David F Dinges

David F Dinges

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David F Dinges

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Tracking intermediate performance of vigilant attention using multiple eye metrics.

Sleep 2020 Feb 10. Epub 2020 Feb 10.

Astronaut and Operation Control Unit, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1093/sleep/zsz219DOI Listing
February 2020

Brain Changes in Response to Long Antarctic Expeditions.

N Engl J Med 2019 12;381(23):2273-2275

Max Planck Institute for Human Development, Berlin, Germany.

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http://dx.doi.org/10.1056/NEJMc1904905DOI Listing
December 2019

Electrocortical Evidence for Impaired Affective Picture Processing after Long-Term Immobilization.

Sci Rep 2019 Nov 12;9(1):16610. Epub 2019 Nov 12.

Charité - Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Physiology, Charitéplatz 1, CharitéCrossOver, Virchowweg 6, 10117, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-019-52555-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851182PMC
November 2019

Sleep and Work in ICU Physicians During a Randomized Trial of Nighttime Intensivist Staffing.

Crit Care Med 2019 Jul;47(7):894-902

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/CCM.0000000000003773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579612PMC
July 2019

Test-retest reliability of cerebral blood flow for assessing brain function at rest and during a vigilance task.

Neuroimage 2019 06 17;193:157-166. Epub 2019 Mar 17.

Laboratory of Applied Brain and Cognitive Sciences, Shanghai International Studies University, Shanghai, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193018
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http://dx.doi.org/10.1016/j.neuroimage.2019.03.016DOI Listing
June 2019

Data and methods for studying commercial motor vehicle driver fatigue, highway safety and long-term driver health.

Accid Anal Prev 2019 May 9;126:37-42. Epub 2018 Mar 9.

Department of Work Environment, School of Health and Environment, University of Massachusetts, Lowell, MA 01854, United States. Electronic address:

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http://dx.doi.org/10.1016/j.aap.2018.02.021DOI Listing
May 2019

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Science 2019 04;364(6436)

Northwestern University, Evanston, IL, USA.

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http://dx.doi.org/10.1126/science.aau8650DOI Listing
April 2019

Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules.

N Engl J Med 2019 03;380(10):905-914

From the Center for Outcomes Research, Children's Hospital of Philadelphia (J.H.S., O.E.-S., A.S.H., L.L.H., R.N.R.), the Departments of Pediatrics (J.H.S.), Anesthesiology and Critical Care (J.H.S.), and Medicine (L.M.B., J.A.S., K.G.V., D.A.A.), University of Pennsylvania School of Medicine, the Departments of Health Care Management (J.H.S., K.G.V., D.A.A.) and Statistics (D.S.S.), the Wharton School, the Leonard Davis Institute of Health Economics (J.H.S., J.A.S., D.S.S., K.G.V., D.A.A.), and the Department of Psychiatry (D.F.D., M.B.), University of Pennsylvania, and the Corporal Michael J. Crescenz Veterans Affairs Medical Center (K.G.V., D.A.A.) - all in Philadelphia; the Departments of Medicine (S.V.D.), Epidemiology (D.M.S., A.L.S., J.T.), and Biostatistics (J.T.), Johns Hopkins University, Baltimore; and the Department of Medicine, Brigham and Women's Hospital, Boston (J.T.K.).

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http://www.nejm.org/doi/10.1056/NEJMoa1810642
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http://dx.doi.org/10.1056/NEJMoa1810642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476299PMC
March 2019

Sleep and Alertness in a Duty-Hour Flexibility Trial in Internal Medicine.

N Engl J Med 2019 03;380(10):915-923

From the University of Pennsylvania (M.B., D.A.A., J.A.S., L.M.B., M.C., A.J.E., S.K.M., D.S.S., K.G.V., D.F.D.), Corporal Michael J. Crescenz Veterans Affairs Medical Center (D.A.A., K.G.V.), Children's Hospital of Philadelphia (O.E.-S., J.H.S.), and Pulsar Informatics (C.G.M., S.C., D.J.M.) - all in Philadelphia; Johns Hopkins University, Baltimore (S.V.D., A.L.S., J.T., D.M.S.); and Brigham and Women's Hospital, Boston (J.T.K., D.W.B.).

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http://dx.doi.org/10.1056/NEJMoa1810641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457111PMC
March 2019

Sleep deprivation enhances inter-stimulus interval effect on vigilant attention performance.

Sleep 2018 12;41(12)

Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1093/sleep/zsy189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289239PMC
December 2018

Interindividual variability in neurobehavioral response to sleep loss: A comprehensive review.

Neurosci Biobehav Rev 2018 06 18;89:29-48. Epub 2018 Mar 18.

Department of Psychiatry, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2018.03.017DOI Listing
June 2018

Response to Letters to the Editor by Dr. Glozier and Grunstein and by Drs. Hertenstein, Riemann, and Nissen in response to our article "Sleep duration in the United States 2003-2016: first signs of success in the fight against sleep deficiency?"

Sleep 2018 05;41(5)

Department of Psychiatry, Unit of Experimental Psychiatry, Division of Sleep and Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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https://academic.oup.com/sleep/article/doi/10.1093/sleep/zsy
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http://dx.doi.org/10.1093/sleep/zsy074DOI Listing
May 2018

Sleep duration in the United States 2003-2016: first signs of success in the fight against sleep deficiency?

Sleep 2018 04;41(4)

Department of Psychiatry, Unit of Experimental Psychiatry, Division of Sleep and Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1093/sleep/zsy012DOI Listing
April 2018

Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine.

N Engl J Med 2018 Apr 20;378(16):1494-1508. Epub 2018 Mar 20.

From the Departments of Medicine (S.V.D.), Epidemiology (A.L.S., J.T., D.M.S.), and Biostatistics (J.T.), Johns Hopkins University, Baltimore; the Departments of Medicine (D.A.A., L.M.B., K.H.C., M.L., A.M.Y., J.M.A., J.A.S.), Psychiatry (M.B., D.F.D.), and Medical Ethics and Policy (K.G.V.) and the Department of Statistics, the Wharton School (D.S.S.), University of Pennsylvania, the Corporal Michael J. Crescenz Veterans Affairs Medical Center (D.A.A., K.H.C., K.G.V.), and the Department of Pediatrics, Children's Hospital of Philadelphia (O.E.-S., J.H.S.) - all in Philadelphia; the Department of Medicine, Brigham and Women's Hospital, Boston (J.T.K., D.W.B.); and the Department of Surgery and Center for Healthcare Studies, Northwestern University, Chicago (K.Y.B.).

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http://www.nejm.org/doi/10.1056/NEJMoa1800965
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http://dx.doi.org/10.1056/NEJMoa1800965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101652PMC
April 2018

Effects of -12° head-down tilt with and without elevated levels of CO on cognitive performance: the SPACECOT study.

J Appl Physiol (1985) 2018 03 14;124(3):750-760. Epub 2017 Dec 14.

Department of Neurology and Center for Space Medicine, Baylor College of Medicine , Houston, Texas.

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http://dx.doi.org/10.1152/japplphysiol.00855.2017DOI Listing
March 2018

Determinants of sleepiness in obstructive sleep apnea.

Sleep 2018 Feb;41(2)

Center for Narcolepsy, Sleep and Health Research, College of Nursing, University of Illinois at Chicago, Chicago, IL.

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http://dx.doi.org/10.1093/sleep/zsx199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018835PMC
February 2018

Repeated Administration Effects on Psychomotor Vigilance Test Performance.

Sleep 2018 01;41(1)

Department of Psychiatry, Unit of Experimental Psychiatry, Division of Sleep and Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1093/sleep/zsx187DOI Listing
January 2018

Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation.

J Clin Psychiatry 2017 Sep/Oct;78(8):e1020-e1034

Department of Psychiatry, University of Pennsylvania, 3535 Market St, Ste 670, Philadelphia, PA 19104.

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http://www.psychiatrist.com/JCP/article/Pages/2017/v78n08/16
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http://dx.doi.org/10.4088/JCP.16r11332DOI Listing
November 2017

Sleep and Alertness in Medical Interns and Residents: An Observational Study on the Role of Extended Shifts.

Sleep 2017 04;40(4)

Center for Health Equity Research and Promotion, Philadelphia Corporal Michael J. Cresencz Veterans Affairs Medical Center, Philadelphia, PA.

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http://dx.doi.org/10.1093/sleep/zsx027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806581PMC
April 2017

Human and rat gut microbiome composition is maintained following sleep restriction.

Proc Natl Acad Sci U S A 2017 02 8;114(8):E1564-E1571. Epub 2017 Feb 8.

Chronobiology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1620673114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338418PMC
February 2017

Objective Measurements of Energy Balance Are Associated With Sleep Architecture in Healthy Adults.

Sleep 2017 Jan;40(1)

Unit for Experimental Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1093/sleep/zsw018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084752PMC
January 2017

Response to: "Can Racial Differences in Resting Metabolic Rate be Explained by Body Composition?".

Obesity (Silver Spring) 2016 06 4;24(6):1204. Epub 2016 May 4.

Department of Psychiatry, Division of Sleep and Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/oby.21525DOI Listing
June 2016

Human and rat gut microbiome composition is maintained following sleep restriction.

Proc Natl Acad Sci U S A 2017 02 8;114(8):E1564-E1571. Epub 2017 Feb 8.

Chronobiology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1620673114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338418PMC
February 2017

Determinants of Behavioral Alertness in Adults with Heart Failure.

J Clin Sleep Med 2016 Apr 15;12(4):589-96. Epub 2016 Apr 15.

University of Pennsylvania, School of Nursing, Philadelphia, PA.

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http://dx.doi.org/10.5664/jcsm.5698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795287PMC
April 2016

A new likelihood ratio metric for the psychomotor vigilance test and its sensitivity to sleep loss.

J Sleep Res 2015 Dec 29;24(6):702-13. Epub 2015 Jun 29.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/jsr.12322DOI Listing
December 2015

Resting metabolic rate varies by race and by sleep duration.

Obesity (Silver Spring) 2015 Dec 5;23(12):2349-56. Epub 2015 Nov 5.

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/oby.21198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701627PMC
December 2015

Phenotyping of neurobehavioral vulnerability to circadian phase during sleep loss.

Methods Enzymol 2015 26;552:285-308. Epub 2014 Dec 26.

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/bs.mie.2014.10.024DOI Listing
November 2015

Development and Validation of the Cognition Test Battery for Spaceflight.

Aerosp Med Hum Perform 2015 Nov;86(11):942-52

Division of Sleep and Chronobiology, Department of Psychiatry, and the Behavior Laboratory, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3357/AMHP.4343.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691281PMC
November 2015

Agreement between 24-hour salt ingestion and sodium excretion in a controlled environment.

Hypertension 2015 Oct 10;66(4):850-7. Epub 2015 Aug 10.

From the Interdisciplinary Center for Clinical Research (K.L., N.R., U.G., J.T.), Department of Nephrology and Hypertension (A.D., K.-U.E., J.T.), and Department of Pediatrics (M.R.), Friedrich-Alexander-University, Erlangen-Nürnberg, Germany; Experimental and Clinical Research Center, an institutional cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (N.R., F.C.L.); Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia (M.B., D.F.D.); Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (L.B., B.J.); State Scientific Center of Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia (A.A., I.L., V.B., B.M., G.V.); Fresenius Medical Care-D GmbH, Bad Homburg, Germany (P.W., J.V.); Center for Space Medicine, Institute of Physiology, Charité - University Clinic Berlin, Berlin, Germany (K.K.); Department of Biostatistics, Coordination Center for Clinical Trials, Charité University Medicine Berlin, Berlin, Germany (A.K.); and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (F.C.L., J.T.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567387PMC
October 2015

Phenotypic vulnerability of energy balance responses to sleep loss in healthy adults.

Sci Rep 2015 Oct 8;5:14920. Epub 2015 Oct 8.

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1038/srep14920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597338PMC
October 2015

Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to mars.

PLoS One 2014 27;9(3):e93298. Epub 2014 Mar 27.

National Space Biomedical Research Institute, Houston, Texas, United States of America; Center for Space Medicine and Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093298PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968121PMC
May 2015

How acute total sleep loss affects the attending brain: a meta-analysis of neuroimaging studies.

Sleep 2015 Feb 1;38(2):233-40. Epub 2015 Feb 1.

Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.5665/sleep.4404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288604PMC
February 2015

Altered salience network connectivity predicts macronutrient intake after sleep deprivation.

Sci Rep 2015 Feb 3;5:8215. Epub 2015 Feb 3.

1] Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA [2] Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1038/srep08215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314629PMC
February 2015

Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.

Proc Natl Acad Sci U S A 2015 Feb 9;112(8):2569-74. Epub 2015 Feb 9.

Program in Chronobiology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104; and

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http://dx.doi.org/10.1073/pnas.1417432112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345602PMC
February 2015

Sociodemographic characteristics and waking activities and their role in the timing and duration of sleep.

Sleep 2014 Dec 1;37(12):1889-906. Epub 2014 Dec 1.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.5665/sleep.4238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548514PMC
December 2014

Effects of sex and gender on adaptation to space: behavioral health.

J Womens Health (Larchmt) 2014 Nov 26;23(11):975-86. Epub 2014 Sep 26.

1 Department of Psychiatry, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/jwh.2014.4911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235984PMC
November 2014

Cognitive workload and sleep restriction interact to influence sleep homeostatic responses.

Sleep 2014 Nov 1;37(11):1745-56. Epub 2014 Nov 1.

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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https://academic.oup.com/sleep/article/37/11/1745/2416724
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http://dx.doi.org/10.5665/sleep.4164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196058PMC
November 2014

Cumulative neurobehavioral and physiological effects of chronic caffeine intake: individual differences and implications for the use of caffeinated energy products.

Nutr Rev 2014 Oct;72 Suppl 1:34-47

Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/nure.12151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404626PMC
October 2014

Lost in space: sleep.

Lancet Neurol 2014 Sep 7;13(9):860-2. Epub 2014 Aug 7.

Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104-6021, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70176-0DOI Listing
September 2014

Sex and race differences in caloric intake during sleep restriction in healthy adults.

Am J Clin Nutr 2014 Aug 25;100(2):559-66. Epub 2014 Jun 25.

From the Department of Psychology, School of Arts and Sciences (AMS) and the Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine (DFD and NG), University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.3945/ajcn.114.086579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095659PMC
August 2014

A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans.

Sleep 2014 Aug 1;37(8):1327-36. Epub 2014 Aug 1.

Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA ; Division of Sleep Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.5665/sleep.3924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096202PMC
August 2014

Sleepiness and Safety: Where Biology Needs Technology.

Sleep Biol Rhythms 2014 Apr;12(2):74-84

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1111/sbr.12067
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http://dx.doi.org/10.1111/sbr.12067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061704PMC
April 2014

A randomized trial of a three-hour protected nap period in a medicine training program: sleep, alertness, and patient outcomes.

Acad Med 2014 Mar;89(3):452-9

Dr. Shea is professor of medicine-clinician educator and associate dean of medical education research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Dr. Dinges is professor of psychology in psychiatry and chief of the division of sleep and chronobiology, department of psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Dr. Small is associate professor, department of statistics, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania. Dr. Basner is assistant professor of sleep and chronobiology in psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Mr. Zhu is assistant director of data analytics, LDI Center for Health Incentives and Behavioral Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Ms. Norton is research project manager, CHERP, Philadelphia VA Medical Center, and CHIBE, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Mr. Ecker is a senior information technology project leader, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Ms. Novak was research coordinator, CHERP, Philadelphia VA Medical Center, and CHIBE, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, at the time this study was conducted. Currently she is a second-year medical student, Temple University School of Medicine, Philadelphia, Pennsylvania. Dr. Bellini is professor of medicine, and vice chair for education, department of medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Dr. Dine is assistant professor of medicine, division of pulmonary and critical care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Dr. Mollicone is president and CEO of Pulsar Informatics, Inc., Philadelphia, Pennsylvania. Dr. Volpp is staff ph

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http://pdfs.journals.lww.com/academicmedicine/2014/03000/A_R
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/ACM.0000000000000144DOI Listing
March 2014

Circadian rhythms, sleep deprivation, and human performance.

Prog Mol Biol Transl Sci 2013 ;119:155-90

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/B978-0-12-396971-2.00007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963479PMC
February 2014

The growth of sleep science and the role of SLEEP.

Authors:
David F Dinges

Sleep 2014 Jan 1;37(1):7-8. Epub 2014 Jan 1.

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http://dx.doi.org/10.5665/sleep.3296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902868PMC
January 2014

Dynamic circadian modulation in a biomathematical model for the effects of sleep and sleep loss on waking neurobehavioral performance.

Sleep 2013 Dec 1;36(12):1987-97. Epub 2013 Dec 1.

Sleep and Performance Research Center, Washington State University, Spokane, WA ; Department of Mathematical Sciences, University of Montana, Missoula, MT.

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https://academic.oup.com/sleep/article/36/12/1987/2709425
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http://dx.doi.org/10.5665/sleep.3246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825450PMC
December 2013

Sleep deprivation and neurobehavioral dynamics.

Curr Opin Neurobiol 2013 Oct 20;23(5):854-63. Epub 2013 Mar 20.

Unit of Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2013.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700596PMC
October 2013

Effects of Experimental Sleep Restriction on Weight Gain, Caloric Intake, and Meal Timing in Healthy Adults.

Sleep 2013 Jul 1;36(7):981-990. Epub 2013 Jul 1.

Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.5665/sleep.2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669080PMC
July 2013

Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing.

Proc Natl Acad Sci U S A 2013 Feb 7;110(7):2635-40. Epub 2013 Jan 7.

Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1212646110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574912PMC
February 2013

Managing neurobehavioral capability when social expediency trumps biological imperatives.

Prog Brain Res 2012 ;199:377-398

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-59427-3.00021-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600847PMC
January 2013

Predicting Risk in Space: Genetic Markers for Differential Vulnerability to Sleep Restriction.

Acta Astronaut 2012 Aug;77:207-213

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1016/j.actaastro.2012.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602842PMC
August 2012

Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.

PLoS One 2011 27;6(12):e29283. Epub 2011 Dec 27.

Division of Sleep and Chronobiology, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029283PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246458PMC
May 2012

Systematic individual differences in sleep homeostatic and circadian rhythm contributions to neurobehavioral impairment during sleep deprivation.

Accid Anal Prev 2012 Mar 23;45 Suppl:11-6. Epub 2011 Nov 23.

Sleep and Performance Research Center, Washington State University Spokane, PO Box 1495, Spokane, WA 99210-1495, USA.

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http://dx.doi.org/10.1016/j.aap.2011.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260461PMC
March 2012

An adaptive-duration version of the PVT accurately tracks changes in psychomotor vigilance induced by sleep restriction.

Sleep 2012 Feb 1;35(2):193-202. Epub 2012 Feb 1.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6021, USA.

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http://dx.doi.org/10.5665/sleep.1620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250358PMC
February 2012

Validity and Sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to Total and Partial Sleep Deprivation.

Acta Astronaut 2011 Dec;69(11-12):949-959

Unit of Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.actaastro.2011.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197786PMC
December 2011

Behavioral and genetic markers of sleepiness.

J Clin Sleep Med 2011 Oct;7(5 Suppl):S19-21

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6021, USA.

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http://dx.doi.org/10.5664/JCSM.1348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190416PMC
October 2011

Case-control study of subjective and objective differences in sleep patterns in older adults with insomnia symptoms.

J Sleep Res 2011 Sep 30;20(3):434-44. Epub 2010 Sep 30.

Division of Geriatric Medicine and Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania, 3615 Chestnut Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1365-2869.2010.00889.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638716PMC
September 2011

Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss.

Sleep 2011 May 1;34(5):581-91. Epub 2011 May 1.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079937PMC
http://dx.doi.org/10.1093/sleep/34.5.581DOI Listing
May 2011

Sleep disordered breathing with excessive daytime sleepiness is a risk factor for mortality in older adults.

Sleep 2011 Apr 1;34(4):435-42. Epub 2011 Apr 1.

Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065253PMC
http://dx.doi.org/10.1093/sleep/34.4.435DOI Listing
April 2011

The challenges and opportunities of technological approaches to fatigue management.

Accid Anal Prev 2011 Mar;43(2):565-72

Walter Reed Army Institute of Research, Dept of Behavioral Biology, Silver Spring, MD 20910, USA.

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http://dx.doi.org/10.1016/j.aap.2009.12.006DOI Listing
March 2011

Effects of sleep restriction on adiponectin levels in healthy men and women.

Physiol Behav 2010 Dec 17;101(5):693-8. Epub 2010 Aug 17.

Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave/DA-779, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.physbeh.2010.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975754PMC
December 2010

DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue.

Neurology 2010 Oct;75(17):1509-19

Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine, 1013 Blockley Hall, Philadelphia, PA 19104-6021, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3181f9615dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974463PMC
October 2010

Time of day effects on neurobehavioral performance during chronic sleep restriction.

Aviat Space Environ Med 2010 Aug;81(8):735-44

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA.

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http://dx.doi.org/10.3357/asem.2756.2010DOI Listing
August 2010

Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery.

Sleep 2010 Aug;33(8):1013-26

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910531PMC
http://dx.doi.org/10.1093/sleep/33.8.1013DOI Listing
August 2010

Sleep restriction is associated with increased morning plasma leptin concentrations, especially in women.

Biol Res Nurs 2010 Jul 7;12(1):47-53. Epub 2010 May 7.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1177/1099800410366301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564645PMC
July 2010

Extreme cognitive interviewing: a blueprint for false memories through imagination inflation.

Int J Clin Exp Hypn 2010 Jul;58(3):269-87

Department of Psychology, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1080/00207141003760587DOI Listing
July 2010

A meta-analysis of the impact of short-term sleep deprivation on cognitive variables.

Psychol Bull 2010 May;136(3):375-89

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1037/a0018883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290659PMC
May 2010

Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect.

Neuroimage 2010 Feb 24;49(4):3426-35. Epub 2009 Nov 24.

Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2009.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830749PMC
February 2010

Sleep deprivation impairs object-selective attention: a view from the ventral visual cortex.

PLoS One 2010 Feb 5;5(2):e9087. Epub 2010 Feb 5.

Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009087PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816724PMC
February 2010

Behavioral persistence in carrying out a posthypnotic suggestion beyond the hypnotic context: a consideration of the role of perceived demand characteristics.

Int J Clin Exp Hypn 2010 Jan;58(1):1-20

Private practice, and Unit for Experimental Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA.

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http://dx.doi.org/10.1080/00207140903316201DOI Listing
January 2010

Neurocognitive consequences of sleep deprivation.

Semin Neurol 2009 Sep 9;29(4):320-39. Epub 2009 Sep 9.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA.

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http://dx.doi.org/10.1055/s-0029-1237117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564638PMC
September 2009

Sleep deprivation and sustained attention performance: integrating mathematical and cognitive modeling.

Cogn Sci 2009 Jul 8;33(5):880-910. Epub 2009 Apr 8.

Air Force Research Laboratory, Mesa The Pennsylvania State University, University Park University of Pennsylvania School of Medicine, Philadelphia.

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http://dx.doi.org/10.1111/j.1551-6709.2009.01032.xDOI Listing
July 2009

PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.

PLoS One 2009 Jun 11;4(6):e5874. Epub 2009 Jun 11.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005874PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689932PMC
June 2009

Dubious bargain: trading sleep for Leno and Letterman.

Sleep 2009 Jun;32(6):747-52

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690561PMC
http://dx.doi.org/10.1093/sleep/32.6.747DOI Listing
June 2009

Confinement and sleep deprivation effects on propensity to take risks.

Aviat Space Environ Med 2009 Feb;80(2):73-80

Department of Psychology, University of Bordeaux, Bordeaux, France.

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http://dx.doi.org/10.3357/asem.2366.2009DOI Listing
February 2009

Interaction of chronic sleep restriction and circadian system in humans.

J Sleep Res 2008 Dec;17(4):406-11

Brain & Mind Research Institute, University of Sydney and Central Clinical School-Medicine, University of Sydney, Camperdown, NSW, Australia.

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http://doi.wiley.com/10.1111/j.1365-2869.2008.00681.x
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http://dx.doi.org/10.1111/j.1365-2869.2008.00681.xDOI Listing
December 2008

Effects of night work, sleep loss and time on task on simulated threat detection performance.

Sleep 2008 Sep;31(9):1251-9

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542965PMC
September 2008

Sleep deprivation and vigilant attention.

Ann N Y Acad Sci 2008 ;1129:305-22

Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1196/annals.1417.002DOI Listing
July 2008

Lapsing during sleep deprivation is associated with distributed changes in brain activation.

J Neurosci 2008 May;28(21):5519-28

Cognitive Neuroscience Laboratory, Duke-National University of Singapore Graduate Medical School, Singapore.

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http://dx.doi.org/10.1523/JNEUROSCI.0733-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670628PMC
May 2008

Response Surface Mapping of Neurobehavioral Performance: Testing the Feasibility of Split Sleep Schedules for Space Operations.

Acta Astronaut 2008 ;63(7-10):833-840

Division of Sleep and Chronobiology, Department of Psychiatry, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009457650700312
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http://dx.doi.org/10.1016/j.actaastro.2007.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633932PMC
January 2008

The relationship between nurse work schedules, sleep duration, and drowsy driving.

Sleep 2007 Dec;30(12):1801-7

Kirkhof College of Nursing, Grand Valley State University, 312 Cook-Devos Center for Health Sciences, 301 Michigan Avenue NE, Grand Rapids, MI 49503, USA.

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https://pdfs.semanticscholar.org/93b7/6f4b97174be8b91f37e296
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276124PMC
http://dx.doi.org/10.1093/sleep/30.12.1801DOI Listing
December 2007