David G Denardo

David G Denardo

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David G Denardo

David G Denardo

Publications by authors named "David G Denardo"

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A Single-Cell Window into Pancreas Cancer Fibroblast Heterogeneity.

Cancer Discov 2019 Aug;9(8):1001-1002

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0576DOI Listing
August 2019

Macrophages as regulators of tumour immunity and immunotherapy.

Nat Rev Immunol 2019 Jun;19(6):369-382

Department of Immunology, Department of Breast Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

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http://dx.doi.org/10.1038/s41577-019-0127-6DOI Listing
June 2019

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion.

Gut 2019 May 10. Epub 2019 May 10.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1136/gutjnl-2018-317424DOI Listing
May 2019

Better Together: B7S1 Checkpoint Blockade Synergizes with anti-PD1.

Immunity 2018 04;48(4):621-623

Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.03.029DOI Listing
April 2018

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy.

Cancer Immunol Immunother 2017 Aug 27;66(8):1037-1048. Epub 2017 Apr 27.

Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave., Box 8069, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00262-017-2003-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603233PMC
August 2017

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.

Immunity 2017 08;47(2):323-338.e6

Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; ICCE Institute, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578409PMC
August 2017

Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance in Pancreatic Ductal Adenocarcinoma.

Clin Cancer Res 2017 Apr 4;23(7):1748-1759. Epub 2016 Oct 4.

Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378683PMC
April 2017

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.

Cell Rep 2016 06 2;15(11):2510-23. Epub 2016 Jun 2.

ICCE Institute, Washington University, St. Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University, St. Louis, MO 63110, USA; Department of Medicine, Washington University, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909540PMC
June 2016

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.

J Exp Med 2016 05 4;213(5):827-40. Epub 2016 Apr 4.

Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110 Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1084/jem.20150950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854727PMC
May 2016

Regramming myeloid responses to improve cancer immunotherapy.

Oncoimmunology 2015 Jun 22;4(6):e974399. Epub 2015 May 22.

Department of Medicine; Washington University School of Medicine ; St. Louis, MO, USA ; Siteman Cancer Center; Washington University School of Medicine ; St. Louis, MO, USA ; ICCE Institute; Washington University School of Medicine ; St. Louis, MO, USA ; Department of Pathology and Immunology; Washington University School of Medicine ; St. Louis, MO, USA.

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http://www.tandfonline.com/doi/full/10.4161/2162402X.2014.97
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http://dx.doi.org/10.4161/2162402X.2014.974399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492504PMC
June 2015

TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy.

Cancer Immunol Res 2015 May 25;3(5):518-25. Epub 2015 Feb 25.

Department of Cell, Developmental and Cancer Biology and Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-14-0232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420686PMC
May 2015

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

Cancer Res 2014 Sep 31;74(18):5057-69. Epub 2014 Jul 31.

Department of Medicine, Washington University School of Medicine, St Louis, Missouri. BRIGHT Institute, Washington University School of Medicine, St Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182950PMC
September 2014

Targeting tumor-infiltrating macrophages to combat cancer.

Immunotherapy 2013 Oct;5(10):1075-87

Department of Surgery, Washington University School of Medicine, St Louis, MO 63132, USA.

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http://dx.doi.org/10.2217/imt.13.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867255PMC
October 2013

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity.

Cancer Metastasis Rev 2010 Jun;29(2):309-16

Department of Pathology, University of California, 513 Parnassus Ave., HSW-450C, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1007/s10555-010-9223-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865635PMC
June 2010

Lymphocytes in cancer development: polarization towards pro-tumor immunity.

Cytokine Growth Factor Rev 2010 Feb 11;21(1):3-10. Epub 2009 Dec 11.

Department of Pathology, University of California, San Francisco, CA 94143, United States.

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http://dx.doi.org/10.1016/j.cytogfr.2009.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834837PMC
February 2010

Inflaming gastrointestinal oncogenic programming.

Cancer Cell 2008 Jul;14(1):7-9

Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.06.010DOI Listing
July 2008

Polarized immune responses differentially regulate cancer development.

Immunol Rev 2008 Apr;222:145-54

Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00600.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494984PMC
April 2008

Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression.

Breast Cancer Res 2007 ;9(4):212

Department of Pathology, University of California, San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr1746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206719PMC
March 2008

Immune cells as mediators of solid tumor metastasis.

Cancer Metastasis Rev 2008 Mar;27(1):11-8

Department of Pathology, University of California, San Francisco, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.1007/s10555-007-9100-0DOI Listing
March 2008

Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth.

Mol Cell Endocrinol 2007 Oct 19;277(1-2):13-25. Epub 2007 Jul 19.

Department of Molecular and Cellular Biology, and Breast Center, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.mce.2007.07.006DOI Listing
October 2007

Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha.

Breast Cancer Res Treat 2006 Sep 16;99(2):121-34. Epub 2006 Mar 16.

Department of Medicine, Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://link.springer.com/10.1007/s10549-006-9191-2
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http://dx.doi.org/10.1007/s10549-006-9191-2DOI Listing
September 2006

Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes.

Mol Endocrinol 2005 Feb 28;19(2):362-78. Epub 2004 Oct 28.

Department of Medicine, Baylor Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1210/me.2004-0267DOI Listing
February 2005