David G Kirsch

David G Kirsch

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David G Kirsch

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Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.

Radiat Res 2019 Sep 2;192(3):258-266. Epub 2019 Jul 2.

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.

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http://dx.doi.org/10.1667/RR15371.1DOI Listing
September 2019

Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.

Cell Rep 2019 Sep;28(11):2837-2850.e5

Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA; Duke Cancer Institute, Duke University, Durham, NC, USA; Regeneration Next Initiative, Duke University, Durham, NC, USA; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750751PMC
September 2019

Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy.

Cancer Res 2019 Aug 19. Epub 2019 Aug 19.

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1323DOI Listing
August 2019

The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice.

Sarcoma 2019 25;2019:1340261. Epub 2019 Jul 25.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27708, USA.

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http://dx.doi.org/10.1155/2019/1340261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683777PMC
July 2019

Functional assay to guide precision radiotherapy by assessing individual patient radiosensitivity.

EBioMedicine 2019 Mar 7;41:26-27. Epub 2019 Mar 7.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443667PMC
March 2019

Safely combining trabectedin with radiotherapy to treat myxoid liposarcoma.

EClinicalMedicine 2019 Mar 31;9:5-6. Epub 2019 Mar 31.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27708, United States of America.

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http://dx.doi.org/10.1016/j.eclinm.2019.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510721PMC
March 2019

Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.

Theranostics 2018 12;8(7):1782-1797. Epub 2018 Feb 12.

Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC 27710, United States.

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http://dx.doi.org/10.7150/thno.22621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858500PMC
February 2019

Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas.

EBioMedicine 2019 Feb 31;40:224-230. Epub 2019 Jan 31.

Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, United States; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.01.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413473PMC
February 2019

Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.

Int J Radiat Oncol Biol Phys 2018 12 26;102(5):1569-1576. Epub 2018 Jul 26.

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.07.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348051PMC
December 2018

Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.

Cancer 2018 10 3;124(19):3819-3829. Epub 2018 May 3.

Department of Pharmacology and Cancer Biology, Duke University Health System, Durham, North Carolina.

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http://doi.wiley.com/10.1002/cncr.31517
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http://dx.doi.org/10.1002/cncr.31517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215523PMC
October 2018

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.

Cell 2018 10 20;175(2):502-513.e13. Epub 2018 Sep 20.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173642PMC
October 2018

Bone protection by inhibition of microRNA-182.

Nat Commun 2018 10 5;9(1):4108. Epub 2018 Oct 5.

Arthritis and Tissue Degeneration Program, The David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, 10021, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-06446-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173760PMC
October 2018

Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome.

Radiat Res 2018 06 10;189(6):627-633. Epub 2018 Apr 10.

a   Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710.

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http://dx.doi.org/10.1667/RR15001.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020684PMC
June 2018

Current Opportunities and Future Vision of Precision Medicine in Radiation Oncology.

Authors:
David G Kirsch

Int J Radiat Oncol Biol Phys 2018 06;101(2):267-270

Department of Radiation Oncology and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499377PMC
June 2018

Multidisciplinary Management of Oligometastatic Soft Tissue Sarcoma.

Am Soc Clin Oncol Educ Book 2018 May;38:939-948

From the Department of Medicine, Division of Hematology-Oncology, UNC Lineberger Cancer Center, The University of North Carolina, Chapel Hill, NC; Orthopaedic Oncology at Aurora Cancer Care, Orthopaedic Surgery, Aurora St. Luke's Medical Center, Milwaukee, WI; Department of Cardiothoracic Surgery, Aurora Healthcare, Milwaukee, WI; Department of Radiology, Duke University Medical Center, Durham, NC; Department of Radiation Oncology, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC.

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http://dx.doi.org/10.1200/EDBK_200573DOI Listing
May 2018

Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma.

Am J Ophthalmol 2018 02 2;186:32-40. Epub 2017 Dec 2.

Department of Ophthalmology, Duke University, Durham, North Carolina; Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajo.2017.11.008DOI Listing
February 2018

A precision 3D conformal treatment technique in rats: Application to whole-brain radiotherapy with hippocampal avoidance.

Med Phys 2017 Nov 30;44(11):6008-6017. Epub 2017 Sep 30.

Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA.

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http://dx.doi.org/10.1002/mp.12533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816589PMC
November 2017

Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.

Cancer J 2016 Jul-Aug;22(4):267-73

From the *Department of Radiation Oncology, Duke University, Durham; †Department of Internal Medicine, Moses H. Cone Memorial Hospital, Greensboro; and ‡Department of Pharmacology & Cancer Biology, Duke University, Durham, NC.

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http://dx.doi.org/10.1097/PPO.0000000000000203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957656PMC
August 2017

Genetically engineered mouse models for studying radiation biology.

Transl Cancer Res 2017 Jul;6(Suppl 5):S900-S913

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.21037/tcr.2017.06.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363345PMC
July 2017

Externally applied high-dose-rate brachytherapy for deeply invasive cutaneous squamous cell carcinoma in an older patient.

Pract Radiat Oncol 2016 Jul-Aug;6(4):e141-4. Epub 2015 Nov 17.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18798500150040
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http://dx.doi.org/10.1016/j.prro.2015.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808413PMC
March 2017

p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.

Cell Rep 2016 11;17(9):2173-2182

Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Cell Biology, Duke University Medical Center, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.007DOI Listing
November 2016

Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy.

Surg Oncol Clin N Am 2016 10 6;25(4):841-60. Epub 2016 Aug 6.

Department of Radiation Oncology, Duke University Medical Center, 450 Research Drive, Durham, NC 27708, USA; Department of Pharmacology & Cancer Biology, Duke University Medical Center, 450 Research Drive, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.soc.2016.05.012DOI Listing
October 2016

Distal airway epithelial progenitor cells are radiosensitive to High-LET radiation.

Sci Rep 2016 Sep 23;6:33455. Epub 2016 Sep 23.

Department of Cell Biology, Duke University Medical Center, Durham, NC, 27708, USA.

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http://dx.doi.org/10.1038/srep33455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034250PMC
September 2016

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.

Clin Cancer Res 2016 07 6;22(13):3138-47. Epub 2016 May 6.

Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930691PMC
July 2016

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Cell Rep 2016 07 14;16(4):917-927. Epub 2016 Jul 14.

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Department of Orthopaedic Surgery, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963269PMC
July 2016

An extra copy of suppresses development of spontaneous Kras-driven but not radiation-induced cancer.

JCI Insight 2016 Jul;1(10)

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA; Department of Radiation Oncology, Duke University, Durham, North Carolina, USA.

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https://insight.jci.org/articles/view/86698
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http://dx.doi.org/10.1172/jci.insight.86698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955525PMC
July 2016

A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.

Theranostics 2015 23;5(9):946-60. Epub 2015 May 23.

1. Fitzpatrick Institute for Photonics, Duke University, Durham, NC, 27708, United States ; 2. Department of Biomedical Engineering, Duke University, Durham, NC, 27708, United States ; 3. Department of Chemistry, Duke University, Durham, NC, 27708, United States.

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http://dx.doi.org/10.7150/thno.11974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493533PMC
March 2016

Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.

Cancer Lett 2015 Dec 24;369(1):202-11. Epub 2015 Aug 24.

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600675PMC
December 2015

Spectrotemporal CT data acquisition and reconstruction at low dose.

Med Phys 2015 Nov;42(11):6317-36

Department of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710.

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http://dx.doi.org/10.1118/1.4931407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600087PMC
November 2015

Biomarkers for Predicting Radiation Response.

Authors:
David G Kirsch

Semin Radiat Oncol 2015 Oct 22;25(4):225-6. Epub 2015 May 22.

Department of Radiation Oncology, Duke University Medical Center, Durham, NC; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2015.05.011DOI Listing
October 2015

Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.

Semin Radiat Oncol 2015 Oct 14;25(4):313-21. Epub 2015 May 14.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC; Department of Radiation Oncology, Duke University Medical Center, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575408PMC
October 2015

Methods to generate genetically engineered mouse models of soft tissue sarcoma.

Methods Mol Biol 2015 ;1267:283-95

Duke University Medical Center, Box 91006, Durham, NC, 27708, USA.

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http://dx.doi.org/10.1007/978-1-4939-2297-0_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612825PMC
September 2015

The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.

Ann Surg Oncol 2015 Sep 4;22(9):2831-8. Epub 2015 Jun 4.

Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1245/s10434-015-4639-4DOI Listing
September 2015

The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis.

Dis Model Mech 2015 Sep 16;8(9):1155-66. Epub 2015 Jul 16.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27708, USA Department of Radiation Oncology, Duke University Medical Center, Box 91006, LSRC Bldg, Rm B230, Durham, NC 27708, USA

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http://dx.doi.org/10.1242/dmm.021204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582108PMC
September 2015

Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.

J Surg Oncol 2015 Sep 4;112(4):352-8. Epub 2015 Aug 4.

Department of Surgery, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1002/jso.23996DOI Listing
September 2015

Cell Death Identification in Anticancer Therapy-Letter.

Cancer Res 2015 Sep 18;75(17):3681. Epub 2015 Aug 18.

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558372PMC
September 2015

Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.

Nat Commun 2015 Sep 24;6:8477. Epub 2015 Sep 24.

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/ncomms9477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586051PMC
September 2015

MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.

Dis Model Mech 2015 Aug 4;8(8):867-75. Epub 2015 Jun 4.

Department of Radiation Oncology, Duke University Medical Center, Durham, NC NC27708, USA Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA

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http://dx.doi.org/10.1242/dmm.017897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527278PMC
August 2015

Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial.

J Clin Oncol 2015 Jul 9;33(20):2231-8. Epub 2015 Feb 9.

Dian Wang, Rush University Medical Center, Chicago, IL; Qiang Zhang, NRG Oncology Statistics and Data Management Center, Philadelphia, PA; Burton L. Eisenberg, Hoag/University of Southern California Norris Cancer Center, Los Angeles, CA; John M. Kane and Anurag K. Singh, Roswell Park Cancer Institute, Buffalo, NY; X. Allen Li and Manpreet Bedi, Medical College of Wisconsin, Milwaukee, WI; David Lucas, University of Michigan, Ann Arbor, MI; Ivy A. Petersen, Mayo Clinic, Rochester, MN; Thomas F. DeLaney, Massachusetts General Hospital, Boston, MA; Carolyn R. Freeman, McGill University Health Centre, Montreal, Quebec; George Dundas, Cross Cancer Institute, Edmonton, Alberta, Canada; Steven E. Finkelstein, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Ying J. Hitchcock, University of Utah, Salt Lake City, UT; and David G. Kirsch, Duke University Medical Center, Durham, NC.

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http://dx.doi.org/10.1200/JCO.2014.58.5828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486342PMC
July 2015

The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.

Sarcoma 2015 7;2015:186581. Epub 2015 May 7.

Department of Surgery, Division of Orthopedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1155/2015/186581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439510PMC
June 2015

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy.

Sci Transl Med 2015 Mar;7(278):278ra34

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa4214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360135PMC
March 2015

Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway.

Cancer Res 2015 Feb 12;75(3):605-14. Epub 2014 Dec 12.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina. Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327867PMC
February 2015

Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo.

Radiat Res 2015 Jan 7;183(1):124-32. Epub 2015 Jan 7.

a  Departments of Medicine and Cell Biology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1667/RR13878.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409869PMC
January 2015

Combining targeted agents with modern radiotherapy in soft tissue sarcomas.

J Natl Cancer Inst 2014 Nov 18;106(11). Epub 2014 Oct 18.

Department of Radiation Oncology, Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada (PW); Research Institute at Nationwide Children's Hospital, Columbus, OH (PH); Departments of Radiation Oncology and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC (DGK); 21st Century Oncology Translational Research Consortium (TRC) Headquarters, Scottsdale, AZ (SEF); Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA (AMM); Department of Radiation Oncology, the Ohio State University, Columbus, OH (MXW); Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA (APD); Radiotherapy Development Branch & Molecular Radiation Therapeutics Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD (MA, CNC); Clinical Radiation Oncology Branch, National Cancer Institute, Bethesda, MD (BV); Molecular Pharmacology Branch, National Cancer Institute, Bethesda, MD (BAT); Department of Radiation Oncology, University Hospitals Case Medical Center, Cleveland, OH (MM); Winship Cancer Institute, Woodruff Health Science Center, Emory University, Atlanta, GA (WJC); Department of Radiation Oncology, Rush University Medical Center, Chicago, IL (DW).

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http://dx.doi.org/10.1093/jnci/dju329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207861PMC
November 2014

Enhancing the efficacy of radiation therapy: premises, promises, and practicality.

J Clin Oncol 2014 Sep 11;32(26):2832-5. Epub 2014 Aug 11.

Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1200/JCO.2014.57.3865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152710PMC
September 2014

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Sci Signal 2014 Sep 30;7(345):ra92. Epub 2014 Sep 30.

Ludwig Institute for Cancer Research, Melbourne, Victoria 3052, Australia. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1126/scisignal.2005411DOI Listing
September 2014

Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes.

Int J Radiat Oncol Biol Phys 2014 May 7;89(1):127-36. Epub 2014 Mar 7.

Department of Radiation Oncology, Duke University, Durham, North Carolina; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016140010
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http://dx.doi.org/10.1016/j.ijrobp.2014.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988201PMC
May 2014

Europium- and lithium-doped yttrium oxide nanocrystals that provide a linear emissive response with X-ray radiation exposure.

Nanoscale 2014 May;6(10):5284-8

Department of Chemistry, French Family Science Center, Duke University, 124 Science Drive, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1039/c4nr00497cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519031PMC
May 2014

Reining in radiation injury: HIF2α in the gut.

Sci Transl Med 2014 May;6(236):236fs20

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/scitranslmed.3009155DOI Listing
May 2014

PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.

PLoS One 2013 2;8(10):e77639. Epub 2013 Oct 2.

Department of Pediatrics, Duke University, Durham, North Carolina, United States of America ; Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788718PMC
April 2014

Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.

Int J Radiat Oncol Biol Phys 2014 Mar;88(3):686-93

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2013.11.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985387PMC
March 2014

RAS and ROS in rhabdomyosarcoma.

Cancer Cell 2013 Dec;24(6):689-91

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985483PMC
December 2013

Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.

Mol Cancer Ther 2013 Nov 21;12(11):2591-600. Epub 2013 Aug 21.

Corresponding Author: Sam S. Yoon, Department of Surgery, Memorial Sloan-Kettering Cancer Center, H-1209, 1275 York Avenue, New York, NY 10065.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823674PMC
November 2013

Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.

Cell Rep 2013 Nov 14;5(4):933-40. Epub 2013 Nov 14.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Program in Molecular Cancer Biology, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893104PMC
November 2013

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis.

Transl Cancer Res 2013 Oct;2(5):412-421

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA ; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898670PMC
October 2013