13;203(3):767-76. Epub 2006 Mar 13.

CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20051732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118248PMC
March 2006

Randomized trial of long-term follow-up for early-stage breast cancer: a comparison of family physician versus specialist care.

J Clin Oncol 2006 Feb 17;24(6):848-55. Epub 2006 Jan 17.

Cancer Outcomes Research Program, Cancer Care Nova Scotia and Dalhousie University, Halifax, Nova Scotia.

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http://dx.doi.org/10.1200/JCO.2005.03.2235DOI Listing
February 2006

Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?

J Biol Chem 2005 Dec 3;280(48):39934-41. Epub 2005 Oct 3.

Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA.

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http://dx.doi.org/10.1074/jbc.M504919200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582217PMC
December 2005

ADAMTS13 turns 3.

Blood 2005 Jul 17;106(1):11-7. Epub 2005 Mar 17.

Cell and Molecular Biology Program and Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1182/blood-2004-10-4097DOI Listing
July 2005

LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway.

J Biol Chem 2005 Jul 10;280(27):25881-6. Epub 2005 May 10.

Life Sciences Institute, the Departments of Biological Chemistry, Internal Medicine, Human Genetics Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M502160200DOI Listing
July 2005

Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice.

Circulation 2005 Apr 4;111(14):1822-5. Epub 2005 Apr 4.

Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109-0644, USA.

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http://dx.doi.org/10.1161/01.CIR.0000160854.75779.E8DOI Listing
April 2005

Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.

Science 2004 Aug;305(5688):1283-6

Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/science.1101245DOI Listing
August 2004

A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia.

Blood Coagul Fibrinolysis 2004 Jan;15(1):99-102

Thrombosis and Hemostasis Research Institute, Chaim Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Israel.

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http://dx.doi.org/10.1097/00001721-200401000-00016DOI Listing
January 2004

Getting secretory granules ready for prime time.

Cell 2003 Nov;115(4):372-3

Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00894-8DOI Listing
November 2003

Biosynthetic origin and functional significance of murine platelet factor V.

Blood 2003 Oct 19;102(8):2851-5. Epub 2003 Jun 19.

Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1182/blood-2003-04-1224DOI Listing
October 2003

The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis.

Blood 2003 Oct 10;102(8):2856-61. Epub 2003 Jul 10.

Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan, Ann Arbor, 48109,USA.

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http://dx.doi.org/10.1182/blood-2003-04-1225DOI Listing
October 2003

ADAMTS13 gene mutation in congenital thrombotic thrombocytopenic purpura with previously reported normal VWF cleaving protease activity.

Blood 2003 Jun 6;101(11):4449-51. Epub 2003 Feb 6.

Children's Hospital of Michigan, Division of Hematology/Oncology, Wayne State University, Detroit, MI, USA.

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http://dx.doi.org/10.1182/blood-2002-12-3796DOI Listing
June 2003

Strain-specific modification of lethality in fucose-deficient mice.

Mamm Genome 2003 Feb;14(2):130-9

Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1007/s00335-002-2212-5DOI Listing
February 2003

The history and evolution of the ASCI: déjà vu all over again. American Society for Clinical Investigation.

Authors:
David Ginsburg

J Clin Invest 2002 Dec;110(12):S1-4

Howard Hughes Medical Institute, Ann Arbor, Michigan 48109, USA.

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December 2002

Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.

Proc Natl Acad Sci U S A 2002 Jul 3;99(15):10042-7. Epub 2002 Jul 3.

Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive 0625, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.142005099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126621PMC
July 2002

Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden.

Circulation 2002 May;105(18):2139-42

Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Mich 48109-0644, USA.

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http://dx.doi.org/10.1161/01.cir.0000017361.39256.82DOI Listing
May 2002