David E Kaplan

David E Kaplan

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David E Kaplan

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Incidence and Mortality of Acute-on-Chronic Liver Failure Using Two Definitions in Patients with Compensated Cirrhosis.

Hepatology 2019 May 20;69(5):2150-2163. Epub 2019 Mar 20.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://doi.wiley.com/10.1002/hep.30494
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http://dx.doi.org/10.1002/hep.30494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461492PMC
May 2019

Utility of bevacizumab in advanced hepatocellular carcinoma: A veterans affairs experience.

Cancer Med 2019 Apr 20;8(4):1442-1446. Epub 2019 Feb 20.

Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/cam4.2015DOI Listing
April 2019

Multidisciplinary Approach to HCC Management: How Can This Be Done?

Dig Dis Sci 2019 Apr;64(4):968-975

Department of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, 7th Floor, 3400 Civic Center Drive, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s10620-019-05593-8DOI Listing
April 2019

A Psoriasiform Drug Eruption Secondary to Nivolumab for Hepatocellular Carcinoma: a Case Report.

Hepatology 2019 Apr 20. Epub 2019 Apr 20.

Corporal Michael J Crescenz VA Medical Center, Pathology, 3900 Woodland Avenue, Philadelphia, Pennsylvania, United States.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30659
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http://dx.doi.org/10.1002/hep.30659DOI Listing
April 2019

Aspirin Use and Risk of Hepatocellular Carcinoma in Hepatitis B.

JAMA Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Division of Gastroenterology, School of Medicine, University of Pennsylvania Philadelphia.

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http://dx.doi.org/10.1001/jamainternmed.2018.8314DOI Listing
March 2019

The Use of Statins in Patients With Cirrhosis.

Authors:
David E Kaplan

Gastroenterol Hepatol (N Y) 2018 Aug;14(8):485-487

Associate Professor of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170890PMC
August 2018

Cost/Benefit of Hepatitis C Treatment: It Does Not End with SVR.

Authors:
David E Kaplan

Dig Dis Sci 2018 06;63(6):1376-1377

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, PCAM 7th Floor, 3400 Civic Center Drive, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s10620-018-5014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955839PMC
June 2018

Transarterial Chemoembolization within First 3 Months of Sorafenib Initiation Improves Overall Survival in Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study with Propensity Matching.

J Vasc Interv Radiol 2018 04 22;29(4):540-549.e4. Epub 2018 Feb 22.

Yale University School of Medicine, New Haven, Connecticut; VA Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1016/j.jvir.2017.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104514PMC
April 2018

Enhanced B-cell differentiation driven by advanced cirrhosis resulting in hyperglobulinemia.

J Gastroenterol Hepatol 2018 Feb 10. Epub 2018 Feb 10.

Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.

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http://dx.doi.org/10.1111/jgh.14123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107433PMC
February 2018

Identifying Patient and Provider-specific Gaps in Care Among Patients With Hepatitis B.

J Clin Gastroenterol 2017 Nov/Dec;51(10):900-906

*Division of Gastroenterology/Liver Transplant, University of California San Francisco, San Francisco, CA †Sidney Kimmel Medical College, Thomas Jefferson University ‡Gastroenterology Section, Corporal Michael J. Crescenz VA Medical Center §Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/MCG.0000000000000806DOI Listing
January 2018

T-bet-expressing B cells during HIV and HCV infections.

Cell Immunol 2017 Nov 11;321:26-34. Epub 2017 Jul 11.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2017.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732046PMC
November 2017

Starting Dose of Sorafenib for the Treatment of Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study.

J Clin Oncol 2017 Nov 5;35(31):3575-3581. Epub 2017 Sep 5.

Kim A. Reiss, Shun Yu, Ronac Mamtani, E. Paul Wileyto, and David E. Kaplan, University of Pennsylvania Perelman School of Medicine; David E. Kaplan, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA; Rajni Mehta, Kathryn D'Addeo, and Tamar H. Taddei, Yale University School of Medicine, New Haven; and Tamar H. Taddei, VA Connecticut Healthcare System, West Haven, CT.

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http://dx.doi.org/10.1200/JCO.2017.73.8245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662845PMC
November 2017

Comparing Child-Pugh, MELD, and FIB-4 to Predict Clinical Outcomes in Hepatitis C Virus-Infected Persons: Results From ERCHIVES.

Clin Infect Dis 2017 Jul;65(1):64-72

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/cid/cix224DOI Listing
July 2017

Persistence of exhaustion in cured hep C.

Authors:
David E Kaplan

Blood 2017 07;130(1)

UNIVERSITY OF PENNSYLVANIA; CORPORAL MICHAEL J. CRESCENZ VA MEDICAL CENTER.

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http://dx.doi.org/10.1182/blood-2017-05-786368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501153PMC
July 2017

Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality.

Gastroenterology 2017 06 7;152(8):1954-1964. Epub 2017 Mar 7.

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania; Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664153PMC
June 2017

Strategies to Improve Hepatocellular Carcinoma Surveillance in Veterans With Hepatitis B Infection.

Fed Pract 2017 Jun;34(Suppl 4):S30-S39

is an infectious disease physician at the Nationwide Children's Hospital and assistant professor of pediatrics at the Ohio State University College of Medicine in Columbus, Ohio. is a medical student at the St. Louis University School of Medicine in Missouri. is assistant professor of clinical medicine, is associate professor of medicine, is assistant professor of medicine, and is associate professor of clinical medicine, all at Perelman School of Medicine in Philadelphia, Pennsylvania. is assistant professor of medicine and assistant professor of epidemiology in biostatistics and epidemiology at Penn Medicine in Philadelphia. Dr. Chang is associate chief of staff for research and associate dean for research, Dr. Kaplan is assistant professor of medicine, and Dr. Amorosa is an attending physician, all at the Corporal Michael J. Crescenz VAMC in Philadelphia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375474PMC
June 2017

Prediction of Mortality in Chronic Liver Disease Using Non-hepatic Comorbidities: No SI of Relief as Yet.

Authors:
David E Kaplan

Dig Dis Sci 2017 01;62(1):1-3

Division of Gastroenterology, Perelman University of Pennsylvania School of Medicine, 914 BRB, 421 Curie Blvd., Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s10620-016-4378-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216086PMC
January 2017

Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis.

Sci Rep 2016 11 18;6:36862. Epub 2016 Nov 18.

Medicine and Research Services, Corporal Michael J. Crescenz VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.

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http://www.nature.com/articles/srep36862
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http://dx.doi.org/10.1038/srep36862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114671PMC
November 2016

Care delivery and outcomes among US veterans with hepatitis B: A national cohort study.

Hepatology 2016 06 25;63(6):1774-82. Epub 2016 Feb 25.

Gastroenterology Section, Philadelphia VA Medical Center, Philadelphia, PA.

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http://dx.doi.org/10.1002/hep.28340DOI Listing
June 2016

CD14(+) regulatory dendritic cells in patients with hepatocellular carcinoma and cirrhosis.

Hepatology 2016 Apr 19;63(4):1391-2. Epub 2016 Feb 19.

Medicine and Research Services, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.

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http://dx.doi.org/10.1002/hep.28419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805440PMC
April 2016

Immunopathogenesis of Hepatitis C Virus Infection.

Authors:
David E Kaplan

Gastroenterol Clin North Am 2015 Dec 13;44(4):735-60. Epub 2015 Aug 13.

Medicine and Research Services, Corporal Michael J. Crescenz VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA; Division of Gastroenterology, Department of Medicine, University of Pennsylvania, BRB II/III, 9th Floor, 415 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2015.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660249PMC
December 2015

Cosmological Relaxation of the Electroweak Scale.

Phys Rev Lett 2015 Nov 23;115(22):221801. Epub 2015 Nov 23.

Berkeley Center for Theoretical Physics, Department of Physics, University of California, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1103/PhysRevLett.115.221801DOI Listing
November 2015

Delta hepatitis within the Veterans Affairs medical system in the United States: Prevalence, risk factors, and outcomes.

J Hepatol 2015 Sep 8;63(3):586-92. Epub 2015 May 8.

Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, United States; Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574953PMC
September 2015

Monocyte-derived dendritic cells from cirrhotic patients retain similar capacity for maturation/activation and antigen presentation as those from healthy subjects.

Cell Immunol 2015 May 25;295(1):36-45. Epub 2015 Feb 25.

Medicine and Research Services, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA; Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 914 BRB, 421 Curie Blvd., Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2015.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405471PMC
May 2015

Does Massive Antigen Burden Allow Hepatic Viruses to Induce Regulatory T Cells and Their Tolerance and Persistence?

Authors:
David E Kaplan

Cell Mol Gastroenterol Hepatol 2015 May 16;1(3):259-261. Epub 2015 Apr 16.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jcmgh.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301269PMC
May 2015

Distinct features in natural history and outcomes of acute hepatitis C.

J Clin Gastroenterol 2015 Apr;49(4):e31-40

*Department of Medicine, University of Pennsylvania ‡Department of Medicine, Division of Gastroenterology and Hepatology, Philadelphia VA Medical Center §Pennsylvania Hospital, Philadelphia, PA †Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand ∥VA New York Harbor Healthcare System, Brooklyn, NY.

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http://dx.doi.org/10.1097/MCG.0000000000000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112167PMC
April 2015

Prevalence and risk factors for patient-reported joint pain among patients with HIV/hepatitis C coinfection, hepatitis C monoinfection, and HIV monoinfection.

BMC Musculoskelet Disord 2015 Apr 19;16:93. Epub 2015 Apr 19.

Department of Medicine, Division of Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/s12891-015-0552-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404567PMC
April 2015

Liver transplants among US veterans--reply.

JAMA 2014 Jul 23-30;312(4):437

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jama.2014.7158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584394PMC
August 2014

Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival among US veterans.

JAMA 2014 Mar;311(12):1234-43

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia9Gastroenterology Section, Philadelphia VA Medical Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1001/jama.2014.2520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586113PMC
March 2014

Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis.

Clin Immunol 2014 Feb 17;150(2):184-91. Epub 2013 Dec 17.

Medicine and Research Services, Philadelphia VA Medical Center, Philadelphia, PA, USA; Division of Gastroenterology, Department of Medicine, University of Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580910PMC
February 2014

Evaluation of the significance of pretreatment liver biopsy and baseline mental health disorder diagnosis on hepatitis C treatment completion rates at a veterans affairs medical center.

Hepat Res Treat 2013 16;2013:653976. Epub 2013 May 16.

Department of Pharmacy, Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA ; Department of Pharmacy, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1155/2013/653976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670541PMC
June 2013

Adherence to hepatitis C virus therapy in HIV/hepatitis C-coinfected patients.

AIDS Behav 2013 Jan;17(1):94-103

Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s10461-012-0288-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514597PMC
January 2013

Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized C Magnetic Resonance Spectroscopy.

J Liver Disease Transplant 2012 Sep;1(1)

Departments of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.4172/2325-9612.1000101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820166PMC
September 2012

Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library.

BMC Biotechnol 2012 May 7;12:23. Epub 2012 May 7.

Medicine and Research Services, Philadelphia VA Medical Center, PA 19104, USA.

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http://dx.doi.org/10.1186/1472-6750-12-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425314PMC
May 2012

Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.

Hepatology 2012 Mar 19;55(3):709-19. Epub 2012 Jan 19.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/hep.24689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245804PMC
March 2012

Short hairpin RNA-mediated silencing of bovine rotavirus NSP4 gene prevents diarrhoea in suckling mice.

J Gen Virol 2011 Apr 9;92(Pt 4):945-51. Epub 2010 Dec 9.

Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, PR China.

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http://dx.doi.org/10.1099/vir.0.027680-0DOI Listing
April 2011

Homeostasis of peripheral FoxP3(+) CD4 (+) regulatory T cells in patients with early and late stage breast cancer.

Cancer Immunol Immunother 2010 Apr 24;59(4):599-607. Epub 2009 Oct 24.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 551 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00262-009-0780-xDOI Listing
April 2010

Do statins reduce hepatitis C RNA titers during routine clinical use?

World J Gastroenterol 2009 Oct;15(40):5020-7

Research Section, Philadelphia Veterans Administration Medical Center, Research A402A, 3900 Woodland Avenue, Philadelphia, PA 19104, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768880PMC
http://dx.doi.org/10.3748/wjg.15.5020DOI Listing
October 2009

Top tagging: a method for identifying boosted hadronically decaying top quarks.

Phys Rev Lett 2008 Oct 2;101(14):142001. Epub 2008 Oct 2.

Department of Physics, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1103/PhysRevLett.101.142001DOI Listing
October 2008

Hepatitis C virus. Preface.

Clin Liver Dis 2008 Aug;12(3):xiii-xiv

Department of Hepatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cld.2008.03.014DOI Listing
August 2008

Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans.

Hepatology 2008 Jul;48(1):70-9

Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19014, USA.

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http://dx.doi.org/10.1002/hep.22287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749605PMC
July 2008

Constraining light colored particles with event shapes.

Phys Rev Lett 2008 Jul 11;101(2):022002. Epub 2008 Jul 11.

Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1103/PhysRevLett.101.022002DOI Listing
July 2008

Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.

Gastroenterology 2008 Jun 17;134(7):1927-37, 1937.e1-2. Epub 2008 Feb 17.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665722PMC
June 2008

Six-quark decays of the Higgs boson in supersymmetry with R-parity violation.

Phys Rev Lett 2007 Nov 20;99(21):211801. Epub 2007 Nov 20.

Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1103/PhysRevLett.99.211801DOI Listing
November 2007

How they do it better. More stressed, but still safer.

Authors:
David E Kaplan

US News World Rep 2007 Mar 26-Apr 2;142(11):66

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May 2007

A smokin' old time in Tehran.

Authors:
David E Kaplan

US News World Rep 2007 Mar;142(10):34

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March 2007

Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.

Gastroenterology 2007 Feb 29;132(2):654-66. Epub 2006 Nov 29.

Gastroenterology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

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http://dx.doi.org/10.1053/j.gastro.2006.11.044DOI Listing
February 2007

Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection.

J Virol 2005 Jun;79(11):6976-83

Department of Medicine, GI Division, University of Pennsylvania, and Philadelphia VAMC, A212 Medical Research, PVAMC, University and Woodland Avenues, Philadelphia, PA 19104, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.79.11.6976-6983.2005
Publisher Site
http://dx.doi.org/10.1128/JVI.79.11.6976-6983.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112102PMC
June 2005

T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C.

Hepatology 2005 Jun;41(6):1365-75

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA.

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http://dx.doi.org/10.1002/hep.20706DOI Listing
June 2005

Rising incidence of hepatocellular carcinoma: the role of hepatitis B and C; the impact on transplantation and outcomes.

Clin Liver Dis 2003 Aug;7(3):683-714

Division of Gastroenterology and Hepatology, University of Pennsylvania School of Medicine, 3 Raydin, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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August 2003