David G Huntsman

David G Huntsman

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David G Huntsman

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Oncogenic mutations in histologically normal endometrium: the new normal?

J Pathol 2019 Jun 12. Epub 2019 Jun 12.

Department of Molecular Oncology, BC Cancer Research Centre, Room 3-218, 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.

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http://dx.doi.org/10.1002/path.5314DOI Listing
June 2019

Expression of L1 retrotransposon open reading frame protein 1 (L1ORF1p) in gynecologic cancers.

Hum Pathol 2019 Jun 17. Epub 2019 Jun 17.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2019.06.001DOI Listing
June 2019

A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases.

Mod Pathol 2019 Jun 25. Epub 2019 Jun 25.

Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, AB, Canada.

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http://dx.doi.org/10.1038/s41379-019-0302-0DOI Listing
June 2019

Use of Immunohistochemical Markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to Distinguish Endometrial Clear Cell Carcinoma From Its Morphologic Mimics Including Arias-Stella Reaction.

Int J Gynecol Pathol 2019 May 13. Epub 2019 May 13.

Department of Pathology and Laboratory Medicine, University of British Columbia (J.X.J., B.T.-C, B.G., D.G.H., L.N.H.) Department of Molecular Oncology, British Columbia Cancer Research Centre (D.R.C.) Genetic Pathology Evaluation Centre (S.L., A.S.C., C.C.) Department of Pathology, Vancouver General Hospital (B.G., L.N.H.), Vancouver, British Columbia, Canada.

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http://Insights.ovid.com/crossref?an=00004347-900000000-9910
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http://dx.doi.org/10.1097/PGP.0000000000000609DOI Listing
May 2019

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Authors:
Yaohua Yang Lang Wu Xiang Shu Yingchang Lu Xiao-Ou Shu Qiuyin Cai Alicia Beeghly-Fadiel Bingshan Li Fei Ye Andrew Berchuck Hoda Anton-Culver Susana Banerjee Javier Benitez Line Bjørge James D Brenton Ralf Butzow Ian G Campbell Jenny Chang-Claude Kexin Chen Linda S Cook Daniel W Cramer Anna deFazio Joe Dennis Jennifer A Doherty Thilo Dörk Diana M Eccles Digna Velez Edwards Peter A Fasching Renée T Fortner Simon A Gayther Graham G Giles Rosalind M Glasspool Ellen L Goode Marc T Goodman Jacek Gronwald Holly R Harris Florian Heitz Michelle A Hildebrandt Estrid Høgdall Claus K Høgdall David G Huntsman Siddhartha P Kar Beth Y Karlan Linda E Kelemen Lambertus A Kiemeney Susanne K Kjaer Anita Koushik Diether Lambrechts Nhu D Le Douglas A Levine Leon F Massuger Keitaro Matsuo Taymaa May Iain A McNeish Usha Menon Francesmary Modugno Alvaro N Monteiro Patricia G Moorman Kirsten B Moysich Roberta B Ness Heli Nevanlinna Håkan Olsson N Charlotte Onland-Moret Sue K Park James Paul Celeste L Pearce Tanja Pejovic Catherine M Phelan Malcolm C Pike Susan J Ramus Elio Riboli Cristina Rodriguez-Antona Isabelle Romieu Dale P Sandler Joellen M Schildkraut Veronica W Setiawan Kang Shan Nadeem Siddiqui Weiva Sieh Meir J Stampfer Rebecca Sutphen Anthony J Swerdlow Lukasz M Szafron Soo Hwang Teo Shelley S Tworoger Jonathan P Tyrer Penelope M Webb Nicolas Wentzensen Emily White Walter C Willett Alicja Wolk Yin Ling Woo Anna H Wu Li Yan Drakoulis Yannoukakos Georgia Chenevix-Trench Thomas A Sellers Paul D P Pharoah Wei Zheng Jirong Long

Cancer Res 2019 02 17;79(3):505-517. Epub 2018 Dec 17.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359948PMC
February 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Distinct developmental trajectories of endometriotic epithelium and stroma: implications for the origins of endometriosis.

J Pathol 2018 Nov 1;246(3):257-260. Epub 2018 Oct 1.

Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.5136DOI Listing
November 2018

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.

Authors:
Peter F Rambau Robert A Vierkant Maria P Intermaggio Linda E Kelemen Marc T Goodman Esther Herpel Paul D Pharoah Stefan Kommoss Mercedes Jimenez-Linan Beth Y Karlan Aleksandra Gentry-Maharaj Usha Menon Susanna Hernando Polo Francisco J Candido Dos Reis Jennifer Anne Doherty Simon A Gayther Raghwa Sharma Melissa C Larson Paul R Harnett Emma Hatfield Jurandyr M de Andrade Gregg S Nelson Helen Steed Joellen M Schildkraut Micheal E Carney Estrid Høgdall Alice S Whittemore Martin Widschwendter Catherine J Kennedy Frances Wang Qin Wang Chen Wang Sebastian M Armasu Frances Daley Penny Coulson Micheal E Jones Micheal S Anglesio Christine Chow Anna de Fazio Montserrat García-Closas Sara Y Brucker Cezary Cybulski Holly R Harris Andreas D Hartkopf Tomasz Huzarski Allan Jensen Jan Lubiński Oleg Oszurek Javier Benitez Fady Mina Annette Staebler Florin Andrei Taran Jana Pasternak Aline Talhouk Mary Anne Rossing Joy Hendley Robert P Edwards Sian Fereday Francesmary Modugno Roberta B Ness Weiva Sieh Mona A El-Bahrawy Stacey J Winham Jenny Lester Susanne K Kjaer Jacek Gronwald Peter Sinn Peter A Fasching Jenny Chang-Claude Kirsten B Moysich David D Bowtell Brenda Y Hernandez Hugh Luk Sabine Behrens Mitul Shah Audrey Jung Prafull Ghatage Jennifer Alsop Kathryn Alsop Jesús García-Donas Pamela J Thompson Anthony J Swerdlow Chloe Karpinskyj Alicia Cazorla-Jiménez María J García Susha Deen Lynne R Wilkens José Palacios Andrew Berchuck Jennifer M Koziak James D Brenton Linda S Cook Ellen L Goode David G Huntsman Susan J Ramus Martin Köbel

J Pathol Clin Res 2018 10 21;4(4):250-261. Epub 2018 Sep 21.

Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, AB, Canada.

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http://dx.doi.org/10.1002/cjp2.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174617PMC
October 2018

Histotype classification of ovarian carcinoma: A comparison of approaches.

Gynecol Oncol 2018 10 16;151(1):53-60. Epub 2018 Aug 16.

Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1016/j.ygyno.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292681PMC
October 2018

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.

Authors:
Yingchang Lu Alicia Beeghly-Fadiel Lang Wu Xingyi Guo Bingshan Li Joellen M Schildkraut Hae Kyung Im Yian A Chen Jennifer B Permuth Brett M Reid Jamie K Teer Kirsten B Moysich Irene L Andrulis Hoda Anton-Culver Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Javier Benitez Line Bjorge James Brenton Ralf Butzow Trinidad Caldes Maria A Caligo Ian Campbell Jenny Chang-Claude Kathleen B M Claes Fergus J Couch Daniel W Cramer Mary B Daly Anna deFazio Joe Dennis Orland Diez Susan M Domchek Thilo Dörk Douglas F Easton Diana M Eccles Peter A Fasching Renée T Fortner George Fountzilas Eitan Friedman Patricia A Ganz Judy Garber Graham G Giles Andrew K Godwin David E Goldgar Marc T Goodman Mark H Greene Jacek Gronwald Ute Hamann Florian Heitz Michelle A T Hildebrandt Claus K Høgdall Antoinette Hollestelle Peter J Hulick David G Huntsman Evgeny N Imyanitov Claudine Isaacs Anna Jakubowska Paul James Beth Y Karlan Linda E Kelemen Lambertus A Kiemeney Susanne K Kjaer Ava Kwong Nhu D Le Goska Leslie Fabienne Lesueur Douglas A Levine Amalia Mattiello Taymaa May Lesley McGuffog Iain A McNeish Melissa A Merritt Francesmary Modugno Marco Montagna Susan L Neuhausen Heli Nevanlinna Finn C Nielsen Liene Nikitina-Zake Robert L Nussbaum Kenneth Offit Edith Olah Olufunmilayo I Olopade Sara H Olson Håkan Olsson Ana Osorio Sue K Park Michael T Parsons Petra H M Peeters Tanja Pejovic Paolo Peterlongo Catherine M Phelan Miquel Angel Pujana Susan J Ramus Gad Rennert Harvey Risch Gustavo C Rodriguez Cristina Rodríguez-Antona Isabelle Romieu Matti A Rookus Mary Anne Rossing Iwona K Rzepecka Dale P Sandler Rita K Schmutzler Veronica W Setiawan Priyanka Sharma Weiva Sieh Jacques Simard Christian F Singer Honglin Song Melissa C Southey Amanda B Spurdle Rebecca Sutphen Anthony J Swerdlow Manuel R Teixeira Soo H Teo Mads Thomassen Marc Tischkowitz Amanda E Toland Antonia Trichopoulou Nadine Tung Shelley S Tworoger Elizabeth J van Rensburg Adriaan Vanderstichele Ana Vega Digna Velez Edwards Penelope M Webb Jeffrey N Weitzel Nicolas Wentzensen Emily White Alicja Wolk Anna H Wu Drakoulis Yannoukakos Kristin K Zorn Simon A Gayther Antonis C Antoniou Andrew Berchuck Ellen L Goode Georgia Chenevix-Trench Thomas A Sellers Paul D P Pharoah Wei Zheng Jirong Long

Cancer Res 2018 Sep 27;78(18):5419-5430. Epub 2018 Jul 27.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139053PMC
September 2018

DICER1 hot-spot mutations in ovarian gynandroblastoma.

Histopathology 2018 Aug 5;73(2):306-313. Epub 2018 Jun 5.

Institute of Pathology, Medizin Campus Bodensee, Friedrichshafen, Germany.

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http://dx.doi.org/10.1111/his.13630DOI Listing
August 2018

Extending the safety evidence for opportunistic salpingectomy in prevention of ovarian cancer: a cohort study from British Columbia, Canada.

Am J Obstet Gynecol 2018 08 28;219(2):172.e1-172.e8. Epub 2018 May 28.

Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, University of British Columbia, Vancouver BC, Canada.

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http://dx.doi.org/10.1016/j.ajog.2018.05.019DOI Listing
August 2018

High Frequency of Ovarian Cyst Development in Vhl;Snf5 Mice.

Am J Pathol 2018 07 22;188(7):1510-1516. Epub 2018 Apr 22.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024179PMC
July 2018

Changing Clinical Practice: Evaluation of Implementing Recommendations for Opportunistic Salpingectomy in British Columbia and Ontario.

Int J Gynecol Cancer 2018 07;28(6):1101-1107

Division of Gynecologic Oncology, University of British Columbia, Vancouver General Hospital.

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http://dx.doi.org/10.1097/IGC.0000000000001288DOI Listing
July 2018

Tubo-Ovarian Transitional Cell Carcinoma and High-grade Serous Carcinoma Show Subtly Different Immunohistochemistry Profiles.

Int J Gynecol Pathol 2018 Jul 27. Epub 2018 Jul 27.

British Columbia Cancer Agency (J.M., A.N.K., A.T., D.C., D.G.H.) Department of Pathology, University of British Columbia (A.N.K., B.T.-C., C.C., A.C., C.B.G., D.G.H.), Vancouver, British Columbia, Canada Memorial Sloan Kettering Cancer Center, New York, New York (R.S.) Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands (S.H.) Department of Women's Health, Tübingen University Hospital, Tübingen (S.K.) Department of Gynecologic Oncology, Kliniken Essen Mitte, Essen (A.D.B.) Gynecologic Oncology Center, Kiel (J.P.) Institute of Pathology, Friedrichshafen (F.K.), Germany.

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http://dx.doi.org/10.1097/PGP.0000000000000538DOI Listing
July 2018

Clear cell carcinomas of the ovary and kidney: clarity through genomics.

J Pathol 2018 04 23;244(5):550-564. Epub 2018 Feb 23.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.5037DOI Listing
April 2018

The molecular pathology of cancer: from pan-genomics to post-genomics.

J Pathol 2018 04;244(5):509-511

Department of Pathology and Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1002/path.5057DOI Listing
April 2018

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer.

Mayo Clin Proc 2018 03;93(3):307-320

Department of Health Sciences Research, Mayo Clinic, Rochester, MN. Electronic address:

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http://dx.doi.org/10.1016/j.mayocp.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870793PMC
March 2018

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers.

Gynecol Oncol 2017 12 9;147(3):642-647. Epub 2017 Oct 9.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258173135
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http://dx.doi.org/10.1016/j.ygyno.2017.09.032DOI Listing
December 2017

Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.

Authors:
Ellen L Goode Matthew S Block Kimberly R Kalli Robert A Vierkant Wenqian Chen Zachary C Fogarty Aleksandra Gentry-Maharaj Aleksandra Tołoczko Alexander Hein Aliecia L Bouligny Allan Jensen Ana Osorio Andreas Hartkopf Andy Ryan Anita Chudecka-Głaz Anthony M Magliocco Arndt Hartmann Audrey Y Jung Bo Gao Brenda Y Hernandez Brooke L Fridley Bryan M McCauley Catherine J Kennedy Chen Wang Chloe Karpinskyj Christiani B de Sousa Daniel G Tiezzi David L Wachter Esther Herpel Florin Andrei Taran Francesmary Modugno Gregg Nelson Jan Lubiński Janusz Menkiszak Jennifer Alsop Jenny Lester Jesús García-Donas Jill Nation Jillian Hung José Palacios Joseph H Rothstein Joseph L Kelley Jurandyr M de Andrade Luis Robles-Díaz Maria P Intermaggio Martin Widschwendter Matthias W Beckmann Matthias Ruebner Mercedes Jimenez-Linan Naveena Singh Oleg Oszurek Paul R Harnett Peter F Rambau Peter Sinn Philipp Wagner Prafull Ghatage Raghwa Sharma Robert P Edwards Roberta B Ness Sandra Orsulic Sara Y Brucker Sharon E Johnatty Teri A Longacre Eilber Ursula Valerie McGuire Weiva Sieh Yanina Natanzon Zheng Li Alice S Whittemore deFazio Anna Annette Staebler Beth Y Karlan Blake Gilks David D Bowtell Estrid Høgdall Francisco J Candido dos Reis Helen Steed Ian G Campbell Jacek Gronwald Javier Benítez Jennifer M Koziak Jenny Chang-Claude Kirsten B Moysich Linda E Kelemen Linda S Cook Marc T Goodman María José García Peter A Fasching Stefan Kommoss Suha Deen Susanne K Kjaer Usha Menon James D Brenton Paul DP Pharoah Georgia Chenevix-Trench David G Huntsman Stacey J Winham Martin Köbel Susan J Ramus

JAMA Oncol 2017 12;3(12):e173290

School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia

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http://dx.doi.org/10.1001/jamaoncol.2017.3290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744673PMC
December 2017

APELA promotes tumour growth and cell migration in ovarian cancer in a p53-dependent manner.

Gynecol Oncol 2017 12 24;147(3):663-671. Epub 2017 Oct 24.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada; Cell and Developmental Biology Program, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.10.016DOI Listing
December 2017

Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary.

Ann Med 2017 08 6;49(5):435-447. Epub 2017 Mar 6.

b Children's Hospital , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

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http://dx.doi.org/10.1080/07853890.2017.1294760DOI Listing
August 2017

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.

J Pathol 2017 07 2;242(3):371-383. Epub 2017 Jun 2.

Department of Pathology and Laboratory Medicine, University of British Columbia and Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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http://doi.wiley.com/10.1002/path.4912
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http://dx.doi.org/10.1002/path.4912DOI Listing
July 2017

Frequent NFIB-associated Gene Rearrangement in Adenoid Cystic Carcinoma of the Vulva.

Int J Gynecol Pathol 2017 May;36(3):289-293

Department of Pathology (D.X., B.M.R.), The Johns Hopkins Medical Institutions, Baltimore, MDDepartment of Pathology and Laboratory Medicine (S.B., N.M., J.H., D.G.H., C.B.G., H.H.), University of British Columbia, Vancouver, BC, CanadaCellNetix Pathology (C.I.), Seattle, WA.

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http://dx.doi.org/10.1097/PGP.0000000000000324DOI Listing
May 2017

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Authors:
Catherine M Phelan Karoline B Kuchenbaecker Jonathan P Tyrer Siddhartha P Kar Kate Lawrenson Stacey J Winham Joe Dennis Ailith Pirie Marjorie J Riggan Ganna Chornokur Madalene A Earp Paulo C Lyra Janet M Lee Simon Coetzee Jonathan Beesley Lesley McGuffog Penny Soucy Ed Dicks Andrew Lee Daniel Barrowdale Julie Lecarpentier Goska Leslie Cora M Aalfs Katja K H Aben Marcia Adams Julian Adlard Irene L Andrulis Hoda Anton-Culver Natalia Antonenkova Gerasimos Aravantinos Norbert Arnold Banu K Arun Brita Arver Jacopo Azzollini Judith Balmaña Susana N Banerjee Laure Barjhoux Rosa B Barkardottir Yukie Bean Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Marina Bermisheva Marcus Q Bernardini Michael J Birrer Line Bjorge Amanda Black Kenneth Blankstein Marinus J Blok Clara Bodelon Natalia Bogdanova Anders Bojesen Bernardo Bonanni Åke Borg Angela R Bradbury James D Brenton Carole Brewer Louise Brinton Per Broberg Angela Brooks-Wilson Fiona Bruinsma Joan Brunet Bruno Buecher Ralf Butzow Saundra S Buys Trinidad Caldes Maria A Caligo Ian Campbell Rikki Cannioto Michael E Carney Terence Cescon Salina B Chan Jenny Chang-Claude Stephen Chanock Xiao Qing Chen Yoke-Eng Chiew Jocelyne Chiquette Wendy K Chung Kathleen B M Claes Thomas Conner Linda S Cook Jackie Cook Daniel W Cramer Julie M Cunningham Aimee A D'Aloisio Mary B Daly Francesca Damiola Sakaeva Dina Damirovna Agnieszka Dansonka-Mieszkowska Fanny Dao Rosemarie Davidson Anna DeFazio Capucine Delnatte Kimberly F Doheny Orland Diez Yuan Chun Ding Jennifer Anne Doherty Susan M Domchek Cecilia M Dorfling Thilo Dörk Laure Dossus Mercedes Duran Matthias Dürst Bernd Dworniczak Diana Eccles Todd Edwards Ros Eeles Ursula Eilber Bent Ejlertsen Arif B Ekici Steve Ellis Mingajeva Elvira Kevin H Eng Christoph Engel D Gareth Evans Peter A Fasching Sarah Ferguson Sandra Fert Ferrer James M Flanagan Zachary C Fogarty Renée T Fortner Florentia Fostira William D Foulkes George Fountzilas Brooke L Fridley Tara M Friebel Eitan Friedman 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Walker Christine Walsh Dorothea Wand Shan Wang-Gohrke Barbara Wappenschmidt Penelope M Webb Clarice R Weinberg Jeffrey N Weitzel Nicolas Wentzensen Alice S Whittemore Juul T Wijnen Lynne R Wilkens Alicja Wolk Michelle Woo Xifeng Wu Anna H Wu Hannah Yang Drakoulis Yannoukakos Argyrios Ziogas Kristin K Zorn Steven A Narod Douglas F Easton Christopher I Amos Joellen M Schildkraut Susan J Ramus Laura Ottini Marc T Goodman Sue K Park Linda E Kelemen Harvey A Risch Mads Thomassen Kenneth Offit Jacques Simard Rita Katharina Schmutzler Dennis Hazelett Alvaro N Monteiro Fergus J Couch Andrew Berchuck Georgia Chenevix-Trench Ellen L Goode Thomas A Sellers Simon A Gayther Antonis C Antoniou Paul D P Pharoah

Nat Genet 2017 May 27;49(5):680-691. Epub 2017 Mar 27.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612337PMC
May 2017

Cancer-Associated Mutations in Endometriosis without Cancer.

N Engl J Med 2017 05;376(19):1835-1848

From the Departments of Obstetrics and Gynaecology (M.S.A., C.A., C.W., P.J.Y., D.G.H.) and Pathology and Laboratory Medicine (M.S.A., T.M.N., J. Senz, B.T.-C., C.B.G., D.G.H.), University of British Columbia, the Department of Anatomical Pathology, Vancouver General Hospital (T.M.N., H.M.H., J.H., V.L., B.T.-C., A.W., C.B.G., D.G.H.), the Department of Molecular Oncology, British Columbia Cancer Agency (H.M.H., A.L., V.L., N.B., D.G.H.), and the BC Women's Centre for Pelvic Pain and Endometriosis, BC Women's Hospital and Health Centre (F.W., N.O., C.A., C.W., P.J.Y.) - all in Vancouver, BC, Canada; the Department of Oncology (N.P., C.T., K.W.K., L.D., T.-L.W., B.V., I.-M.S.) and Ludwig Center (N.P., Y.W., J.D.C., M.Z., M.P., W.M., A.M., K.W.K., L.D., B.V.), Sidney Kimmel Comprehensive Cancer Center, the Departments of Pathology (N.P., A.A., M.N., L.D.W., T.-L.W., B.V., I.-M.S.) and Gynecology and Obstetrics (J. Segars, I.-M.S.), Johns Hopkins Medical Institutions, Personal Genome Diagnostics (S.J.), and Johns Hopkins University Howard Hughes Medical Institute (B.V.) - all in Baltimore; the Department of Pathology, Seirei Mikatahara Hospital (A.A., H.O.), and the Department of Tumor Pathology, Hamamatsu University School of Medicine (A.A.), Hamamatsu, and the Department of Molecular Pathology, Hiroshima University School of Medicine, Hiroshima (A.A.) - all in Japan; the Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands (M.N.); the Departments of Obstetrics and Gynecology (T.S.) and Pathology (R.A., A.H.), Lenox Hill Hospital-Northwell Health (Hofstra University), New York; and the Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan City, Taiwan (R.-C.W.).

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http://dx.doi.org/10.1056/NEJMoa1614814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555376PMC
May 2017

Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.

Cancer 2017 03 6;123(5):802-813. Epub 2017 Jan 6.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cncr.30496DOI Listing
March 2017

Interobserver Agreement in Endometrial Carcinoma Histotype Diagnosis Varies Depending on The Cancer Genome Atlas (TCGA)-based Molecular Subgroup.

Am J Surg Pathol 2017 Feb;41(2):245-252

*Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY †Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital, University of British Columbia **Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, BC ‡Department of Pathology, Saskatoon City Hospital, Saskatoon, SK §Department of Pathology, Laval University, Quebec City #Department of Human Genetics, McGill University, Research Institute of the McGill University Health Network, Montreal, QC ∥Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital, University of Alberta, Edmonton ¶Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1097/PAS.0000000000000764DOI Listing
February 2017

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.

Br J Cancer 2017 Feb 19;116(4):524-535. Epub 2017 Jan 19.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1038/bjc.2016.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318969PMC
February 2017

FOXL2 402C>G Mutation Can Be Identified in the Circulating Tumor DNA of Patients with Adult-Type Granulosa Cell Tumor.

J Mol Diagn 2017 01 1;19(1):126-136. Epub 2016 Nov 1.

Department of Pathology and Laboratory Medicine, University of British Columbia, and the Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada. Electronic address:

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January 2017

The disparate origins of ovarian cancers: pathogenesis and prevention strategies.

Nat Rev Cancer 2017 01 25;17(1):65-74. Epub 2016 Nov 25.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

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January 2017

Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas.

Mod Pathol 2016 12 26;29(12):1586-1593. Epub 2016 Aug 26.

Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, Canada.

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December 2016

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

J Natl Cancer Inst 2016 11 13;108(11). Epub 2016 Jun 13.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital and BC Cancer Agency, Vancouver, Canada (MKM, HMH, AT, WY, NR, CBG, DGH); Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (AF, LUK, SB, MA); Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland (AF, LUK, SB, MA); Centre of Gynaecologic Oncology Amsterdam (HSvM, MRB, GGK) and Department of Pathology (JBGH, GKJH, MJvdV, MCGB), Academic Medical Center, Amsterdam, the Netherlands; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (NA, MH); Department of Obstetrics and Gynaecology, Tübingen University Hospital, Department of Women's Health, Tübingen, Germany (KZ, SYB, BK, SK); Department of Pathology (RB) and Department of Clinical Chemistry and Hematology (MA), Helsinki University Hospital, University of Helsinki and HUSLAB, Helsinki, Finland; Institute of Pathology, Tübingen University Hospital, Tübingen, Germany (AS); Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO (MH); Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada (DGH); Department of Human Genetics, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada (MKM)

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http://dx.doi.org/10.1093/jnci/djw134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241905PMC
November 2016

Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment.

Gynecol Oncol 2016 10 14;143(1):46-53. Epub 2016 Jul 14.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, 2775 Laurel St., 6th Floor, Vancouver, British Columbia V5Z 1M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.07.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521211PMC
October 2016

Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research.

Sci Rep 2016 10 7;6:34949. Epub 2016 Oct 7.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/srep34949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054533PMC
October 2016

Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines.

Am J Cancer Res 2016 1;6(10):2235-2251. Epub 2016 Oct 1.

Department of Obstetrics & Gynaecology, University of British ColumbiaVancouver, British Columbia, Canada; Department of Surgical Oncology, BC Cancer AgencyVancouver, British Columbia, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088288PMC
October 2016

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.

Clin Cancer Res 2016 06 13;22(12):2865-73. Epub 2016 Jan 13.

Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2233DOI Listing
June 2016

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.

J Natl Cancer Inst 2016 Jun 1;108(6):djv428. Epub 2016 Feb 1.

Department of Pathology and Laboratory Medicine, (MSA, HMH, JS, HLC, ANK, BSS, MKM, CBG, SK, DGH) and Department of Obstetrics and Gynaecology (MSA, DGH), University of British Columbia, Vancouver, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, Canada (YKW, AB, RM, DSG, SPS); Department of Women's Health, University Hospital Tuebingen, Tuebingen, Germany (MM, FAT, DW, SB, SK); Division of Anatomic Pathology, Synlab MVZ, Institute of Pathology, Mannheim, Germany (FK); Division of Gynecologic Pathology, Institute of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany (AS); Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, Canada (CBG).

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June 2016

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Gynecol Oncol 2016 06 19;141(3):454-460. Epub 2016 Mar 19.

Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Institute and Segal Cancer Center, Jewish General Hospital, Montreal, QC, Canada; Department of Medical Genetics and Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

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June 2016

BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer.

Int J Gynecol Cancer 2016 06;26(5):825-32

Departments of *Obstetrics and Gynecology, and †Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ‡Faculty of Medicine, Universiteit van Amsterdam, Amsterdam, the Netherlands; §Department of Pathology and Laboratory Medicine, BC Cancer Agency; ∥Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia; ¶Division of Gynecologic Oncology, Princess Margaret Cancer Centre, Toronto, Ontario; and #Hereditary Cancer Program, BC Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/IGC.0000000000000698DOI Listing
June 2016

Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant.

Am J Hum Genet 2016 05 14;98(5):830-842. Epub 2016 Apr 14.

Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863475PMC
May 2016

Rare cancers: a sea of opportunity.

Lancet Oncol 2016 Feb;17(2):e52-e61

Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine and Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00386-1DOI Listing
February 2016

The genomic landscape of epithelioid sarcoma cell lines and tumours.

J Pathol 2016 Jan 19;238(1):63-73. Epub 2015 Oct 19.

Genetic Pathology Evaluation Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.4636DOI Listing
January 2016

Morphologic and Molecular Characteristics of Mixed Epithelial Ovarian Cancers.

Am J Surg Pathol 2015 Nov;39(11):1548-57

*Department of Molecular Oncology §Cancer Control Research, BC Cancer Agency Cancer Research Centre †Department of Pathology and Laboratory Medicine ‡Genetic Pathology Evaluation Centre, Anatomical Pathology at the Vancouver General Hospital ‡‡Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, BC, Canada ∥Department of Internal Medicine, University of New Mexico, Albuquerque, NM §§Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB ¶The Leeds Teaching Hospitals NHS Trust, Leeds #Barts Health NHS Trust, London, United Kingdom **Institut für Pathologie, Referenzzentrum für Gynäkopathologie, Mannheim ††Gynecologic Oncology Center, Kiel ∥∥Department of Gynecology and Obstetrics, Tuebingen University Women's Hospital, Tuebingen, Germany.

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http://dx.doi.org/10.1097/PAS.0000000000000476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604016PMC
November 2015

Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.

J Pathol 2015 Oct 6;237(2):215-25. Epub 2015 Jul 6.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.4569DOI Listing
October 2015

Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma.

Int J Gynecol Cancer 2015 Sep;25(7):1187-93

*Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital; †University of British Columbia, Vancouver; ‡Department of Pathology and Laboratory Medicine, Calgary Laboratory Services; §University of Calgary, Calgary, Canada; ∥Department of Gynecology and Obstetrics, Tübingen University, Tübingen, Germany; ¶Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital; #University of Alberta; **Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; ††Department of Public Health Sciences, Medical University of South Carolina; ‡‡Hollings Cancer Center, Charleston, SC; and §§Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1097/IGC.0000000000000492DOI Listing
September 2015

Categorization of cancer through genomic complexity could guide research and management strategies.

J Pathol 2015 Aug 22;236(4):397-402. Epub 2015 May 22.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.4542DOI Listing
August 2015

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.

Neoplasia 2015 Aug;17(8):650-60

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674484PMC
August 2015

In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

J Pathol Clin Res 2015 Jul 9;1(3):173-85. Epub 2015 Apr 9.

Department of Laboratory Medicine and Pathology Royal Alexandra Hospital and University of Alberta Edmonton Canada.

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http://dx.doi.org/10.1002/cjp2.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939881PMC
July 2015

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition.

Mol Cancer Ther 2015 Jun 7;14(6):1495-503. Epub 2015 Apr 7.

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0039DOI Listing
June 2015

Using Somatic Mutations to Guide Treatment Decisions: Context Matters.

JAMA Oncol 2015 Jun;1(3):275-6

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada2Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada4Department of Obstetrics and Gynecol.

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http://dx.doi.org/10.1001/jamaoncol.2015.35DOI Listing
June 2015

FOXL2 mutation is absent in uterine tumors resembling ovarian sex cord tumors.

Am J Surg Pathol 2015 May;39(5):618-23

*Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY †Department of Pathology, University of Maryland School of Medicine, Baltimore, MD **Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA ∥Institute of Pathology, Mannheim, Germany ¶Department of Pathology, San Salvatore Hospital, Pesaro, Italy ‡Center for Translational and Applied Genomics §Genetic Pathology Evaluation Center #Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/PAS.0000000000000367DOI Listing
May 2015

Lapatinib or Trastuzumab Plus Taxane Therapy for Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: Final Results of NCIC CTG MA.31.

J Clin Oncol 2015 May 16;33(14):1574-83. Epub 2015 Mar 16.

Karen A. Gelmon, David G. Huntsman, and Samuel Aparicio, British Columbia Cancer Agency, Vancouver Cancer Centre, Vancouver; Susan L. Ellard, British Columbia Cancer Agency, Cancer Centre for the Southern Interior, Kelowna, British Columbia; Julie Lemieux, Centre Hospitalier Affilié Hopital Du St Sacrement, Quebec City, Quebec; Lois E. Shepherd, Dora Nomikos, Judith-Anne W. Chapman, and Wendy R. Parulekar, NCIC Clinical Trials Group, Queen's University, Kingston; Susan Dent, Ottawa Health Research Institute, Ottawa; Kathleen I. Pritchard, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto; Timothy J. Whelan, Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario; Katia Tonkin, Cross Cancer Institute, Edmonton, Alberta, Canada; Frances M. Boyle, Patricia Ritchie Centre for Cancer Care and Research, Mater Hospital, North Sydney, New South Wales, Australia; Bella Kaufman, Sheba Medical Centre, Tel Hashomer; Shulamith Rizel, Rabin Medical Center, Petach Tikva, Israel; Alexey Manikhas, City Clinical Oncological Dispensery, St Petersburg; Sergei Tjulandin, Russian Cancer Research Center, Moscow; Rustem Khasanov, Clinical Oncology Dispensary, Kazan, Russia; Angelo Di Leo, Sandro Pitgliani Medical Oncology Unit, Prato, Italy; Miguel Martin, Servicio Oncologia Hospital Gregorio Marañon, Madrid, Spain; Lee S. Schwartzberg, West Clinic, Memphis, TN; Arnd Nusch, Praxis, Velbert, Germany; Robert E. Coleman, Weston Park Hospital, Cancer Research Centre, Sheffield, United Kingdom; Hirofumi Mukai, National Cancer Center Hospital East, Kashiwa-shi, Japan; Anne P. Connor, GlaxoSmithKline, Collegeville, PA; and Sergio L. Santillana, GlaxoSmithKline, Rio de Janeiro, Brazil.

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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.56.9590
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http://dx.doi.org/10.1200/JCO.2014.56.9590DOI Listing
May 2015

Targeted mutation analysis of endometrial clear cell carcinoma.

Histopathology 2015 Apr 13;66(5):664-74. Epub 2015 Jan 13.

Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Center, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/his.12581DOI Listing
April 2015

Cancer genomics: why rare is valuable.

J Mol Med (Berl) 2015 Apr 14;93(4):369-81. Epub 2015 Feb 14.

Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada,

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http://dx.doi.org/10.1007/s00109-015-1260-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366545PMC
April 2015

Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.

PLoS One 2013 23;8(12):e82406. Epub 2013 Dec 23.

Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia, Canada ; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada ; Department of Biology, University of Victoria, Victoria, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082406PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871161PMC
March 2015

Costs and benefits of opportunistic salpingectomy as an ovarian cancer prevention strategy.

Obstet Gynecol 2015 Feb;125(2):338-45

Division of Gynecologic Oncology, University of British Columbia and OVCARE, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/AOG.0000000000000630DOI Listing
February 2015

Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion.

FEBS Lett 2015 Jan 20;589(3):302-9. Epub 2014 Dec 20.

Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, Canada. Electronic address:

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http://doi.wiley.com/10.1016/j.febslet.2014.12.012
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http://dx.doi.org/10.1016/j.febslet.2014.12.012DOI Listing
January 2015

Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait.

Hum Pathol 2014 Dec 4;45(12):2453-62. Epub 2014 Sep 4.

Department of Laboratory Medicine and Pathology, University of Alberta and Royal Alexandra Hospital, Edmonton, AB T5H 3V9, Canada.

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http://dx.doi.org/10.1016/j.humpath.2014.08.012DOI Listing
December 2014

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Genome Res 2014 Nov 24;24(11):1881-93. Epub 2014 Jul 24.

Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Computer Science, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada;

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http://dx.doi.org/10.1101/gr.180281.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216928PMC
November 2014

Boveri at 100: Theodor Boveri and genetic predisposition to cancer.

J Pathol 2014 Oct;234(2):142-5

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, and British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.4414DOI Listing
October 2014

ARID1A/BAF250a as a prognostic marker for gastric carcinoma: a study of 2 cohorts.

Hum Pathol 2014 Jun 20;45(6):1258-68. Epub 2014 Feb 20.

Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, V6T 2B5, Canada; The University of British Columbia (UBC), Vancouver, British Columbia, V6T 1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2014.02.006DOI Listing
June 2014

Diagnostic value of next-generation sequencing in an unusual sphenoid tumor.

Oncologist 2014 Jun 7;19(6):623-30. Epub 2014 May 7.

Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada; Division of Oncology/Hematology/BMT, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1634/theoncologist.2013-0390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041668PMC
June 2014

Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention.

Am J Obstet Gynecol 2014 May 9;210(5):471.e1-11. Epub 2014 Jan 9.

Department of Gynecology and Obstetrics Division of Gynecologic Oncology, University of British Columbia and BC Cancer Agency.

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https://linkinghub.elsevier.com/retrieve/pii/S00029378140001
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May 2014