David E Kleiner

David E Kleiner

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David E Kleiner

David E Kleiner

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Expanding the phenotype of COPA syndrome: a kindred with typical and atypical features.

J Med Genet 2019 Nov 1;56(11):778-782. Epub 2018 Nov 1.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105560
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http://dx.doi.org/10.1136/jmedgenet-2018-105560DOI Listing
November 2019

Vibration-Controlled Transient Elastography for the Detection of Cirrhosis in Chronic Hepatitis D Infection.

J Viral Hepat 2019 Nov 19. Epub 2019 Nov 19.

Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jvh.13235DOI Listing
November 2019

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer.

Cancer Cell 2019 Oct 3;36(4):418-430.e6. Epub 2019 Oct 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Liver Cancer Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801104PMC
October 2019

Complete Pathological Response to Crizotinib in a Patient with ALK-rearranged Lung Adenocarcinoma.

Clin Lung Cancer 2019 Oct 13. Epub 2019 Oct 13.

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1016/j.cllc.2019.10.002DOI Listing
October 2019

Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C.

Dig Dis Sci 2019 Aug 12. Epub 2019 Aug 12.

Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Dr. MSC 1800, Bethesda, MD, 20892-1800, USA.

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http://dx.doi.org/10.1007/s10620-019-05760-xDOI Listing
August 2019

Rely to HEP-19-1327.

Hepatology 2019 Aug 21. Epub 2019 Aug 21.

National Cancer Institute.

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http://dx.doi.org/10.1002/hep.30901DOI Listing
August 2019

Portal Pressure in Noncirrhotic Portal Hypertension: To Measure or Not to Measure.

Hepatology 2019 Jul 18. Epub 2019 Jul 18.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.30862DOI Listing
July 2019

Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection.

Open Forum Infect Dis 2019 Jul;6(7)

Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1093/ofid/ofz255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667717PMC
July 2019

The Spectrum of Hepatic Involvement in Patients With Telomere Disease.

Hepatology 2019 Jun 10;69(6):2579-2585. Epub 2019 Apr 10.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.30578DOI Listing
June 2019

Hepatic Manifestations of Cystic Fibrosis.

Clin Liver Dis 2019 05 21;23(2):263-277. Epub 2019 Feb 21.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9B-16, MSC 1800, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cld.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452885PMC
May 2019

The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma.

Cancer Immunol Immunother 2019 Apr 28;68(4):599-608. Epub 2019 Jan 28.

Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00262-019-02299-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662600PMC
April 2019

The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection.

J Gastroenterol Hepatol 2019 Apr 25;34(4):764-775. Epub 2019 Feb 25.

Liver Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jgh.14617DOI Listing
April 2019

Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B.

Viruses 2019 04 25;11(4). Epub 2019 Apr 25.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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https://www.mdpi.com/1999-4915/11/4/386
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http://dx.doi.org/10.3390/v11040386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520809PMC
April 2019

Molecular Signature and Mechanisms of Hepatitis D Virus-Associated Hepatocellular Carcinoma.

Mol Cancer Res 2018 09 1;16(9):1406-1419. Epub 2018 Jun 1.

Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0012DOI Listing
September 2018

Hepatocellular carcinoma: Liver biopsy in the balance.

Authors:
David E Kleiner

Hepatology 2018 07;68(1):13-15

Laboratory of Pathology, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.29831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033634PMC
July 2018

Recent Advances in the Histopathology of Drug-Induced Liver Injury.

Authors:
David E Kleiner

Surg Pathol Clin 2018 Jun;11(2):297-311

Laboratory of Pathology, National Cancer Institute, 10 Center Drive, Building 10, Room 2S235, MSC1500, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953206PMC
June 2018

Histopathology, grading and staging of nonalcoholic fatty liver disease.

Authors:
David E Kleiner

Minerva Gastroenterol Dietol 2018 Mar 25;64(1):28-38. Epub 2017 Sep 25.

Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA -

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http://dx.doi.org/10.23736/S1121-421X.17.02445-XDOI Listing
March 2018

Histopathological challenges in suspected drug-induced liver injury.

Authors:
David E Kleiner

Liver Int 2018 02 19;38(2):198-209. Epub 2017 Sep 19.

Post-Mortem Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/liv.13584DOI Listing
February 2018

Mounier-Kuhn Syndrome Mimicking Lymphangioleiomyomatosis.

Chest 2018 02;153(2):e19-e23

Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692173297
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http://dx.doi.org/10.1016/j.chest.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026286PMC
February 2018

Identification and Characterization of Fenofibrate-Induced Liver Injury.

Dig Dis Sci 2017 12 8;62(12):3596-3604. Epub 2017 Nov 8.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s10620-017-4812-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694705PMC
December 2017

Nonalcoholic fatty liver disease in spinal and bulbar muscular atrophy.

Neurology 2017 Dec 15;89(24):2481-2490. Epub 2017 Nov 15.

From the Neurogenetics Branch (R.D.G., A.K., D.A.F., I.K., D.B., K.H.F., C.G.), National Institute of Neurological Disorders and Stroke; Liver Diseases Branch (V.T., H.A., Y.R.), National Institute of Diabetes and Digestive and Kidney Diseases; Cardiovascular and Pulmonary Branch (A.T.R.), National Heart Lung & Blood Institute; Laboratory of Pathology (S.M.H., D.E.K.), National Cancer Institute; Radiology and Imaging Sciences (C.-Y.L.), Clinical Center, National Institute of Allergy and Infectious Diseases; and NIH (C.H.), Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000004748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729799PMC
December 2017

Three variants in the nicotinamide adenine dinucleotide phosphate oxidase complex are associated with HCV-related liver damage.

Hepatol Commun 2017 11 23;1(9):973-982. Epub 2017 Oct 23.

Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda MD.

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http://dx.doi.org/10.1002/hep4.1103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721460PMC
November 2017

Challenges in the hepatic histopathology in non-alcoholic fatty liver disease.

Gut 2017 09 3;66(9):1539-1540. Epub 2017 Feb 3.

Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1136/gutjnl-2016-313379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561367PMC
September 2017

Drug-induced Liver Injury: The Hepatic Pathologist's Approach.

Authors:
David E Kleiner

Gastroenterol Clin North Am 2017 06;46(2):273-296

Laboratory of Pathology, National Cancer Institute, 10 Center Drive, Building 10, Room 2S235, MSC 1500, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434713PMC
June 2017

On beyond staging and grading: Liver biopsy evaluation in a posttreatment world.

Authors:
David E Kleiner

Hepatology 2017 05 30;65(5):1432-1434. Epub 2017 Mar 30.

Post-mortem Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.29111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397352PMC
May 2017

Effects of Metreleptin in Pediatric Patients With Lipodystrophy.

J Clin Endocrinol Metab 2017 05;102(5):1511-1519

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1210/jc.2016-3628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443330PMC
May 2017

National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Subsequent Neoplasms Working Group Report.

Biol Blood Marrow Transplant 2017 Mar 12;23(3):367-378. Epub 2016 Sep 12.

National Marrow Donor Program/Be The Match and Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.bbmt.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285307PMC
March 2017

Vemurafenib-induced granulomatous hepatitis.

Hepatology 2017 02 26;65(2):745-748. Epub 2016 Jul 26.

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1002/hep.28692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182184PMC
February 2017

A Wolf in Sheep's Clothing in the Era of Non-Invasive Staging: Non-Hodgkin's Lymphoma Masquerading as Serologic HCV Cirrhosis.

Am J Gastroenterol 2017 Feb;112(2):398-399

Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ajg.2016.550DOI Listing
February 2017

The Role of the Hepatopathologist in the Assessment of Drug-induced Liver Injury.

Authors:
David E Kleiner

Clin Liver Dis (Hoboken) 2017 Feb 1;9(2):34-37. Epub 2017 Mar 1.

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http://dx.doi.org/10.1002/cld.612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604852PMC
February 2017

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury.

Clin Gastroenterol Hepatol 2017 01 14;15(1):103-112.e2. Epub 2016 Jun 14.

Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370577PMC
January 2017

Azathioprine and 6-Mercaptopurine-induced Liver Injury: Clinical Features and Outcomes.

J Clin Gastroenterol 2017 01;51(1):63-69

*Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institutes of Health, Bethesda, MD †The Faculty of Medicine, University of Iceland ‡National University Hospital of Iceland, Reykjavik, Iceland §Duke Clinical Research Institute, Durham, NC ∥Laboratory of Pathology, National Cancer Institute, National Institutes of Health ¶Indiana University School of Medicine, Indianapolis, IN #University of North Carolina, Chapel Hill, NC.

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http://dx.doi.org/10.1097/MCG.0000000000000568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505863PMC
January 2017

The histopathological evaluation of drug-induced liver injury.

Authors:
David E Kleiner

Histopathology 2017 Jan;70(1):81-93

Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/his.13082DOI Listing
January 2017

Reply.

Clin Gastroenterol Hepatol 2016 12 19;14(12):1845-1846. Epub 2016 Aug 19.

Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.cgh.2016.08.011DOI Listing
December 2016

Erratum to: Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series.

Dig Dis Sci 2016 12;61(12):3638

Department of Internal Medicine, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI, 48109-0362, USA.

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http://dx.doi.org/10.1007/s10620-016-4290-3DOI Listing
December 2016

Ataxia telangiectasia associated with nodular regenerative hyperplasia.

J Clin Immunol 2016 11 26;36(8):739-742. Epub 2016 Sep 26.

Primary Immunodeficiency Clinic, NIAID, NIH, Building 10, Room 2C410, 10 Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s10875-016-0334-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097878PMC
November 2016

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology.

J Transl Med 2016 11 28;14(1):328. Epub 2016 Nov 28.

Laboratory of Infectious Diseases, Hepatic Pathogenesis Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s12967-016-1085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125040PMC
November 2016

Association between metabolic syndrome and liver histology among NAFLD patients without diabetes.

BMJ Open Gastroenterol 2016 9;3(1):e000114. Epub 2016 Nov 9.

Benaroya Research Institute, Seattle, Washington, USA; Swedish Medical Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1136/bmjgast-2016-000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128831PMC
November 2016

Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series.

Dig Dis Sci 2016 09 3;61(9):2741-8. Epub 2016 May 3.

Department of Internal Medicine, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI, 48109-0362, USA.

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http://dx.doi.org/10.1007/s10620-016-4181-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982804PMC
September 2016

Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Metabolism 2016 08 2;65(8):1080-6. Epub 2015 Dec 2.

Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2015.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889547PMC
August 2016

Amoxicillin-Clavulanate-Induced Liver Injury.

Dig Dis Sci 2016 08 22;61(8):2406-2416. Epub 2016 Mar 22.

Department of Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.

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http://dx.doi.org/10.1007/s10620-016-4121-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945382PMC
August 2016

Utilization of HPASubC for the Identification of Sinusoid-Specific Proteins in the Liver.

J Proteome Res 2016 05 29;15(5):1623-9. Epub 2016 Mar 29.

Department of Pathology, Johns Hopkins University School of Medicine , 720 Rutland Avenue, Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00073DOI Listing
May 2016

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children.

Clin Liver Dis 2016 May 28;20(2):293-312. Epub 2015 Dec 28.

Cancer Diagnosis Program, Pathology Investigation and Resources Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Drive, Room 4W438, Bethesda, MD 20892, USA; Department of Pathology, Ain Shams University, Faculty of Medicine, 38 Al Abbassyah, Cairo, Greater Cairo 11566, Egypt.

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http://dx.doi.org/10.1016/j.cld.2015.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829204PMC
May 2016

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Nature 2016 Mar 2;531(7593):253-7. Epub 2016 Mar 2.

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature16969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786464PMC
March 2016

Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1375-80. Epub 2016 Jan 19.

Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1516879113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747736PMC
February 2016