David F Stern

David F Stern

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David F Stern

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Keeping Tumors Out of the MAPK Fitness Zone.

Authors:
David F Stern

Cancer Discov 2018 01;8(1):20-23

Department of Pathology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1243DOI Listing
January 2018

p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis.

J Invest Dermatol 2017 10 7;137(10):2187-2196. Epub 2017 Jun 7.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA; Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342201PMC
October 2017

GRAPE: a pathway template method to characterize tissue-specific functionality from gene expression profiles.

BMC Bioinformatics 2017 Jun 26;18(1):317. Epub 2017 Jun 26.

Department of Biostatistics, Yale University, 60 College Street, P.O. Box 208034, New Haven, 06520-8034, CT, USA.

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http://dx.doi.org/10.1186/s12859-017-1711-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485588PMC
June 2017

Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer.

Cancer Res 2017 01 21;77(2):566-578. Epub 2016 Nov 21.

Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582957PMC
January 2017

A Computational Approach for Identifying Synergistic Drug Combinations.

PLoS Comput Biol 2017 01 13;13(1):e1005308. Epub 2017 Jan 13.

Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234777PMC
January 2017

Transcriptional Profiles from Paired Normal Samples Offer Complementary Information on Cancer Patient Survival--Evidence from TCGA Pan-Cancer Data.

Sci Rep 2016 Feb 3;6:20567. Epub 2016 Feb 3.

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1038/srep20567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738355PMC
February 2016

PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.

Proc Natl Acad Sci U S A 2016 Jan 4;113(3):E282-90. Epub 2016 Jan 4.

Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1516138113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725473PMC
January 2016

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.

Sci Signal 2015 Nov 3;8(401):ra111. Epub 2015 Nov 3.

Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/scisignal.aac5124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666504PMC
November 2015

BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume.

Mol Cancer Ther 2015 Jul 6;14(7):1680-92. Epub 2015 May 6.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut. Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497841PMC
July 2015

Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration.

Sci Signal 2014 Dec 9;7(355):ra116. Epub 2014 Dec 9.

Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1126/scisignal.2005770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648367PMC
December 2014

Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells.

Mol Cancer Res 2014 Aug 14;12(8):1140-55. Epub 2014 May 14.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728083PMC
August 2014

Enhancing reproducibility in cancer drug screening: how do we move forward?

Cancer Res 2014 Aug 11;74(15):4016-23. Epub 2014 Jul 11.

Princess Margaret Cancer Centre, University Health Network; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119520PMC
August 2014

EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.

Cancer Res 2013 Aug 21;73(16):5053-65. Epub 2013 Jun 21.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745527PMC
August 2013

MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.

Pigment Cell Melanoma Res 2013 Jul 21;26(4):527-41. Epub 2013 May 21.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/pcmr.12110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918898PMC
July 2013

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.

Nucleic Acids Res 2012 May 10;40(9):3898-912. Epub 2012 Jan 10.

Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University, Beijing 100048, China.

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http://dx.doi.org/10.1093/nar/gkr1296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351156PMC
May 2012

NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53.

Mol Cancer Res 2011 Jun 6;9(6):766-81. Epub 2011 May 6.

Yale University, 333 Cedar Street, P.O. Box 208023, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901581PMC
June 2011

"Competence" progress.

Authors:
David F Stern

Mol Cell 2011 May;42(4):411-2

Department of Pathology and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117586PMC
May 2011

EGFs and ERBBs--brief history and prospects.

Authors:
David F Stern

Semin Cell Dev Biol 2010 Dec 21;21(9):917-21. Epub 2010 Oct 21.

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http://dx.doi.org/10.1016/j.semcdb.2010.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992880PMC
December 2010

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

Mol Cancer Res 2010 Oct 21;8(10):1388-98. Epub 2010 Sep 21.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901583PMC
October 2010

Centrosomal Chk2 in DNA damage responses and cell cycle progression.

Cell Cycle 2010 Jul;9(13):2647-56

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233491PMC
http://dx.doi.org/10.4161/cc.9.13.12121DOI Listing
July 2010

ErbB3 is required for ductal morphogenesis in the mouse mammary gland.

Breast Cancer Res 2008 18;10(6):R96. Epub 2008 Nov 18.

Department of Pathology, Yale School of Medicine, New Haven, CT 06520-8023, USA.

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http://dx.doi.org/10.1186/bcr2198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656891PMC
April 2009

BRCTing up is hard to do.

Authors:
David F Stern

Mol Cell 2009 Jan;33(2):137-8

Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.01.005DOI Listing
January 2009

NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.

Cell Cycle 2008 Nov 29;7(22):3584-94. Epub 2008 Nov 29.

Department of Pathology and Graduate Program in Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763172PMC
http://dx.doi.org/10.4161/cc.7.22.7102DOI Listing
November 2008

ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer.

Authors:
David F Stern

J Mammary Gland Biol Neoplasia 2008 Jun 3;13(2):215-23. Epub 2008 May 3.

Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT 06520-8023, USA.

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http://dx.doi.org/10.1007/s10911-008-9083-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590701PMC
June 2008

Regulation of the Rad53 protein kinase in signal amplification by oligomer assembly and disassembly.

Cell Cycle 2008 Mar 8;7(6):808-17. Epub 2008 Jan 8.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.4161/cc.7.6.5595DOI Listing
March 2008

Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1.

J Biol Chem 2006 Feb 19;281(7):3954-63. Epub 2005 Dec 19.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1074/jbc.M507508200DOI Listing
February 2006

In situ detection of specific DNA double strand breaks using rolling circle amplification.

Cell Cycle 2005 Dec 27;4(12):1767-73. Epub 2005 Dec 27.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.4161/cc.4.12.2211DOI Listing
December 2005

DNA damage regulates Chk2 association with chromatin.

J Biol Chem 2005 Nov 8;280(45):37948-56. Epub 2005 Sep 8.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1074/jbc.M509299200DOI Listing
November 2005

Neuregulin-regulated gene expression in mammary carcinoma cells.

Exp Cell Res 2005 Sep;309(1):12-23

Department of Pathology, Yale University School of Medicine, BML-342, 310 Cedar Street, P.O. Box 208023, New Haven, CT 06520-8023, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270500227
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http://dx.doi.org/10.1016/j.yexcr.2005.04.034DOI Listing
September 2005

Phosphoproteomics for oncology discovery and treatment.

Authors:
David F Stern

Expert Opin Ther Targets 2005 Aug;9(4):851-60

Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA.

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http://dx.doi.org/10.1517/14728222.9.4.851 DOI Listing
August 2005

The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2.

Cell Cycle 2005 Apr 9;4(4):609-17. Epub 2005 Apr 9.

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA.

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April 2005

Interaction of chromatin-associated Plk1 and Mcm7.

J Biol Chem 2005 Mar 15;280(12):11943-7. Epub 2005 Jan 15.

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1074/jbc.M413514200DOI Listing
March 2005

Regulation of CHK2 by DNA-dependent protein kinase.

J Biol Chem 2005 Mar 24;280(12):12041-50. Epub 2005 Jan 24.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1074/jbc.M412445200DOI Listing
March 2005

Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients.

J Clin Oncol 2005 Feb;23(6):1152-60

Department of Internal Medicine, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1200/JCO.2005.09.055DOI Listing
February 2005

Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Cell Cycle 2005 Jan 5;4(1):166-71. Epub 2005 Jan 5.

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.4161/cc.4.1.1348DOI Listing
January 2005

A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation.

Mol Biol Cell 2004 Dec 29;15(12):5443-55. Epub 2004 Sep 29.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1091/mbc.e04-07-0608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC532024PMC
December 2004

ErbB2 is required for ductal morphogenesis of the mammary gland.

Proc Natl Acad Sci U S A 2004 Dec 29;101(49):17138-43. Epub 2004 Nov 29.

Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.

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http://dx.doi.org/10.1073/pnas.0407057101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535384PMC
December 2004

More than a marker... Phosphorylated Akt in prostate carcinoma.

Authors:
David F Stern

Clin Cancer Res 2004 Oct;10(19):6407-10

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1783DOI Listing
October 2004

Establishment of a cell-free system to study the activation of Chk2.

Methods Mol Biol 2004 ;280:165-74

Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1385/1-59259-788-2:165DOI Listing
September 2004

Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.

J Biol Chem 2004 Aug 25;279(33):34091-4. Epub 2004 Jun 25.

Department of Pathology, School of Medicine, Yale University, 310 Cedar Street, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1074/jbc.C400139200DOI Listing
August 2004

FHA domain-mediated DNA checkpoint regulation of Rad53.

Cell Cycle 2003 Jul-Aug;2(4):384-96

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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May 2004

Gene expression profiling of ErbB receptor and ligand-dependent transcription.

Oncogene 2004 Feb;23(7):1428-38

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1038/sj.onc.1207257DOI Listing
February 2004

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.

FASEB J 2003 Oct;17(13):1842-8

Department of Pathology, School of Medicine, Yale University, 310 Cedar St., BML342, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1096/fj.03-0310comDOI Listing
October 2003

Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling.

Mol Cell Biol 2003 Sep;23(17):6300-14

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC180918PMC
http://dx.doi.org/10.1128/mcb.23.17.6300-6314.2003DOI Listing
September 2003

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality.

Proc Natl Acad Sci U S A 2003 Jul 24;100(14):8281-6. Epub 2003 Jun 24.

Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1436402100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166220PMC
July 2003

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.

J Biol Chem 2003 Mar 18;278(10):8468-75. Epub 2002 Dec 18.

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06511, USA.

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http://www.jbc.org/content/278/10/8468.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M211202200
Publisher Site
http://dx.doi.org/10.1074/jbc.M211202200DOI Listing
March 2003

NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.

J Biol Chem 2003 Mar 23;278(10):8795-803. Epub 2002 Dec 23.

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1074/jbc.M211392200DOI Listing
March 2003

ErbBs in mammary development.

Authors:
David F Stern

Exp Cell Res 2003 Mar;284(1):89-98

Department of Pathology, Yale University School of Medicine, CT, New Haven 06520, USA.

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http://dx.doi.org/10.1016/s0014-4827(02)00103-9DOI Listing
March 2003

Active signaling by HER-2/neu in a subpopulation of HER-2/neu-overexpressing ductal carcinoma in situ: clinicopathological correlates.

Cancer Res 2002 Nov;62(22):6667-73

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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November 2002

Production of antibodies that recognize specific tyrosine-phosphorylated peptides.

Curr Protoc Immunol 2002 Nov;Chapter 11:Unit 11.6

Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1002/0471142735.im0101s50DOI Listing
November 2002

Chk2 activation and phosphorylation-dependent oligomerization.

Mol Cell Biol 2002 Jun;22(12):4419-32

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133858PMC
http://dx.doi.org/10.1128/mcb.22.12.4419-4432.2002DOI Listing
June 2002

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint.

Mol Cell 2002 May;9(5):1055-65

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00532-4DOI Listing
May 2002

Production of antibodies that recognize specific tyrosine-phosphorylated peptides.

Curr Protoc Cell Biol 2002 Feb;Chapter 16:Unit 16.6

Yale University School of Medicine, New Haven, Connecticut, USA.

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http://doi.wiley.com/10.1002/0471143030.cb1606s13
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http://dx.doi.org/10.1002/0471143030.cb1606s13DOI Listing
February 2002