David G Spiller

David G Spiller

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David G Spiller

David G Spiller

Publications by authors named "David G Spiller"

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ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions.

Cell Death Discov 2019 3;5:132. Epub 2019 Sep 3.

1Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 8TX UK.

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http://dx.doi.org/10.1038/s41420-019-0212-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718399PMC
September 2019

Disentangling juxtacrine from paracrine signalling in dynamic tissue.

PLoS Comput Biol 2019 Jun 13;15(6):e1007030. Epub 2019 Jun 13.

Zeeman Institute for Systems Biology & Infectious Disease Epidemiology Research, University of Warwick, Coventry, United Kingdom, Mathematics Institute, University of Warwick, Coventry, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1007030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592563PMC
June 2019

Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis.

Nat Commun 2019 06 27;10(1):2835. Epub 2019 Jun 27.

School of Medical Sciences, Division of Developmental Biology and Medicine, Faculty of Biology Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1038/s41467-019-10734-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597611PMC
June 2019

Live Imaging of Label-Free Graphene Oxide Reveals Critical Factors Causing Oxidative-Stress-Mediated Cellular Responses.

ACS Nano 2018 02 31;12(2):1373-1389. Epub 2018 Jan 31.

Nanomedicine Lab, Faculty of Biology, Medicine and Health, The University of Manchester , AV Hill Building, Manchester M13 9PT, U.K.

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http://dx.doi.org/10.1021/acsnano.7b07734DOI Listing
February 2018

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

Methods Mol Biol 2016 ;1417:75-88

Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1007/978-1-4939-3566-6_4DOI Listing
December 2017

Asymmetry between Activation and Deactivation during a Transcriptional Pulse.

Cell Syst 2017 12 15;5(6):646-653.e5. Epub 2017 Nov 15.

Division of Endocrinology, Diabetes and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747351PMC
December 2017

Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity.

Protein J 2017 10;36(5):425-432

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.

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http://dx.doi.org/10.1007/s10930-017-9734-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626787PMC
October 2017

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.

Sci Rep 2017 01 23;7:40981. Epub 2017 Jan 23.

Academic Unit of Reproductive and Developmental Medicine, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1038/srep40981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256028PMC
January 2017

p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma.

Br J Cancer 2016 10 1;115(8):983-992. Epub 2016 Sep 1.

Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.

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http://dx.doi.org/10.1038/bjc.2016.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061904PMC
October 2016

Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing.

Mol Endocrinol 2016 Feb 21;30(2):189-200. Epub 2015 Dec 21.

Systems Microscopy Centre (A.V.M., A.D.A., D.G.S., M.R.H.W.), Faculty of Life Sciences, and Faculty of Medical and Human Sciences (L.S.S.D., J.R.E.D.), Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester M13 9PT, United Kingdom; and The Molecular Physiology Group (S.S., J.J.M.), Centre for Cardiovascular Science, and Medical Research Council Human Reproductive Sciences Unit (A.S.M.), Centre for Reproductive Biology, Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1210/me.2015-1186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792233PMC
February 2016

Quantitative measurement of single cell dynamics.

Curr Opin Biotechnol 2012 Feb 30;23(1):103-9. Epub 2011 Nov 30.

The University of Manchester, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1016/j.copbio.2011.11.007DOI Listing
February 2012

Pulsatile patterns of pituitary hormone gene expression change during development.

J Cell Sci 2011 Oct 7;124(Pt 20):3484-91. Epub 2011 Oct 7.

Developmental Biomedicine Research Group, Faculty of Medical and Human Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK.

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http://jcs.biologists.org/content/joces/124/20/3484.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.088500
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http://dx.doi.org/10.1242/jcs.088500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196859PMC
October 2011

Microencapsulation using an oil-in-water-in-air 'dry water emulsion'.

Chem Commun (Camb) 2011 Aug 27;47(29):8253-5. Epub 2011 Jun 27.

Department of Chemistry and Centre for Materials Discovery, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK.

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http://dx.doi.org/10.1039/c1cc12698aDOI Listing
August 2011

The molecular action of the novel insecticide, Pyridalyl.

Insect Biochem Mol Biol 2011 Jul 8;41(7):459-69. Epub 2011 Apr 8.

School of Biological Sciences, The University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.1016/j.ibmb.2011.03.007DOI Listing
July 2011

The organisation of elastin and fibrillins 1 and 2 in the cruciate ligament complex.

J Anat 2011 Jun 6;218(6):600-7. Epub 2011 Apr 6.

Department of Musculoskeletal Biology, Institute of Aging and Chronic disease and School of Veterinary Science, Leahurst Campus, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/j.1469-7580.2011.01374.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125893PMC
June 2011

Dynamic analysis of stochastic transcription cycles.

PLoS Biol 2011 Apr 12;9(4):e1000607. Epub 2011 Apr 12.

Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1000607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075210PMC
April 2011

Interactive segmentation of clustered cells via geodesic commute distance and constrained density weighted Nyström method.

Cytometry A 2010 Dec;77(12):1137-47

Warwick Systems Biology Centre, University of Warwick, Coventry, United Kingdom.

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http://doi.wiley.com/10.1002/cyto.a.20993
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http://dx.doi.org/10.1002/cyto.a.20993DOI Listing
December 2010

Low molecular weight gelator-dextran composites.

Chem Commun (Camb) 2010 Sep 18;46(36):6738-40. Epub 2010 Aug 18.

Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK.

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http://dx.doi.org/10.1039/c0cc01842bDOI Listing
September 2010

Population robustness arising from cellular heterogeneity.

Proc Natl Acad Sci U S A 2010 Jun 7;107(25):11644-9. Epub 2010 Jun 7.

Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0913798107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895068PMC
June 2010

Measurement of single-cell dynamics.

Nature 2010 Jun;465(7299):736-45

Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown Street, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.1038/nature09232DOI Listing
June 2010

Is frequency-encoding of information a major theme in cellular processes?

Cell Cycle 2009 Sep 23;8(17):2677-8. Epub 2009 Sep 23.

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September 2009

Information management for high content live cell imaging.

BMC Bioinformatics 2009 Jul 21;10:226. Epub 2009 Jul 21.

Manchester Centre for Integrative Systems Biology, School of Chemistry, and Manchester Interdisciplinary Biocentre, University of Manchester, 131, Princess St, Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1186/1471-2105-10-226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723092PMC
July 2009

Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine.

Cancer Res 2008 Oct;68(20):8429-36

Division of Hematology, School of Cancer Studies, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-1758DOI Listing
October 2008

In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibers by real time fluorescence microscopy.

Antioxid Redox Signal 2008 Aug;10(8):1463-74

Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1089/ars.2007.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536563PMC
August 2008

A simple method for preparing spectrally encoded magnetic beads for multiplexed detection.

ACS Nano 2007 Dec;1(5):487-93

Department of Chemistry, Liverpool University, Liverpool L69 7ZD, UK.

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http://dx.doi.org/10.1021/nn700289mDOI Listing
December 2007

Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.

J Exp Med 2007 Sep 27;204(9):2213-24. Epub 2007 Aug 27.

Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1084/jem.20062324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118706PMC
September 2007

Automated tracking of gene expression in individual cells and cell compartments.

J R Soc Interface 2006 Dec;3(11):787-94

School of Chemistry, The University of Manchester, Faraday Building, Sackville Street, PO Box 88, Manchester M60 1QD, UK.

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http://dx.doi.org/10.1098/rsif.2006.0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885368PMC
December 2006

Encoded microcarriers for high-throughput multiplexed detection.

Angew Chem Int Ed Engl 2006 Sep;45(37):6104-17

Department of Chemistry, Liverpool University, Liverpool L69 7ZD, UK.

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http://dx.doi.org/10.1002/anie.200600288DOI Listing
September 2006

CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium.

Blood 2005 Jun 24;105(12):4813-9. Epub 2005 Feb 24.

Department of Haematology, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1182/blood-2004-10-4054DOI Listing
June 2005

Calcium-dependent regulation of the cell cycle via a novel MAPK--NF-kappaB pathway in Swiss 3T3 cells.

J Cell Biol 2004 Aug 23;166(5):661-72. Epub 2004 Aug 23.

Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, England, UK.

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http://dx.doi.org/10.1083/jcb.200402136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172420PMC
August 2004

Density-dependent location and interactions of truncated APC and beta-catenin.

Oncogene 2004 Feb;23(7):1412-9

School of Biological Sciences, University of Wales Bangor, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK.

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http://dx.doi.org/10.1038/sj.onc.1207266DOI Listing
February 2004

Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein.

Biochem J 2003 Sep;374(Pt 2):329-35

Cell Regulation and Signalling Group, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.1042/BJ20030441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223609PMC
September 2003

The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store.

J Biol Chem 2003 Jul 8;278(30):27910-5. Epub 2003 May 8.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35 QA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M304193200DOI Listing
July 2003

NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms.

J Cell Sci 2003 Jun 6;116(Pt 12):2495-503. Epub 2003 May 6.

Biosciences Building, School of Biological Sciences, University of Liverpool, Crown Street, UK.

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http://dx.doi.org/10.1242/jcs.00461DOI Listing
June 2003

The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis.

J Immunol 2003 Feb;170(4):1964-72

Department of Medicine, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.4049/jimmunol.170.4.1964DOI Listing
February 2003

Dynamic analysis of STAT6 signalling in living cells.

FEBS Lett 2002 Dec;532(1-2):188-92

School of Biological Sciences, Life Sciences Building, University of Liverpool, Crown St., Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.1016/s0014-5793(02)03672-4DOI Listing
December 2002

The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?

Trends Parasitol 2002 Oct;18(10):441-4

School of Biological Sciences, The University of Liverpool, L69 7ZB, Liverpool, UK.

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October 2002

Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells.

J Cell Sci 2002 Mar;115(Pt 6):1137-48

School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.

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March 2002